Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | PHD-finger family protein | 0.0019 | 0.0278 | 0.0319 |
Trypanosoma brucei | ISWI complex protein | 0.0014 | 0.0038 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1182 | 0.1357 |
Echinococcus multilocularis | lamin dm0 | 0.0025 | 0.0563 | 0.2325 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0044 | 0.1459 | 0.7 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0044 | 0.1459 | 0.6587 |
Brugia malayi | PHD-finger family protein | 0.0023 | 0.047 | 0.054 |
Schistosoma mansoni | lamin | 0.0025 | 0.0563 | 0.2432 |
Echinococcus multilocularis | lamin | 0.0025 | 0.0563 | 0.2325 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0028 | 0.0693 | 0.3001 |
Brugia malayi | Bromodomain containing protein | 0.0036 | 0.1072 | 0.1232 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0021 | 0.0364 | 0.1287 |
Leishmania major | hypothetical protein, conserved | 0.0014 | 0.0038 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0044 | 0.1459 | 0.6587 |
Echinococcus multilocularis | zinc finger protein | 0.0018 | 0.0231 | 0.0592 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0021 | 0.0364 | 0.151 |
Echinococcus granulosus | lamin | 0.0025 | 0.0563 | 0.2325 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0056 | 0.2035 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0223 | 1 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0071 | 0.2722 | 0.3127 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0034 | 0.0966 | 0.4427 |
Schistosoma mansoni | bromodomain containing protein | 0.006 | 0.2195 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0025 | 0.0563 | 0.0646 |
Trypanosoma cruzi | ISWI complex protein | 0.0014 | 0.0038 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0196 | 0.8707 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0028 | 0.0693 | 0.3033 |
Schistosoma mansoni | lamin | 0.0025 | 0.0563 | 0.2432 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0056 | 0.2035 | 1 |
Echinococcus multilocularis | musashi | 0.0025 | 0.0563 | 0.2325 |
Plasmodium vivax | SET domain protein, putative | 0.0028 | 0.0693 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0541 | 0.0621 |
Echinococcus granulosus | zinc finger protein | 0.0018 | 0.0231 | 0.0592 |
Schistosoma mansoni | zinc finger protein | 0.0018 | 0.0231 | 0.0891 |
Loa Loa (eye worm) | intermediate filament protein | 0.0025 | 0.0563 | 0.0646 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0027 | 0.0643 | 0.2743 |
Brugia malayi | Pre-SET motif family protein | 0.0196 | 0.8707 | 1 |
Onchocerca volvulus | 0.0028 | 0.0693 | 0.0137 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1268 | 0.1456 |
Brugia malayi | intermediate filament protein | 0.0025 | 0.0563 | 0.0646 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0028 | 0.0693 | 0.3033 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0016 | 0.0117 | 0.0366 |
Schistosoma mansoni | intermediate filament proteins | 0.0025 | 0.0563 | 0.2432 |
Echinococcus granulosus | lamin dm0 | 0.0025 | 0.0563 | 0.2325 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0034 | 0.0966 | 0.4427 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0278 | 0.1112 |
Trypanosoma cruzi | ISWI complex protein | 0.0014 | 0.0038 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.253 | 0.2906 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0016 | 0.0117 | 0.0366 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1076 | 0.1235 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0021 | 0.0364 | 0.1287 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0028 | 0.0693 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0563 | 0.0646 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0025 | 0.0563 | 0.0646 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1459 | 0.1676 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0017 | 0.0145 | 0.0166 |
Brugia malayi | Pre-SET motif family protein | 0.0028 | 0.0693 | 0.0795 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0044 | 0.1459 | 0.7 |
Echinococcus granulosus | intermediate filament protein | 0.0025 | 0.0563 | 0.2325 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.