Detailed information for compound 699818

Basic information

Technical information
  • TDR Targets ID: 699818
  • Name: 4,7,8-trimethyl-6-(2-methylphenyl)-2-propylpu rino[7,8-a]imidazole-1,3-dione
  • MW: 365.429 | Formula: C20H23N5O2
  • H donors: 0 H acceptors: 3 LogP: 4.2 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCn1c(=O)n(C)c2c(c1=O)n1c(n2)n(c(c1C)C)c1ccccc1C
  • InChi: 1S/C20H23N5O2/c1-6-11-23-18(26)16-17(22(5)20(23)27)21-19-24(13(3)14(4)25(16)19)15-10-8-7-9-12(15)2/h7-10H,6,11H2,1-5H3
  • InChiKey: WIBWAIWMISILOM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4,7,8-trimethyl-6-(2-methylphenyl)-2-propyl-purino[7,8-a]imidazole-1,3-dione
  • 4,7,8-trimethyl-6-(2-methylphenyl)-2-propyl-purino[7,8-a]imidazole-1,3-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) acyl carrier protein 0.0012 0.0032 0.003
Loa Loa (eye worm) RGS-3 protein 0.002 0.021 0.0209
Toxoplasma gondii type I fatty acid synthase, putative 0.0018 0.0176 0.219
Echinococcus multilocularis axis inhibition protein axin 0.002 0.021 0.0209
Echinococcus granulosus lamin 0.0028 0.039 0.0388
Schistosoma mansoni hypothetical protein 0.0048 0.0848 0.2902
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.2002 0.6858
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0599 0.7848
Mycobacterium tuberculosis Conserved protein 0.0037 0.0599 0.118
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0599 0.118
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0599 0.9443
Schistosoma mansoni hypothetical protein 0.0048 0.0848 0.2902
Loa Loa (eye worm) TAR-binding protein 0.0065 0.1229 0.1227
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0712 0.071
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0342 0.4065
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.021 0.0209
Schistosoma mansoni hypothetical protein 0.0048 0.0848 0.2902
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0378 0.0743
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0712 0.071
Onchocerca volvulus 0.0028 0.039 0.4842
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.3183 0.3181
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.021 0.0209
Mycobacterium leprae Probable polyketide synthase Pks1 0.0027 0.0378 0.481
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1229 0.4206
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0599 0.9443
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1229 0.4206
Mycobacterium ulcerans thioesterase TesA 0.0021 0.0246 0.2064
Trichomonas vaginalis conserved hypothetical protein 0.002 0.021 0.0438
Schistosoma mansoni regulator of G protein signaling 0.002 0.021 0.0715
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0378 0.481
Echinococcus granulosus muscleblind protein 0.0455 1 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0342 0.4065
Schistosoma mansoni hypothetical protein 0.0041 0.0678 0.2318
Toxoplasma gondii exonuclease III APE 0.0019 0.0188 0.2393
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.1968 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0188 0.0837
Loa Loa (eye worm) hypothetical protein 0.0028 0.039 0.0388
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.1229 0.1227
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0848 0.0846
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.1968 0.1967
Loa Loa (eye worm) hypothetical protein 0.0042 0.0712 0.071
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0025 0.0324 0.0639
Mycobacterium ulcerans beta-lactamase 0.0037 0.0599 0.9443
Onchocerca volvulus 0.0037 0.0599 0.7459
Schistosoma mansoni intermediate filament proteins 0.0028 0.039 0.1329
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0188 0.5
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0026 0.0342 0.4065
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.021 0.0209
Echinococcus granulosus lamin dm0 0.0028 0.039 0.0388
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0038 0.0626 0.1232
Loa Loa (eye worm) hypothetical protein 0.0037 0.0599 0.0597
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.013 0.2684 0.2683
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0599 0.7848
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.021 0.0209
Loa Loa (eye worm) hypothetical protein 0.002 0.021 0.0209
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.021 0.0715
Echinococcus multilocularis tar DNA binding protein 0.0065 0.1229 0.1227
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0026 0.0342 0.0673
Entamoeba histolytica hypothetical protein 0.002 0.021 0.0129
Onchocerca volvulus 0.0028 0.039 0.4842
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0599 0.118
Mycobacterium tuberculosis Conserved protein 0.0037 0.0599 0.118
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0599 0.7848
Entamoeba histolytica hypothetical protein 0.002 0.021 0.0129
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.021 0.0209
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.021 0.0715
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0188 0.5
Mycobacterium ulcerans polyketide synthase 0.0027 0.0378 0.481
Echinococcus granulosus expressed conserved protein 0.0092 0.1835 0.1833
Brugia malayi beta-lactamase family protein 0.0037 0.0599 0.0597
Schistosoma mansoni regulator of G protein signaling 0.002 0.021 0.0715
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0027 0.0378 0.481
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0021 0.0246 0.2064
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0101 0.0099
Echinococcus multilocularis protein dispatched 1 0.0048 0.0846 0.0844
Loa Loa (eye worm) hypothetical protein 0.0013 0.0057 0.0055
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.021 0.0438
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.021 0.0209
Mycobacterium tuberculosis Conserved protein 0.0037 0.0599 0.118
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0025 0.0324 0.0639
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0599 0.118
Schistosoma mansoni axis inhibition protein axin 0.002 0.021 0.0715
Mycobacterium ulcerans thioesterase 0.0021 0.0246 0.2064
Loa Loa (eye worm) hypothetical protein 0.0455 1 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0712 0.071
Schistosoma mansoni serine/threonine protein kinase 0.002 0.021 0.0715
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.021 0.0209
Echinococcus multilocularis thyroid hormone receptor alpha 0.014 0.2918 0.2917
Loa Loa (eye worm) hypothetical protein 0.0152 0.3183 0.3181
Entamoeba histolytica hypothetical protein 0.002 0.021 0.0129
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0188 0.0369
Brugia malayi PXA domain containing protein 0.002 0.021 0.0209
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0026 0.0342 0.034
Schistosoma mansoni serine/threonine protein kinase 0.002 0.021 0.0715
Loa Loa (eye worm) hypothetical protein 0.0037 0.0599 0.0597
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0599 0.118
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0599 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0599 0.118
Echinococcus granulosus axis inhibition protein axin 0.002 0.021 0.0209
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0026 0.0342 0.4065
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0848 0.0846
Toxoplasma gondii type I fatty acid synthase, putative 0.0027 0.0378 0.5905
Brugia malayi beta-lactamase 0.0037 0.0599 0.0597
Brugia malayi intermediate filament protein 0.0028 0.039 0.0388
Trichomonas vaginalis conserved hypothetical protein 0.002 0.021 0.0438
Loa Loa (eye worm) hypothetical protein 0.002 0.021 0.0209
Brugia malayi PXA domain containing protein 0.002 0.021 0.0209
Echinococcus multilocularis lamin dm0 0.0028 0.039 0.0388
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0304 0.0302
Loa Loa (eye worm) hypothetical protein 0.0013 0.0068 0.0066
Schistosoma mansoni hypothetical protein 0.0104 0.2102 0.7201
Loa Loa (eye worm) hypothetical protein 0.0037 0.0599 0.0597
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0599 0.9443
Loa Loa (eye worm) hypothetical protein 0.0455 1 1
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.1968 0.1967
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.3183 0.3181
Schistosoma mansoni serine/threonine protein kinase 0.002 0.021 0.0715
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.021 0.0209
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.021 0.0209
Loa Loa (eye worm) hypothetical protein 0.002 0.021 0.0209
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0027 0.0378 0.481
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0599 0.118
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0848 0.0846
Onchocerca volvulus Fatty acid synthase homolog 0.0046 0.0803 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0599 0.2048
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0017 0.014 0.152
Schistosoma mansoni thyroid hormone receptor 0.014 0.2918 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.3183 0.3181
Loa Loa (eye worm) hypothetical protein 0.0037 0.0599 0.0597
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.021 0.0209
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0599 0.7848
Echinococcus multilocularis muscleblind protein 1 0.0455 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0599 0.2048
Toxoplasma gondii ABC1 family protein 0.0037 0.0599 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0024 0.0304 0.0599
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0599 1
Schistosoma mansoni thyroid hormone receptor 0.014 0.2918 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.021 0.0209
Loa Loa (eye worm) hypothetical protein 0.0014 0.0089 0.0088
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0848 0.0846
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0018 0.018 0.0355
Onchocerca volvulus 0.0037 0.0599 0.7459
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0027 0.0378 0.481
Loa Loa (eye worm) beta-lactamase 0.0037 0.0599 0.0597
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0021 0.023 0.172
Onchocerca volvulus 0.0044 0.0767 0.9555
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0188 0.0186
Loa Loa (eye worm) hypothetical protein 0.0037 0.0599 0.0597
Schistosoma mansoni regulator of G protein signaling 0.002 0.021 0.0715
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0599 0.0597
Loa Loa (eye worm) hypothetical protein 0.0027 0.0378 0.0376
Mycobacterium ulcerans polyketide synthase Pks13 0.0038 0.0626 1
Schistosoma mansoni patched 1 0.0042 0.0712 0.2435
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0101 0.0099
Loa Loa (eye worm) hypothetical protein 0.0098 0.1968 0.1967
Brugia malayi hypothetical protein 0.002 0.021 0.0209
Loa Loa (eye worm) intermediate filament protein 0.0028 0.039 0.0388
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.021 0.0209
Loa Loa (eye worm) hypothetical protein 0.0051 0.0925 0.0923
Echinococcus granulosus axis inhibition protein axin 0.002 0.021 0.0209
Echinococcus granulosus GPCR family 2 0.0048 0.0848 0.0846
Mycobacterium ulcerans Type I modular polyketide synthase 0.0026 0.0342 0.4065
Loa Loa (eye worm) hypothetical protein 0.0037 0.0599 0.0597
Brugia malayi TAR-binding protein 0.0065 0.1229 0.1227
Onchocerca volvulus 0.0024 0.0304 0.3774
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0712 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.2102 0.2101
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.021 0.0209
Brugia malayi CHE-14 protein 0.0042 0.0712 0.071
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.5079 1
Schistosoma mansoni z-protein (S1r protein) 0.002 0.021 0.0715
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0027 0.0378 0.0743
Schistosoma mansoni hypothetical protein 0.0041 0.0678 0.2318
Mycobacterium ulcerans lipase LipD 0.0037 0.0599 0.9443
Loa Loa (eye worm) hypothetical protein 0.0043 0.0732 0.073
Leishmania major hypothetical protein, conserved 0.0037 0.0599 1
Echinococcus multilocularis expressed protein 0.0384 0.8386 0.8386
Schistosoma mansoni regulator of G protein signaling 0.002 0.021 0.0715
Echinococcus multilocularis expressed conserved protein 0.0092 0.1835 0.1833
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.021 0.0209
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.2912 0.2911
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1229 0.4206
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0599 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.0304 0.0302
Schistosoma mansoni ap endonuclease 0.0019 0.0188 0.0636
Loa Loa (eye worm) hypothetical protein 0.0048 0.0848 0.0846
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0021 0.023 0.172
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.021 0.0209
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.021 0.0209
Mycobacterium ulcerans hypothetical protein 0.0037 0.0599 0.9443
Loa Loa (eye worm) RNA binding protein 0.0065 0.1229 0.1227
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0599 0.7848
Echinococcus granulosus intermediate filament protein 0.0028 0.039 0.0388
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.1229 0.1227
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0342 0.0673
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0015 0.0094 0.0185
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0188 0.5
Trichomonas vaginalis conserved hypothetical protein 0.002 0.021 0.0438
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0188 0.0186
Loa Loa (eye worm) hypothetical protein 0.002 0.021 0.0209
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0188 0.0186
Schistosoma mansoni lamin 0.0028 0.039 0.1329
Echinococcus granulosus expressed protein 0.0384 0.8386 0.8386
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.021 0.0209
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0021 0.0237 0.0467
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0048 0.0856 0.0854
Echinococcus granulosus tar DNA binding protein 0.0065 0.1229 0.1227
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0038 0.0626 0.1232
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0342 0.0673
Echinococcus multilocularis musashi 0.0028 0.039 0.0388
Onchocerca volvulus 0.0037 0.0599 0.7459
Brugia malayi beta-lactamase family protein 0.0037 0.0599 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.002 0.021 0.0438
Echinococcus multilocularis GPCR, family 2 0.0048 0.0848 0.0846
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.2912 0.2911
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.021 0.0209
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0188 0.5
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.021 0.0209
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0068 0.0066
Schistosoma mansoni ap endonuclease 0.0019 0.0188 0.0636
Schistosoma mansoni hypothetical protein 0.0048 0.0848 0.2902
Echinococcus multilocularis protein patched 0.0042 0.0712 0.071
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1229 0.4206
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0712 0.071
Trichomonas vaginalis esterase, putative 0.0037 0.0599 0.7848
Mycobacterium leprae Polyketide synthase Pks13 0.0038 0.0626 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0057 0.0055
Schistosoma mansoni hypothetical protein 0.0041 0.0678 0.2318
Echinococcus multilocularis axis inhibition protein axin 0.002 0.021 0.0209
Mycobacterium tuberculosis Probable thioesterase TesA 0.0021 0.0246 0.0485
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.013 0.2684 0.2683
Schistosoma mansoni hypothetical protein 0.0041 0.0678 0.2318
Echinococcus multilocularis lamin 0.0028 0.039 0.0388
Loa Loa (eye worm) hypothetical protein 0.002 0.021 0.0209
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0026 0.0342 0.4065
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0021 0.023 0.172
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0599 1
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.2102 0.2101
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0599 0.0597
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.039 0.0388
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.021 0.0209
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.021 0.0209
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0848 0.0846
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.1968 0.1967
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0599 0.0597
Schistosoma mansoni axis inhibition protein axin 0.002 0.021 0.0715
Schistosoma mansoni regulator of G protein signaling 0.002 0.021 0.0715
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0027 0.0378 0.0743
Brugia malayi RNA binding protein 0.0065 0.1229 0.1227
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0848 0.0846
Loa Loa (eye worm) hypothetical protein 0.002 0.021 0.0209
Loa Loa (eye worm) fatty acid synthase 0.0025 0.0334 0.0332
Trichomonas vaginalis conserved hypothetical protein 0.002 0.021 0.0438
Schistosoma mansoni hypothetical protein 0.013 0.2684 0.9197
Schistosoma mansoni lamin 0.0028 0.039 0.1329
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.021 0.0209
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.021 0.0715
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.021 0.0209
Mycobacterium leprae Probable lipase LipE 0.0037 0.0599 0.9443
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0599 0.0597
Mycobacterium ulcerans polyketide synthase 0.0026 0.0342 0.4065
Trichomonas vaginalis conserved hypothetical protein 0.002 0.021 0.0438
Echinococcus multilocularis regulator of G protein signaling 0.002 0.021 0.0209
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1229 0.4206
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0848 0.0846
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.039 0.0388
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.021 0.0209
Echinococcus multilocularis muscleblind protein 0.0455 1 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0068 0.0066
Brugia malayi hypothetical protein 0.002 0.021 0.0209
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0599 0.118
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0188 0.0186

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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