Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0136 | 0.3274 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0708 | 0.2161 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0126 | 0.2986 | 0.2986 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0126 | 0.2986 | 0.2986 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.2093 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0094 | 0.2093 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0136 | 0.3274 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.043 | 0.1313 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0126 | 0.2986 | 0.9122 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0708 | 0.0708 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0 | 0.5 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0094 | 0.2093 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.043 | 0.1313 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0094 | 0.2093 | 0.2093 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0136 | 0.3274 | 0.3274 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0957 | 0.4575 |
Giardia lamblia | Kinase, PLK | 0.0094 | 0.2093 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.043 | 0.043 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.043 | 0.2054 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0708 | 0.2161 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.043 | 0.2054 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0708 | 0.0708 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.2093 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.2093 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.2093 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.2093 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.2093 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0371 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0036 | 0.043 | 0.2054 |
Trypanosoma brucei | polo-like protein kinase | 0.0094 | 0.2093 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0708 | 0.0708 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0708 | 0.2161 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0054 | 0.0957 | 0.2924 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0708 | 0.0708 |
Schistosoma mansoni | kinase | 0.0048 | 0.0772 | 0.2358 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0 | 0.5 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0094 | 0.2093 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0094 | 0.2093 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0708 | 0.3381 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0094 | 0.2093 | 0.2093 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.043 | 0.2054 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0094 | 0.2093 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0094 | 0.2093 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0094 | 0.2093 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.043 | 0.2054 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.043 | 0.043 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0047 | 0.0736 | 0.3519 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0047 | 0.0736 | 0.3519 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0708 | 0.3381 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0094 | 0.2093 | 0.6392 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0094 | 0.2093 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.