Detailed information for compound 697783

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 424.946 | Formula: C22H21ClN4OS
  • H donors: 1 H acceptors: 3 LogP: 5.54 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1nc2n(n1)c(c(s2)CCNC(=O)c1ccc(c(c1)C)C)C
  • InChi: 1S/C22H21ClN4OS/c1-13-4-5-17(12-14(13)2)21(28)24-11-10-19-15(3)27-22(29-19)25-20(26-27)16-6-8-18(23)9-7-16/h4-9,12H,10-11H2,1-3H3,(H,24,28)
  • InChiKey: GCLGJZPEQXDPQF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0185 0.0185
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0089 0.0196
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0051 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0051 0.0051
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0685 0.3618
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0468 0.5538 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0831 1 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0696 0.1217
Brugia malayi RNA recognition motif domain containing protein 0.0831 1 1
Toxoplasma gondii ABC1 family protein 0.0073 0.0696 0.3678
Brugia malayi hypothetical protein 0.0242 0.2767 0.2767
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0072 0.0685 0.3396
Brugia malayi hypothetical protein 0.0017 0.0008 0.0008
Echinococcus multilocularis pyruvate kinase 0.0086 0.0851 0.0851
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0084 0.0824 0.0824
Entamoeba histolytica hypothetical protein 0.0177 0.1969 1
Schistosoma mansoni alpha glucosidase 0.0038 0.0266 0.0266
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.023 0.1125
Echinococcus multilocularis tumor protein p63 0.0666 0.7973 0.7973
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.023 0.0621
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0696 0.3678
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0051
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 0.2769 0.2769
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0696 0.2036
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0341 0.174
Onchocerca volvulus 0.0032 0.0185 0.0475
Leishmania major pyruvate kinase 0.0167 0.185 1
Schistosoma mansoni hypothetical protein 0.0139 0.1501 0.1501
Schistosoma mansoni transcription factor LCR-F1 0.0177 0.1969 0.1969
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0063 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0051 0.0051
Onchocerca volvulus 0.0049 0.0403 0.1251
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1509 0.1509
Loa Loa (eye worm) hypothetical protein 0.0027 0.0124 0.0124
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0063 0.0206
Brugia malayi beta-lactamase 0.0073 0.0696 0.0696
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 0.3641 0.3641
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0051 0.0051
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0063 0.0206
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0341 0.0341
Trypanosoma cruzi pyruvate kinase 2, putative 0.0167 0.185 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0051 0.0051
Echinococcus multilocularis inositol monophosphatase 1 0.0072 0.0685 0.0685
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0177 0.1969 0.1969
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0091 0.0199
Brugia malayi hypothetical protein 0.0076 0.0725 0.0725
Plasmodium vivax SET domain protein, putative 0.0032 0.0185 0.0874
Mycobacterium ulcerans hypothetical protein 0.0073 0.0696 0.2036
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0266 0.0732
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0266 0.1322
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0089 0.0196
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0341 0.1626
Schistosoma mansoni glutaminase 0.0287 0.3322 0.3322
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0696 0.1217
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0063 0.0063
Mycobacterium tuberculosis Conserved protein 0.0073 0.0696 0.1217
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0586 0.0586
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0158 0.0158
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0696 0.2036
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0696 0.2036
Onchocerca volvulus 0.025 0.2869 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0266 0.1241
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0158 0.0735
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0122 0.0295
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0051
Echinococcus multilocularis pyruvate kinase 0.0132 0.1417 0.1417
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.2496 0.2496
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0586 0.0586
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.0994 0.0994
Echinococcus multilocularis GPCR, family 2 0.0064 0.0586 0.0586
Leishmania major importin beta-1 subunit, putative 0.0024 0.0089 0.0353
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0063 0.0063
Echinococcus granulosus histone acetyltransferase KAT2B 0.0285 0.3301 0.3301
Schistosoma mansoni pyruvate kinase 0.0086 0.0851 0.0851
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0185 0.0185
Brugia malayi latrophilin 2 splice variant baaae 0.0139 0.1501 0.1501
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0403 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0202 0.0536
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0089 0.0196
Toxoplasma gondii pyruvate kinase PyK1 0.0167 0.185 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.015 0.038
Loa Loa (eye worm) pyruvate kinase 0.0167 0.185 0.185
Loa Loa (eye worm) hypothetical protein 0.0032 0.0185 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0119 0.0285
Schistosoma mansoni ran 0.0022 0.0063 0.0063
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0696 0.0696
Loa Loa (eye worm) pyruvate kinase-PB 0.0117 0.1229 0.1229
Entamoeba histolytica acetyltransferase, GNAT family 0.0079 0.0769 0.3828
Echinococcus granulosus importin subunit beta 1 0.0029 0.0158 0.0158
Trichomonas vaginalis ran, putative 0.0022 0.0063 0.0114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0051 0.0051
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0051 0.0418 0.0418
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0072 0.0685 0.3618
Entamoeba histolytica hypothetical protein 0.0177 0.1969 1
Echinococcus granulosus pyruvate kinase 0.0086 0.0851 0.0851
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0025 0.0009
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0086 0.0857 0.4562
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0051 0.0051
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0341 0.1732
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0063 0.0206
Loa Loa (eye worm) hypothetical protein 0.0064 0.0586 0.0586
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0051
Echinococcus granulosus snurportin 1 0.0313 0.3641 0.3641
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0089 0.0353
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0051 0.0051
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0072 0.0685 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0185 0.0185
Mycobacterium ulcerans lipase LipD 0.0073 0.0696 0.2036
Trypanosoma brucei glucosidase, putative 0.0038 0.0266 0.133
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0266 0.0266
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0051 0.0051
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0586 0.0586
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0124 0.0541
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0051
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0696 0.0696
Schistosoma mansoni microtubule-associated protein tau 0.0729 0.8745 0.8745
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0051 0.0051
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0086 0.0857 0.4562
Echinococcus multilocularis geminin 0.0338 0.3949 0.3949
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0086 0.0857 0.4562
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0202 0.0536
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.1509 0.1509
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0051 0.0051
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0185 0.0185
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0185 0.0185
Trichomonas vaginalis set domain proteins, putative 0.025 0.2869 0.8626
Trichomonas vaginalis pyruvate kinase, putative 0.0167 0.185 0.5535
Leishmania major hypothetical protein, conserved 0.0027 0.0124 0.0541
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0051 0.0051
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0051 0.0051
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0063 0.0063
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0051 0.0051
Brugia malayi nuclear receptor NHR-88 0.0021 0.0051 0.0051
Chlamydia trachomatis pyruvate kinase 0.0167 0.185 0.5
Echinococcus granulosus inositol monophosphatase 1 0.0072 0.0685 0.0685
Entamoeba histolytica hypothetical protein 0.0177 0.1969 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0586 0.0586
Schistosoma mansoni tar DNA-binding protein 0.0831 1 1
Brugia malayi Pre-SET motif family protein 0.022 0.2496 0.2496
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0051 0.0051
Echinococcus granulosus lysosomal alpha glucosidase 0.0172 0.191 0.191
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0051 0.0051
Onchocerca volvulus 0.0073 0.0696 0.229
Loa Loa (eye worm) hypothetical protein 0.0084 0.0824 0.0824
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0685 0.3618
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0185 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0091 0.02
Brugia malayi Pyruvate kinase, muscle isozyme 0.0167 0.185 0.185
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0341 0.0341
Entamoeba histolytica Ran family GTPase 0.0022 0.0063 0.0193
Echinococcus granulosus tumor protein p63 0.0666 0.7973 0.7973
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0084 0.0824 0.4382
Brugia malayi hypothetical protein 0.0027 0.0124 0.0124
Schistosoma mansoni hypothetical protein 0.0064 0.0586 0.0586
Loa Loa (eye worm) hypothetical protein 0.0139 0.1501 0.1501
Plasmodium vivax pyruvate kinase 2, putative 0.0086 0.0851 0.4526
Loa Loa (eye worm) inositol-1 0.0072 0.0685 0.0685
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0051 0.0051
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.1509 0.1509
Brugia malayi ecdysteroid receptor 0.0021 0.0051 0.0051
Brugia malayi pyruvate kinase, muscle isozyme 0.0035 0.023 0.023
Loa Loa (eye worm) pyruvate kinase 0.0167 0.185 0.185
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0063 0.0206
Loa Loa (eye worm) hypothetical protein 0.0117 0.1229 0.1229
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0341 0.1626
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0051
Echinococcus granulosus pyruvate kinase 0.0086 0.0851 0.0851
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.023 0.0621
Loa Loa (eye worm) hypothetical protein 0.0167 0.185 0.185
Schistosoma mansoni ap endonuclease 0.0019 0.0025 0.0025
Entamoeba histolytica hypothetical protein 0.0177 0.1969 1
Schistosoma mansoni hypothetical protein 0.0177 0.1969 0.1969
Leishmania major hypothetical protein, conserved 0.0073 0.0696 0.3678
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0051 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0341 0.0959
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0586 0.0586
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0051 0.0051
Schistosoma mansoni alpha-glucosidase 0.0148 0.1616 0.1616
Echinococcus multilocularis pyruvate kinase 0.0167 0.185 0.185
Schistosoma mansoni hypothetical protein 0.0064 0.0586 0.0586
Brugia malayi Pyruvate kinase, M2 isozyme 0.0167 0.185 0.185
Loa Loa (eye worm) transcription factor SMAD2 0.0242 0.2769 0.2769
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0063 0.0063
Leishmania major GTP-binding protein, putative 0.0022 0.0063 0.0206
Schistosoma mansoni tar DNA-binding protein 0.0831 1 1
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.2767 0.2767
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0051 0.0051
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0266 0.1322
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0266 0.0266
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0072 0.0685 0.2002
Schistosoma mansoni importin beta-1 0.0029 0.0158 0.0158
Loa Loa (eye worm) pyruvate kinase 0.0167 0.185 0.185
Schistosoma mansoni tar DNA-binding protein 0.0831 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0091 0.0199
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0696 0.0826
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0696 0.2036
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0124 0.0541
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0084 0.0824 0.4382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.023 0.0621
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0696 0.1217
Brugia malayi Pre-SET motif family protein 0.0032 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0073 0.0696 0.0696
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0025 0.5
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0202 0.0536
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0122 0.0295
Leishmania major pyruvate kinase 0.0167 0.185 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0266 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0091 0.02
Trichomonas vaginalis glutaminase, putative 0.0287 0.3322 1
Mycobacterium ulcerans glutaminase 0.0287 0.3322 1
Echinococcus multilocularis pyruvate kinase 0.0086 0.0851 0.0851
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0586 0.0586
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1509 0.1509
Schistosoma mansoni hypothetical protein 0.0049 0.0403 0.0403
Brugia malayi steroid hormone receptor 0.0021 0.0051 0.0051
Entamoeba histolytica hypothetical protein 0.0024 0.0089 0.0332
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0185 0.0185
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0294 0.3402 0.3402
Echinococcus granulosus pyruvate kinase 0.0086 0.0851 0.0851
Plasmodium falciparum pyruvate kinase 2 0.0086 0.0851 0.4526
Toxoplasma gondii pyruvate kinase PyKII 0.0086 0.0851 0.4526
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0266 0.1322
Onchocerca volvulus Pyruvate kinase homolog 0.0167 0.185 0.6384
Brugia malayi Glycosyl hydrolases family 31 protein 0.0172 0.191 0.191
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0266 0.0732
Echinococcus granulosus pyruvate kinase 0.0167 0.185 0.185
Mycobacterium leprae Probable lipase LipE 0.0073 0.0696 0.0826
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0696 0.1217
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.023 0.1125
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0696 0.2036
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0051 0.0051
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0696 0.0696
Plasmodium falciparum pyruvate kinase 0.0167 0.185 1
Mycobacterium tuberculosis Conserved protein 0.0073 0.0696 0.1217
Brugia malayi nuclear hormone receptor 0.0021 0.0051 0.0051
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0696 0.0696
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0124 0.0541
Echinococcus granulosus histone acetyltransferase KAT2B 0.0086 0.0857 0.0857
Brugia malayi TAR-binding protein 0.0831 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0696 0.0696
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0051 0.0051
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0025 0.0025
Mycobacterium ulcerans pyruvate kinase 0.0167 0.185 0.5535
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0696 0.3684
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0696 0.3678
Onchocerca volvulus Pyruvate kinase homolog 0.0167 0.185 0.6384
Brugia malayi acetyltransferase, GNAT family protein 0.0294 0.3402 0.3402
Loa Loa (eye worm) TAR-binding protein 0.0831 1 1
Schistosoma mansoni hypothetical protein 0.0313 0.3641 0.3641
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0586 0.0586
Loa Loa (eye worm) beta-lactamase 0.0073 0.0696 0.0696
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0051 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0051 0.0051
Loa Loa (eye worm) RNA binding protein 0.0831 1 1
Schistosoma mansoni hypothetical protein 0.0064 0.0586 0.0586
Mycobacterium leprae Probable pyruvate kinase PykA 0.0167 0.185 1
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0084 0.0824 0.0824
Mycobacterium tuberculosis Conserved protein 0.0073 0.0696 0.1217
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0203 0.229 0.229
Brugia malayi Inositol-1 0.0072 0.0685 0.0685
Echinococcus granulosus microtubule associated protein 2 0.0729 0.8745 0.8745
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0158 0.0727
Onchocerca volvulus 0.0073 0.0696 0.229
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0051 0.0051
Brugia malayi Importin beta-1 subunit 0.0029 0.0158 0.0158
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0051 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0051 0.0051
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.023 0.1134
Onchocerca volvulus Pyruvate kinase homolog 0.0167 0.185 0.6384
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.1509 0.1509
Trichomonas vaginalis pyruvate kinase, putative 0.0167 0.185 0.5535
Plasmodium falciparum importin beta, putative 0.0029 0.0158 0.0727
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0696 0.3678
Plasmodium falciparum histone acetyltransferase GCN5 0.0079 0.0769 0.4078
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0266 0.0732
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0051 0.0051
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0051 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0202 0.0536
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0696 0.1217
Schistosoma mansoni hypothetical protein 0.0338 0.3949 0.3949
Loa Loa (eye worm) hypothetical protein 0.0098 0.0994 0.0994
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1509 0.1509
Loa Loa (eye worm) glutaminase 2 0.0287 0.3322 0.3322
Giardia lamblia Pyruvate kinase 0.0086 0.0851 0.4526
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0051 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.023 0.0621
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0091 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0341 0.0959
Schistosoma mansoni inositol monophosphatase 0.0072 0.0685 0.0685
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0084 0.0824 0.4382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0202 0.0536
Giardia lamblia GTOR 0.0044 0.0341 0.1732
Plasmodium vivax importin-beta 2, putative 0.0029 0.0158 0.0727
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.1509 0.1509
Onchocerca volvulus 0.0073 0.0696 0.229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0202 0.0536
Trichomonas vaginalis bromodomain-containing protein, putative 0.0086 0.0857 0.2525
Echinococcus granulosus geminin 0.0338 0.3949 0.3949
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0158
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0341 0.0341
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0341 0.1732
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0124 0.0541
Onchocerca volvulus 0.01 0.1019 0.3437
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0341 0.0959
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0685 0.3618
Echinococcus multilocularis tar DNA binding protein 0.0831 1 1
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0051 0.0051
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0051 0.0051
Brugia malayi beta-lactamase family protein 0.0073 0.0696 0.0696
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0696 0.2036
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0266 0.0732
Loa Loa (eye worm) acetyltransferase 0.0294 0.3402 0.3402
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0051 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0162 0.0416
Echinococcus granulosus GPCR family 2 0.0064 0.0586 0.0586
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0266 0.0266
Loa Loa (eye worm) glutaminase 0.0287 0.3322 0.3322
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0696 0.2036
Entamoeba histolytica pyruvate kinase, putative 0.0117 0.1229 0.6192
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0073 0.0696 0.0696
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0185 0.0874
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.1509 0.1509
Schistosoma mansoni ap endonuclease 0.0019 0.0025 0.0025
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0341 0.1732
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0202 0.0969
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0051 0.0051
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.191 0.191
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0055 0.0171
Trypanosoma brucei pyruvate kinase 1 0.0167 0.185 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0086 0.0857 0.2525
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0266 0.0732
Echinococcus multilocularis snurportin 1 0.0313 0.3641 0.3641
Schistosoma mansoni ran 0.0022 0.0063 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0091 0.02
Brugia malayi beta-lactamase family protein 0.0073 0.0696 0.0696
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0091 0.0199
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0266 0.0732
Brugia malayi MH2 domain containing protein 0.0242 0.2769 0.2769
Onchocerca volvulus 0.0098 0.0994 0.3348
Schistosoma mansoni inositol monophosphatase 0.0072 0.0685 0.0685
Loa Loa (eye worm) hypothetical protein 0.0203 0.229 0.229
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0065 0.0592 0.1029
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0063 0.0206
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0073 0.0696 0.0696
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0167 0.185 0.331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0122 0.0295
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0341 0.0341
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0696 0.1217
Plasmodium vivax pyruvate kinase, putative 0.0167 0.185 1
Schistosoma mansoni tar DNA-binding protein 0.0831 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0177 0.1969 0.1969
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0051 0.0051
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0072 0.0685 0.3624
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0338 0.3949 0.3949
Schistosoma mansoni tar DNA-binding protein 0.0831 1 1
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0051 0.0051
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0051 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0262 0.0718
Brugia malayi hypothetical protein 0.0177 0.1969 0.1969
Brugia malayi Calcitonin receptor-like protein seb-1 0.0203 0.229 0.229
Giardia lamblia Histone acetyltransferase GCN5 0.0079 0.0769 0.4078
Loa Loa (eye worm) hypothetical protein 0.0073 0.0696 0.0696
Loa Loa (eye worm) pyruvate kinase 0.0035 0.023 0.023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0119 0.0285
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0072 0.0685 0.2002
Schistosoma mansoni alpha-glucosidase 0.0148 0.1616 0.1616
Trichomonas vaginalis esterase, putative 0.0073 0.0696 0.2036
Echinococcus multilocularis microtubule associated protein 2 0.0729 0.8745 0.8745
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0084 0.0824 0.0824
Brugia malayi RNA, U transporter 1 0.0083 0.0821 0.0821
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0051 0.0051
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0341 0.174
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0051 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0051 0.0051
Trypanosoma brucei pyruvate kinase 1, putative 0.0167 0.185 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0266 0.1241
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0025 0.0025
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0051 0.0051
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0696 0.0696
Trichomonas vaginalis inositol monophosphatase, putative 0.0072 0.0685 0.2002
Schistosoma mansoni hypothetical protein 0.0084 0.0824 0.0824
Schistosoma mansoni coup transcription factor 0.0021 0.0051 0.0051
Echinococcus granulosus pyruvate kinase 0.0167 0.185 0.185
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0696 0.0696
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0124 0.0541
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0172 0.191 0.191
Mycobacterium ulcerans beta-lactamase 0.0073 0.0696 0.2036
Loa Loa (eye worm) hypothetical protein 0.0073 0.0696 0.0696
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0051 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.023 0.0621
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0266 0.0732
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0202 0.0536
Schistosoma mansoni pyruvate kinase 0.0167 0.185 0.185
Brugia malayi glutaminase DH11.1 0.0287 0.3322 0.3322
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0064 0.0586 0.0586
Loa Loa (eye worm) hypothetical protein 0.0242 0.2767 0.2767
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0084 0.0824 0.0824
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0341 0.0341
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0051 0.0051
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0696 0.1217
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0051 0.0051
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0341 0.1732
Brugia malayi hypothetical protein 0.0076 0.0725 0.0725
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0051 0.0051
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0124 0.0541
Schistosoma mansoni pyruvate kinase 0.0167 0.185 0.185
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.1509 0.1509
Giardia lamblia Pyruvate kinase 0.0167 0.185 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0266 0.0732
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0051 0.0051
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.2767 0.2767
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.191 0.191
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0266 0.0732
Echinococcus multilocularis pyruvate kinase 0.0167 0.185 0.185
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0072 0.0685 0.2002
Echinococcus granulosus tar DNA binding protein 0.0831 1 1
Schistosoma mansoni survival motor neuron protein 0.0049 0.0403 0.0403
Trypanosoma cruzi pyruvate kinase 2, putative 0.0167 0.185 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0051 0.0051
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.017 0.017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0051 0.0051
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0051 0.0051
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0051 0.0051
Brugia malayi pyruvate kinase 0.0035 0.023 0.023
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0158 0.0735
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0203 0.229 0.229
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0063 0.0206
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0124 0.055
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0051 0.0051
Echinococcus multilocularis pyruvate kinase 0.0086 0.0851 0.0851
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0294 0.3402 0.3402
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0025 0.0025
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0266 0.1322

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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