Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Alcohol dehydrogenase | Starlite/ChEMBL | References |
Homo sapiens | alcohol dehydrogenase 1B (class I), beta polypeptide | Starlite/ChEMBL | References |
Homo sapiens | alcohol dehydrogenase 1C (class I), gamma polypeptide | Starlite/ChEMBL | References |
Homo sapiens | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0886 | 0.1848 | 0.1747 | |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Schistosoma mansoni | notch | 0.0886 | 0.1848 | 0.1747 |
Onchocerca volvulus | 0.3771 | 1 | 1 | |
Schistosoma mansoni | notch | 0.0886 | 0.1848 | 0.1747 |
Loa Loa (eye worm) | animal heme peroxidase | 0.3771 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Loa Loa (eye worm) | animal heme peroxidase | 0.3771 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3771 | 1 | 1 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0886 | 0.1848 | 0.1747 |
Loa Loa (eye worm) | Notch2 | 0.0886 | 0.1848 | 0.1747 |
Brugia malayi | notch-like transmembrane receptor | 0.0886 | 0.1848 | 0.1747 |
Brugia malayi | Animal haem peroxidase family protein | 0.3771 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.3771 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Brugia malayi | EGF-like domain containing protein | 0.0886 | 0.1848 | 0.1747 |
Brugia malayi | Animal haem peroxidase family protein | 0.3771 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Schistosoma mansoni | notch | 0.0886 | 0.1848 | 0.1747 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.3771 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.3771 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3771 | 1 | 1 |
Onchocerca volvulus | 0.3771 | 1 | 1 | |
Schistosoma mansoni | laminin gamma-3 chain | 0.0886 | 0.1848 | 0.1747 |
Loa Loa (eye worm) | hypothetical protein | 0.3771 | 1 | 1 |
Onchocerca volvulus | Putative cubilin | 0.0886 | 0.1848 | 0.1747 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0886 | 0.1848 | 0.1747 |
Onchocerca volvulus | 0.0886 | 0.1848 | 0.1747 | |
Brugia malayi | Muscle positioning protein 4 | 0.0886 | 0.1848 | 0.1747 |
Loa Loa (eye worm) | animal heme peroxidase | 0.3771 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Schistosoma mansoni | slit | 0.0886 | 0.1848 | 0.1747 |
Loa Loa (eye worm) | hypothetical protein | 0.3771 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Schistosoma mansoni | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Onchocerca volvulus | Peroxidase homolog | 0.3771 | 1 | 1 |
Onchocerca volvulus | 0.0886 | 0.1848 | 0.1747 | |
Loa Loa (eye worm) | notch protein | 0.0886 | 0.1848 | 0.1747 |
Brugia malayi | Cadherin domain containing protein | 0.0886 | 0.1848 | 0.1747 |
Mycobacterium leprae | Probable S-nitrosomycothiol reductase MscR | 0.0276 | 0.0122 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.3771 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3771 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) | 0.0276 | 0.0122 | 1 |
Onchocerca volvulus | 0.3771 | 1 | 1 | |
Schistosoma mansoni | septate junction protein | 0.0886 | 0.1848 | 0.1747 |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Schistosoma mansoni | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Schistosoma mansoni | notch | 0.0886 | 0.1848 | 0.1747 |
Loa Loa (eye worm) | hypothetical protein | 0.3771 | 1 | 1 |
Onchocerca volvulus | 0.0886 | 0.1848 | 0.1747 | |
Loa Loa (eye worm) | hypothetical protein | 0.3771 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Schistosoma mansoni | peroxidasin | 0.3771 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Onchocerca volvulus | Peroxidasin homolog | 0.3771 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.3771 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.3771 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Brugia malayi | EGF-like domain containing protein | 0.0886 | 0.1848 | 0.1747 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase | 0.0276 | 0.0122 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0886 | 0.1848 | 0.1747 |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Schistosoma mansoni | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase AdhE2 | 0.0276 | 0.0122 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Onchocerca volvulus | Dual oxidase homolog | 0.3771 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3771 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Brugia malayi | EGF-like domain containing protein | 0.0886 | 0.1848 | 0.1747 |
Schistosoma mansoni | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0276 | 0.0122 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.3771 | 1 | 1 |
Schistosoma mansoni | notch | 0.0886 | 0.1848 | 0.1747 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0886 | 0.1848 | 0.1747 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0886 | 0.1848 | 0.1747 |
Onchocerca volvulus | Slit protein homolog | 0.0886 | 0.1848 | 0.1747 |
Brugia malayi | Delta serrate ligand family protein | 0.0886 | 0.1848 | 0.1747 |
Onchocerca volvulus | 0.0886 | 0.1848 | 0.1747 | |
Loa Loa (eye worm) | hypothetical protein | 0.3771 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0886 | 0.1848 | 0.1747 |
Brugia malayi | EGF-like domain containing protein | 0.0886 | 0.1848 | 0.1747 |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Loa Loa (eye worm) | hypothetical protein | 0.3771 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3771 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Schistosoma mansoni | notch | 0.0886 | 0.1848 | 0.1747 |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Onchocerca volvulus | Peroxidase homolog | 0.3771 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Giardia lamblia | High cysteine protein | 0.0886 | 0.1848 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.3771 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.3771 | 1 | 1 |
Mycobacterium ulcerans | zinc-type alcohol dehydrogenase AdhD | 0.0276 | 0.0122 | 0.5 |
Brugia malayi | Cadherin domain containing protein | 0.0886 | 0.1848 | 0.1747 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0886 | 0.1848 | 0.1747 |
Brugia malayi | Blistered cuticle protein 3 | 0.3771 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.3771 | 1 | 1 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD-dependent AdhB | 0.0276 | 0.0122 | 0.5 |
Brugia malayi | EGF-like domain containing protein | 0.0886 | 0.1848 | 0.1747 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0886 | 0.1848 | 0.1747 |
Brugia malayi | Peroxidasin | 0.3771 | 1 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0886 | 0.1848 | 0.1747 |
Schistosoma mansoni | cell polarity protein | 0.0886 | 0.1848 | 0.1747 |
Loa Loa (eye worm) | hypothetical protein | 0.3771 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Brugia malayi | EGF-like domain containing protein | 0.0886 | 0.1848 | 0.1747 |
Loa Loa (eye worm) | hypothetical protein | 0.3771 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3771 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0886 | 0.1848 | 0.1747 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0886 | 0.1848 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.52 | Inhibitory activity against horse liver alcohol dehydrogenase (ADH) | ChEMBL. | 2939242 |
Ki (binding) | = 0.33 uM | Inhibition of human alcohol dehydrogenase beta 1 activity | ChEMBL. | 9572895 |
Ki (binding) | = 0.33 uM | Inhibition of human alcohol dehydrogenase beta 1 activity | ChEMBL. | 9572895 |
Ki (binding) | = 0.74 uM | Inhibition of horse liver alcohol dehydrogenase activity | ChEMBL. | 9572895 |
Ki (binding) | = 0.74 uM | Inhibition of horse liver alcohol dehydrogenase activity | ChEMBL. | 9572895 |
Ki (binding) | = 4.9 uM | Inhibition of human alcohol dehydrogenase gamma2 activity | ChEMBL. | 9572895 |
Ki (binding) | = 4.9 uM | Inhibition of human alcohol dehydrogenase gamma2 activity | ChEMBL. | 9572895 |
Ki (binding) | = 11 uM | Inhibition of human alcohol dehydrogenase sigma activity | ChEMBL. | 9572895 |
Ki (binding) | = 11 uM | Inhibition of human alcohol dehydrogenase sigma activity | ChEMBL. | 9572895 |
Ki (binding) | = 31 uM | Inhibition of human alcohol dehydrogenase alpha activity | ChEMBL. | 9572895 |
Ki (binding) | = 31 uM | Inhibition of human alcohol dehydrogenase alpha activity | ChEMBL. | 9572895 |
Ki (binding) | = 110 uM | Inhibition of human alcohol dehydrogenase pi activity | ChEMBL. | 9572895 |
Ki (binding) | = 110 uM | Inhibition of human alcohol dehydrogenase pi activity | ChEMBL. | 9572895 |
Log 1/Ki (binding) | = 5.52 | Inhibitory activity against horse liver alcohol dehydrogenase (ADH) | ChEMBL. | 2939242 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.