Detailed information for compound 698792

Basic information

Technical information
  • TDR Targets ID: 698792
  • Name: 4-fluoro-N-[2-[6-[2-[(3-methylphenyl)amino]-2 -oxoethyl]sulfanyl-[1,2,4]triazolo[5,4-f]pyri dazin-3-yl]ethyl]benzamide
  • MW: 464.515 | Formula: C23H21FN6O2S
  • H donors: 2 H acceptors: 5 LogP: 3.22 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)C)CSc1ccc2n(n1)c(CCNC(=O)c1ccc(cc1)F)nn2
  • InChi: 1S/C23H21FN6O2S/c1-15-3-2-4-18(13-15)26-21(31)14-33-22-10-9-19-27-28-20(30(19)29-22)11-12-25-23(32)16-5-7-17(24)8-6-16/h2-10,13H,11-12,14H2,1H3,(H,25,32)(H,26,31)
  • InChiKey: LIKKOMDSRDHZNU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-fluoro-N-[2-[6-[2-[(3-methylphenyl)amino]-2-oxo-ethyl]sulfanyl-[1,2,4]triazolo[5,4-f]pyridazin-3-yl]ethyl]benzamide
  • 4-fluoro-N-[2-[6-[[2-[(3-methylphenyl)amino]-2-oxoethyl]thio]-[1,2,4]triazolo[5,4-f]pyridazin-3-yl]ethyl]benzamide
  • 4-fluoro-N-[2-[6-[[2-keto-2-[(3-methylphenyl)amino]ethyl]thio]-[1,2,4]triazolo[5,4-f]pyridazin-3-yl]ethyl]benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0091 0.0262
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0012 0.001
Schistosoma mansoni hypothetical protein 0.1552 0.9464 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0012 0.001
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0012 0.001
Echinococcus granulosus neuropeptide receptor A26 0.0476 0.2827 0.2986
Plasmodium vivax hypothetical protein, conserved 0.003 0.0077 0.0243
Schistosoma mansoni tar DNA-binding protein 0.0322 0.1876 0.198
Brugia malayi hypothetical protein 0.0022 0.0026 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0145 0.0456
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0149 0.0498
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0091 0.0264
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0374 0.0393
Schistosoma mansoni Mername-AA248 (C02 family) 0.002 0.0014 0.0012
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0358 0.1249
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0026 0.0078
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.002 0.0014 0.0047
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0358 0.1049
Schistosoma mansoni nuclear receptor 0.0019 0.0012 0.001
Trypanosoma brucei PAB1-binding protein , putative 0.0102 0.0522 0.1735
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.001 0.0008
Schistosoma mansoni hypothetical protein 0.0128 0.0683 0.0719
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0145 0.0151
Schistosoma mansoni ferritin 0.0026 0.0056 0.0056
Chlamydia trachomatis hypothetical protein 0.002 0.0014 0.0025
Schistosoma mansoni hypothetical protein 0.0046 0.0175 0.0182
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0045 0.0131
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0091 0.03
Loa Loa (eye worm) hypothetical protein 0.0102 0.0522 0.1767
Echinococcus granulosus tar DNA binding protein 0.0322 0.1876 0.198
Echinococcus multilocularis calpain family protein 1, d 0.0047 0.018 0.0177
Brugia malayi Calcitonin receptor-like protein seb-1 0.0405 0.2391 0.8121
Loa Loa (eye worm) hypothetical protein 0.004 0.014 0.0467
Loa Loa (eye worm) DR-78 0.0019 0.0012 0.0031
Echinococcus granulosus calpain A 0.002 0.0014 0.0012
Loa Loa (eye worm) calpain 0.002 0.0014 0.0039
Echinococcus multilocularis muscleblind protein 0.0301 0.1751 0.1749
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0077 0.0218
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0012 0.001
Echinococcus multilocularis calpain 7 (C02 family) 0.002 0.0014 0.0012
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0495 0.2941 1
Loa Loa (eye worm) beta-lactamase 0.0076 0.0358 0.121
Loa Loa (eye worm) hypothetical protein 0.003 0.0077 0.0254
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0031
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0012 0.001
Schistosoma mansoni hypothetical protein 0.005 0.0199 0.0207
Echinococcus granulosus peregrin 0.0032 0.0093 0.0095
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0498 0.0496
Mycobacterium ulcerans lipase LipD 0.0076 0.0358 0.12
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0126 0.041
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0322 0.1876 0.6374
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0126 0.0391
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0358 0.1249
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0031
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0126 0.0384
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0145 0.0456
Echinococcus granulosus expressed protein 0.0026 0.0056 0.0056
Brugia malayi hypothetical protein 0.0297 0.1723 0.584
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0495 0.2941 0.3106
Loa Loa (eye worm) hypothetical protein 0.0047 0.018 0.0602
Echinococcus multilocularis hypothetical protein 0.002 0.0014 0.0012
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0058 0.0056
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0012 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0145 0.0485
Mycobacterium ulcerans hypothetical protein 0.0076 0.0358 0.12
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0079
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.001 0.0008
Schistosoma mansoni nuclear receptor 0.0019 0.0012 0.001
Schistosoma mansoni hypothetical protein 0.0277 0.16 0.1689
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0145 0.0151
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0043 0.0155 0.0519
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0145 0.0151
Mycobacterium tuberculosis Conserved protein 0.0076 0.0358 0.1249
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0012 0.0031
Echinococcus granulosus zinc finger protein 0.0024 0.0039 0.0039
Schistosoma mansoni bromodomain containing protein 0.007 0.0321 0.0337
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0145 0.0456
Brugia malayi beta-NAC-like protein 0.0107 0.0553 0.1847
Echinococcus multilocularis calpain 5 0.002 0.0014 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0012
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0495 0.2941 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0358 0.0376
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0014 0.0012
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0026 0.0025
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0077 0.0254
Schistosoma mansoni apoferritin-2 0.0026 0.0056 0.0056
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0091 0.0088
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0046 0.0175 0.0172
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0495 0.2941 1
Echinococcus granulosus transcription factor btf3 0.0107 0.0553 0.0582
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0026 0.0049
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0128 0.0683 0.0681
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0026 0.0025
Mycobacterium ulcerans hypothetical protein 0.002 0.0014 0.0025
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0077 0.0079
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0145 0.0151
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0145 0.0456
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0358 0.1249
Trypanosoma cruzi PAB1-binding protein , putative 0.0102 0.0522 0.1735
Loa Loa (eye worm) calpain family protein 1 0.0066 0.0301 0.1016
Brugia malayi PHD-finger family protein 0.0029 0.0073 0.0211
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0045 0.0105
Brugia malayi calpain family protein 1 0.0066 0.0301 0.0988
Echinococcus granulosus neuropeptide s receptor 0.0476 0.2827 0.2986
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0358 0.1249
Loa Loa (eye worm) hypothetical protein 0.0041 0.0145 0.0485
Echinococcus granulosus CAAX prenyl protease 2 0.0095 0.0479 0.0504
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0145 0.0485
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0768 0.0809
Echinococcus granulosus GPCR family 2 0.0128 0.0683 0.0719
Loa Loa (eye worm) hypothetical protein 0.0041 0.0145 0.0485
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0045 0.0131
Brugia malayi hypothetical protein 0.0022 0.0026 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0145 0.0456
Plasmodium vivax basic transcription factor 3b, putative 0.0107 0.0553 0.1862
Leishmania major basic transcription factor 3a, putative 0.0107 0.0553 0.1841
Echinococcus multilocularis neuropeptide receptor A26 0.0476 0.2827 0.2826
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0145 0.0456
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0126 0.0245
Schistosoma mansoni cpg binding protein 0.0058 0.0249 0.0261
Echinococcus multilocularis GPCR, family 2 0.0128 0.0683 0.0681
Echinococcus granulosus dnaJ subfamily B 0.0428 0.2532 0.2673
Trypanosoma cruzi transcription factor btf3, putative 0.0107 0.0553 0.1841
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0405 0.2391 0.8127
Schistosoma mansoni ap endonuclease 0.0038 0.0126 0.0131
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0145 0.0143
Brugia malayi Bromodomain containing protein 0.004 0.014 0.0436
Entamoeba histolytica hypothetical protein 0.0147 0.0802 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0143
Brugia malayi nuclear receptor RXR 0.0022 0.0026 0.0049
Trypanosoma brucei transcription factor BTF3, putative 0.0107 0.0553 0.1841
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0091 0.0088
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0358 0.121
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.1393 0.1391
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0358 0.1049
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0358 0.1049
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0358 0.0356
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0145 0.0143
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0145 0.0151
Loa Loa (eye worm) RNA binding protein 0.0322 0.1876 0.6374
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0091 0.0088
Schistosoma mansoni tar DNA-binding protein 0.0322 0.1876 0.198
Brugia malayi hypothetical protein 0.0066 0.0299 0.098
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.021 0.1186 0.4026
Schistosoma mansoni hypothetical protein 0.0128 0.0683 0.0719
Loa Loa (eye worm) hypothetical protein 0.0066 0.0301 0.1016
Onchocerca volvulus 0.0047 0.018 0.0981
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0045 0.0105
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0358 0.12
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0145 0.0151
Plasmodium falciparum ataxin-2 like protein, putative 0.0102 0.0522 0.1757
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0145 0.0143
Brugia malayi CAAX amino terminal protease family protein 0.0095 0.0479 0.1596
Trypanosoma brucei CAAX amino terminal protease, putative 0.0095 0.0479 0.159
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0126 0.0124
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0012 0.0009
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0495 0.2941 0.2939
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.0768 0.2603
Entamoeba histolytica calpain large subunit domain III containing protein 0.002 0.0014 0.0007
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0145 0.0143
Schistosoma mansoni zinc finger protein 0.0019 0.0012 0.001
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0045 0.0131
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0046 0.0175 0.0182
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0116 0.0114
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0091 0.027
Schistosoma mansoni hypothetical protein 0.0128 0.0683 0.0719
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0145 0.0151
Plasmodium falciparum ataxin-2 like protein, putative 0.0102 0.0522 0.1757
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0031
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0014 0.0012
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0012 0.0009
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0045 0.0131
Echinococcus multilocularis muscleblind protein 1 0.0301 0.1751 0.1749
Onchocerca volvulus 0.0025 0.0045 0.0193
Echinococcus granulosus muscleblind protein 0.0301 0.1751 0.1848
Brugia malayi calpain family protein 1 0.0066 0.0301 0.0988
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0091 0.0262
Entamoeba histolytica protein kinase, putative 0.002 0.0014 0.0007
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0249 0.0838
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0145 0.0151
Mycobacterium tuberculosis Conserved protein 0.0076 0.0358 0.1249
Trypanosoma cruzi PAB1-binding protein , putative 0.0102 0.0522 0.1735
Mycobacterium ulcerans integral membrane protein 0.002 0.0014 0.0025
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0358 0.1049
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0056 0.0194
Brugia malayi nuclear receptor NHR-88 0.0041 0.0145 0.0456
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0095 0.0479 0.0504
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0145 0.0456
Echinococcus granulosus jumonji domain containing protein 0.0042 0.015 0.0156
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0358 0.1176
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0091 0.0262
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0126 0.0421
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0031
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0495 0.2941 1
Echinococcus multilocularis cpg binding protein 0.0063 0.0282 0.0279
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0145 0.0456
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0323 0.1884 0.6388
Plasmodium falciparum protease, putative 0.002 0.0014 0.0025
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0145 0.0456
Loa Loa (eye worm) latrophilin receptor protein 2 0.0128 0.0683 0.2315
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0145 0.0143
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0079
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0014 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0553 0.1723
Schistosoma mansoni ferritin 0.0026 0.0056 0.0056
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0495 0.2941 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0126 0.0384
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0145 0.0151
Loa Loa (eye worm) hypothetical protein 0.0041 0.0145 0.0485
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0274 0.0925
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0128 0.0683 0.0719
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0553 0.1723
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0143
Leishmania major hypothetical protein, conserved 0.0102 0.0522 0.1735
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0091 0.0288
Echinococcus granulosus cpg binding protein 0.0063 0.0282 0.0295
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0124 0.0129
Loa Loa (eye worm) hypothetical protein 0.0041 0.0145 0.0485
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0006 0.0022
Loa Loa (eye worm) hypothetical protein 0.0041 0.0145 0.0485
Giardia lamblia Hypothetical protein 0.0095 0.0479 0.1403
Loa Loa (eye worm) hypothetical protein 0.0041 0.0145 0.0485
Entamoeba histolytica hypothetical protein 0.0107 0.0553 0.6842
Schistosoma mansoni cpg binding protein 0.0063 0.0282 0.0295
Schistosoma mansoni cpg binding protein 0.0063 0.0282 0.0295
Brugia malayi RNA binding protein 0.0322 0.1876 0.6363
Loa Loa (eye worm) hypothetical protein 0.0126 0.067 0.2271
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0026 0.0056 0.0349
Echinococcus multilocularis CAAX prenyl protease 2 0.0095 0.0479 0.0477
Loa Loa (eye worm) hypothetical protein 0.0301 0.1751 0.595
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0006 0.0012
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.007 0.0322 0.032
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0126 0.0245
Mycobacterium ulcerans hypothetical protein 0.0025 0.0045 0.0131
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0495 0.2941 1
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0358 0.1176
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0126 0.0131
Loa Loa (eye worm) hypothetical protein 0.0128 0.0683 0.2315
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0358 0.0376
Onchocerca volvulus 0.0076 0.0358 0.2026
Schistosoma mansoni hypothetical protein 0.0428 0.2532 0.2673
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0124 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0145 0.0456
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0079
Onchocerca volvulus 0.0076 0.0358 0.2026
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0145 0.0143
Loa Loa (eye worm) hypothetical protein 0.0297 0.1723 0.5853
Echinococcus multilocularis transcription factor btf3 0.0107 0.0553 0.0551
Mycobacterium ulcerans hypothetical protein 0.002 0.0014 0.0025
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0012 0.001
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0095 0.0479 0.1468
Schistosoma mansoni tar DNA-binding protein 0.0322 0.1876 0.198
Mycobacterium tuberculosis Conserved protein 0.0076 0.0358 0.1249
Echinococcus multilocularis microtubule associated protein 2 0.1433 0.8725 0.8725
Echinococcus multilocularis calpain A 0.007 0.0322 0.032
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0077 0.0079
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0145 0.0151
Loa Loa (eye worm) hypothetical protein 0.0301 0.1751 0.595
Echinococcus multilocularis peregrin 0.0032 0.0093 0.009
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0145 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0145 0.0456
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0012 0.0009
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0145 0.0151
Echinococcus granulosus ferritin 0.0026 0.0056 0.0056
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0045 0.0105
Schistosoma mansoni coup transcription factor 0.0041 0.0145 0.0151
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.0768 0.2581
Onchocerca volvulus 0.0058 0.0249 0.1387
Echinococcus granulosus calpain A 0.007 0.0322 0.0338
Schistosoma mansoni transcription factor LCR-F1 0.0147 0.0802 0.0845
Brugia malayi jmjC domain containing protein 0.0042 0.0149 0.0469
Loa Loa (eye worm) transcription factor SMAD2 0.0251 0.144 0.4891
Brugia malayi TAR-binding protein 0.0322 0.1876 0.6363
Brugia malayi Bromodomain containing protein 0.0032 0.0093 0.0276
Loa Loa (eye worm) hypothetical protein 0.0041 0.0145 0.0485
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0768 0.0809
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0149 0.0155
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0045 0.0113
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0031
Trypanosoma cruzi transcription factor btf3, putative 0.0107 0.0553 0.1841
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0091 0.0093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0145 0.0485
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0145 0.0456
Schistosoma mansoni ferritin 0.0026 0.0056 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0145 0.0456
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.001 0.0008
Brugia malayi latrophilin 2 splice variant baaae 0.0277 0.16 0.5423
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0145 0.0781
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0172 0.095 0.3311
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0091 0.0262
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0012
Entamoeba histolytica hypothetical protein 0.0147 0.0802 1
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0095 0.0479 0.159
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0358 0.1176
Echinococcus multilocularis ferritin 0.0026 0.0056 0.0053
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0298 0.0296
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0012 0.0031
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0031
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0145 0.0151
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0768 0.0809
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0358 0.1183
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0145 0.0485
Brugia malayi Bromodomain containing protein 0.0082 0.0397 0.1314
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0498 0.0524
Schistosoma mansoni tar DNA-binding protein 0.0322 0.1876 0.198
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0145 0.0781
Echinococcus granulosus microtubule associated protein 2 0.1433 0.8725 0.9219
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0045 0.0113
Mycobacterium leprae Probable lipase LipE 0.0076 0.0358 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0045 0.0396
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0145 0.0485
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0768 0.0765
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.0056 0.0168
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0091 0.0088
Echinococcus granulosus calpain 5 0.002 0.0014 0.0012
Brugia malayi hypothetical protein 0.0102 0.0522 0.1742
Schistosoma mansoni hypothetical protein 0.0022 0.0026 0.0024
Schistosoma mansoni hypothetical protein 0.0128 0.0683 0.0719
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0495 0.2941 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.007 0.0322 0.0338
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0026 0.0024
Brugia malayi beta-lactamase family protein 0.0076 0.0358 0.1183
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.0649 0.0683
Echinococcus multilocularis tar DNA binding protein 0.0322 0.1876 0.1874
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0149 0.0155
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0126 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0483 0.2869 1
Brugia malayi beta-lactamase 0.0076 0.0358 0.1183
Brugia malayi PHD-finger family protein 0.003 0.0077 0.0224
Echinococcus granulosus transcription factor eb 0.0211 0.1192 0.1257
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0012 0.001
Mycobacterium ulcerans beta-lactamase 0.0076 0.0358 0.12
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0126 0.0384
Schistosoma mansoni hypothetical protein 0.0147 0.0802 0.0845
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0095 0.0479 0.159
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0012
Onchocerca volvulus Huntingtin homolog 0.0126 0.067 0.3848
Trichomonas vaginalis esterase, putative 0.0076 0.0358 0.1049
Loa Loa (eye worm) hypothetical protein 0.0405 0.2391 0.8127
Schistosoma mansoni calpain (C02 family) 0.002 0.0014 0.0012
Brugia malayi steroid hormone receptor 0.0041 0.0145 0.0456
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0298 0.0312
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.015 0.0148
Plasmodium falciparum phd finger protein, putative 0.003 0.0077 0.0243
Echinococcus multilocularis neuropeptide s receptor 0.0476 0.2827 0.2826
Echinococcus granulosus calpain 0.002 0.0014 0.0012
Echinococcus multilocularis calpain 0.002 0.0014 0.0012
Loa Loa (eye worm) hypothetical protein 0.0076 0.0358 0.121
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0553 0.1723
Echinococcus multilocularis transcription factor eb 0.0211 0.1192 0.119
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0077 0.0075
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0091 0.0316
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0128 0.0683 0.2291
Schistosoma mansoni zinc finger protein 0.0024 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0051 0.021 0.0704
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0126 0.0384
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0143
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.002 0.0014 0.0047
Echinococcus multilocularis dnaJ subfamily B 0.0428 0.2532 0.253
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0128 0.0683 0.0681
Toxoplasma gondii NAC domain-containing protein 0.0107 0.0553 0.1842
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0145 0.0151
Schistosoma mansoni ferritin light chain 0.0026 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.1552 0.9464 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.067 0.2271
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0358 0.1249
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0199 0.0638
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0145 0.0151
Loa Loa (eye worm) hypothetical protein 0.0048 0.0188 0.063
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0145 0.0143
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0145 0.0485
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0358 0.0376
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0145 0.0151
Loa Loa (eye worm) hypothetical protein 0.0047 0.018 0.0602
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0145 0.0781
Plasmodium vivax ataxin-2 like protein, putative 0.0102 0.0522 0.1757
Loa Loa (eye worm) hypothetical protein 0.0076 0.0358 0.121
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0495 0.2941 1
Brugia malayi RNA recognition motif domain containing protein 0.0322 0.1876 0.6363
Loa Loa (eye worm) hypothetical protein 0.0076 0.0358 0.121
Schistosoma mansoni microtubule-associated protein tau 0.1433 0.8725 0.9219
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0211 0.1192 0.4029
Echinococcus granulosus calpain 7 C02 family 0.002 0.0014 0.0012
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0495 0.2941 1
Brugia malayi calpain 7 0.002 0.0014 0.0008
Loa Loa (eye worm) hypothetical protein 0.0095 0.0479 0.1622
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0495 0.2941 0.3106
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0026 0.0079
Loa Loa (eye worm) hypothetical protein 0.021 0.1186 0.4026
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0095 0.0479 0.159
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0079
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0095 0.0479 0.0504
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.0768 0.0809
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0045 0.0131
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0147 0.0802 0.0845
Loa Loa (eye worm) hypothetical protein 0.0277 0.16 0.5437
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0147 0.0802 0.0799
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0145 0.0151
Schistosoma mansoni transcription factor btf3 0.0107 0.0553 0.0582
Echinococcus multilocularis expressed protein 0.0026 0.0056 0.0053
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.007 0.0322 0.0338
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.0768 0.0809
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0058 0.0059
Loa Loa (eye worm) hypothetical protein 0.0076 0.0358 0.121
Echinococcus granulosus geminin 0.1552 0.9464 1
Brugia malayi calpain 5 0.002 0.0014 0.0008
Brugia malayi nuclear hormone receptor 0.0041 0.0145 0.0456
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0358 0.1249
Loa Loa (eye worm) calpain 5 0.002 0.0014 0.0039
Plasmodium vivax protease, putative 0.002 0.0014 0.0025
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0074 0.0213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0031
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0145 0.0143
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0358 0.1049
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0056 0.0194
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0495 0.2941 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0091 0.0093
Brugia malayi MH2 domain containing protein 0.0251 0.144 0.4875
Onchocerca volvulus Alhambra homolog 0.003 0.0077 0.0384
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0145 0.0485
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0045 0.0396
Brugia malayi ecdysteroid receptor 0.0041 0.0145 0.0456
Loa Loa (eye worm) hypothetical protein 0.0076 0.0358 0.121
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0026 0.0025
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0358 0.1249
Onchocerca volvulus Huntingtin homolog 0.0126 0.067 0.3848
Entamoeba histolytica hypothetical protein 0.0147 0.0802 1
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0145 0.0456
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0045 0.0156
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0128 0.0683 0.0719
Loa Loa (eye worm) hypothetical protein 0.0074 0.0349 0.1178
Loa Loa (eye worm) ICD-1 protein 0.0107 0.0553 0.1872
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.007 0.0322 0.0338
Loa Loa (eye worm) hypothetical protein 0.0076 0.0358 0.121
Brugia malayi Muscleblind-like protein 0.0301 0.1751 0.5937
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0045 0.0396
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0012 0.001
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0164 0.0903 0.3036
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0145 0.0456
Plasmodium falciparum basic transcription factor 3b, putative 0.0107 0.0553 0.1862
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0012 0.001
Echinococcus multilocularis geminin 0.1552 0.9464 0.9464
Mycobacterium tuberculosis Probable integral membrane protein 0.002 0.0014 0.0047
Leishmania major hypothetical protein, conserved 0.0076 0.0358 0.1176
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.0768 0.0765
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0031
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0058 0.0059
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0031
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0026 0.0049
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0091 0.0262
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0045 0.0131
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0045 0.0131
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0091 0.0088
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0495 0.2941 1
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0159 0.0873 0.2936
Toxoplasma gondii exonuclease III APE 0.0038 0.0126 0.0386
Loa Loa (eye worm) MH2 domain-containing protein 0.0251 0.144 0.4891
Brugia malayi isocitrate dehydrogenase 0.0032 0.0091 0.027
Schistosoma mansoni tar DNA-binding protein 0.0322 0.1876 0.198
Schistosoma mansoni ferritin 0.0026 0.0056 0.0056
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0012 0.0009
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0301 0.0316
Schistosoma mansoni apoferritin-2 0.0026 0.0056 0.0056
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0145 0.0151
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0031
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0077 0.0218
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0126 0.1432
Brugia malayi hypothetical protein 0.0243 0.1393 0.4716
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0145 0.0151
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0056 0.0144
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0012 0.0031
Entamoeba histolytica transcription factor BTF3, putative 0.0107 0.0553 0.6842
Brugia malayi glucose-6-phosphate dehydrogenase 0.0495 0.2941 1
Brugia malayi beta-lactamase family protein 0.0076 0.0358 0.1183
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0126 0.0441
Plasmodium vivax calpain, putative 0.002 0.0014 0.0027
Loa Loa (eye worm) hypothetical protein 0.0041 0.0145 0.0485
Brugia malayi hypothetical protein 0.0147 0.0802 0.2697
Loa Loa (eye worm) hypothetical protein 0.0243 0.1393 0.4732
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0012 0.0009
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0126 0.041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0079
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0091 0.0264
Schistosoma mansoni survival motor neuron protein 0.005 0.0199 0.0207
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0012
Onchocerca volvulus 0.0297 0.1723 1
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0358 1
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0012 0.001
Brugia malayi jmjC domain containing protein 0.0098 0.0498 0.1661
Brugia malayi hypothetical protein 0.0126 0.067 0.2247
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0358 0.12
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0145 0.0151
Schistosoma mansoni calpain C (C02 family) 0.002 0.0014 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0031
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0358 0.12
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0323 0.1884 0.6397
Loa Loa (eye worm) hypothetical protein 0.0066 0.0301 0.1016
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0145 0.0151
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0405 0.2391 0.8121
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0126 0.041
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0091 0.0288
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0026
Toxoplasma gondii histone lysine methyltransferase SET1 0.0112 0.0583 0.1946
Schistosoma mansoni hypothetical protein 0.003 0.0077 0.0079
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0145 0.0143
Onchocerca volvulus 0.0041 0.0145 0.0781
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0126 0.0386
Entamoeba histolytica hypothetical protein 0.0147 0.0802 1
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.0056 0.0168
Loa Loa (eye worm) calpain family protein 1 0.0047 0.018 0.0602
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0145 0.0456
Brugia malayi CXXC zinc finger family protein 0.0058 0.0249 0.081
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0031
Schistosoma mansoni ap endonuclease 0.0038 0.0126 0.0131
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0149 0.0155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0145 0.0485
Toxoplasma gondii LsmAD domain-containing protein 0.0102 0.0522 0.1737
Echinococcus multilocularis zinc finger protein 0.0024 0.0039 0.0037
Toxoplasma gondii ABC1 family protein 0.0076 0.0358 0.1178
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0495 0.2941 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0012
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0495 0.2941 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0045 0.0113
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0126 0.0171
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0045 0.0156
Brugia malayi Latrophilin receptor protein 2 0.0128 0.0683 0.2291
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0031
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.1393 0.147
Onchocerca volvulus 0.005 0.0199 0.1092
Entamoeba histolytica CAAX prenyl protease family 0.0095 0.0479 0.591
Loa Loa (eye worm) TAR-binding protein 0.0322 0.1876 0.6374
Schistosoma mansoni ferritin light chain 0.0026 0.0056 0.0056
Onchocerca volvulus 0.0076 0.0358 0.2026
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0495 0.2941 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.