Detailed information for compound 697123

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 401.229 | Formula: C19H14BrFN2O2
  • H donors: 1 H acceptors: 2 LogP: 3.23 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)Cn1cc(ccc1=O)C(=O)Nc1cccc(c1)Br
  • InChi: 1S/C19H14BrFN2O2/c20-15-2-1-3-17(10-15)22-19(25)14-6-9-18(24)23(12-14)11-13-4-7-16(21)8-5-13/h1-10,12H,11H2,(H,22,25)
  • InChiKey: IMYDARWKYLUMCT-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0063 0.0415 0.1185
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0226 0.1662
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0046
Echinococcus multilocularis PHD finger protein rhinoceros 0.0017 0.0068 0.0194
Onchocerca volvulus 0.0098 0.0686 0.4881
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0118 0.0173
Toxoplasma gondii PHD-finger domain-containing protein 0.0017 0.0068 0.1492
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0033 0.0187 0.0533
Loa Loa (eye worm) hypothetical protein 0.0028 0.0154 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0058 0.0377 0.8742
Loa Loa (eye worm) latrophilin receptor protein 2 0.042 0.3122 0.3122
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0014 0.0047 0.0069
Loa Loa (eye worm) hypothetical protein 0.003 0.0163 0.0163
Brugia malayi Pax transcription factor protein 2 0.0113 0.0796 0.0796
Echinococcus multilocularis lysine specific demethylase 5A 0.0021 0.0095 0.0271
Toxoplasma gondii FATC domain-containing protein 0.002 0.0087 0.1969
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0007
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0046 0.2031
Schistosoma mansoni smad1 5 8 and 0.0011 0.0024 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0413 0.3075 0.4511
Loa Loa (eye worm) glutathione reductase 0.0023 0.0112 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Echinococcus multilocularis short transient receptor potential channel 6 0.0057 0.0371 0.1058
Echinococcus granulosus lysosomal alpha glucosidase 0.017 0.123 0.394
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0226 0.0643
Echinococcus multilocularis jumonji domain containing protein 0.0024 0.0118 0.0337
Brugia malayi Transient-receptor-potential like protein 0.0033 0.0187 0.0187
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0063 0.0415 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0087 0.0087
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0118 0.0173
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0046 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.123 0.3508
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.042 0.3122 0.3122
Echinococcus granulosus mothers against decapentaplegic 5 0.0011 0.0024 0.0077
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0068
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0226 0.1662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0118 0.0173
Schistosoma mansoni P2X receptor subunit 0.0049 0.0309 0.0454
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0014 0.0047 0.0047
Loa Loa (eye worm) thioredoxin reductase 0.0023 0.0112 0.0112
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0014 0.0047 0.1133
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1327 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0052 0.0333 0.7293
Onchocerca volvulus Alhambra homolog 0.0017 0.0068 0.0168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0046 0.1103
Loa Loa (eye worm) phosphatidylinositol 3 0.0014 0.0047 0.0047
Loa Loa (eye worm) Smad1 0.0011 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0118 0.0833 0.0833
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0011 0.0024 0.0069
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0226 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Entamoeba histolytica hypothetical protein 0.002 0.0087 0.3874
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0194 0.1411 0.2069
Toxoplasma gondii target of rapamycin (TOR), putative 0.0014 0.0047 0.0982
Schistosoma mansoni hypothetical protein 0.0098 0.0685 0.1004
Echinococcus granulosus microsomal glutathione S transferase 3 0.0044 0.0276 0.0885
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0066 0.0441 0.1412
Plasmodium vivax aspartyl proteinase, putative 0.003 0.0163 0.2743
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Echinococcus granulosus peregrin 0.0017 0.0068 0.0217
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0145 0.0213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Echinococcus granulosus PHD finger protein rhinoceros 0.0017 0.0068 0.0217
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0046 0.0046
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0017 0.0068 0.01
Brugia malayi MH2 domain containing protein 0.0011 0.0024 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.002 0.0087 0.1969
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0052 0.0333 0.7293
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0052 0.0333 0.7293
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0009 0.0014
Echinococcus multilocularis smad 0.0011 0.0024 0.0069
Loa Loa (eye worm) hypothetical protein 0.042 0.3122 0.3122
Echinococcus granulosus muscleblind protein 0.0118 0.0833 0.2669
Loa Loa (eye worm) hypothetical protein 0.0085 0.0586 0.0586
Brugia malayi Pre-SET motif family protein 0.0164 0.1185 0.1185
Brugia malayi TAR-binding protein 0.0413 0.3075 0.3075
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0063 0.0415 0.061
Echinococcus multilocularis transient receptor potential gamma protein 0.0085 0.0586 0.1672
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0014 0.0047 0.0047
Leishmania major phosphatidylinositol kinase related protein, putative 0.0014 0.0047 0.004
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0046 0.0338
Brugia malayi Pre-SET motif family protein 0.0024 0.0118 0.0118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0066 0.0441 0.0647
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.042 0.3122 0.8904
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0145 0.0213
Brugia malayi MH1 domain containing protein 0.0011 0.0024 0.0024
Schistosoma mansoni jumonji domain containing protein 0.0044 0.0274 0.0402
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0066 0.0441 0.1257
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0046 0.0951
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0066 0.0441 0.0647
Echinococcus multilocularis voltage gated potassium channel 0.0009 0.0009 0.0027
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.047 0.3507 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0063 0.0415 1
Brugia malayi Bromodomain containing protein 0.0017 0.0068 0.0068
Echinococcus multilocularis tar DNA binding protein 0.0413 0.3075 0.8768
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Plasmodium falciparum glutathione reductase 0.0023 0.0112 0.1266
Schistosoma mansoni cathepsin D (A01 family) 0.0087 0.06 0.088
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0058 0.0377 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0046 0.0338
Plasmodium falciparum plasmepsin IV 0.003 0.0163 0.2743
Echinococcus granulosus TGF beta signal transducer SmadC 0.0011 0.0024 0.0077
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0063 0.0415 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0014 0.0047 0.0034
Echinococcus granulosus voltage gated potassium channel 0.0009 0.0009 0.003
Echinococcus multilocularis muscleblind protein 1 0.0118 0.0833 0.2376
Plasmodium falciparum plasmepsin I 0.003 0.0163 0.2743
Toxoplasma gondii PHD-finger domain-containing protein 0.0017 0.0068 0.1492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Giardia lamblia PHD finger protein 15 0.0017 0.0068 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.042 0.3122 1
Schistosoma mansoni tar DNA-binding protein 0.0413 0.3075 0.4511
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0226 0.1662
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0063 0.0415 0.1185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Brugia malayi MH2 domain containing protein 0.0165 0.1187 0.1187
Plasmodium vivax thioredoxin reductase, putative 0.0023 0.0112 0.1266
Mycobacterium tuberculosis Probable dehydrogenase 0.0052 0.0333 0.7293
Brugia malayi Glycosyl hydrolases family 31 protein 0.017 0.123 0.123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0226 0.1662
Brugia malayi Smad1 0.0011 0.0024 0.0024
Trypanosoma brucei trypanothione reductase 0.0023 0.0112 0.2569
Trypanosoma cruzi target of rapamycin kinase 3 0.0014 0.0047 0.1133
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0014 0.0047 0.1133
Brugia malayi latrophilin 2 splice variant baaae 0.0907 0.6817 0.6817
Trypanosoma brucei glucosidase, putative 0.0038 0.0226 0.5352
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0009 0.0014
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0014 0.0047 0.0982
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0014 0.0047 0.2086
Loa Loa (eye worm) PHD-finger family protein 0.0017 0.0068 0.0068
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0014 0.0047 0.0151
Loa Loa (eye worm) phosphatidylinositol 3 0.0014 0.0047 0.0047
Brugia malayi jmjC domain containing protein 0.0021 0.0095 0.0095
Brugia malayi jmjC domain containing protein 0.0056 0.0361 0.0361
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0046 0.1103
Echinococcus multilocularis muscleblind protein 0.0118 0.0833 0.2376
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0226 0.1662
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.042 0.3122 0.8904
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0046 0.0338
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0063 0.0415 1
Brugia malayi RNA recognition motif domain containing protein 0.0413 0.3075 0.3075
Leishmania major phosphatidylinositol 3-kinase, putative 0.0014 0.0047 0.0034
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0226 0.5352
Echinococcus granulosus transient receptor potential gamma protein 0.0085 0.0586 0.1878
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0066 0.0441 0.0441
Echinococcus granulosus lysine specific demethylase 5A 0.0021 0.0095 0.0304
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0044 0.0276 0.0788
Loa Loa (eye worm) hypothetical protein 0.0029 0.016 0.016
Toxoplasma gondii isocitrate dehydrogenase 0.0063 0.0415 1
Echinococcus granulosus geminin 0.0098 0.0685 0.2193
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0014 0.0047 0.0982
Toxoplasma gondii isocitrate dehydrogenase 0.0063 0.0415 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0025 0.013 0.013
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0046 0.0338
Loa Loa (eye worm) pax transcription factor protein 2 0.0113 0.0796 0.0796
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0087 0.0644
Loa Loa (eye worm) isocitrate dehydrogenase 0.0063 0.0415 0.0415
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.003 0.0163 0.0239
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0014 0.0047 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Loa Loa (eye worm) transcription factor SMAD2 0.0165 0.1187 0.1187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Schistosoma mansoni hypothetical protein 0.0017 0.0068 0.01
Loa Loa (eye worm) hypothetical protein 0.0024 0.0118 0.0118
Brugia malayi Latrophilin receptor protein 2 0.042 0.3122 0.3122
Schistosoma mansoni smad1 5 8 and 0.0011 0.0024 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0226 0.543
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0066 0.0441 0.1412
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0066 0.0441 0.0441
Plasmodium falciparum plasmepsin II 0.003 0.0163 0.2743
Schistosoma mansoni tar DNA-binding protein 0.0413 0.3075 0.4511
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0413 0.3075 0.3075
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0009 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0051
Echinococcus multilocularis transient receptor potential ion channel A 0.0081 0.0554 0.1579
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0024 0.0118 0.0336
Schistosoma mansoni tar DNA-binding protein 0.0413 0.3075 0.4511
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0014 0.0047 0.1133
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.003 0.0163 0.1203
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0009 0.0009 0.003
Brugia malayi Calcitonin receptor-like protein seb-1 0.1327 1 1
Echinococcus granulosus short transient receptor potential channel 6 0.0057 0.0371 0.1188
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0063 0.0415 1
Brugia malayi Isocitrate dehydrogenase 0.0063 0.0415 0.0415
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.0087 0.2104
Plasmodium falciparum thioredoxin reductase 0.0023 0.0112 0.1266
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0226 0.1662
Toxoplasma gondii MAPEG family protein 0.0044 0.0276 0.6594
Brugia malayi Thioredoxin reductase 0.0023 0.0112 0.0112
Plasmodium vivax glutathione reductase, putative 0.0023 0.0112 0.1266
Echinococcus multilocularis thioredoxin glutathione reductase 0.0023 0.0114 0.0326
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0023 0.0111 0.0356
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0226 0.1662
Loa Loa (eye worm) RNA binding protein 0.0413 0.3075 0.3075
Trypanosoma cruzi trypanothione reductase, putative 0.0023 0.0112 0.2694
Echinococcus granulosus GPCR family 2 0.042 0.3122 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0011 0.0024 0.0024
Echinococcus multilocularis geminin 0.0098 0.0685 0.1952
Echinococcus granulosus p2X purinoceptor 4 0.0049 0.0309 0.099
Schistosoma mansoni hypothetical protein 0.042 0.3122 0.4581
Schistosoma mansoni hypothetical protein 0.042 0.3122 0.4581
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0014 0.0047 0.0034
Echinococcus multilocularis mothers against decapentaplegic 5 0.0011 0.0024 0.0069
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0063 0.0415 1
Echinococcus granulosus short transient receptor potential channel 6 0.0057 0.0371 0.1188
Brugia malayi MH1 domain containing protein 0.0011 0.0024 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Onchocerca volvulus 0.0113 0.0796 0.5718
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.003 0.0163 0.3826
Brugia malayi isocitrate dehydrogenase 0.0063 0.0415 0.0415
Echinococcus multilocularis isocitrate dehydrogenase 0.0063 0.0415 0.1185
Leishmania major trypanothione reductase 0.0023 0.0112 0.1788
Mycobacterium tuberculosis Probable reductase 0.0052 0.0333 0.7293
Loa Loa (eye worm) hypothetical protein 0.1327 1 1
Echinococcus multilocularis p2X purinoceptor 4 0.0049 0.0309 0.0882
Loa Loa (eye worm) hypothetical protein 0.0017 0.0067 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0007 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0226 0.543
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0014 0.0047 0.0982
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0025 0.013 0.0369
Echinococcus granulosus thioredoxin glutathione reductase 0.0023 0.0114 0.0366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0014 0.0047 0.0034
Schistosoma mansoni alpha glucosidase 0.0038 0.0226 0.0331
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0063 0.0415 1
Echinococcus granulosus tar DNA binding protein 0.0413 0.3075 0.9848
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0056 0.0361 0.1029
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.003 0.0163 0.0466
Brugia malayi glutathione reductase 0.0023 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0907 0.6817 0.6817
Toxoplasma gondii aspartyl protease ASP1 0.003 0.0163 0.3826
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0164 0.1185 0.1185
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0014 0.0047 0.1133
Schistosoma mansoni smad1 5 8 and 0.0011 0.0024 0.0035
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.002 0.0087 0.0128
Schistosoma mansoni smad 0.0011 0.0024 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Echinococcus multilocularis serine protein kinase ATM 0.002 0.0087 0.0249
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0063 0.0415 0.1331
Schistosoma mansoni P2X receptor subunit 0.0049 0.0309 0.0454
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.0118 0.0173
Loa Loa (eye worm) hypothetical protein 0.0033 0.0187 0.0187
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0056 0.0361 0.1156
Plasmodium vivax SET domain protein, putative 0.0024 0.0118 0.1436
Schistosoma mansoni transient receptor potential channel 4 0.0085 0.0586 0.086
Toxoplasma gondii thioredoxin reductase 0.0023 0.0112 0.2569
Echinococcus multilocularis Smad4 0.0011 0.0024 0.0069
Schistosoma mansoni hypothetical protein 0.042 0.3122 0.4581
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0014 0.0047 0.0069
Echinococcus multilocularis GPCR, family 2 0.042 0.3122 0.8904
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0014 0.0047 0.0034
Loa Loa (eye worm) hypothetical protein 0.0022 0.0107 0.0107
Schistosoma mansoni jumonji/arid domain-containing protein 0.0021 0.0095 0.0139
Echinococcus granulosus smad 0.0011 0.0024 0.0077
Brugia malayi PHD-finger family protein 0.0017 0.0068 0.0068
Schistosoma mansoni hypothetical protein 0.0098 0.0685 0.1004
Echinococcus granulosus TRP transient receptor potential channel 0.0033 0.0187 0.0598
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0046 0.0338
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.0053 0.0339 0.0339
Echinococcus multilocularis short transient receptor potential channel 6 0.0057 0.0371 0.1058
Brugia malayi Muscleblind-like protein 0.0118 0.0833 0.0833
Schistosoma mansoni P2X receptor subunit 0.0049 0.0309 0.0454
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.123 0.3508
Plasmodium falciparum plasmepsin VI 0.003 0.0163 0.2743
Echinococcus granulosus transient receptor potential ion channel A 0.0081 0.0554 0.1774
Echinococcus multilocularis p2X purinoceptor 4 0.0049 0.0309 0.0882
Loa Loa (eye worm) TAR-binding protein 0.0413 0.3075 0.3075
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0014 0.0047 0.0982
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0014 0.0047 0.1138
Brugia malayi RNA binding protein 0.0413 0.3075 0.3075
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0226 0.1662
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0066 0.0441 0.1257
Mycobacterium tuberculosis Probable oxidoreductase 0.0058 0.0377 0.8742
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.042 0.3122 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0052 0.0333 0.7293
Plasmodium vivax plasmepsin IV, putative 0.003 0.0163 0.2743
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0226 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0014 0.0047 0.0134
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0024 0.0118 0.0336
Schistosoma mansoni microsomal glutathione s-transferase 0.0044 0.0276 0.0405
Echinococcus granulosus Smad4 0.0011 0.0024 0.0077
Schistosoma mansoni transient receptor potential channel 0.0057 0.0371 0.0544
Schistosoma mansoni transient receptor potential channel 0.0057 0.0371 0.0544
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0063 0.0415 0.1185
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0095 0.0095
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0097 0.0716
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0025 0.013 0.0415
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.003 0.0163 0.0523
Echinococcus multilocularis peregrin 0.0017 0.0068 0.0194
Loa Loa (eye worm) MH2 domain-containing protein 0.0165 0.1187 0.1187
Schistosoma mansoni jumonji/arid domain-containing protein 0.0021 0.0095 0.0139
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0097 0.0716
Brugia malayi MH2 domain containing protein 0.0011 0.0024 0.0024
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0063 0.0415 0.1185
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0014 0.0047 0.2086
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0024 0.0118 0.2714
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0226 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Loa Loa (eye worm) MH2 domain-containing protein 0.0011 0.0024 0.0024
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0014 0.0047 0.0982
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0017 0.0067 0.1604
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0014 0.0047 0.0134
Echinococcus granulosus p2X purinoceptor 4 0.0049 0.0309 0.099
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0058 0.0377 0.8742
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.017 0.123 0.123
Schistosoma mansoni alpha-glucosidase 0.0147 0.105 0.1541
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0063 0.0415 1
Echinococcus multilocularis p2X purinoceptor 4 0.0049 0.0309 0.0882
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0011 0.0024 0.0035
Loa Loa (eye worm) hypothetical protein 0.0118 0.0833 0.0833
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Schistosoma mansoni tar DNA-binding protein 0.0413 0.3075 0.4511
Schistosoma mansoni Smad4 0.0011 0.0024 0.0035
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0226 0.1662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Schistosoma mansoni cathepsin D (A01 family) 0.0087 0.06 0.088
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0009 0.0009 0.0027
Schistosoma mansoni P2X receptor subunit 0.0049 0.0309 0.0454
Trichomonas vaginalis set domain proteins, putative 0.0187 0.1357 1
Onchocerca volvulus 0.0024 0.0118 0.0549
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0226 0.0723
Schistosoma mansoni hypothetical protein 0.042 0.3122 0.4581
Echinococcus granulosus jumonji domain containing protein 0.0024 0.0118 0.0379
Schistosoma mansoni transient receptor potential channel 0.0085 0.0586 0.086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0047 0.0347
Loa Loa (eye worm) aspartic protease BmAsp-2 0.003 0.0163 0.0163
Schistosoma mansoni alpha-glucosidase 0.0147 0.105 0.1541
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0025 0.013 0.013
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0226 0.4864
Echinococcus granulosus histone lysine methyltransferase setb 0.0024 0.0118 0.0377
Echinococcus granulosus serine protein kinase ATM 0.002 0.0087 0.028
Schistosoma mansoni hypothetical protein 0.0907 0.6817 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0066 0.0441 0.0647
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0205 0.0205
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0046 0.0338
Echinococcus granulosus p2X purinoceptor 4 0.0049 0.0309 0.099
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0046 0.0338
Onchocerca volvulus 0.0187 0.1357 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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