Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0082 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0082 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0082 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0082 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0082 | 1 | 0.5 |
Toxoplasma gondii | deoxyhypusine synthase | 0.007 | 0.7022 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0073 | 0.7743 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0073 | 0.7743 | 0.2424 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0082 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0082 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0082 | 1 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0073 | 0.7743 | 0.2424 |
Echinococcus multilocularis | deoxyhypusine synthase | 0.007 | 0.7022 | 0.6077 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0082 | 1 | 1 |
Echinococcus granulosus | deoxyhypusine synthase | 0.007 | 0.7022 | 0.6077 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0082 | 1 | 1 |
Entamoeba histolytica | deoxyhypusine synthase, putative | 0.007 | 0.7022 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0082 | 1 | 1 |
Loa Loa (eye worm) | deoxyhypusine synthase | 0.007 | 0.7022 | 0.6077 |
Schistosoma mansoni | deoxyhypusine synthase | 0.007 | 0.7022 | 0.7022 |
Brugia malayi | FAD binding domain containing protein | 0.0082 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0051 | 0.2407 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0082 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0082 | 1 | 1 |
Entamoeba histolytica | deoxyhypusine synthase, putative | 0.007 | 0.7022 | 0.5 |
Leishmania major | cytochrome P450 reductase, putative | 0.0073 | 0.7743 | 0.2424 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0082 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0073 | 0.7743 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0082 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0041 | 0.0151 | 0.0151 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0082 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0082 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0051 | 0.2407 | 0.2407 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0082 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0082 | 1 | 1 |
Brugia malayi | deoxyhypusine synthase | 0.007 | 0.7022 | 0.6077 |
Leishmania major | p450 reductase, putative | 0.0082 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 48 uM | Inhibitory activity against histamine release from antigen-challenged, sensitized human basophils | ChEMBL. | 2415706 |
IC50 (functional) | > 48 uM | Inhibitory activity against histamine release from antigen-challenged, sensitized human basophils | ChEMBL. | 2415706 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.