Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.3228 | 0.3584 |
Echinococcus multilocularis | chromobox protein 1 | 0.0073 | 0.9006 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0073 | 0.9006 | 0.8877 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.1149 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.1149 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.3228 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0021 | 0.0435 | 0.0483 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0114 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0114 | 0.0123 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.1149 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0947 | 0.1052 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0114 | 0.0123 |
Echinococcus multilocularis | zinc finger protein | 0.0021 | 0.0435 | 0.0483 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.1149 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.3228 | 0.3584 |
Schistosoma mansoni | chromobox protein | 0.0073 | 0.9006 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0618 | 0.0667 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.3755 | 0.2714 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.3228 | 1 |
Onchocerca volvulus | 0.0032 | 0.2308 | 0.3722 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1149 | 0.124 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.3228 | 0.3584 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.4087 | 0.4413 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.1149 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.9262 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0038 | 0.3258 | 0.3617 |
Brugia malayi | PHD-finger family protein | 0.0026 | 0.1356 | 0.0234 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.1149 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.1149 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.1149 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.1149 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0073 | 0.9006 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0019 | 0.0106 | 0.0114 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0063 | 0.736 | 0.8172 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0025 | 0.1149 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0073 | 0.9006 | 1 |
Brugia malayi | hypothetical protein | 0.0038 | 0.3228 | 0.2349 |
Trichomonas vaginalis | chromobox protein, putative | 0.0073 | 0.9006 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.3755 | 0.2714 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0073 | 0.9006 | 0.9724 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.0114 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.3679 | 0.3972 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0025 | 0.1149 | 0.5 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.3755 | 0.8367 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.3228 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.4264 | 0.3419 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.4417 | 0.4769 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.1149 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0021 | 0.0435 | 0.0483 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.3228 | 0.3584 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1149 | 0.124 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0618 | 0.0686 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0947 | 0.1052 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.1149 | 1 |
Brugia malayi | chromobox protein homolog 3 | 0.0041 | 0.3755 | 0.2945 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.3667 | 0.2845 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0038 | 0.3258 | 0.3617 |
Trichomonas vaginalis | chromobox protein, putative | 0.0073 | 0.9006 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.4264 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1149 | 0.124 |
Schistosoma mansoni | bromodomain containing protein | 0.0067 | 0.7978 | 0.8858 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.3228 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0114 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0114 | 0.0123 |
Echinococcus multilocularis | chromobox protein 1 | 0.0073 | 0.9006 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0073 | 0.9006 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0019 | 0.0114 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0114 | 0.0123 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.1149 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2308 | 0.2492 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0947 | 0.1052 |
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.4264 | 0.3419 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0063 | 0.736 | 0.8172 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.1149 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3755 | 0.4055 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.