TDR Targets

Basic information

Technical information

TDR Targets ID: 698343
Name: 1-[(2-chloro-6-fluorophenyl)methyl]-N-(2-meth oxy-4-nitrophenyl)-2-oxopyridine-3-carboxamid e
MW: 431.802 | Formula: C20H15ClFN3O5
H donors: 1 H acceptors: 4 LogP: 3.46 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1NC(=O)c1cccn(c1=O)Cc1c(F)cccc1Cl)[N+](=O)[O-]
InChi: 1S/C20H15ClFN3O5/c1-30-18-10-12(25(28)29)7-8-17(18)23-19(26)13-4-3-9-24(20(13)27)11-14-15(21)5-2-6-16(14)22/h2-10H,11H2,1H3,(H,23,26)
InChiKey: AKOGBJUMJBLGTG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[(2-chloro-6-fluoro-phenyl)methyl]-N-(2-methoxy-4-nitro-phenyl)-2-oxo-pyridine-3-carboxamide
1-[(2-chloro-6-fluorophenyl)methyl]-N-(2-methoxy-4-nitrophenyl)-2-oxo-3-pyridinecarboxamide
1-(2-chloro-6-fluoro-benzyl)-2-keto-N-(2-methoxy-4-nitro-phenyl)nicotinamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0088	0.1019
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0101	0.2652	0.3801
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1652	0.2291
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0615	0.08
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0065	0.1517	0.1458
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0615	0.08
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0088	0.0507
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0615	0.3599
Onchocerca volvulus	Huntingtin homolog	0.013	0.3562	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0088	0.1019
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0088	0.1019
Schistosoma mansoni	zinc finger protein	0.0021	0.0155	0.0145
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0041	0.0777	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0938	0.1258
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0491	0.0703
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0088	0.1019
Schistosoma mansoni	hypothetical protein	0.0069	0.1652	0.1644
Leishmania major	hypothetical protein, conserved	0.0036	0.0615	0.3924
Brugia malayi	RNA binding protein	0.0125	0.3405	0.488
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0491	0.0424
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.2399	0.2392
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.028	0.5
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0229	0.6674	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0066	0.1552	0.1493
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0615	0.08
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0088	0.1019
Schistosoma mansoni	hypothetical protein	0.0335	1	1
Schistosoma mansoni	hypothetical protein	0.0032	0.0491	0.0481
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0615	0.7889
Trypanosoma brucei	unspecified product	0.0019	0.0088	0.1019
Loa Loa (eye worm)	hypothetical protein	0.013	0.3562	0.5057
Echinococcus granulosus	dna polymerase eta	0.0019	0.0088	0.0019
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0256	0.0188
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0256	0.0246
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0069	0.006
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0041	0.0777	0.1411
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0041	0.0777	1
Loa Loa (eye worm)	hypothetical protein	0.0179	0.5124	0.7318
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.028	0.3524
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0041	0.0777	0.0712
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0615	0.3599
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0041	0.0777	1
Loa Loa (eye worm)	bromodomain containing protein	0.0019	0.009	0.003
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0041	0.0777	0.0712
Echinococcus granulosus	tar DNA binding protein	0.0125	0.3405	0.3359
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0615	0.079
Trichomonas vaginalis	esterase, putative	0.0036	0.0615	0.1079
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0491	0.0424
Brugia malayi	TAR-binding protein	0.0125	0.3405	0.488
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0088	0.1019
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0615	0.7889
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0615	0.0881
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0615	0.08
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.2399	0.2346
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0039	0.071	0.0645
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.1652	0.2367
Brugia malayi	hypothetical protein	0.013	0.3562	0.5106
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2346	0.3296
Brugia malayi	beta-lactamase family protein	0.0036	0.0615	0.0881
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0615	0.0606
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1552	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1891	0.2638
Toxoplasma gondii	ABC1 family protein	0.0036	0.0615	0.2632
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.3405	0.3398
Brugia malayi	MH2 domain containing protein	0.0131	0.3599	0.5159
Schistosoma mansoni	hypothetical protein	0.0022	0.0191	0.0181
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.3405	0.3398
Schistosoma mansoni	hypothetical protein	0.0335	1	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0125	0.3405	0.4829
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0088	0.0027
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0088	0.1019
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0065	0.1517	0.1458
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0069	0.006
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0615	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0873	0.1164
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0069	0.006
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0256	0.0188
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0491	0.0424
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0088	0.1019
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1552	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.2399	0.2346
Loa Loa (eye worm)	transcription factor SMAD2	0.0131	0.3599	0.5111
Echinococcus granulosus	zinc finger protein	0.0021	0.0155	0.0086
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.1552	0.1543
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0615	0.1079
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0088	0.1019
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.3405	0.3398
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0088	0.1019
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0088	0.1019
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0088	0.1019
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0615	0.7889
Loa Loa (eye worm)	hypothetical protein	0.0025	0.028	0.0305
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.3405	0.3398
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0615	0.1079
Echinococcus multilocularis	ubiquitin specific protease 41	0.0041	0.0777	0.0712
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0238	0.6977	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.2399	0.2392
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0088	0.1019
Brugia malayi	RNA recognition motif domain containing protein	0.0125	0.3405	0.488
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0041	0.0777	0.0768
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0088	0.0019
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0615	0.3599
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0088	0.0126
Schistosoma mansoni	bromodomain containing protein	0.0068	0.1639	0.163
Loa Loa (eye worm)	hypothetical protein	0.013	0.3562	0.5057
Brugia malayi	hypothetical protein	0.0091	0.2346	0.3362
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0615	0.08
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2346	0.3296
Loa Loa (eye worm)	PHD-finger family protein	0.0022	0.0191	0.0176
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0615	0.0606
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0039	0.071	0.0645
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0088	0.1019
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2652	0.3739
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0066	0.1552	1
Brugia malayi	follicle stimulating hormone receptor	0.0238	0.6977	1
Brugia malayi	PHD-finger family protein	0.0027	0.0336	0.0481
Schistosoma mansoni	hypothetical protein	0.0032	0.0491	0.0481
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0093	0.2399	0.3439
Brugia malayi	beta-lactamase family protein	0.0036	0.0615	0.0881
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0088	0.0507
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0615	0.08
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.028	0.5
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0615	0.0549
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.2399	0.2346
Echinococcus multilocularis	zinc finger protein	0.0021	0.0155	0.0086
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0041	0.0777	0.0712
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0088	0.0019
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.3405	0.3398
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0615	0.079
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0615	0.3599
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0066	0.1552	0.2223
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0041	0.0777	1
Onchocerca volvulus	Huntingtin homolog	0.013	0.3562	1
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0041	0.0777	0.0712
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0088	0.1019
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0088	0.1019
Brugia malayi	Bromodomain containing protein	0.0041	0.079	0.1133
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0041	0.0777	0.0768
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0041	0.0777	0.4974
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0615	0.08
Toxoplasma gondii	aldehyde dehydrogenase	0.0066	0.1552	1
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0615	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0615	0.1079
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1552	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0066	0.1552	0.1493
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0615	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0615	0.079
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0615	0.079
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0093	0.2399	0.3373
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0101	0.2652	0.3801
Schistosoma mansoni	hypothetical protein	0.0032	0.0491	0.0481
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0615	0.1079
Echinococcus multilocularis	tar DNA binding protein	0.0125	0.3405	0.3359
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0491	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0615	0.079
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0088	0.0019
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0088	0.1019
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.1552	0.1543
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0491	0.0424
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0615	0.08
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0088	0.0019
Schistosoma mansoni	hypothetical protein	0.0032	0.0491	0.0481
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0088	0.0078
Echinococcus granulosus	ubiquitin specific protease 41	0.0041	0.0777	0.0712
Schistosoma mansoni	eyes absent homolog	0.0091	0.2346	0.2338
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0491	0.0424
Trichomonas vaginalis	conserved hypothetical protein	0.0175	0.497	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.028	0.3524
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0088	0.0027
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0069	0.006
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0179	0.5124	0.7345
Loa Loa (eye worm)	RNA binding protein	0.0125	0.3405	0.4829
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0615	0.1079
Leishmania major	DNA polymerase eta, putative	0.0019	0.0088	0.0507
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0777	0.1411
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0615	0.5
Echinococcus granulosus	GPCR family 2	0.0032	0.0491	0.0424
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0101	0.2652	0.3739
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0041	0.0777	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0491	0.061
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0793	0.1048
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0088	0.0078
Brugia malayi	hypothetical protein	0.0025	0.028	0.0401
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0088	0.0078
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0088	0.1019
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0088	0.0126
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0615	0.08
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0615	0.079
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.028	0.3524
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0088	0.1019
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0088	0.0019
Brugia malayi	Bromodomain containing protein	0.0081	0.2036	0.2919
Brugia malayi	beta-lactamase	0.0036	0.0615	0.0881
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.2399	0.2392
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0491	0.061
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0615	0.079
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0041	0.0777	0.1113
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0615	0.08
Leishmania major	hypothetical protein, conserved	0.0025	0.028	0.1753
Mycobacterium ulcerans	lipase LipD	0.0036	0.0615	0.3599
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0615	0.079
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0777	0.1024
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.2399	0.2346
Echinococcus multilocularis	geminin	0.0335	1	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0131	0.3599	0.5111
Loa Loa (eye worm)	TAR-binding protein	0.0125	0.3405	0.4829
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0041	0.0777	0.1411

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 698343