Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0222 | 0.6154 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0437 | 0.078 |
Echinococcus multilocularis | tumor protein p63 | 0.0339 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.013 | 0.3111 | 0.3567 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0437 | 0.0437 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1979 | 0.2269 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.016 | 0.411 | 0.411 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0437 | 0.0437 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0437 | 0.0437 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.013 | 0.3111 | 0.3567 |
Echinococcus multilocularis | muscleblind protein | 0.016 | 0.411 | 0.411 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0095 | 0.1979 | 0.2269 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0437 | 0.078 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0095 | 0.1979 | 0.2269 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0095 | 0.1979 | 0.1979 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3111 | 0.5555 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.411 | 0.4712 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.8723 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.013 | 0.3111 | 0.3567 |
Loa Loa (eye worm) | TAR-binding protein | 0.013 | 0.3111 | 0.3567 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0437 | 0.0501 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0437 | 0.0437 |
Schistosoma mansoni | hypothetical protein | 0.0095 | 0.1979 | 0.3533 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0205 | 0.5601 | 0.6422 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.005 | 0.0489 | 0.0873 |
Brugia malayi | hypothetical protein | 0.0149 | 0.3744 | 0.4292 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0095 | 0.1979 | 0.3533 |
Brugia malayi | RNA recognition motif domain containing protein | 0.013 | 0.3111 | 0.3567 |
Echinococcus granulosus | tar DNA binding protein | 0.013 | 0.3111 | 0.3111 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0095 | 0.1979 | 0.1979 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3111 | 0.5555 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.5601 | 0.6422 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0095 | 0.1979 | 0.2269 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0 | 0.5 |
Brugia malayi | Muscleblind-like protein | 0.016 | 0.411 | 0.4712 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.013 | 0.3111 | 0.3111 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.3744 | 0.4292 |
Echinococcus granulosus | muscleblind protein | 0.016 | 0.411 | 0.411 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3111 | 0.5555 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0437 | 0.0501 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0095 | 0.1979 | 0.1979 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3111 | 0.5555 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.5601 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.411 | 0.4712 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.03 | 0.8723 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.013 | 0.3111 | 0.3567 |
Schistosoma mansoni | hypothetical protein | 0.0095 | 0.1979 | 0.3533 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.03 | 0.8723 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0095 | 0.1979 | 0.1979 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0489 | 0.056 |
Echinococcus granulosus | GPCR family 2 | 0.0095 | 0.1979 | 0.1979 |
Onchocerca volvulus | 0.0149 | 0.3744 | 1 | |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0095 | 0.1979 | 0.1979 |
Onchocerca volvulus | 0.005 | 0.0489 | 0.1306 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0437 | 0.078 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.3111 | 0.5555 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.03 | 0.8723 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0095 | 0.1979 | 0.3533 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.