Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0466 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0551 | 0.0551 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0551 | 0.0551 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0551 | 0.088 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0551 | 0.0551 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.0436 | 0.0436 |
Schistosoma mansoni | lamin | 0.003 | 0.0436 | 0.0436 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.0466 | 1 |
Onchocerca volvulus | 0.0246 | 0.803 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0868 | 0.1215 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.005 | 0.1123 | 0.1123 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0367 | 0.0505 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0101 | 0.2913 | 0.4652 |
Brugia malayi | PHD-finger family protein | 0.0026 | 0.0288 | 0.0391 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0079 | 0.2158 | 0.2158 |
Brugia malayi | RNA binding protein | 0.014 | 0.429 | 0.6138 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1123 | 0.1582 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.014 | 0.429 | 0.6134 |
Onchocerca volvulus | 0.005 | 0.1123 | 0.0904 | |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.0551 | 0.0769 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.0551 | 0.0759 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.1563 | 0.2495 |
Brugia malayi | Bromodomain containing protein | 0.0078 | 0.2123 | 0.3027 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0101 | 0.2913 | 0.4652 |
Schistosoma mansoni | lamin | 0.003 | 0.0436 | 0.0436 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0551 | 0.088 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0092 | 0.0092 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0092 | 0.0148 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0466 | 0.0744 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0367 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0436 | 0.0595 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.429 | 0.429 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.1365 | 0.193 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0101 | 0.2913 | 0.4161 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0367 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0133 | 0.403 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1915 | 0.2721 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0101 | 0.2913 | 0.4652 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0101 | 0.2913 | 0.4652 |
Echinococcus multilocularis | tar DNA binding protein | 0.014 | 0.429 | 0.685 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0057 | 0.1365 | 0.2179 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0131 | 0.0156 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.0436 | 0.0697 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0201 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0551 | 0.0759 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0367 | 0.0495 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.1915 | 0.1915 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 0.2913 | 0.2913 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0057 | 0.1365 | 0.2179 |
Echinococcus granulosus | lamin | 0.003 | 0.0436 | 0.0697 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0551 | 0.088 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0106 | 0.3091 | 0.4411 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.0551 | 0.0769 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0466 | 0.0466 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.2158 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.2158 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1091 | 0.1536 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.3091 | 0.4411 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0049 | 0.1091 | 0.1091 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0201 | 0.0321 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0057 | 0.1365 | 0.2179 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.2158 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0466 | 0.0466 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0367 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0551 | 0.0551 |
Trichomonas vaginalis | set domain proteins, putative | 0.0246 | 0.803 | 0.5 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.1123 | 0.159 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.0778 | 0.1096 |
Onchocerca volvulus | 0.0031 | 0.0466 | 0.0039 | |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0938 | 0.1316 |
Brugia malayi | intermediate filament protein | 0.003 | 0.0436 | 0.0604 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.005 | 0.1123 | 0.1793 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0131 | 0.0131 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.403 | 0.5761 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 0.2913 | 0.2913 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.003 | 0.0426 | 0.068 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.403 | 0.5761 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0436 | 0.0595 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.2158 | 0.2158 |
Onchocerca volvulus | Huntingtin homolog | 0.0133 | 0.403 | 0.4733 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.005 | 0.1123 | 0.0904 |
Echinococcus multilocularis | musashi | 0.003 | 0.0436 | 0.0697 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0092 | 0.0148 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.005 | 0.1123 | 0.1793 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0049 | 0.1091 | 0.1742 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0466 | 0.0647 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0057 | 0.1365 | 0.1938 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.429 | 0.429 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.0551 | 0.088 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0049 | 0.1091 | 0.1091 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.429 | 0.429 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0217 | 0.6979 | 1 |
Brugia malayi | TAR-binding protein | 0.014 | 0.429 | 0.6138 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0196 | 0.6263 | 1 |
Echinococcus multilocularis | lamin | 0.003 | 0.0436 | 0.0697 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.1123 | 0.159 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0551 | 0.088 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0201 | 0.0201 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0367 | 0.5 |
Brugia malayi | hypothetical protein | 0.0133 | 0.403 | 0.5765 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.0436 | 0.0697 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.1915 | 0.2728 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0079 | 0.2158 | 0.3446 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.0551 | 0.088 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.005 | 0.1123 | 0.1793 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0367 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.429 | 0.429 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.005 | 0.1123 | 0.1793 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0079 | 0.2158 | 0.3446 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0106 | 0.3091 | 0.4416 |
Loa Loa (eye worm) | MBCTL1 | 0.0057 | 0.1365 | 0.193 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.0436 | 0.0604 |
Loa Loa (eye worm) | TAR-binding protein | 0.014 | 0.429 | 0.6134 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0049 | 0.1091 | 0.1742 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0101 | 0.2913 | 0.4156 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0781 | 0.109 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.1123 | 0.1123 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.1123 | 0.1123 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1966 | 0.2794 |
Brugia malayi | Pre-SET motif family protein | 0.0217 | 0.6979 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0692 | 0.1105 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0106 | 0.3091 | 0.4416 |
Schistosoma mansoni | tar DNA-binding protein | 0.014 | 0.429 | 0.429 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 0.2913 | 0.2913 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0057 | 0.1365 | 0.2179 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0692 | 0.1105 |
Loa Loa (eye worm) | RNA binding protein | 0.014 | 0.429 | 0.6134 |
Loa Loa (eye worm) | mbt repeat family protein | 0.005 | 0.1123 | 0.1582 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0367 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.014 | 0.429 | 0.6138 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0417 | 0.0567 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0436 | 0.0595 |
Echinococcus granulosus | tar DNA binding protein | 0.014 | 0.429 | 0.685 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0057 | 0.1365 | 0.1365 |
Brugia malayi | hypothetical protein | 0.0079 | 0.2158 | 0.3077 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.1563 | 0.2495 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0196 | 0.6263 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0079 | 0.2158 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.0436 | 0.0697 |
Schistosoma mansoni | bromodomain containing protein | 0.0066 | 0.1694 | 0.1694 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.