Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0116 | 0.7773 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.254 | 0.3284 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0016 | 0.0313 | 0.0405 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.254 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0105 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Probable reductase | 0.0105 | 0.6906 | 0.8837 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0016 | 0.0313 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.254 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0313 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.254 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.7736 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0016 | 0.0313 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0016 | 0.0313 | 0.5 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0016 | 0.0313 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.254 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0116 | 0.7773 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0046 | 0.254 | 0.2985 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0016 | 0.0313 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.254 | 1 |
Brugia malayi | glutathione reductase | 0.0046 | 0.254 | 0.3284 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0116 | 0.7773 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.7736 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.254 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0116 | 0.7773 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0105 | 0.6906 | 0.8837 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0313 | 0.5 |
Leishmania major | trypanothione reductase | 0.0046 | 0.254 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.7736 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0016 | 0.0313 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0016 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0105 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0105 | 0.6906 | 0.8837 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.254 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0016 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0105 | 0.6906 | 0.8837 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.254 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.254 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.