Detailed information for compound 698305

Basic information

Technical information
  • TDR Targets ID: 698305
  • Name: 1-[(3-methylphenyl)methyl]-2-oxo-N-phenylpyri dine-3-carboxamide
  • MW: 318.369 | Formula: C20H18N2O2
  • H donors: 1 H acceptors: 2 LogP: 3.29 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)Cn1cccc(c1=O)C(=O)Nc1ccccc1
  • InChi: 1S/C20H18N2O2/c1-15-7-5-8-16(13-15)14-22-12-6-11-18(20(22)24)19(23)21-17-9-3-2-4-10-17/h2-13H,14H2,1H3,(H,21,23)
  • InChiKey: VULVNTLPWUGUPK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[(3-methylphenyl)methyl]-2-oxo-N-phenyl-pyridine-3-carboxamide
  • 1-[(3-methylphenyl)methyl]-2-oxo-N-phenyl-3-pyridinecarboxamide
  • 2-keto-1-(3-methylbenzyl)-N-phenyl-nicotinamide
  • ZINC05269607

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0673 0.0519
Brugia malayi RNA recognition motif domain containing protein 0.0262 0.7688 1
Schistosoma mansoni bromodomain containing protein 0.0065 0.1498 0.1498
Brugia malayi PHD-finger family protein 0.0029 0.0353 0.0414
Trichomonas vaginalis chromobox protein, putative 0.007 0.1633 0.1913
Brugia malayi jmjC domain containing protein 0.0037 0.0605 0.0744
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0605 0.0605
Echinococcus multilocularis chromobox protein 1 0.007 0.1633 0.1633
Brugia malayi hypothetical protein 0.0029 0.036 0.0423
Schistosoma mansoni zinc finger protein 0.002 0.0082 0.0082
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.036 0.5
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0353 0.0353
Brugia malayi RNA binding protein 0.0262 0.7688 1
Schistosoma mansoni chromobox protein 0.007 0.1633 0.1633
Brugia malayi Bromodomain containing protein 0.0031 0.043 0.0514
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.6264 0.8144
Loa Loa (eye worm) hypothetical protein 0.004 0.0691 0.0875
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0766 0.0602
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1415 0.5
Brugia malayi jmjC domain containing protein 0.0094 0.2413 0.3106
Onchocerca volvulus 0.0031 0.0408 0.008
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0893 0.1139
Brugia malayi hypothetical protein 0.0087 0.2179 0.28
Loa Loa (eye worm) hypothetical protein 0.0087 0.2179 0.2816
Loa Loa (eye worm) hypothetical protein 0.0029 0.0353 0.0434
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0893 0.0893
Brugia malayi TAR-binding protein 0.0262 0.7688 1
Echinococcus granulosus chromobox protein 1 0.007 0.1633 0.1633
Schistosoma mansoni hypothetical protein 0.0021 0.0116 0.0116
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0612 0.0612
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1415 0.5
Brugia malayi Heterochromatin protein 1 0.007 0.1633 0.2087
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0893 0.0893
Schistosoma mansoni jumonji domain containing protein 0.0075 0.1804 0.1804
Loa Loa (eye worm) hypothetical protein 0.0044 0.083 0.1056
Brugia malayi PHD-finger family protein 0.0026 0.0255 0.0285
Trichomonas vaginalis conserved hypothetical protein 0.017 0.4801 0.6509
Loa Loa (eye worm) RNA binding protein 0.0262 0.7688 1
Onchocerca volvulus 0.0043 0.0783 0.0627
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0783 0.0783
Schistosoma mansoni tar DNA-binding protein 0.0262 0.7688 0.7688
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.1415 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0893 0.0893
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.1415 0.1415
Echinococcus granulosus peregrin 0.0031 0.043 0.043
Echinococcus multilocularis zinc finger protein 0.002 0.0082 0.0082
Loa Loa (eye worm) TAR-binding protein 0.0262 0.7688 1
Trichomonas vaginalis chromobox protein, putative 0.007 0.1633 0.1913
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.1317 0.1692
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0893 0.112
Echinococcus multilocularis peregrin 0.0031 0.043 0.043
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.2413 0.2413
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0425 0.068
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0049 0.0978 0.1249
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.1415 0.1415
Echinococcus multilocularis chromobox protein 1 0.007 0.1633 0.1633
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.036 0.0066
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0708 0.0708
Echinococcus granulosus zinc finger protein 0.002 0.0082 0.0082
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0605 0.0605
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0893 0.0893
Brugia malayi Bromodomain containing protein 0.004 0.0689 0.0852
Schistosoma mansoni eyes absent homolog 0.0087 0.2179 0.2179
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0353 0.0434
Brugia malayi Pre-SET motif family protein 0.0031 0.0425 0.0508
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0262 0.7688 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1415 0.5
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.036 0.5
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0178 0.0178
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0605 0.0764
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.1382 0.1382
Schistosoma mansoni hypothetical protein 0.0029 0.0353 0.0353
Schistosoma mansoni hypothetical protein 0.0336 1 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0353 0.0353
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0425 0.0425
Schistosoma mansoni hypothetical protein 0.0336 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0978 0.0978
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0178 0.0178
Brugia malayi Pre-SET motif family protein 0.0217 0.6264 0.814
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.036 0.5
Schistosoma mansoni tar DNA-binding protein 0.0262 0.7688 0.7688
Echinococcus multilocularis tar DNA binding protein 0.0262 0.7688 0.7688
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0673 0.0467
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.1633 0.2104
Brugia malayi chromobox protein homolog 3 0.0039 0.0673 0.0832
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0978 0.0978
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0116 0.0125
Schistosoma mansoni tar DNA-binding protein 0.0262 0.7688 0.7688
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0389 0.0389
Echinococcus granulosus chromobox protein 1 0.007 0.1633 0.1633
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.2413 0.2413
Loa Loa (eye worm) hypothetical protein 0.0087 0.2179 0.2816
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.1382 0.1382
Loa Loa (eye worm) hypothetical protein 0.0031 0.0408 0.0506
Loa Loa (eye worm) hypothetical protein 0.0175 0.4951 0.6432
Plasmodium vivax SET domain protein, putative 0.0031 0.0425 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0425 0.0425
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0605 0.0605
Echinococcus multilocularis geminin 0.0336 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0978 0.0978
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0175 0.4951 0.6424
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0673 0.0519
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0766 0.0654
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.036 0.0968
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.036 1
Echinococcus granulosus jumonji domain containing protein 0.004 0.0708 0.0708
Onchocerca volvulus 0.0247 0.7206 1
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0766 0.0654
Loa Loa (eye worm) hypothetical protein 0.0049 0.1 0.1278
Schistosoma mansoni tar DNA-binding protein 0.0262 0.7688 0.7688
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0893 0.0893
Trichomonas vaginalis set domain proteins, putative 0.0247 0.7206 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.1739 0.2243
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0893 0.0893
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.036 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0612 0.0612
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.1415 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0893 0.0893
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0178 0.0178
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.1415 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0673 0.0851
Echinococcus granulosus tar DNA binding protein 0.0262 0.7688 0.7688
Giardia lamblia PHD finger protein 15 0.0029 0.0353 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1415 0.1415
Loa Loa (eye worm) hypothetical protein 0.0029 0.036 0.0443
Schistosoma mansoni tar DNA-binding protein 0.0262 0.7688 0.7688
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0353 0.0353
Brugia malayi Bromodomain containing protein 0.0077 0.1878 0.2407
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0543 0.0543
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0978 0.0978
Schistosoma mansoni chromobox protein 0.007 0.1633 0.1633
Loa Loa (eye worm) hypothetical protein 0.0042 0.0768 0.0975

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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