Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 1 | 1 |
Toxoplasma gondii | ATPase, AAA family protein | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 1 | 1 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.001 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) | 0.001 | 0 | 0.5 |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.001 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Mycobacterium ulcerans | NAD-dependent DNA ligase LigA | 0.001 | 0 | 0.5 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.001 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.001 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.001 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 1 | 1 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.001 | 0 | 0.5 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.001 | 0 | 0.5 |
Treponema pallidum | DNA ligase (lig) | 0.001 | 0 | 0.5 |
Giardia lamblia | Replication factor C, subunit 1 | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.001 | 0 | 0.5 |
Plasmodium vivax | replication factor C subunit 1, putative | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.001 | 0 | 0.5 |
Chlamydia trachomatis | DNA ligase | 0.001 | 0 | 0.5 |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0 | 0.5 |
Plasmodium falciparum | replication factor C subunit 1, putative | 0.001 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.