Detailed information for compound 699758

Basic information

Technical information
  • TDR Targets ID: 699758
  • Name: 4-fluoro-N-[1-(4-methoxyphenyl)-5-oxopyrrolid in-3-yl]benzenesulfonamide
  • MW: 364.391 | Formula: C17H17FN2O4S
  • H donors: 1 H acceptors: 3 LogP: 1.79 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)N1CC(CC1=O)NS(=O)(=O)c1ccc(cc1)F
  • InChi: 1S/C17H17FN2O4S/c1-24-15-6-4-14(5-7-15)20-11-13(10-17(20)21)19-25(22,23)16-8-2-12(18)3-9-16/h2-9,13,19H,10-11H2,1H3
  • InChiKey: CCLCEGYROFJKIW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-fluoro-N-[1-(4-methoxyphenyl)-5-oxo-pyrrolidin-3-yl]benzenesulfonamide
  • 4-fluoro-N-[1-(4-methoxyphenyl)-5-oxo-3-pyrrolidinyl]benzenesulfonamide
  • 4-fluoro-N-[5-keto-1-(4-methoxyphenyl)pyrrolidin-3-yl]benzenesulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0039 0.0356 0.0357
Schistosoma mansoni retinoic acid receptor RXR 0.0035 0.0298 0.0275
Schistosoma mansoni hypothetical protein 0.0019 0.0084 0.006
Schistosoma mansoni hypothetical protein 0.0056 0.0577 0.0556
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0076 0.0834 0.1965
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0286 0.0251
Onchocerca volvulus 0.0056 0.0577 0.0568
Entamoeba histolytica Ran family GTPase 0.0021 0.0106 0.0537
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0113 0.1327 0.126
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0113 0.1327 0.3164
Schistosoma mansoni nuclear receptor 0.0017 0.0054 0.0029
Loa Loa (eye worm) hypothetical protein 0.0035 0.0298 0.0299
Loa Loa (eye worm) hypothetical protein 0.0113 0.1327 0.1332
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.002 0.01 0.0091
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0113 0.1327 0.138
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.0577 0.0579
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0054
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.048 0.0541
Echinococcus multilocularis sex peptide receptor 0.0056 0.0577 0.0579
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0077 0.0127
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0298 0.0771
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.008 0.008
Brugia malayi Steroid receptor seven-up type 2 0.0035 0.0298 0.0326
Echinococcus granulosus carboxylesterase 5A 0.0067 0.0723 0.0725
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0577 0.0579
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0577 0.0579
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0113 0.1327 0.138
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Leishmania major hypothetical protein, conserved 0.0015 0.0031 0.0015
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0203 0.0204
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0054
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0076 0.0834 0.1965
Trypanosoma cruzi dihydroorotase, putative 0.0019 0.0084 0.0145
Onchocerca volvulus Bile acid receptor homolog 0.0035 0.0298 0.0265
Mycobacterium ulcerans n-acetylglucosamine-6-phosphate deacetylase NagA 0.0019 0.0084 0.0201
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0113 0.1327 0.138
Mycobacterium ulcerans imidazolonepropionase 0.0019 0.0084 0.0201
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0054 0.0054
Loa Loa (eye worm) steroid hormone receptor 0.0035 0.0298 0.0299
Trypanosoma cruzi ISWI complex protein 0.0015 0.0031 0.0015
Trichomonas vaginalis glutamate synthase, putative 0.002 0.01 0.0049
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0035 0.0298 0.0299
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.002 0.01 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.1327 0.138
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0113 0.1327 0.4781
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0113 0.1327 0.3164
Echinococcus multilocularis carboxylesterase 5A 0.0067 0.0723 0.0725
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0054 0.0036
Brugia malayi Serotonin receptor 0.0056 0.0577 0.0656
Schistosoma mansoni thyroid hormone receptor 0.016 0.1948 0.1934
Brugia malayi hypothetical protein 0.0056 0.0577 0.0656
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0283 0.3574 1
Schistosoma mansoni disulfide oxidoreductase 0.002 0.01 0.0076
Schistosoma mansoni glutamate synthase 0.002 0.01 0.0076
Schistosoma mansoni importin beta-1 0.0028 0.0203 0.0179
Brugia malayi ecdysone receptor 0.0017 0.0054 0.0036
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0113 0.1327 0.131
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0054
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0076 0.0834 0.5259
Onchocerca volvulus 0.0035 0.0298 0.0265
Brugia malayi RE15519p 0.0056 0.0577 0.0656
Leishmania major chitinase 0.0113 0.1326 0.3161
Trichomonas vaginalis guanine deaminase, putative 0.0129 0.1536 0.1607
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0113 0.1327 0.138
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0106 0.0192
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0113 0.1327 0.126
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.01 0.0183
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0056 0.0577 0.0656
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0326 0.4141 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0054
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0373 0.2149
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.002 0.01 0.0499
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.002 0.01 0.0171
Echinococcus granulosus somatostatin receptor 0.0056 0.0577 0.0579
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0056 0.0577 0.0579
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0035 0.0298 0.0326
Echinococcus multilocularis dna polymerase eta 0.0014 0.0025 0.0025
Entamoeba histolytica glutamate synthase beta subunit, putative 0.002 0.01 0.0499
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0577 0.0579
Loa Loa (eye worm) hypothetical protein 0.0239 0.2997 0.3006
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0113 0.1327 0.126
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0076 0.0834 0.2926
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0577 0.0556
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0035 0.0298 0.0326
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0035 0.0298 0.0326
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0113 0.1327 0.126
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.002 0.01 0.0023
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0056 0.0577 0.0579
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0077 0.0077
Brugia malayi nuclear receptor RXR 0.0019 0.008 0.0067
Brugia malayi steroid hormone receptor 0.0035 0.0298 0.0326
Plasmodium falciparum glutathione reductase 0.0218 0.2717 1
Mycobacterium ulcerans beta-lactamase 0.0035 0.0298 0.1645
Echinococcus multilocularis neuropeptide s receptor 0.0056 0.0577 0.0579
Schistosoma mansoni biogenic amine receptor 0.0056 0.0577 0.0556
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0767 0.9968 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0052 0.0067
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0298 0.0264
Plasmodium vivax dihydroorotase, putative 0.0019 0.0084 0.0112
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0077 0.0127
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.002 0.01 0.0023
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.0577 0.0579
Echinococcus granulosus ecdysone induced protein 78C 0.0035 0.0298 0.0299
Brugia malayi hypothetical protein 0.0056 0.0577 0.0656
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0501 0.0502
Echinococcus multilocularis dihydropyrimidinase 0.0019 0.0084 0.0085
Mycobacterium ulcerans NADH dehydrogenase 0.002 0.01 0.0307
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0076 0.0834 0.2926
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0056 0.0577 0.0579
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0113 0.1327 0.4781
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0006 0.0006
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.0577 0.0579
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.002 0.01 0.01
Schistosoma mansoni adenoreceptor 0.0056 0.0577 0.0556
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.002 0.01 0.0049
Brugia malayi nuclear receptor NHR-88 0.0017 0.0054 0.0036
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0373 0.0846
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0035 0.0298 0.0299
Plasmodium vivax SET domain protein, putative 0.0091 0.1032 0.3671
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0056 0.0577 0.0556
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0133 0.0085
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.002 0.01 0.0171
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.002 0.01 0.0049
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.002 0.01 0.01
Leishmania major hypothetical protein, conserved 0.002 0.01 0.0183
Trypanosoma cruzi trypanothione reductase, putative 0.0218 0.2717 0.6539
Onchocerca volvulus 0.0056 0.0577 0.0568
Echinococcus multilocularis allatostatin A receptor 0.0056 0.0577 0.0579
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0242 0.0529
Echinococcus multilocularis cpg binding protein 0.0033 0.0274 0.0275
Loa Loa (eye worm) hypothetical protein 0.0107 0.125 0.1254
Echinococcus granulosus fmrfamide receptor 0.0056 0.0577 0.0579
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0373 0.0846
Echinococcus granulosus histone lysine methyltransferase setb 0.0107 0.125 0.1254
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0076 0.0834 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0035 0.0298 0.0299
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0054 0.0036
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.01 0.0049
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.008 0.008
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0077 0.0077
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0025 0.0025
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0577 0.0579
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0113 0.1327 0.126
Schistosoma mansoni dihydropyrimidinase related protein-1 (M38 family) 0.0019 0.0084 0.006
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0106 0.0106
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0054 0.0054
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0501 0.0427
Plasmodium falciparum importin beta, putative 0.0028 0.0203 0.0557
Trypanosoma cruzi NADH dehydrogenase, putative 0.002 0.01 0.0183
Brugia malayi Carboxylesterase family protein 0.0067 0.0723 0.0828
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0327 0.0328
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.01 0.0183
Loa Loa (eye worm) microfilarial chitinase 0.0096 0.1106 0.111
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0298 0.0771
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0056 0.0577 0.0556
Brugia malayi glutathione reductase 0.0218 0.2717 0.3187
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0025
Giardia lamblia NADH oxidase lateral transfer candidate 0.0076 0.0834 0.0765
Echinococcus multilocularis dihydropyrimidinase 2 0.0019 0.0084 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0373 0.0846
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0056 0.0577 0.0579
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0035 0.0298 0.0275
Onchocerca volvulus Neuropeptide F receptor homolog 0.0056 0.0577 0.0568
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0054
Echinococcus granulosus lamin dm0 0.0027 0.0188 0.0189
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0501 0.0484
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Trichomonas vaginalis esterase, putative 0.0035 0.0298 0.0264
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0076 0.0834 0.1965
Schistosoma mansoni neuropeptide receptor 0.0056 0.0577 0.0556
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.002 0.01 0.0213
Loa Loa (eye worm) cuticular endochitinase 0.0113 0.1326 0.133
Brugia malayi hypothetical protein 0.0017 0.0054 0.0036
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.071 0.0689
Onchocerca volvulus 0.0056 0.0577 0.0568
Loa Loa (eye worm) hypothetical protein 0.0767 0.9968 1
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0363 0.034
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0228 0.284 0.7933
Entamoeba histolytica hypothetical protein 0.0023 0.0133 0.0719
Plasmodium vivax importin-beta 2, putative 0.0028 0.0203 0.0557
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0111 0.0244
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0077 0.0077
Brugia malayi AKH receptor 0.0056 0.0577 0.0656
Schistosoma mansoni glutamate synthase 0.002 0.01 0.0076
Echinococcus multilocularis g-protein coupled receptor 0.0056 0.0577 0.0579
Loa Loa (eye worm) hypothetical protein 0.0113 0.1327 0.1332
Schistosoma mansoni nuclear hormone receptor 0.0035 0.0298 0.0275
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0298 0.0665
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0113 0.1327 0.131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0577 0.0556
Echinococcus multilocularis neuropeptide receptor A26 0.0056 0.0577 0.0579
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.5416 0.5434
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Echinococcus granulosus neuropeptide receptor 0.0056 0.0577 0.0579
Leishmania major NADH dehydrogenase, putative 0.002 0.01 0.0183
Onchocerca volvulus 0.002 0.01 0.005
Giardia lamblia Glutamate synthase 0.002 0.01 0.0023
Entamoeba histolytica hypothetical protein, conserved 0.0017 0.0055 0.0199
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0577 0.0579
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0077 0.0347
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.008
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.002 0.01 0.0305
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.002 0.01 0.0183
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0054 0.0036
Echinococcus multilocularis imidazolonepropionase 0.0019 0.0084 0.0085
Echinococcus granulosus biogenic amine 5HT receptor 0.0056 0.0577 0.0579
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.002 0.01 0.01
Plasmodium falciparum phosphodiesterase gamma, putative 0.0113 0.1327 0.4781
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0054 0.0029
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0113 0.1327 0.126
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.002 0.01 0.01
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.002 0.01 0.01
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0054
Brugia malayi hypothetical protein 0.0056 0.0577 0.0656
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0056 0.0577 0.0579
Brugia malayi hypothetical protein 0.0056 0.0577 0.0656
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0113 0.1327 0.131
Leishmania major hypothetical protein, conserved 0.0035 0.0298 0.0665
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0577 0.0579
Trichomonas vaginalis set domain proteins, putative 0.0715 0.9274 1
Mycobacterium ulcerans urease subunit alpha 0.0019 0.0084 0.0201
Giardia lamblia DINP protein human, muc B family 0.0021 0.0111 0.0034
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0228 0.284 0.7933
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.002 0.01 0.0213
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0076 0.0834 0.2926
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.008 0.008
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.002 0.01 0.0305
Schistosoma mansoni sulfide quinone reductase 0.002 0.01 0.0076
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0228 0.284 0.7933
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0133 0.0085
Onchocerca volvulus Putative endochitinase 0.0113 0.1326 0.138
Loa Loa (eye worm) PDE1B protein 0.0199 0.2457 0.2465
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0298 0.0299
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0501 0.0484
Echinococcus multilocularis acetylcholinesterase 0.0067 0.0723 0.0725
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0298 0.0915
Entamoeba histolytica D-hydantoinase, putative 0.0019 0.0084 0.0395
Mycobacterium ulcerans dihydroorotase 0.0019 0.0084 0.0201
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0577 0.0579
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0113 0.1327 0.126
Brugia malayi nuclear receptor RXR 0.0017 0.0054 0.0036
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0113 0.1327 0.3164
Echinococcus granulosus Glycoside hydrolase chitinase domain containing protein 1 0.0017 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Onchocerca volvulus 0.0056 0.0577 0.0568
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0373 0.0846
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.002 0.01 0.0213
Schistosoma mansoni lamin 0.0027 0.0188 0.0165
Brugia malayi larval opioid receptor 0.0056 0.0577 0.0656
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0107 0.125 0.1254
Brugia malayi Dopamine receptor protein 1 0.0056 0.0577 0.0656
Schistosoma mansoni bromodomain containing protein 0.0063 0.0667 0.0646
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.002 0.01 0.0183
Mycobacterium tuberculosis Conserved protein 0.0035 0.0298 0.0771
Brugia malayi Pre-SET motif family protein 0.0091 0.1032 0.1194
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.002 0.01 0.0307
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0106 0.0029
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0054
Schistosoma mansoni aspartate carbamoyltransferase 0.0019 0.0084 0.006
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0113 0.1327 0.138
Echinococcus granulosus 7TM GPCR rhodopsin 0.0056 0.0577 0.0579
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.002 0.01 0.0307
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0501 0.1157
Leishmania major importin beta-1 subunit, putative 0.0023 0.0133 0.0264
Plasmodium vivax ferrodoxin reductase, putative 0.002 0.01 0.0171
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0106 0.0029
Toxoplasma gondii thioredoxin reductase 0.0218 0.2717 0.266
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0113 0.1327 0.1332
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0054 0.0054
Mycobacterium ulcerans monoxygenase 0.002 0.01 0.0307
Schistosoma mansoni biogenic amine receptor 0.0056 0.0577 0.0556
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0056 0.0577 0.0656
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.1327 0.3164
Brugia malayi RNA, U transporter 1 0.0079 0.0881 0.1015
Loa Loa (eye worm) hypothetical protein 0.0069 0.074 0.0742
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0035 0.0298 0.0299
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0091 0.1032 0.0962
Onchocerca volvulus 0.0027 0.0188 0.0146
Entamoeba histolytica hypothetical protein 0.0037 0.0327 0.1999
Echinococcus granulosus snurportin 1 0.0297 0.3762 0.3774
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0056 0.0577 0.0579
Echinococcus multilocularis musashi 0.0027 0.0188 0.0189
Brugia malayi polk-prov protein 0.0031 0.0242 0.0259
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.0577 0.0556
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0501 0.0484
Leishmania major hypothetical protein, conserved 0.0113 0.1327 0.3164
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0113 0.1327 0.138
Echinococcus multilocularis ecdysone induced protein 78C 0.0035 0.0298 0.0299
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0113 0.1327 0.3164
Schistosoma mansoni opsin-like receptor 0.0056 0.0577 0.0556
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0076 0.0834 0.1965
Schistosoma mansoni sulfide quinone reductase 0.002 0.01 0.0076
Onchocerca volvulus Putative endochitinase 0.0113 0.1326 0.138
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0076 0.0834 0.1965
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0056 0.0569 0.0646
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0767 0.9968 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0242 0.0243
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Echinococcus multilocularis glutamate synthase 0.002 0.01 0.01
Mycobacterium ulcerans hydroxydechloroatrazine ethylaminohydrolase 0.0129 0.1536 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0373 0.0846
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0577 0.0556
Schistosoma mansoni hypothetical protein 0.0019 0.0084 0.006
Schistosoma mansoni amine GPCR 0.0056 0.0577 0.0556
Echinococcus multilocularis G-protein coupled receptor, putative 0.0056 0.0577 0.0579
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0077 0.0151
Leishmania major DNA polymerase kappa, putative 0.0021 0.0111 0.021
Echinococcus multilocularis thyroid hormone receptor alpha 0.016 0.1948 0.1954
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0076 0.0834 0.0763
Brugia malayi hypothetical protein 0.0146 0.1763 0.2058
Trichomonas vaginalis apoptosis inducing factor, putative 0.002 0.01 0.0049
Loa Loa (eye worm) programmed cell death 8 0.002 0.01 0.01
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.01 0.0183
Trypanosoma cruzi NADH dehydrogenase, putative 0.002 0.01 0.0183
Echinococcus multilocularis neuropeptide FF receptor 2 0.0056 0.0577 0.0579
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0298 0.0299
Brugia malayi Glycosyl hydrolases family 18 protein 0.0017 0.0055 0.0038
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0298 0.0771
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0056 0.0577 0.0579
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0298 0.0264
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0318 0.0319
Loa Loa (eye worm) hypothetical protein 0.0032 0.0254 0.0255
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0077 0.0127
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0287 0.0636
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0286 0.0251
Onchocerca volvulus 0.003 0.0227 0.0188
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0298 0.0275
Schistosoma mansoni hypothetical protein 0.0423 0.5416 0.5422
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.0577 0.0579
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.1327 0.138
Trypanosoma brucei guanine deaminase, putative 0.0129 0.1536 0.3671
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0577 0.0579
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0113 0.1327 0.1332
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0298 0.0299
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0577 0.0579
Schistosoma mansoni hypothetical protein 0.0125 0.1484 0.1468
Loa Loa (eye worm) hypothetical protein 0.0067 0.0723 0.0725
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Toxoplasma gondii selenide, water dikinase 0.002 0.01 0.0023
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0054 0.0029
Loa Loa (eye worm) thioredoxin reductase 0.0218 0.2717 0.2726
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.002 0.01 0.0307
Trichomonas vaginalis hypothetical protein 0.0019 0.0084 0.0032
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.002 0.01 0.0023
Echinococcus multilocularis orexin receptor type 2 0.0056 0.0577 0.0579
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0054
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0188 0.0189
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0056 0.0577 0.0579
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0054
Echinococcus granulosus g protein coupled receptor 0.0056 0.0577 0.0579
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0373 0.0846
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0113 0.1327 0.1543
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.01 0.0049
Onchocerca volvulus Putative endochitinase 0.0017 0.0055 0.0001
Echinococcus granulosus peptide allatostatin:somatostatin 0.0056 0.0577 0.0579
Schistosoma mansoni neuropeptide receptor 0.0056 0.0577 0.0556
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.1484 0.1489
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.002 0.01 0.0305
Schistosoma mansoni RAR-like nuclear receptor 0.0035 0.0298 0.0275
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0199 0.2457 0.2465
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0113 0.1327 0.131
Trypanosoma cruzi dihydroorotase, putative 0.0019 0.0084 0.0145
Brugia malayi Tachykinin-like peptides receptor 99D 0.0056 0.0577 0.0656
Loa Loa (eye worm) hypothetical protein 0.0146 0.1763 0.1768
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0076 0.0834 0.1965
Schistosoma mansoni intermediate filament proteins 0.0027 0.0188 0.0165
Mycobacterium tuberculosis Probable reductase 0.0228 0.284 0.7933
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0113 0.1327 0.1332
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0501 0.1157
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.002 0.01 0.0049
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0053 0.0053
Onchocerca volvulus 0.0027 0.0188 0.0146
Brugia malayi nuclear hormone receptor 0.0035 0.0298 0.0326
Schistosoma mansoni glutamate synthase 0.002 0.01 0.0076
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0326 0.4141 1
Mycobacterium tuberculosis Conserved protein 0.0019 0.0084 0.0168
Trichomonas vaginalis glutamate synthase, putative 0.002 0.01 0.0049
Trichomonas vaginalis protein ssnA, putative 0.0129 0.1536 0.1607
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0577 0.0579
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.0577 0.0579
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0106 0.0106
Trypanosoma cruzi imidazolonepropionase, putative 0.0019 0.0084 0.0145
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0115 0.1359 0.1292
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Giardia lamblia hypothetical protein 0.0113 0.1327 0.1264
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0113 0.1327 0.131
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0298 0.0771
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0077 0.0127
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0767 0.9968 1
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0577 0.0579
Echinococcus granulosus importin subunit beta 1 0.0028 0.0203 0.0204
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0283 0.3574 1
Schistosoma mansoni amine GPCR 0.0056 0.0577 0.0556
Schistosoma mansoni amine GPCR 0.0056 0.0577 0.0556
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0621 0.0623
Schistosoma mansoni hypothetical protein 0.0056 0.0577 0.0556
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0298 0.0264
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0056 0.0577 0.0579
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0373 0.0846
Brugia malayi hypothetical protein 0.0056 0.0577 0.0656
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0054 0.0054
Brugia malayi Importin beta-1 subunit 0.0028 0.0203 0.0213
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.002 0.01 0.0045
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0113 0.1327 0.138
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.002 0.01 0.0023
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0501 0.0428
Echinococcus granulosus thioredoxin glutathione reductase 0.0218 0.2717 0.2726
Echinococcus granulosus sulfide:quinone oxidoreductase 0.002 0.01 0.01
Schistosoma mansoni cpg binding protein 0.0033 0.0274 0.025
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0056 0.0577 0.0556
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.1032 0.1013
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.1327 0.3164
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0025 0.0002
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0113 0.1327 0.4781
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Echinococcus multilocularis somatostatin receptor 0.0056 0.0577 0.0579
Echinococcus multilocularis dihydropyrimidinase protein 4 0.0019 0.0084 0.0085
Echinococcus granulosus FTZ F1 alpha 0.0035 0.0298 0.0299
Schistosoma mansoni growth hormone secretagogue receptor 0.0056 0.0577 0.0556
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Schistosoma mansoni dihydropyrimidinase related protein-2 (M38 family) 0.0019 0.0084 0.006
Echinococcus multilocularis serotonin receptor 0.0056 0.0577 0.0579
Trypanosoma cruzi guanine deaminase, putative 0.0129 0.1536 0.3671
Trypanosoma brucei ISWI complex protein 0.0015 0.0031 0.0015
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0199 0.2457 0.288
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.01 0.0049
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0091 0.1032 0.1035
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0373 0.0345
Treponema pallidum oxidoreductase 0.002 0.01 0.0305
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.008
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0373 0.0846
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0654 0.8476 0.8503
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.002 0.01 0.0307
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.002 0.01 0.01
Onchocerca volvulus 0.0056 0.0577 0.0568
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0298 0.0771
Brugia malayi Amidohydrolase family protein 0.0019 0.0084 0.0073
Trichomonas vaginalis D-aminoacylase, putative 0.0019 0.0084 0.0032
Brugia malayi Serotonin receptor 0.0056 0.0577 0.0656
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0577 0.0579
Echinococcus multilocularis microtubule associated protein 2 0.0685 0.8875 0.8903
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0577 0.0579
Onchocerca volvulus 0.0056 0.0577 0.0568
Schistosoma mansoni neuropeptide receptor 0.0056 0.0577 0.0556
Entamoeba histolytica glutamate synthase beta subunit, putative 0.002 0.01 0.0499
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0076 0.0834 0.1965
Trypanosoma brucei guanine deaminase, putative 0.0129 0.1536 0.3671
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0077 0.0064
Schistosoma mansoni coup transcription factor 0.0035 0.0298 0.0275
Loa Loa (eye worm) hypothetical protein 0.0035 0.0298 0.0299
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0298 0.0326
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0056 0.0577 0.0656
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0077 0.0148
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0298 0.0665
Trypanosoma brucei trypanothione reductase 0.0218 0.2717 0.6539
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0053 0.0029
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.008 0.0056
Brugia malayi nuclear receptor NHR-67 0.0017 0.0054 0.0036
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0203 0.0127
Mycobacterium tuberculosis Urease alpha subunit UreC (urea amidohydrolase) 0.0019 0.0084 0.0168
Echinococcus multilocularis neuropeptide receptor 0.0056 0.0577 0.0579
Brugia malayi beta-lactamase family protein 0.0035 0.0298 0.0326
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.1327 0.3164
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0298 0.0299
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.1327 0.3164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0035 0.0298 0.0299
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.002 0.01 0.0213
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.002 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0035 0.0298 0.0299
Echinococcus granulosus hypothetical protein 0.0056 0.0577 0.0579
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0056 0.0577 0.0579
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.008 0.0067
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0577 0.0556
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0199 0.2457 0.5909
Schistosoma mansoni neuropeptide f receptor 76f 0.0056 0.0577 0.0556
Trypanosoma brucei dihydroorotase, putative 0.0019 0.0084 0.0145
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0055
Brugia malayi intermediate filament protein 0.0027 0.0188 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0052 0.0067
Toxoplasma gondii ABC1 family protein 0.0035 0.0298 0.0223
Echinococcus multilocularis geminin 0.0505 0.6501 0.6521
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0111 0.021
Brugia malayi PHD-finger family protein 0.0026 0.0176 0.0181
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0501 0.0502
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0298 0.0264
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0577 0.0579
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0035 0.0298 0.0326
Echinococcus granulosus neuropeptide s receptor 0.0056 0.0577 0.0579
Schistosoma mansoni lamin 0.0027 0.0188 0.0165
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0146 0.0146
Onchocerca volvulus 0.0056 0.0577 0.0568
Schistosoma mansoni opsin-like receptor 0.0056 0.0577 0.0556
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.002 0.01 0.0183
Mycobacterium ulcerans hypothetical protein 0.0035 0.0298 0.1645
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.002 0.01 0.0171
Brugia malayi ecdysteroid receptor 0.0035 0.0298 0.0326
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0577 0.0556
Brugia malayi Pre-SET motif family protein 0.0628 0.8129 0.959
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0106 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0035 0.0298 0.0326
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0106 0.0197
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0228 0.284 0.7898
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0199 0.2457 0.5909
Schistosoma mansoni neuropeptide receptor 0.0056 0.0577 0.0556
Entamoeba histolytica guanine deaminase, putative 0.0129 0.1536 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Entamoeba histolytica disulphide oxidoreductase, putative 0.002 0.01 0.0499
Brugia malayi nuclear hormone receptor 0.0017 0.0054 0.0036
Schistosoma mansoni chitinase 0.0017 0.0055 0.003
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0577 0.0579
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0056 0.0577 0.0579
Schistosoma mansoni hypothetical protein 0.0056 0.0577 0.0556
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Schistosoma mansoni myosin xvIII 0.0056 0.0577 0.0556
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0505 0.6501 0.6513
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0203 0.0433
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Plasmodium falciparum ferrodoxin reductase-like protein 0.002 0.01 0.0171
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0076 0.0834 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0203 0.0433
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0363 0.034
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0035 0.0298 0.0326
Brugia malayi hypothetical protein 0.0019 0.008 0.0067
Schistosoma mansoni hypothetical protein 0.0505 0.6501 0.6513
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0056 0.0577 0.0556
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0056 0.0577 0.0568
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0113 0.1327 0.126
Loa Loa (eye worm) hypothetical protein 0.0035 0.0298 0.0299
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0298 0.0299
Echinococcus multilocularis thioredoxin glutathione reductase 0.0218 0.2717 0.2726
Trypanosoma brucei hypothetical protein, conserved 0.002 0.01 0.0183
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0298 0.0299
Echinococcus multilocularis dro:myosuppressin receptor 0.0056 0.0577 0.0579
Echinococcus multilocularis acetylcholinesterase 0.0067 0.0723 0.0725
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0106 0.0197
Echinococcus granulosus G protein coupled receptor 139 0.0056 0.0577 0.0579
Loa Loa (eye worm) hypothetical protein 0.0035 0.0298 0.0299
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.0577 0.0579
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0056 0.0577 0.0656
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.002 0.01 0.0307
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0113 0.1327 0.1543
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0199 0.2457 0.5909
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.0577 0.0556
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0577 0.0579
Loa Loa (eye worm) melatonin receptor type 1A 0.0056 0.0577 0.0579
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.0025 0.0025
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.002 0.01 0.0499
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0113 0.1327 0.1543
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0501 0.1157
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0035 0.0298 0.0326
Echinococcus granulosus dihydropyrimidinase 2 0.0019 0.0084 0.0085
Brugia malayi Melatonin receptor type 1A 0.0056 0.0577 0.0656
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.002 0.01 0.0023
Loa Loa (eye worm) hypothetical protein 0.0314 0.398 0.3993
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0298 0.0771
Treponema pallidum NADH oxidase 0.0076 0.0834 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0076 0.0834 0.0836
Leishmania major hypothetical protein, conserved 0.0113 0.1327 0.3164
Mycobacterium tuberculosis Possible chitinase 0.0096 0.1106 0.3048
Echinococcus multilocularis snurportin 1 0.0297 0.3762 0.3774
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0113 0.1327 0.1543
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0035 0.0298 0.0299
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0077 0.0024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0076 0.0834 0.1965
Brugia malayi hypothetical protein 0.0017 0.0054 0.0036
Echinococcus granulosus neuropeptides capa receptor 0.0056 0.0577 0.0579
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0373 0.0846
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.01 0.0049
Echinococcus multilocularis FTZ F1 alpha 0.0035 0.0298 0.0299
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.002 0.01 0.01
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0054 0.0054
Onchocerca volvulus Putative endochitinase 0.0113 0.1326 0.138
Brugia malayi Glycosyl hydrolases family 18 protein 0.0017 0.0055 0.0038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0577 0.0556
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0501 0.0484
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0056 0.0577 0.0656
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0501 0.0502
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Schistosoma mansoni histamine h1 receptor 0.0056 0.0577 0.0556
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0052 0.0067
Loa Loa (eye worm) hypothetical protein 0.0035 0.0298 0.0299
Onchocerca volvulus Putative endochitinase 0.0113 0.1326 0.138
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.002 0.01 0.0499
Trypanosoma brucei unspecified product 0.0034 0.0287 0.0636
Echinococcus granulosus orexin receptor type 2 0.0056 0.0577 0.0579
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Onchocerca volvulus 0.0035 0.0298 0.0265
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0076 0.0834 0.1965
Brugia malayi hypothetical protein 0.0056 0.0577 0.0656
Plasmodium falciparum phosphodiesterase delta, putative 0.0113 0.1327 0.4781
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0283 0.3574 1
Schistosoma mansoni biogenic amine receptor 0.0056 0.0577 0.0556
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Loa Loa (eye worm) hypothetical protein 0.0035 0.0298 0.0299
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0113 0.1327 0.138
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0076 0.0834 0.1965
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0106 0.0098
Giardia lamblia Hypothetical protein 0.0113 0.1327 0.1264
Loa Loa (eye worm) G-protein coupled receptor 0.0056 0.0577 0.0579
Schistosoma mansoni hypothetical protein 0.002 0.01 0.0076
Loa Loa (eye worm) hypothetical protein 0.0035 0.0298 0.0299
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0298 0.0665
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0327 0.0304
Schistosoma mansoni ap endonuclease 0.0018 0.0077 0.0053
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0035 0.0298 0.0275
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Loa Loa (eye worm) hypothetical protein 0.002 0.01 0.01
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0035 0.0298 0.0299
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0076 0.0834 0.5259
Schistosoma mansoni biogenic amine (5HT) receptor 0.0056 0.0577 0.0556
Schistosoma mansoni hypothetical protein 0.0297 0.3762 0.3759
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0373 0.0345
Schistosoma mansoni survival motor neuron protein 0.0049 0.048 0.0458
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.0577 0.0579
Onchocerca volvulus 0.0715 0.9274 1
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0054 0.0054
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0035 0.0298 0.0275
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0054 0.0054
Echinococcus granulosus serotonin receptor 0.0056 0.0577 0.0579
Plasmodium vivax thioredoxin reductase, putative 0.0218 0.2717 1
Mycobacterium ulcerans lipase LipD 0.0035 0.0298 0.1645
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.0054 0.0054
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0076 0.0834 0.2926
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0035 0.0298 0.0299
Brugia malayi MAP kinase sur-1 0.005 0.0501 0.0565
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.002 0.01 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.01 0.0183
Loa Loa (eye worm) hypothetical protein 0.0035 0.0298 0.0299
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0056 0.0577 0.0556
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0218 0.2717 0.7586
Mycobacterium leprae Probable lipase LipE 0.0035 0.0298 0.0613
Schistosoma mansoni neuropeptide F-like receptor 0.0056 0.0577 0.0556
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0577 0.0579
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0056 0.0577 0.0579
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0113 0.1327 0.138
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0501 0.1157
Brugia malayi beta-lactamase family protein 0.0035 0.0298 0.0326
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0298 0.0613
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0188 0.0189
Echinococcus granulosus dna polymerase kappa 0.0041 0.0373 0.0374
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.002 0.01 0.0183
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0113 0.1327 0.4781
Loa Loa (eye worm) amidohydrolase 0.0019 0.0084 0.0085
Brugia malayi Dopamine receptor protein 2 0.0056 0.0577 0.0656
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0056 0.0577 0.0556
Echinococcus multilocularis serotonin receptor 0.0056 0.0577 0.0579
Echinococcus granulosus geminin 0.0505 0.6501 0.6521
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0056 0.0577 0.0579
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0053 0.0053
Echinococcus granulosus zinc finger protein 0.0021 0.0108 0.0108
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0146 0.0122
Brugia malayi endochitinase 0.0113 0.1326 0.1542
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0113 0.1327 0.3164
Echinococcus granulosus glutamate synthase 0.002 0.01 0.01
Mycobacterium tuberculosis Probable dehydrogenase 0.0228 0.284 0.7933
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0577 0.0579
Schistosoma mansoni ran 0.0021 0.0106 0.0082
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0501 0.0479
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0501 0.0502
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0077 0.0024
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0113 0.1327 0.1332
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0373 0.0846
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0035 0.0298 0.0299
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0035 0.0298 0.0299
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0056 0.0569 0.0646
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0373 0.0846
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0113 0.1327 0.126
Brugia malayi beta-lactamase 0.0035 0.0298 0.0326
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.01 0.0183
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0577 0.0556
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0056 0.0577 0.0556
Loa Loa (eye worm) hypothetical protein 0.0096 0.1106 0.111
Brugia malayi hypothetical protein 0.0056 0.0577 0.0656
Schistosoma mansoni dihydropyrimidinase (M38 family) 0.0019 0.0084 0.006
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.002 0.01 0.0183
Brugia malayi Dopamine receptor 0.0056 0.0577 0.0656
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0298 0.0264
Brugia malayi Endochitinase 0.0017 0.0055 0.0038
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0113 0.1327 0.4781
Brugia malayi ORL1-like opioid receptor 0.0056 0.0577 0.0656
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0298 0.0299
Loa Loa (eye worm) carboxylesterase 0.0067 0.0723 0.0725
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0035 0.0298 0.0299
Loa Loa (eye worm) beta-lactamase 0.0035 0.0298 0.0299
Onchocerca volvulus 0.0056 0.0577 0.0568
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0501 0.1157
Plasmodium falciparum thioredoxin reductase 0.0076 0.0834 0.2926
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.002 0.01 0.0045
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0054
Brugia malayi endochitinase 0.0113 0.1326 0.1542
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.0025 0.0025
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.002 0.01 0.0091
Trypanosoma cruzi dihydroorotase, putative 0.0019 0.0084 0.0145
Plasmodium vivax glutathione reductase, putative 0.0218 0.2717 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0056 0.0577 0.0579
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0113 0.1327 0.1332
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0113 0.1327 0.138
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.3762 0.3774
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0054 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0373 0.0846
Schistosoma mansoni zinc finger protein 0.0021 0.0108 0.0084
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.01 0.0049
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0318 0.0319
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0113 0.1327 0.138
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0076 0.0834 0.1965
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0113 0.1327 0.138
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Onchocerca volvulus 0.0056 0.0577 0.0568
Leishmania major trypanothione reductase 0.0218 0.2717 0.6539
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0577 0.0556
Loa Loa (eye worm) DR-78 0.0017 0.0054 0.0054
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0113 0.1327 0.3164
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0054 0.0054
Mycobacterium ulcerans hypothetical protein 0.0019 0.0084 0.0201
Brugia malayi Thioredoxin reductase 0.0218 0.2717 0.3187
Echinococcus granulosus neuropeptide Y receptor 0.0056 0.0577 0.0579
Leishmania major N-acetylglucosamine-6-phosphate deacetylase-like protein 0.0019 0.0084 0.0145
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0056 0.0577 0.0579
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.01 0.0183
Schistosoma mansoni steroid hormone receptor ad4bp 0.0035 0.0298 0.0275
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.002 0.01 0.01
Echinococcus granulosus biogenic amine 5HT receptor 0.0056 0.0577 0.0579
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0056 0.0577 0.0556
Onchocerca volvulus 0.0049 0.048 0.0462
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0076 0.0834 0.1965
Brugia malayi hypothetical protein 0.0056 0.0577 0.0656
Entamoeba histolytica hypothetical protein 0.0037 0.0327 0.1999
Echinococcus multilocularis lamin 0.0027 0.0188 0.0189
Onchocerca volvulus 0.0056 0.0577 0.0568
Schistosoma mansoni biogenic amine (5HT) receptor 0.0056 0.0577 0.0556
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0227 0.0228
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0113 0.1327 0.126
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0188 0.0196
Onchocerca volvulus Protein ultraspiracle homolog 0.0035 0.0298 0.0265
Schistosoma mansoni cpg binding protein 0.003 0.0227 0.0203
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0056 0.0577 0.0579
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0113 0.1327 0.131
Brugia malayi hypothetical protein 0.0056 0.0577 0.0656
Trichomonas vaginalis protein ssnA, putative 0.0129 0.1536 0.1607
Brugia malayi putative neuropeptide receptor NPR1 0.0056 0.0577 0.0656
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.002 0.01 0.0307
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0035 0.0298 0.0326
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0054 0.0054
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0076 0.0834 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0107 0.125 0.1233
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0054 0.0029
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.098 0.0983
Schistosoma mansoni hypothetical protein 0.0056 0.0577 0.0556
Trichomonas vaginalis aminohydrolase, putative 0.0019 0.0084 0.0032
Brugia malayi hypothetical protein 0.012 0.1425 0.1659
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.008
Leishmania major hypothetical protein, conserved 0.002 0.01 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0035 0.0298 0.0326
Brugia malayi G protein-coupled receptor F59B2.13 0.0056 0.0577 0.0656
Brugia malayi hypothetical protein 0.0239 0.2997 0.3518
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0054 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0035 0.0298 0.0326
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0054
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0654 0.8476 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0067 0.0723 0.0702
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0113 0.1327 0.131
Toxoplasma gondii NADPH-glutathione reductase 0.0076 0.0834 0.0763
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0076 0.0834 0.1965
Echinococcus granulosus dnaJ subfamily B 0.0423 0.5416 0.5434
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Schistosoma mansoni amine GPCR 0.0056 0.0577 0.0556
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0077 0.0084
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0298 0.0771
Schistosoma mansoni zinc finger protein 0.0015 0.0031 0.0006
Leishmania major hypothetical protein, conserved 0.002 0.01 0.0183
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0035 0.0298 0.0275
Onchocerca volvulus 0.0056 0.0577 0.0568
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0113 0.1327 0.126
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0054 0.0036
Echinococcus granulosus imidazolonepropionase 0.0019 0.0084 0.0085
Trypanosoma cruzi ISWI complex protein 0.0015 0.0031 0.0015
Brugia malayi neuropeptide F receptor 0.0056 0.0577 0.0656
Onchocerca volvulus 0.0091 0.1032 0.1061
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0035 0.0298 0.0265
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0077 0.0084
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.002 0.01 0.01
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0501 0.1157
Echinococcus granulosus 7tm_1 domain containing protein 0.0056 0.0577 0.0579
Onchocerca volvulus 0.0056 0.0577 0.0568
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0091 0.1032 0.1013
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0767 0.9968 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Echinococcus granulosus acetylcholinesterase 0.0067 0.0723 0.0725
Loa Loa (eye worm) hypothetical protein 0.0035 0.0298 0.0299
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0113 0.1327 0.126
Loa Loa (eye worm) hypothetical protein 0.0035 0.0298 0.0299
Brugia malayi G-protein coupled receptor 0.0056 0.0577 0.0656
Brugia malayi G protein-coupled receptor 0.0056 0.0577 0.0656
Trichomonas vaginalis ran, putative 0.0021 0.0106 0.0055
Mycobacterium ulcerans ferredoxin reductase 0.002 0.01 0.0307
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.002 0.01 0.0045
Loa Loa (eye worm) hypothetical protein 0.0037 0.0326 0.0327
Echinococcus granulosus acetylcholinesterase 0.0067 0.0723 0.0725
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.1327 0.3164
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0327 0.0328
Trypanosoma brucei hypothetical protein, conserved 0.0113 0.1327 0.3164
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0056 0.0577 0.0556
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0199 0.2457 0.9025
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0113 0.1327 0.126
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0035 0.0298 0.0326
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.008
Schistosoma mansoni dihydropyrimidinase (M38 family) 0.0019 0.0084 0.006
Echinococcus granulosus alpha 1A adrenergic receptor 0.0056 0.0577 0.0579
Mycobacterium tuberculosis Probable oxidoreductase 0.0283 0.3574 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Schistosoma mansoni ap endonuclease 0.0018 0.0077 0.0053
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0054 0.0054
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0056 0.0577 0.0579
Brugia malayi photoreceptor-specific nuclear receptor 0.0035 0.0298 0.0326
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Leishmania major cAMP-specific phosphodiesterase, putative 0.0326 0.4141 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Loa Loa (eye worm) TYRA-2 protein 0.0056 0.0577 0.0579
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0113 0.1327 0.138
Brugia malayi hypothetical protein 0.0017 0.0055 0.0038
Brugia malayi Bromodomain containing protein 0.0074 0.0817 0.0939
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Mycobacterium ulcerans dehydrogenase 0.002 0.01 0.0307
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.002 0.01 0.0213
Loa Loa (eye worm) glutathione reductase 0.0218 0.2717 0.2726
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0035 0.0298 0.0299
Brugia malayi Endochitinase 0.0113 0.1326 0.1542
Loa Loa (eye worm) hypothetical protein 0.0043 0.0403 0.0404
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0113 0.1327 0.1332
Echinococcus granulosus tachykinin peptides receptor 99D 0.0056 0.0577 0.0579
Entamoeba histolytica chitinase, putative 0.0113 0.1326 0.8611
Echinococcus granulosus neuropeptide FF receptor 2 0.0056 0.0577 0.0579
Giardia lamblia Thioredoxin reductase 0.002 0.01 0.0023
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.1484 0.1489
Plasmodium falciparum thioredoxin reductase 0.0218 0.2717 1
Echinococcus granulosus lamin 0.0027 0.0188 0.0189
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0199 0.2457 0.2446
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0767 0.9968 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0113 0.1327 0.138
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0654 0.8476 0.8503
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0035 0.0298 0.0299
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0111 0.021
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Loa Loa (eye worm) hypothetical protein 0.0027 0.0188 0.0189
Echinococcus granulosus microtubule associated protein 2 0.0685 0.8875 0.8903
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.01 0.0049
Loa Loa (eye worm) hypothetical protein 0.0035 0.0298 0.0299
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0113 0.1327 0.1332
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0199 0.2457 0.2465
Echinococcus granulosus dna polymerase eta 0.0014 0.0025 0.0025
Loa Loa (eye worm) neuropeptide F receptor 0.0056 0.0577 0.0579
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0113 0.1327 0.1332
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0113 0.1327 0.131
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.002 0.01 0.0091
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0373 0.2149
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0006
Wolbachia endosymbiont of Brugia malayi dihydroorotase, PyrC 0.0019 0.0084 0.0097
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Brugia malayi follicle stimulating hormone receptor 0.0056 0.0577 0.0656
Trichomonas vaginalis glutathione reductase, putative 0.0076 0.0834 0.0845
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0199 0.2457 0.2465
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0577 0.0556
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0298 0.0326
Schistosoma mansoni nuclear receptor 0.0017 0.0054 0.0029
Schistosoma mansoni hypothetical protein 0.005 0.05 0.0479
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0076 0.0834 0.1965
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.0577 0.0579
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.008 0.0056
Brugia malayi putative neuropeptide receptor 0.0056 0.0577 0.0656
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0025 0.0002
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0373 0.0374
Schistosoma mansoni alpha-1 adrenergic receptor 0.0056 0.0577 0.0556
Brugia malayi conserved hypotetical protein 0.0017 0.0054 0.0036
Brugia malayi sulfakinin receptor protein 0.0056 0.0577 0.0656
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0373 0.0846
Mycobacterium ulcerans chitinase/cellulase 0.0096 0.1106 0.71
Brugia malayi G-protein coupled receptor 0.0056 0.0577 0.0656
Trypanosoma cruzi guanine deaminase, putative 0.0129 0.1536 0.3671
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0242 0.0529
Loa Loa (eye worm) hypothetical protein 0.0113 0.1327 0.1332
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0056 0.0577 0.0579
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0228 0.284 0.7933
Echinococcus granulosus intermediate filament protein 0.0027 0.0188 0.0189
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0199 0.2457 0.5909
Trypanosoma cruzi trypanothione reductase, putative 0.0076 0.0834 0.1965
Onchocerca volvulus Putative chitinase 0.0017 0.0055 0.0001
Treponema pallidum thioredoxin reductase (trxB) 0.002 0.01 0.0305
Echinococcus multilocularis zinc finger protein 0.0021 0.0108 0.0108
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0076 0.0834 0.1965
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0035 0.0298 0.0299
Onchocerca volvulus 0.0146 0.1763 0.1854
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0056 0.0577 0.0579
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Echinococcus multilocularis neuropeptide Y receptor 0.0056 0.0577 0.0579
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0113 0.1327 0.138
Loa Loa (eye worm) hypothetical protein 0.0026 0.0182 0.0182
Schistosoma mansoni hypothetical protein 0.0049 0.048 0.0458
Schistosoma mansoni amine GPCR 0.0056 0.0577 0.0556
Onchocerca volvulus 0.0056 0.0577 0.0568
Brugia malayi glutamate synthase 0.002 0.01 0.0091
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.002 0.01 0.0213
Schistosoma mansoni hypothetical protein 0.0037 0.0327 0.0304
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.002 0.01 0.0307
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0054 0.0029
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0024 0.0024
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0113 0.1327 0.3164
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0006 0.0006
Trypanosoma cruzi imidazolonepropionase, putative 0.0019 0.0084 0.0145
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0035 0.0298 0.0275
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0298 0.0275
Brugia malayi hypothetical protein 0.0056 0.0577 0.0656
Brugia malayi hypothetical protein 0.0019 0.008 0.0067
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0076 0.0834 0.0814
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0318 0.0349
Entamoeba histolytica hypothetical protein 0.0037 0.0327 0.1999
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0113 0.1327 0.126
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0053 0.0029
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0654 0.8476 0.8503
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0056 0.0577 0.0556
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0076 0.0834 0.5259
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.2795 0.7805
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0113 0.1327 0.138
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0054 0.0036
Brugia malayi Bromodomain containing protein 0.0037 0.0325 0.0357
Brugia malayi hypothetical protein 0.0037 0.0327 0.036
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0076 0.0834 0.0959
Schistosoma mansoni zinc finger protein 0.0017 0.0054 0.0029
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Schistosoma mansoni cpg binding protein 0.0033 0.0274 0.025
Leishmania major dihydroorotase, putative 0.0019 0.0084 0.0145
Brugia malayi neuropeptide F receptor 0.0056 0.0577 0.0656
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.1327 0.3164
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.002 0.01 0.0183
Onchocerca volvulus 0.0056 0.0577 0.0568
Loa Loa (eye worm) hypothetical protein 0.0056 0.0577 0.0579
Brugia malayi CXXC zinc finger family protein 0.003 0.0227 0.0241
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0055
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0054 0.0054
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.2997 0.3006
Onchocerca volvulus Putative endochitinase 0.0113 0.1326 0.138
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0056 0.0577 0.0579
Mycobacterium ulcerans hypothetical protein 0.002 0.01 0.0307
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Trypanosoma brucei protein kinase, putative 0.005 0.0501 0.1157
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0035 0.0298 0.0326
Schistosoma mansoni ran 0.0021 0.0106 0.0082
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0295 0.0296
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0067 0.0723 0.0725
Echinococcus multilocularis neuropeptides capa receptor 0.0056 0.0577 0.0579
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0199 0.2457 0.2399
Brugia malayi hypothetical protein 0.0017 0.0055 0.0038
Brugia malayi GnHR receptor homolog 0.0056 0.0577 0.0656
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0054 0.0036
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0113 0.1327 0.131
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0113 0.1327 0.3164
Brugia malayi tailless protein 0.0017 0.0054 0.0036
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.002 0.01 0.0171
Echinococcus granulosus tm gpcr rhodopsin 0.0056 0.0577 0.0579
Echinococcus multilocularis fmrfamide receptor 0.0056 0.0577 0.0579
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0133 0.0085
Brugia malayi nuclear receptor NHR-88 0.0035 0.0298 0.0326
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.008
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Loa Loa (eye worm) hypothetical protein 0.0035 0.0298 0.0299
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0318 0.0319
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.2997 0.3006
Echinococcus granulosus g-protein coupled receptor 0.0056 0.0577 0.0579
Plasmodium vivax phosphodiesterase gamma, putative 0.0113 0.1327 0.4781
Echinococcus granulosus rhodopsin orphan GPCR 0.0056 0.0577 0.0579
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.002 0.01 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0035 0.0298 0.0299
Echinococcus granulosus dihydropyrimidinase protein 4 0.0019 0.0084 0.0085
Echinococcus granulosus g protein coupled receptor 0.0056 0.0577 0.0579
Trypanosoma brucei NADH dehydrogenase 0.002 0.01 0.0183
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0113 0.1327 0.138
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0628 0.8129 0.8155
Schistosoma mansoni hypothetical protein 0.0015 0.0031 0.0006
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0054 0.0029
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0076 0.0834 0.1965
Onchocerca volvulus 0.0056 0.0577 0.0568
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0295 0.0296
Mycobacterium tuberculosis Conserved protein 0.0035 0.0298 0.0771
Echinococcus granulosus sex peptide receptor 0.0056 0.0577 0.0579
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0076 0.0834 0.228
Entamoeba histolytica hypothetical protein 0.0037 0.0327 0.1999
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0106 0.0106
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0651 0.0579
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0298 0.1645
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0577 0.0556
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0133 0.0264
Mycobacterium ulcerans chitinase/cellulase 0.0096 0.1106 0.71
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.002 0.01 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0113 0.1327 0.138
Echinococcus multilocularis fmrfamide receptor 0.0056 0.0577 0.0579
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0199 0.2457 0.2465
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0076 0.0834 0.0836
Echinococcus granulosus neuropeptide receptor A26 0.0056 0.0577 0.0579
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0113 0.1327 0.1543
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0024 0.0002
Leishmania major guanine deaminase, putative 0.0129 0.1536 0.3671
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0298 0.1645
Plasmodium falciparum glutathione reductase 0.0076 0.0834 0.2926
Echinococcus granulosus allatostatin A receptor 0.0056 0.0577 0.0579
Schistosoma mansoni hypothetical protein 0.002 0.0099 0.0075
Entamoeba histolytica thioredoxin reductase, putative 0.002 0.01 0.0499
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0113 0.1327 0.1332
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.002 0.01 0.0023
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0501 0.0502
Loa Loa (eye worm) chitinase I 0.0113 0.1326 0.133
Onchocerca volvulus 0.0056 0.0577 0.0568
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0113 0.1327 0.4781
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0373 0.0846
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Trichomonas vaginalis mercuric reductase, putative 0.0076 0.0834 0.0845
Brugia malayi Carboxylesterase family protein 0.0067 0.0723 0.0828
Loa Loa (eye worm) glycosyl hydrolase family 18 protein 0.0017 0.0055 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0035 0.0298 0.0326
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Mycobacterium tuberculosis Conserved protein 0.0035 0.0298 0.0771
Echinococcus multilocularis rhodopsin orphan GPCR 0.0056 0.0577 0.0579
Schistosoma mansoni microtubule-associated protein tau 0.0685 0.8875 0.89
Echinococcus granulosus cpg binding protein 0.0033 0.0274 0.0275
Echinococcus granulosus neuropeptide receptor 0.0056 0.0577 0.0579
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.002 0.01 0.01
Onchocerca volvulus 0.0035 0.0298 0.0265
Loa Loa (eye worm) hypothetical protein 0.0028 0.0203 0.0204
Onchocerca volvulus 0.0056 0.0577 0.0568
Leishmania major GTP-binding protein, putative 0.0021 0.0106 0.0197
Loa Loa (eye worm) acetylcholinesterase 1 0.0067 0.0723 0.0725
Echinococcus granulosus g protein coupled receptor 0.0056 0.0577 0.0579
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0199 0.2457 0.2399
Trypanosoma cruzi imidazolonepropienase, putative 0.0019 0.0084 0.0145
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0113 0.1327 0.138
Echinococcus multilocularis lamin dm0 0.0027 0.0188 0.0189
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.008 0.0067
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0577 0.0579
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0035 0.0298 0.0275
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0113 0.1327 0.3164
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0621 0.0623
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0056 0.0577 0.0579
Echinococcus multilocularis Glycoside hydrolase, chitinase domain containing protein 1 0.0017 0.0055 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0107 0.125 0.1233
Echinococcus granulosus dihydropyrimidinase 0.0019 0.0084 0.0085
Echinococcus multilocularis g protein coupled receptor 0.0056 0.0577 0.0579
Schistosoma mansoni opsin-like receptor 0.0056 0.0577 0.0556
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0035 0.0298 0.0299
Onchocerca volvulus 0.0035 0.0298 0.0265
Echinococcus multilocularis neuropeptide receptor 0.0056 0.0577 0.0579
Schistosoma mansoni thyroid hormone receptor 0.016 0.1948 0.1934
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0061 0.0061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0056 0.0577 0.0556
Mycobacterium ulcerans glutamate synthase subunit beta 0.002 0.01 0.0307
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0501 0.1157
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0106 0.0197
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0767 0.9968 1
Echinococcus granulosus dro:myosuppressin receptor 0.0056 0.0577 0.0579
Loa Loa (eye worm) hypothetical protein 0.0035 0.0298 0.0299
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0373 0.0846
Echinococcus multilocularis G protein coupled receptor 139 0.0056 0.0577 0.0579

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.4581 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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