Detailed information for compound 697702

Basic information

Technical information
  • TDR Targets ID: 697702
  • Name: [4-oxo-6-(pyrimidin-2-ylsulfanylmethyl)pyran- 3-yl] 2-chlorobenzoate
  • MW: 374.798 | Formula: C17H11ClN2O4S
  • H donors: 0 H acceptors: 4 LogP: 3 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1Cl)Oc1coc(cc1=O)CSc1ncccn1
  • InChi: 1S/C17H11ClN2O4S/c18-13-5-2-1-4-12(13)16(22)24-15-9-23-11(8-14(15)21)10-25-17-19-6-3-7-20-17/h1-9H,10H2
  • InChiKey: VWGGUCPXKSYGBE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-chlorobenzoic acid [4-oxo-6-[(2-pyrimidinylthio)methyl]-3-pyranyl] ester
  • 2-chlorobenzoic acid [4-keto-6-[(pyrimidin-2-ylthio)methyl]pyran-3-yl] ester
  • ZINC04377245

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0071 0.0549 0.3244
Loa Loa (eye worm) hypothetical protein 0.0079 0.0639 0.063
Brugia malayi beta-lactamase family protein 0.0079 0.0639 0.063
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0549 0.0826
Echinococcus granulosus lysosomal alpha glucosidase 0.0321 0.3503 0.3497
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0126 0.1195 0.4622
Brugia malayi Glycosyl hydrolases family 31 protein 0.0026 0.002 0.0011
Echinococcus multilocularis pyruvate kinase 0.0123 0.1169 0.116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1387 0.1379
Brugia malayi beta-lactamase family protein 0.0079 0.0639 0.063
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0071 0.0549 0.3244
Echinococcus granulosus microtubule associated protein 2 0.0679 0.7745 0.7743
Loa Loa (eye worm) hypothetical protein 0.0079 0.0639 0.063
Echinococcus granulosus pyruvate kinase 0.0241 0.2555 0.2548
Plasmodium falciparum importin beta, putative 0.0031 0.0068 0.0165
Loa Loa (eye worm) hypothetical protein 0.0033 0.0103 0.0093
Plasmodium vivax pyruvate kinase, putative 0.0241 0.2555 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0026 0.002 0.008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.1387 0.1379
Schistosoma mansoni tar DNA-binding protein 0.0869 1 1
Onchocerca volvulus 0.0233 0.2466 0.9649
Onchocerca volvulus 0.0029 0.0054 0.0134
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0549 0.0826
Onchocerca volvulus 0.0079 0.0639 0.2439
Brugia malayi pyruvate kinase, muscle isozyme 0.0051 0.0307 0.0297
Loa Loa (eye worm) MH2 domain-containing protein 0.0375 0.4153 0.4147
Leishmania major hypothetical protein, conserved 0.0079 0.0639 0.25
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0054 0.0045
Brugia malayi MH2 domain containing protein 0.0375 0.4153 0.4147
Schistosoma mansoni hypothetical protein 0.0326 0.3568 0.3562
Schistosoma mansoni tar DNA-binding protein 0.0869 1 1
Leishmania major hypothetical protein, conserved 0.0027 0.0027 0.0104
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0639 0.2421
Echinococcus granulosus pyruvate kinase 0.0123 0.1169 0.116
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0071 0.0549 0.0826
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2131 0.2123
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1387 0.1379
Giardia lamblia Pyruvate kinase 0.0123 0.1169 0.2641
Brugia malayi Pyruvate kinase, M2 isozyme 0.0241 0.2555 0.2548
Mycobacterium leprae Probable pyruvate kinase PykA 0.0241 0.2555 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0089 0.0759 0.2895
Brugia malayi RNA recognition motif domain containing protein 0.0869 1 1
Schistosoma mansoni hypothetical protein 0.0072 0.0562 0.0553
Mycobacterium ulcerans pyruvate kinase 0.0241 0.2555 0.3189
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0639 0.063
Echinococcus multilocularis neutral alpha glucosidase AB 0.0071 0.0549 0.054
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.002 0.0031
Brugia malayi beta-lactamase 0.0079 0.0639 0.063
Schistosoma mansoni alpha-glucosidase 0.0276 0.2975 0.2968
Trypanosoma brucei glucosidase, putative 0.0071 0.0549 0.2086
Schistosoma mansoni glutaminase 0.0586 0.6647 0.6644
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0071 0.0549 0.054
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0639 0.063
Toxoplasma gondii ABC1 family protein 0.0079 0.0639 0.2421
Schistosoma mansoni alpha glucosidase 0.0071 0.0549 0.054
Schistosoma mansoni hypothetical protein 0.0178 0.1818 0.181
Trypanosoma brucei pyruvate kinase 1, putative 0.0241 0.2555 1
Schistosoma mansoni hypothetical protein 0.0178 0.1818 0.181
Trichomonas vaginalis pyruvate kinase, putative 0.0241 0.2555 0.3844
Loa Loa (eye worm) hypothetical protein 0.0106 0.0959 0.095
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0959 0.095
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.1019 0.1011
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0959 0.095
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0639 0.063
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0326 0.3568 0.3562
Echinococcus multilocularis pyruvate kinase 0.0123 0.1169 0.116
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0068 0.0189
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0027 0.0104
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0103 0.0093
Loa Loa (eye worm) RNA binding protein 0.0869 1 1
Trichomonas vaginalis glutaminase, putative 0.0586 0.6647 1
Brugia malayi acetyltransferase, GNAT family protein 0.0302 0.3284 0.3277
Loa Loa (eye worm) pyruvate kinase 0.0241 0.2555 0.2548
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0639 0.063
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.1019 0.1011
Loa Loa (eye worm) pyruvate kinase 0.0051 0.0307 0.0297
Echinococcus granulosus tar DNA binding protein 0.0869 1 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0321 0.3503 0.3497
Schistosoma mansoni importin beta-1 0.0031 0.0068 0.0059
Echinococcus multilocularis geminin 0.0178 0.1818 0.181
Trichomonas vaginalis bromodomain-containing protein, putative 0.0089 0.0759 0.1141
Brugia malayi RNA, U transporter 1 0.0087 0.0735 0.0726
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0026 0.002 0.0031
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0089 0.0759 0.1141
Schistosoma mansoni pyruvate kinase 0.0241 0.2555 0.2548
Leishmania major pyruvate kinase 0.0241 0.2555 1
Schistosoma mansoni hypothetical protein 0.0033 0.0103 0.0093
Chlamydia trachomatis pyruvate kinase 0.0241 0.2555 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.0011
Loa Loa (eye worm) hypothetical protein 0.0029 0.0054 0.0045
Echinococcus granulosus pyruvate kinase 0.0123 0.1169 0.116
Brugia malayi hypothetical protein 0.0114 0.1051 0.1042
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0073 0.0568 0.0559
Loa Loa (eye worm) hypothetical protein 0.0079 0.0639 0.063
Brugia malayi pyruvate kinase 0.0051 0.0307 0.0297
Echinococcus multilocularis pyruvate kinase 0.0123 0.1169 0.116
Echinococcus multilocularis lysosomal alpha glucosidase 0.0321 0.3503 0.3497
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0071 0.0549 0.2067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0054 0.0045
Brugia malayi Pyruvate kinase, muscle isozyme 0.0241 0.2555 0.2548
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.1387 0.1379
Echinococcus multilocularis snurportin 1 0.0326 0.3568 0.3562
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0071 0.0549 0.0826
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0126 0.1195 0.1187
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0054 0.0045
Leishmania major alpha glucosidase II subunit, putative 0.0071 0.0549 0.215
Brugia malayi hypothetical protein 0.0027 0.0027 0.0017
Schistosoma mansoni hypothetical protein 0.0111 0.1019 0.1011
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.002 0.0031
Brugia malayi hypothetical protein 0.0114 0.1051 0.1042
Schistosoma mansoni tar DNA-binding protein 0.0869 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0103 0.0093
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0302 0.3284 0.3277
Trichomonas vaginalis maltase-glucoamylase, putative 0.0026 0.002 0.0031
Plasmodium vivax SET domain protein, putative 0.0029 0.0054 0.011
Brugia malayi glutaminase DH11.1 0.0586 0.6647 0.6644
Entamoeba histolytica hypothetical protein 0.0111 0.1019 0.6021
Echinococcus granulosus histone acetyltransferase KAT2B 0.0089 0.0759 0.075
Schistosoma mansoni pyruvate kinase 0.0123 0.1169 0.116
Plasmodium falciparum pyruvate kinase 0.0241 0.2555 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0054 0.0045
Trichomonas vaginalis sucrase-isomaltase, putative 0.0071 0.0549 0.0826
Plasmodium vivax pyruvate kinase 2, putative 0.0123 0.1169 0.4517
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.002 0.0031
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0639 0.0961
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0027 0.0024
Brugia malayi Importin beta-1 subunit 0.0031 0.0068 0.0059
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0639 0.063
Brugia malayi Glycosyl hydrolases family 31 protein 0.0321 0.3503 0.3497
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0089 0.0759 0.2895
Echinococcus granulosus neutral alpha glucosidase AB 0.0071 0.0549 0.054
Echinococcus granulosus histone acetyltransferase KAT2B 0.0294 0.3183 0.3177
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0054 0.0045
Entamoeba histolytica hypothetical protein 0.0111 0.1019 0.6021
Toxoplasma gondii pyruvate kinase PyKII 0.0123 0.1169 0.4517
Trichomonas vaginalis maltase-glucoamylase, putative 0.0071 0.0549 0.0826
Loa Loa (eye worm) glutaminase 0.0586 0.6647 0.6644
Schistosoma mansoni hypothetical protein 0.0033 0.0103 0.0093
Loa Loa (eye worm) glutaminase 2 0.0586 0.6647 0.6644
Onchocerca volvulus 0.0079 0.0639 0.2439
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0027 0.0104
Echinococcus granulosus geminin 0.0178 0.1818 0.181
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.1387 0.1379
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0549 0.0826
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0639 0.0961
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0103 0.0093
Loa Loa (eye worm) hypothetical protein 0.0027 0.0027 0.0017
Onchocerca volvulus Pyruvate kinase homolog 0.0241 0.2555 1
Echinococcus multilocularis pyruvate kinase 0.0241 0.2555 0.2548
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0639 0.063
Entamoeba histolytica acetyltransferase, GNAT family 0.0081 0.0671 0.3963
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0549 0.215
Schistosoma mansoni hypothetical protein 0.0126 0.1195 0.1187
Schistosoma mansoni microtubule-associated protein tau 0.0679 0.7745 0.7743
Schistosoma mansoni hypothetical protein 0.0033 0.0103 0.0093
Loa Loa (eye worm) pyruvate kinase 0.0241 0.2555 0.2548
Plasmodium vivax importin-beta 2, putative 0.0031 0.0068 0.0165
Brugia malayi TAR-binding protein 0.0869 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0639 0.25
Loa Loa (eye worm) pyruvate kinase 0.0241 0.2555 0.2548
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.1387 0.1379
Echinococcus granulosus GPCR family 2 0.0033 0.0103 0.0093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0639 0.063
Leishmania major pyruvate kinase 0.0241 0.2555 1
Mycobacterium ulcerans glutaminase 0.0586 0.6647 1
Schistosoma mansoni tar DNA-binding protein 0.0869 1 1
Giardia lamblia Pyruvate kinase 0.0241 0.2555 1
Schistosoma mansoni hypothetical protein 0.0033 0.0103 0.0093
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0302 0.3284 0.3277
Trypanosoma brucei pyruvate kinase 1 0.0241 0.2555 1
Trichomonas vaginalis set domain proteins, putative 0.0233 0.2466 0.371
Schistosoma mansoni tar DNA-binding protein 0.0869 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0549 0.0826
Leishmania major glycosyl hydrolase-like protein 0.0026 0.002 0.008
Echinococcus granulosus pyruvate kinase 0.0123 0.1169 0.116
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0503 0.5661 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0168 0.1693 0.1685
Entamoeba histolytica hypothetical protein 0.0111 0.1019 0.6021
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0639 0.0961
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0103 0.0093
Echinococcus multilocularis microtubule associated protein 2 0.0679 0.7745 0.7743
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0089 0.0759 0.2895
Trichomonas vaginalis esterase, putative 0.0079 0.0639 0.0961
Loa Loa (eye worm) hypothetical protein 0.0031 0.0068 0.0059
Schistosoma mansoni pyruvate kinase 0.0241 0.2555 0.2548
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0054 0.0045
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0103 0.0093
Echinococcus multilocularis GPCR, family 2 0.0033 0.0103 0.0093
Brugia malayi hypothetical protein 0.0111 0.1019 0.1011
Trichomonas vaginalis pyruvate kinase, putative 0.0241 0.2555 0.3844
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0639 0.2439
Loa Loa (eye worm) transcription factor SMAD2 0.0375 0.4153 0.4147
Echinococcus granulosus snurportin 1 0.0326 0.3568 0.3562
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0054 0.011
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0549 0.215
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0639 0.0961
Trichomonas vaginalis alpha-glucosidase, putative 0.0071 0.0549 0.0826
Loa Loa (eye worm) hypothetical protein 0.0079 0.0639 0.063
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.1019 0.1011
Loa Loa (eye worm) hypothetical protein 0.0079 0.0639 0.063
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0321 0.3503 0.3497
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.1387 0.1379
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0869 1 1
Onchocerca volvulus Pyruvate kinase homolog 0.0241 0.2555 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0103 0.0093
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0042 0.0032
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.1387 0.1379
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0068 0.0189
Loa Loa (eye worm) TAR-binding protein 0.0869 1 1
Echinococcus granulosus pyruvate kinase 0.0241 0.2555 0.2548
Echinococcus multilocularis tar DNA binding protein 0.0869 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0054 0.0045
Toxoplasma gondii pyruvate kinase PyK1 0.0241 0.2555 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0241 0.2555 0.3815
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0126 0.1195 0.1187
Brugia malayi Pre-SET motif family protein 0.0205 0.2131 0.2123
Entamoeba histolytica pyruvate kinase, putative 0.0168 0.1693 1
Brugia malayi Pre-SET motif family protein 0.0029 0.0054 0.0045
Loa Loa (eye worm) hypothetical protein 0.0241 0.2555 0.2548
Trypanosoma cruzi pyruvate kinase 2, putative 0.0241 0.2555 1
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0126 0.1195 0.4622
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0026 0.002 0.0031
Loa Loa (eye worm) hypothetical protein 0.0168 0.1693 0.1685
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0126 0.1195 0.1187
Loa Loa (eye worm) beta-lactamase 0.0079 0.0639 0.063
Trypanosoma cruzi pyruvate kinase 2, putative 0.0241 0.2555 1
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0562 0.0553
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0103 0.0093
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0026 0.002 0.008
Onchocerca volvulus Pyruvate kinase homolog 0.0241 0.2555 1
Onchocerca volvulus 0.0185 0.1903 0.7426
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0639 0.0961
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0959 0.095
Schistosoma mansoni alpha-glucosidase 0.0276 0.2975 0.2968
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.002 0.0031
Loa Loa (eye worm) acetyltransferase 0.0302 0.3284 0.3277
Echinococcus granulosus importin subunit beta 1 0.0031 0.0068 0.0059
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0126 0.1195 0.4622
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0026 0.002 0.0121
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.002 0.0031
Plasmodium falciparum pyruvate kinase 2 0.0123 0.1169 0.4517
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0639 0.25
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1387 0.1379
Loa Loa (eye worm) hypothetical protein 0.0072 0.0562 0.0553
Echinococcus multilocularis pyruvate kinase 0.0241 0.2555 0.2548
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0068 0.0059
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0126 0.1195 0.1187
Brugia malayi Glycosyl hydrolases family 31 protein 0.0071 0.0549 0.054
Entamoeba histolytica hypothetical protein 0.0111 0.1019 0.6021
Echinococcus multilocularis pyruvate kinase 0.019 0.1955 0.1947
Loa Loa (eye worm) hypothetical protein 0.0126 0.1195 0.1187
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0068 0.0165
Plasmodium falciparum histone acetyltransferase GCN5 0.0081 0.0671 0.2549
Onchocerca volvulus 0.0079 0.0639 0.2439

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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