Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0077 | 0.2681 | 0.2803 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0077 | 0.2681 | 0.2803 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0414 | 0.0432 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0056 | 0.1688 | 0.1765 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0414 | 0.0432 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0077 | 0.2681 | 1 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0056 | 0.1688 | 0.1765 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0221 | 0.9564 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0115 | 0.4493 | 0.4698 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0077 | 0.2681 | 0.2803 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0057 | 0.1755 | 0.1835 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0414 | 0.0432 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0057 | 0.1755 | 0.1835 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0363 | 0.0379 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0041 | 0.1005 | 0.1051 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0077 | 0.2681 | 0.2803 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.1843 | 0.1927 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0077 | 0.2681 | 0.2803 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0057 | 0.1755 | 0.1835 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0077 | 0.2681 | 0.2803 |
Onchocerca volvulus | 0.0029 | 0.0414 | 0.0414 | |
Trichomonas vaginalis | mercuric reductase, putative | 0.0077 | 0.2681 | 0.2681 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0221 | 0.9564 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0056 | 0.1688 | 0.6295 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0077 | 0.2681 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0221 | 0.9564 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0077 | 0.2681 | 0.2803 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0077 | 0.2681 | 0.2803 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.1843 | 0.1927 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0414 | 0.0432 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0077 | 0.2681 | 0.2803 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.1843 | 0.1927 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0077 | 0.2681 | 0.2803 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0414 | 0.0432 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.1843 | 0.6874 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0137 | 0.5555 | 0.5808 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.1843 | 0.1927 |
Plasmodium falciparum | glutathione reductase | 0.0077 | 0.2681 | 0.2803 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.1843 | 0.1927 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0038 | 0.084 | 0.0879 |
Plasmodium vivax | glutathione reductase, putative | 0.0221 | 0.9564 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0077 | 0.2681 | 0.2803 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.1843 | 0.6874 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.8669 | 0.9064 |
Brugia malayi | glutathione reductase | 0.0221 | 0.9564 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.1843 | 0.1927 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.1843 | 0.6874 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0077 | 0.2681 | 1 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0077 | 0.2681 | 0.2803 |
Treponema pallidum | NADH oxidase | 0.0077 | 0.2681 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.8669 | 0.9064 |
Loa Loa (eye worm) | glutathione reductase | 0.0221 | 0.9564 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0077 | 0.2681 | 0.2803 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0077 | 0.2681 | 0.2803 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0077 | 0.2681 | 0.2803 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0077 | 0.2681 | 0.2803 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0077 | 0.2681 | 0.2803 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0056 | 0.1688 | 0.1765 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0077 | 0.2681 | 1 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0056 | 0.1688 | 0.1765 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0077 | 0.2681 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0221 | 0.9564 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0414 | 0.0432 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0077 | 0.2681 | 0.2803 |
Trypanosoma brucei | trypanothione reductase | 0.0221 | 0.9564 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0414 | 0.0432 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0077 | 0.2681 | 0.2803 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0077 | 0.2681 | 0.2803 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0115 | 0.4493 | 0.4698 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0041 | 0.1005 | 0.1051 |
Plasmodium falciparum | thioredoxin reductase | 0.0221 | 0.9564 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0077 | 0.2681 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0057 | 0.1755 | 0.1835 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0077 | 0.2681 | 0.2803 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.1843 | 0.1927 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0141 | 0.5743 | 0.6005 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0052 | 0.1509 | 0.1578 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0077 | 0.2681 | 0.2803 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0077 | 0.2681 | 0.2803 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0056 | 0.1688 | 0.1765 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0041 | 0.1005 | 0.1051 |
Schistosoma mansoni | lipoxygenase | 0.0115 | 0.4493 | 0.4698 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0041 | 0.1005 | 0.1005 |
Loa Loa (eye worm) | acetyltransferase | 0.0141 | 0.5743 | 0.6005 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0077 | 0.2681 | 0.2803 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0141 | 0.5743 | 0.6005 |
Brugia malayi | jmjC domain containing protein | 0.0057 | 0.1755 | 0.1835 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0077 | 0.2681 | 0.2803 |
Toxoplasma gondii | thioredoxin reductase | 0.0221 | 0.9564 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0057 | 0.1755 | 0.1835 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0077 | 0.2681 | 0.2803 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0077 | 0.2681 | 0.2803 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0221 | 0.9564 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0414 | 0.0432 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0077 | 0.2681 | 1 |
Schistosoma mansoni | lipoxygenase | 0.008 | 0.2849 | 0.2979 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0041 | 0.1005 | 0.1051 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0057 | 0.1755 | 0.1835 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0056 | 0.1712 | 0.179 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0414 | 0.0432 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0221 | 0.9564 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0057 | 0.1755 | 0.1835 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0077 | 0.2681 | 0.2803 |
Trichomonas vaginalis | set domain proteins, putative | 0.023 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0414 | 0.0432 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0056 | 0.1688 | 0.1765 |
Brugia malayi | Thioredoxin reductase | 0.0221 | 0.9564 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0141 | 0.5743 | 0.6005 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0056 | 0.1688 | 0.6295 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0041 | 0.1005 | 0.1005 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0077 | 0.2681 | 0.2803 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0414 | 0.0432 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0077 | 0.2681 | 0.2681 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0077 | 0.2681 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0077 | 0.2681 | 0.2803 |
Schistosoma mansoni | jumonji domain containing protein | 0.0057 | 0.1755 | 0.1835 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0038 | 0.084 | 0.3135 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0221 | 0.9564 | 1 |
Leishmania major | trypanothione reductase | 0.0221 | 0.9564 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0056 | 0.1712 | 0.179 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0038 | 0.084 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0057 | 0.1755 | 0.1835 |
Plasmodium falciparum | thioredoxin reductase | 0.0077 | 0.2681 | 0.2803 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0077 | 0.2681 | 0.2803 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.