Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | animal heme peroxidase | 0.004 | 0.0651 | 0.0263 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0988 | 0.0876 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1306 | 0.1456 |
Loa Loa (eye worm) | animal heme peroxidase | 0.004 | 0.0651 | 0.0263 |
Schistosoma mansoni | gabp alpha | 0.0072 | 0.1618 | 0.2698 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0072 | 0.1618 | 0.1618 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0651 | 0.0263 |
Schistosoma mansoni | peroxidasin | 0.004 | 0.0651 | 0.1086 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.2919 | 0.4393 |
Trichomonas vaginalis | ferritin, putative | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0353 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0854 | 0.0854 |
Echinococcus multilocularis | peroxidasin | 0.004 | 0.0651 | 0.0651 |
Brugia malayi | Ets-domain containing protein | 0.0072 | 0.1618 | 0.2024 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0854 | 0.0854 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0854 | 0.0854 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.0018 | 0 | 0.5 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0507 | 0.0845 |
Schistosoma mansoni | thyroid hormone receptor | 0.0135 | 0.3507 | 0.5847 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0651 | 0.0263 |
Brugia malayi | hypothetical protein | 0.004 | 0.0651 | 0.0263 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0651 | 0.0263 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0018 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0854 | 0.0632 |
Brugia malayi | Ets-domain containing protein | 0.0072 | 0.1618 | 0.2024 |
Loa Loa (eye worm) | fli-1 protein | 0.0219 | 0.5999 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.4605 | 0.7677 |
Echinococcus granulosus | geminin | 0.0172 | 0.4605 | 0.4605 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.4605 | 0.7677 |
Schistosoma mansoni | thyroid hormone receptor | 0.0135 | 0.3507 | 0.5847 |
Brugia malayi | Peroxidasin | 0.004 | 0.0651 | 0.0263 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.004 | 0.0651 | 0.0263 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0651 | 0.0263 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0988 | 0.0876 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0854 | 0.0854 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0125 | 0.3207 | 0.3207 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0072 | 0.1618 | 0.2024 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0651 | 0.0263 |
Brugia malayi | Animal haem peroxidase family protein | 0.004 | 0.0651 | 0.0263 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0988 | 0.0876 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0651 | 0.0263 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0072 | 0.1618 | 0.1618 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0854 | 0.1423 |
Brugia malayi | Animal haem peroxidase family protein | 0.004 | 0.0651 | 0.0263 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0651 | 0.0263 |
Brugia malayi | Animal haem peroxidase family protein | 0.004 | 0.0651 | 0.0263 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0651 | 0.0263 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0052 | 0.1008 | 0.1681 |
Echinococcus granulosus | peroxidasin | 0.004 | 0.0651 | 0.0651 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.2919 | 0.4393 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0854 | 0.1423 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1008 | 0.0913 |
Brugia malayi | Animal haem peroxidase family protein | 0.004 | 0.0651 | 0.0263 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0651 | 0.0263 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.2919 | 0.4393 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0125 | 0.3207 | 0.3207 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.3207 | 0.5346 |
Onchocerca volvulus | 0.0052 | 0.1008 | 1 | |
Treponema pallidum | bacterioferrin (TpF1) | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0135 | 0.3507 | 0.3507 |
Brugia malayi | Fli-1 protein | 0.0219 | 0.5999 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0988 | 0.0876 |
Loa Loa (eye worm) | animal heme peroxidase | 0.004 | 0.0651 | 0.0263 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0854 | 0.0632 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0651 | 0.0263 |
Brugia malayi | Blistered cuticle protein 3 | 0.004 | 0.0651 | 0.0263 |
Echinococcus multilocularis | geminin | 0.0172 | 0.4605 | 0.4605 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0651 | 0.0263 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0651 | 0.0263 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0651 | 0.0263 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0854 | 0.1423 |
Schistosoma mansoni | peroxidasin | 0.004 | 0.0651 | 0.1086 |
Schistosoma mansoni | ets-related | 0.0219 | 0.5999 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0651 | 0.0263 |
Brugia malayi | Animal haem peroxidase family protein | 0.004 | 0.0651 | 0.0263 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.004 | 0.0651 | 0.0263 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.