Detailed information for compound 69997

Basic information

Technical information
  • TDR Targets ID: 69997
  • Name: N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsul fanyl]-1,3-thiazol-2-yl]-1-(2-hydroxyethyl)pi peridine-4-carboxamide
  • MW: 424.581 | Formula: C19H28N4O3S2
  • H donors: 2 H acceptors: 4 LogP: 2.77 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN1CCC(CC1)C(=O)Nc1ncc(s1)SCc1ncc(o1)C(C)(C)C
  • InChi: 1S/C19H28N4O3S2/c1-19(2,3)14-10-20-15(26-14)12-27-16-11-21-18(28-16)22-17(25)13-4-6-23(7-5-13)8-9-24/h10-11,13,24H,4-9,12H2,1-3H3,(H,21,22,25)
  • InChiKey: NASKBLMGBFRGIF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[5-[(5-tert-butyloxazol-2-yl)methylsulfanyl]thiazol-2-yl]-1-(2-hydroxyethyl)piperidine-4-carboxamide
  • N-[5-[(5-tert-butyl-2-oxazolyl)methylthio]-2-thiazolyl]-1-(2-hydroxyethyl)-4-piperidinecarboxamide
  • N-[5-[(5-tert-butyloxazol-2-yl)methylthio]thiazol-2-yl]-1-(2-hydroxyethyl)isonipecotamide
  • BMS-387032 analog 23

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus chromatin regulatory protein sir2 0.0108 0.0093 0.0126
Echinococcus granulosus lysine specific histone demethylase 1A 0.0337 0.0336 0.0456
Schistosoma mansoni SWI/SNF complex-related 0.0028 0.0008 0.0012
Loa Loa (eye worm) endoprotease bli-4 0.6126 0.6513 0.6513
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0024 0.0003 0.0004
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0002 0.0003
Loa Loa (eye worm) WD40 repeat protein 0.0133 0.0119 0.0119
Loa Loa (eye worm) glutamate receptor 1 0.0033 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0026 0.0005 0.0005
Loa Loa (eye worm) apoptosis regulator protein 0.0058 0.0039 0.0039
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0021 0 0.5
Plasmodium falciparum plasmepsin I 0.0023 0.0001 0.0051
Brugia malayi neuroendocrine convertase 1 precursor 0.386 0.4096 0.4096
Onchocerca volvulus 0.0266 0.0261 0.7097
Echinococcus granulosus plasminogen activator inhibitor 2 0.0023 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.1203 0.126 0.3179
Echinococcus multilocularis membrane bound transcription factor site 1 0.0266 0.0261 0.0354
Trichomonas vaginalis conserved hypothetical protein 0.1203 0.126 0.3179
Brugia malayi BmSERPIN 0.0023 0.0002 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0005 0.0005
Toxoplasma gondii subtilisin SUB1 0.0266 0.0261 1
Brugia malayi serpin 0.0023 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0033 0.0012 0.0018
Brugia malayi metalloprotease 0.0065 0.0046 0.0046
Plasmodium falciparum plasmepsin IX 0.0023 0.0001 0.0051
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0049 0.003 0.004
Loa Loa (eye worm) TK/EGFR protein kinase 0.0255 0.0249 0.0249
Echinococcus granulosus disks large 3 0.0023 0.0002 0.0003
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0266 0.0261 1
Onchocerca volvulus 0.0023 0.0002 0.002
Echinococcus multilocularis serine:threonine protein kinase N2 0.0076 0.0059 0.008
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0082 0.0065 0.2406
Echinococcus granulosus integrin alpha ps 0.0629 0.0648 0.0879
Loa Loa (eye worm) hypothetical protein 0.0337 0.0336 0.0336
Schistosoma mansoni furin-1 (S08 family) 0.2658 0.2813 0.4318
Echinococcus multilocularis protoporphyrinogen oxidase 0.0068 0.005 0.0068
Loa Loa (eye worm) integrin alpha pat-2 0.3923 0.4162 0.4162
Loa Loa (eye worm) hypothetical protein 0.0097 0.0081 0.0081
Echinococcus multilocularis adam 0.0512 0.0524 0.0711
Mycobacterium ulcerans oxidoreductase 0.0068 0.005 0.1926
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0082 0.0065 0.2406
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Giardia lamblia Hypothetical protein 0.0108 0.0093 0.038
Schistosoma mansoni serine/threonine protein kinase 0.0245 0.0239 0.0367
Entamoeba histolytica hypothetical protein 0.0028 0.0008 0.0611
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0306 0.0304 0.0466
Plasmodium falciparum subtilisin-like protease 3 0.0266 0.0261 1
Loa Loa (eye worm) hypothetical protein 0.1443 0.1516 0.1516
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0337 0.0336 0.0517
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0065 0.0047 0.1802
Giardia lamblia Tenascin-like 0.0206 0.0198 0.0817
Mycobacterium tuberculosis Probable thioesterase TesA 0.0071 0.0053 0.1946
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0266 0.0261 0.04
Onchocerca volvulus 0.0133 0.0119 0.3212
Brugia malayi Will die slowly protein 0.0133 0.0119 0.0119
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0082 0.0065 0.2482
Loa Loa (eye worm) hypothetical protein 0.0234 0.0227 0.0227
Toxoplasma gondii aspartyl protease 0.0023 0.0001 0.0051
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0234 0.0227 0.0307
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0266 0.0261 0.0354
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0337 0.0336 0.0456
Brugia malayi Furin-like cysteine rich region family protein 0.0255 0.0249 0.0249
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Schistosoma mansoni septate junction protein 0.0022 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.01 0.0084 0.0129
Loa Loa (eye worm) serpin 0.0023 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Brugia malayi AMP-binding enzyme family protein 0.0079 0.0062 0.0062
Toxoplasma gondii subtilisin SUB7 0.0266 0.0261 1
Mycobacterium ulcerans thioesterase TesA 0.0071 0.0053 0.2026
Brugia malayi proprotein convertase 2 0.386 0.4096 0.4096
Toxoplasma gondii aspartyl protease ASP1 0.0023 0.0001 0.0051
Brugia malayi serpin (BmSERPIN) 0.0023 0.0002 0.0002
Echinococcus granulosus fibrillin 2 0.0206 0.0198 0.0268
Onchocerca volvulus 0.0023 0.0002 0.002
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0033 0.0012 0.0016
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0002 0.0003
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0266 0.0261 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0087 0.007 0.2625
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0084 0.0066 0.2473
Echinococcus multilocularis integrin alpha 3 0.2012 0.2124 0.288
Loa Loa (eye worm) hypothetical protein 0.0704 0.0728 0.0728
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0023 0.0001 0.0001
Giardia lamblia hypothetical protein 0.0028 0.0008 0.0023
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0058 0.0039 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.1203 0.126 0.3179
Brugia malayi Integrin alpha cytoplasmic region family protein 0.1931 0.2038 0.2038
Loa Loa (eye worm) serpin 0.0023 0.0002 0.0002
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0108 0.0093 0.3463
Giardia lamblia Neurogenic locus Notch protein precursor 0.0206 0.0198 0.0817
Schistosoma mansoni hypothetical protein 0.0058 0.0039 0.006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Echinococcus granulosus glutamate NMDA receptor subunit 0.0275 0.0271 0.0367
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0033 0.0012 0.0016
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0024 0.0003 0.0034
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0135 0.0121 0.0164
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0266 0.0261 0.0261
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0206 0.0198 0.0198
Leishmania major UDP-galactopyranose mutase 0.0068 0.005 0.1926
Brugia malayi serpin 0.0023 0.0002 0.0002
Brugia malayi endoprotease bli-4 precursor 0.6126 0.6513 0.6513
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0135 0.0121 0.0164
Schistosoma mansoni egf-like domain protein 0.0026 0.0005 0.0008
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0002 0.0003
Echinococcus granulosus furin 0.6126 0.6513 0.8832
Plasmodium vivax subtilisin-like protease 2, putative 0.0266 0.0261 1
Entamoeba histolytica SWIRM domain protein 0.0028 0.0008 0.0611
Trichomonas vaginalis conserved hypothetical protein 0.0266 0.0261 0.0655
Trypanosoma cruzi UDP-galactopyranose mutase 0.0068 0.005 0.1871
Loa Loa (eye worm) metalloprotease 0.0065 0.0046 0.0046
Trichomonas vaginalis hypothetical protein 0.1203 0.126 0.3179
Schistosoma mansoni glutamate receptor AMPA 0.0033 0.0012 0.0018
Brugia malayi aspartic protease BmAsp-2, identical 0.0023 0.0001 0.0001
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1468 0.1544 0.237
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0028 0.0008 0.001
Plasmodium falciparum plasmepsin V 0.0254 0.0248 0.9524
Giardia lamblia High cysteine membrane protein Group 2 0.2266 0.2395 1
Plasmodium vivax aspartyl protease, putative 0.0023 0.0001 0.0051
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0266 0.0261 0.0354
Toxoplasma gondii type I fatty acid synthase, putative 0.0087 0.007 0.2698
Brugia malayi Integrin alpha pat-2 precursor 0.2696 0.2853 0.2853
Echinococcus multilocularis laminin 0.0026 0.0005 0.0007
Schistosoma mansoni integrin alpha-ps 0.0758 0.0786 0.1207
Echinococcus granulosus protein kinase c epsilon type 0.0083 0.0066 0.009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0066 0.0048 0.1766
Schistosoma mansoni serpin 0.0023 0.0002 0.0003
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1203 0.126 0.3179
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0053 0.0034 0.1303
Plasmodium vivax aspartyl protease, putative 0.0023 0.0001 0.0051
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0082 0.0065 0.2424
Plasmodium falciparum plasmepsin VI 0.0023 0.0001 0.0051
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0027 0.0006 0.0122
Echinococcus granulosus lysine specific histone demethylase 1A 0.0068 0.005 0.0068
Plasmodium vivax hypothetical protein, conserved 0.0068 0.005 0.1926
Giardia lamblia Neurogenic locus notch-like protein 0.0206 0.0198 0.0817
Brugia malayi serpin 0.0023 0.0002 0.0002
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0084 0.0066 1
Brugia malayi ADAM-TS Spacer 1 family protein 0.0137 0.0123 0.0123
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0023 0.0001 0.0051
Echinococcus granulosus serine protease inhibitor 0.0023 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Plasmodium falciparum plasmepsin VIII, putative 0.0023 0.0001 0.0051
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Toxoplasma gondii protease inhibitor PI1 0.0023 0.0002 0.0079
Brugia malayi Serpin protein 6 0.0023 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0068 0.005 0.005
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0068 0.005 0.0077
Echinococcus granulosus glutamate receptor 2 0.0049 0.003 0.004
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0087 0.007 0.2534
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0087 0.007 0.2698
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0055 0.0036 0.1384
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.003 0.004
Brugia malayi hypothetical protein 0.0023 0.0002 0.0002
Schistosoma mansoni serpin 0.0023 0.0002 0.0003
Brugia malayi angiogenesis inhibito 0.0137 0.0123 0.0123
Echinococcus multilocularis Estrogen regulated protein EP45 0.0023 0.0002 0.0003
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0068 0.005 0.1926
Brugia malayi hypothetical protein 0.1443 0.1516 0.1516
Brugia malayi serpin precursor 0.0023 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1468 0.1544 0.3895
Schistosoma mansoni glutamate receptor kainate 0.0033 0.0012 0.0018
Toxoplasma gondii subtilisin SUB11 0.0266 0.0261 1
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0273 0.0268 1
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0275 0.0271 0.0367
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Echinococcus granulosus serine protease inhibitor 0.0023 0.0002 0.0003
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0048 0.0029 0.1016
Giardia lamblia Furin precursor putative serine protease 0.1203 0.126 0.5259
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.003 0.004
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0058 0.0039 0.0053
Schistosoma mansoni cathepsin D (A01 family) 0.0023 0.0001 0.0002
Echinococcus multilocularis glutamate receptor 2 0.0033 0.0012 0.0016
Echinococcus multilocularis integrin alpha ps 0.0629 0.0648 0.0879
Echinococcus multilocularis integrin beta 2 0.6934 0.7375 1
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1203 0.126 0.3179
Toxoplasma gondii type I fatty acid synthase, putative 0.0061 0.0042 0.1603
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0093 0.0143
Mycobacterium leprae Probable polyketide synthase Pks1 0.0087 0.007 0.2534
Brugia malayi protein kinase C II. 0.0083 0.0066 0.0066
Onchocerca volvulus 0.0023 0.0002 0.002
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0033 0.0012 0.0016
Echinococcus granulosus neuroendocrine convertase 2 0.386 0.4096 0.5554
Echinococcus multilocularis protein will die slowly 0.0133 0.0119 0.0161
Plasmodium falciparum protoporphyrinogen oxidase 0.0068 0.005 0.1926
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0234 0.0227 0.0348
Brugia malayi Reprolysin 0.0137 0.0123 0.0123
Schistosoma mansoni glutamate receptor kainate 0.0033 0.0012 0.0018
Brugia malayi Guanylate kinase family protein 0.0026 0.0004 0.0004
Echinococcus granulosus Estrogen regulated protein EP45 0.0023 0.0002 0.0003
Echinococcus multilocularis neuroendocrine convertase 2 0.386 0.4096 0.5554
Echinococcus granulosus integrin alpha ps 0.1387 0.1457 0.1976
Brugia malayi transcriptional regulator, Sir2 family protein 0.0108 0.0093 0.0093
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.3734 0.3961 0.5372
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0002 0.0003
Trypanosoma brucei RNA helicase, putative 0.01 0.0084 0.3127
Schistosoma mansoni amine oxidase 0.0068 0.005 0.0077
Chlamydia trachomatis glutamine binding protein 0.0084 0.0066 1
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0061 0.0042 0.1542
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0068 0.005 0.1926
Schistosoma mansoni site-1 peptidase (S08 family) 0.0266 0.0261 0.04
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Loa Loa (eye worm) serpin protein 6 0.0023 0.0002 0.0002
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0023 0.0001 0.0002
Brugia malayi Stress-activated protein kinase jnk-1 0.0245 0.0239 0.0239
Toxoplasma gondii subtilisin SUB4 0.0266 0.0261 1
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0003 0.0096
Loa Loa (eye worm) angiogenesis inhibito 0.0065 0.0046 0.0046
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0118 0.0103 0.0103
Plasmodium falciparum subtilisin-like protease 2 0.0266 0.0261 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0108 0.0093 0.0126
Brugia malayi EGF-like domain containing protein 0.0206 0.0198 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.1203 0.126 0.3179
Mycobacterium ulcerans Type I modular polyketide synthase 0.0082 0.0065 0.2482
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0266 0.0261 1
Schistosoma mansoni hypothetical protein 0.0629 0.0648 0.0996
Brugia malayi Kelch motif family protein 0.145 0.1524 0.1524
Echinococcus granulosus epidermal growth factor receptor 0.0255 0.0249 0.0338
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Onchocerca volvulus 0.0365 0.0367 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3734 0.3961 1
Schistosoma mansoni integrin beta subunit 0.5491 0.5836 0.896
Brugia malayi hypothetical protein 0.0306 0.0304 0.0304
Toxoplasma gondii subtilisin SUB9 0.0266 0.0261 1
Brugia malayi Calcium binding EGF domain containing protein 0.0026 0.0005 0.0005
Toxoplasma gondii histone lysine-specific demethylase 0.0068 0.005 0.1926
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Mycobacterium ulcerans polyketide synthase Pks9 0.0053 0.0034 0.1303
Toxoplasma gondii subtilisin SUB10 0.0266 0.0261 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1468 0.1544 0.3895
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0234 0.0227 0.0348
Loa Loa (eye worm) fatty acid synthase 0.0084 0.0067 0.0067
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0023 0.0001 0.0002
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0158 0.0146 0.0146
Echinococcus multilocularis Furin 1 0.1468 0.1544 0.2093
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0124 0.011 0.4144
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0083 0.0066 0.0066
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0001 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0266 0.0261 0.0655
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.1383 0.1453 0.1453
Loa Loa (eye worm) hypothetical protein 0.0065 0.0046 0.0046
Echinococcus multilocularis fibrillin 1 0.0233 0.0226 0.0307
Schistosoma mansoni glutamate receptor kainate 0.0033 0.0012 0.0018
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0024 0.0003 0.0057
Echinococcus granulosus adam 0.0512 0.0524 0.0711
Brugia malayi serpin (BmSERPIN) 0.0023 0.0002 0.0002
Loa Loa (eye worm) integrin beta-2 0.9394 1 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0025 0.0025
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0079 0.0062 0.0062
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0058 0.0039 0.0039
Echinococcus granulosus protein will die slowly 0.0133 0.0119 0.0161
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0053 0.0034 0.1108
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0266 0.0261 0.9715
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.2392 0.2529 0.2529
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.0022 0.0001 0.0001
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0087 0.007 0.2625
Toxoplasma gondii subtilisin SUB2 0.0266 0.0261 1
Loa Loa (eye worm) transcriptional regulator 0.0108 0.0093 0.0093
Echinococcus multilocularis protein jagged 2 0.0206 0.0198 0.0268
Echinococcus multilocularis serine protease inhibitor 0.0023 0.0002 0.0003
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0118 0.0103 0.0103
Schistosoma mansoni dihydroceramide desaturase 0.0097 0.0081 0.0124
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.014 0.0126 0.0126
Plasmodium vivax subtilisin-like serine protease, putative 0.0266 0.0261 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0005 0.0005
Plasmodium falciparum plasmepsin VII 0.0023 0.0001 0.0051
Onchocerca volvulus 0.0078 0.006 0.1607
Echinococcus granulosus integrin alpha 3 0.2012 0.2124 0.288
Toxoplasma gondii serpin (serine proteinase inhibitor) superfamily protein 0.0023 0.0002 0.0079
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0097 0.0081 0.0109
Brugia malayi ADAMTS-like protease 0.0137 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.6126 0.6513 0.6513
Trichomonas vaginalis conserved hypothetical protein 0.0266 0.0261 0.0655
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0097 0.0081 0.0109
Loa Loa (eye worm) hypothetical protein 0.0033 0.0013 0.0013
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0245 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Schistosoma mansoni amine oxidase 0.0068 0.005 0.0077
Mycobacterium tuberculosis Possible oxidoreductase 0.0068 0.005 0.1845
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0023 0.0001 0.0001
Brugia malayi EGF-like domain containing protein 0.0206 0.0198 0.0198
Toxoplasma gondii subtilisin SUB8 0.0266 0.0261 1
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0266 0.0261 0.0261
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0024 0.0003 0.0099
Echinococcus granulosus Furin 1 0.1468 0.1544 0.2093
Schistosoma mansoni ATP-binding cassette transporter 0.0033 0.0012 0.0018
Brugia malayi serpin 0.0023 0.0002 0.0002
Mycobacterium ulcerans Type I modular polyketide synthase 0.0082 0.0065 0.2482
Echinococcus multilocularis nmda type glutamate receptor 0.0116 0.0101 0.0137
Brugia malayi Glutamate receptor 1 precursor 0.0033 0.0012 0.0012
Giardia lamblia High cysteine protein 0.0206 0.0198 0.0817
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0068 0.005 0.1926
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Echinococcus multilocularis NMDA receptor 0.0033 0.0012 0.0016
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0065 0.0046 0.0071
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.003 0.004
Schistosoma mansoni glutamate receptor NMDA 0.0049 0.003 0.0046
Loa Loa (eye worm) hypothetical protein 0.0075 0.0057 0.0057
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.003 0.004
Loa Loa (eye worm) hypothetical protein 0.1931 0.2038 0.2038
Brugia malayi Eukaryotic aspartyl protease family protein 0.0023 0.0001 0.0001
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0084 0.0066 1
Trypanosoma brucei subtilisin peptidase 0.0266 0.0261 0.9715
Toxoplasma gondii calcium binding egf domain-containing protein 0.0026 0.0005 0.0192
Echinococcus multilocularis epidermal growth factor receptor 0.0255 0.0249 0.0338
Trypanosoma cruzi UDP-galactopyranose mutase 0.0068 0.005 0.1871
Brugia malayi SWIRM domain containing protein 0.0028 0.0008 0.0008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0033 0.0012 0.0016
Loa Loa (eye worm) subtilase 0.0266 0.0261 0.0261
Giardia lamblia hypothetical protein 0.0206 0.0198 0.0817
Schistosoma mansoni protein kinase 0.0135 0.0121 0.0186
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Plasmodium vivax aspartyl protease, putative 0.0023 0.0001 0.0051
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1468 0.1544 0.3895
Plasmodium vivax subtilisin-like protease 1 0.0266 0.0261 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1468 0.1544 0.3895
Trichomonas vaginalis conserved hypothetical protein 0.1203 0.126 0.3179
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Loa Loa (eye worm) acyl carrier protein 0.0039 0.0019 0.0019
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0003 0.0004
Echinococcus granulosus adam 17 protease 0.0097 0.0081 0.0109
Loa Loa (eye worm) hypothetical protein 0.0365 0.0367 0.0367
Trichomonas vaginalis conserved hypothetical protein 0.1203 0.126 0.3179
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0003 0.0096
Mycobacterium ulcerans thioesterase 0.0071 0.0053 0.2026
Brugia malayi aspartic protease BmAsp-1, identical 0.0023 0.0001 0.0001
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0093 0.0143
Echinococcus multilocularis protein kinase c epsilon type 0.0083 0.0066 0.009
Mycobacterium ulcerans polyketide synthase Pks13 0.0124 0.011 0.4202
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0066 0.0102
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0082 0.0065 0.0065
Plasmodium vivax RNA helicase-1, putative 0.0024 0.0003 0.0099
Loa Loa (eye worm) hypothetical protein 0.0337 0.0336 0.0336
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.003 0.004
Brugia malayi Glutamate receptor 2 precursor 0.0033 0.0012 0.0012
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0082 0.0065 0.2313
Brugia malayi BmSERPIN, truncated 0.0023 0.0002 0.0002
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0058 0.0039 0.0053
Plasmodium falciparum plasmepsin II 0.0023 0.0001 0.0051
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0033 0.0012 0.0016
Echinococcus granulosus eukaryotic initiation factor 4A 0.0024 0.0003 0.0004
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0093 0.0231
Mycobacterium ulcerans polyketide synthase MbtD 0.0026 0.0005 0.0196
Brugia malayi hypothetical protein 0.0068 0.005 0.005
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0028 0.0008 0.001
Trichomonas vaginalis hypothetical protein 0.0206 0.0198 0.0495
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0024 0.0003 0.0096
Toxoplasma gondii subtilisin SUB5 0.0266 0.0261 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0116 0.0101 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0008 0.0016
Giardia lamblia Tenascin-37 0.0206 0.0198 0.0817
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0068 0.005 0.1926
Schistosoma mansoni glutamate receptor AMPA 0.0033 0.0012 0.0018
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0108 0.0093 0.0126
Onchocerca volvulus 0.0023 0.0002 0.002
Plasmodium falciparum subtilisin-like protease 1 0.0266 0.0261 1
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0108 0.0093 1
Brugia malayi SWIRM domain containing protein 0.0365 0.0367 0.0367
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0026 0.0005 0.01
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0002 0.0003
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0266 0.0261 1
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0026 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.1203 0.126 0.3179
Loa Loa (eye worm) hypothetical protein 0.2066 0.2182 0.2182
Brugia malayi Disintegrin family protein 0.0097 0.0081 0.0081
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0108 0.0093 0.3463
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0034 0.0014 0.0439
Brugia malayi Fibulin-1 precursor 0.0026 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.1203 0.126 0.3179
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0266 0.0261 1
Brugia malayi amine oxidase, flavin-containing family protein 0.0097 0.0081 0.0081
Leishmania major subtilisin-like serine peptidase 0.0266 0.0261 1
Toxoplasma gondii aspartyl protease ASP3 0.0023 0.0001 0.0051
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0026 0.0005 0.0098
Echinococcus multilocularis integrin alpha ps 0.1387 0.1457 0.1976
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0079 0.0062 0.2301
Loa Loa (eye worm) hypothetical protein 0.0026 0.0005 0.0005
Trypanosoma cruzi subtilisin peptidase 0.0266 0.0261 0.9715
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0093 0.0143
Echinococcus multilocularis disintegrin and metalloproteinase 0.0097 0.0081 0.0109
Onchocerca volvulus 0.0148 0.0135 0.3661
Loa Loa (eye worm) hypothetical protein 0.0758 0.0786 0.0786
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0065 0.0047 0.1802
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0008 0.0016
Plasmodium falciparum plasmepsin X 0.0023 0.0001 0.0051
Schistosoma mansoni protein kinase 0.0135 0.0121 0.0186
Echinococcus multilocularis 0.0068 0.005 0.0068
Mycobacterium ulcerans Type I modular polyketide synthase 0.0082 0.0065 0.2482
Schistosoma mansoni hypothetical protein 0.0058 0.0039 0.006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Brugia malayi celfurPC protein 0.4924 0.523 0.523
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Mycobacterium ulcerans dehydrogenase 0.0068 0.005 0.1926
Entamoeba histolytica PH domain containing protein kinase, putative 0.0068 0.005 0.5273
Echinococcus granulosus laminin 0.0026 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0033 0.0012 0.0016
Mycobacterium ulcerans polyketide synthase 0.0087 0.007 0.2698
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0266 0.0261 1
Toxoplasma gondii calcium binding egf domain-containing protein 0.0026 0.0005 0.0192
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0001 0.0002
Echinococcus granulosus membrane bound transcription factor site 1 0.0266 0.0261 0.0354
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0024 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0206 0.0198 0.0198
Toxoplasma gondii subtilisin SUB12 0.0266 0.0261 1
Giardia lamblia High cysteine protein 0.0206 0.0198 0.0817
Schistosoma mansoni cell polarity protein 0.0023 0.0002 0.0003
Schistosoma mansoni memapsin-2 (A01 family) 0.0023 0.0001 0.0002
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.3734 0.3961 0.5372
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0108 0.0093 1
Loa Loa (eye worm) serpin 0.0023 0.0002 0.0002
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0082 0.0065 0.2406
Loa Loa (eye worm) proprotein convertase 2 0.1468 0.1544 0.1544
Loa Loa (eye worm) hypothetical protein 0.0068 0.005 0.005
Onchocerca volvulus 0.0079 0.0062 0.166
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0049 0.003 0.004
Echinococcus multilocularis chromatin regulatory protein sir2 0.0108 0.0093 0.0126
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0068 0.005 0.1926
Mycobacterium leprae Possible secreted protease 0.0266 0.0261 1
Loa Loa (eye worm) reprolysin 0.0234 0.0227 0.0227
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0071 0.0053 0.1847
Plasmodium vivax hypothetical protein, conserved 0.0068 0.005 0.1926
Loa Loa (eye worm) hypothetical protein 0.0137 0.0123 0.0123
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0273 0.0268 1
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0033 0.0013 0.0013
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0023 0.0001 0.0051
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Toxoplasma gondii SWIRM domain-containing protein 0.0028 0.0008 0.0292
Brugia malayi serpin 0.0023 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Brugia malayi eukaryotic initiation factor 4A 0.0024 0.0003 0.0003
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1468 0.1544 0.3895
Echinococcus granulosus integrin beta 2 0.6934 0.7375 1
Loa Loa (eye worm) hypothetical protein 0.0206 0.0198 0.0198
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0087 0.007 0.2534
Schistosoma mansoni hypothetical protein 0.1203 0.126 0.1935
Echinococcus multilocularis integrin alpha ps 0.1312 0.1377 0.1868
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1468 0.1544 0.3895
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0087 0.007 0.2698
Echinococcus granulosus disintegrin and metalloproteinase 0.0097 0.0081 0.0109
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0082 0.0065 0.2424
Schistosoma mansoni protein kinase 0.0135 0.0121 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.1203 0.126 0.3179
Loa Loa (eye worm) hypothetical protein 0.0028 0.0008 0.0008
Echinococcus granulosus serine:threonine protein kinase N2 0.0068 0.005 0.0068
Echinococcus multilocularis 0.4924 0.523 0.7092
Brugia malayi Subtilase family protein 0.0266 0.0261 0.0261
Echinococcus multilocularis Estrogen regulated protein EP45 0.0023 0.0002 0.0003
Plasmodium falciparum plasmepsin IV 0.0023 0.0001 0.0051
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0068 0.005 0.1926
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0024 0.0003 0.0004
Echinococcus multilocularis Tolloid protein 1 0.0033 0.0013 0.0017
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0003 0.0099
Plasmodium falciparum eukaryotic initiation factor 4A 0.0024 0.0003 0.0099
Echinococcus multilocularis glutamate receptor 2 0.0049 0.003 0.004
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0003 0.0003
Toxoplasma gondii hypothetical protein 0.0206 0.0198 0.7575
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Giardia lamblia Tenascin precursor 0.0206 0.0198 0.0817
Brugia malayi EGF-like domain containing protein 0.0206 0.0198 0.0198
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0084 0.0066 1
Echinococcus multilocularis disks large 3 0.0023 0.0002 0.0003
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.073 0.0756 0.1024
Loa Loa (eye worm) serpin 0.0023 0.0002 0.0002
Plasmodium vivax plasmepsin V, putative 0.0254 0.0248 0.9524
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0084 0.0066 0.2547
Mycobacterium tuberculosis Conserved hypothetical protein 0.0068 0.005 0.1845
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.6126 0.6513 1
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0068 0.005 0.1745
Echinococcus granulosus Tolloid protein 1 0.0033 0.0013 0.0017
Brugia malayi serpin 0.0023 0.0002 0.0002
Trichomonas vaginalis WD repeat domain, putative 0.0133 0.0119 0.0296
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0273 0.0268 1
Loa Loa (eye worm) aspartyl protease 6 0.0023 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0266 0.0261 0.0655
Schistosoma mansoni cathepsin D (A01 family) 0.0023 0.0001 0.0002
Mycobacterium ulcerans polyketide synthase 0.0082 0.0065 0.2482
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Brugia malayi EGF-like domain containing protein 0.0206 0.0198 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.1203 0.126 0.3179
Trichomonas vaginalis conserved hypothetical protein 0.1203 0.126 0.3179
Schistosoma mansoni hypothetical protein 0.0058 0.0039 0.006
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1203 0.126 0.3179
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0266 0.0261 1
Brugia malayi hypothetical protein 0.0023 0.0001 0.0001
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0266 0.0261 0.0261
Echinococcus granulosus Estrogen regulated protein EP45 0.0023 0.0002 0.0003
Entamoeba histolytica SWIRM domain protein 0.0028 0.0008 0.0611
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0003 0.0004
Schistosoma mansoni hypothetical protein 0.0133 0.0119 0.0182
Echinococcus multilocularis serine protease inhibitor 0.0023 0.0002 0.0003
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0003 0.0099
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0033 0.0013 0.0019
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0245 0.0239 0.0324
Brugia malayi Pepsin A precursor 0.0023 0.0001 0.0001
Echinococcus granulosus serine protease inhibitor 0.0023 0.0002 0.0003
Echinococcus granulosus fibrillin 1 0.0207 0.0198 0.0269
Mycobacterium ulcerans fatty acid synthase Fas 0.0027 0.0006 0.022
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0065 0.0047 0.1618
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0024 0.0003 0.0002
Schistosoma mansoni tyrosine kinase 0.0255 0.0249 0.0383
Schistosoma mansoni integrin alpha 0.2696 0.2853 0.438
Trichomonas vaginalis conserved hypothetical protein 0.0266 0.0261 0.0655
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0068 0.005 0.1926
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0093 0.0231
Mycobacterium leprae Polyketide synthase Pks13 0.0124 0.011 0.4072
Loa Loa (eye worm) hypothetical protein 0.0206 0.0198 0.0198
Echinococcus granulosus nmda type glutamate receptor 0.0116 0.0101 0.0137
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0266 0.0261 1
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0003 0.0003
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.073 0.0756 0.1024
Loa Loa (eye worm) hypothetical protein 0.0045 0.0026 0.0026
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.003 0.004
Brugia malayi hypothetical protein 0.0023 0.0001 0.0001
Giardia lamblia Tenascin-X 0.0206 0.0198 0.0817
Onchocerca volvulus Arrow homolog 0.0026 0.0005 0.0101
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0001 0.0002
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0266 0.0261 0.04
Echinococcus granulosus c-Jun N-terminal kinases 0.0245 0.0239 0.0324
Echinococcus granulosus glutamate receptor subunit protein glur 0.0033 0.0012 0.0016
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0058 0.0039 0.006
Schistosoma mansoni apoptosis regulator bax 0.0058 0.0039 0.006
Plasmodium falciparum plasmepsin III 0.0023 0.0001 0.0051
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3734 0.3961 1
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0026 0.0005 0.0005
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0068 0.005 0.1926
Toxoplasma gondii aspartyl protease ASP5 0.0232 0.0224 0.86
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0234 0.0227 0.0307
Plasmodium vivax plasmepsin IV, putative 0.0023 0.0001 0.0051
Onchocerca volvulus Fatty acid synthase homolog 0.0153 0.0141 0.3815
Loa Loa (eye worm) glutamate receptor 2 0.0033 0.0012 0.0012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Echinococcus multilocularis fibrillin 2 0.0206 0.0198 0.0268
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0043 0.0023 0.0885
Plasmodium vivax aspartyl proteinase, putative 0.0023 0.0001 0.0051
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Loa Loa (eye worm) hypothetical protein 0.0137 0.0123 0.0123
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0266 0.0261 1
Schistosoma mansoni integrin alpha-ps 0.1312 0.1377 0.2115
Onchocerca volvulus 0.0206 0.0198 0.5368
Schistosoma mansoni site-1 peptidase (S08 family) 0.0266 0.0261 0.04
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0001 0.0002
Leishmania major silent information regulator 2, putative 0.0108 0.0093 0.3565
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0124 0.011 0.4144
Onchocerca volvulus 0.0023 0.0002 0.002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0108 0.0093 0.3463
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0087 0.007 0.2625
Toxoplasma gondii subtilisin SUB6 0.0266 0.0261 1
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0206 0.0198 0.0495
Loa Loa (eye worm) hypothetical protein 0.0072 0.0054 0.0054
Chlamydia trachomatis protoporphyrinogen oxidase 0.0068 0.005 0.7561
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0001 0.0002
Onchocerca volvulus 0.0023 0.0002 0.002
Brugia malayi hypothetical protein 0.0023 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0266 0.0261 0.0655
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0082 0.0065 0.2313
Loa Loa (eye worm) hypothetical protein 0.0097 0.0081 0.0081
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0026 0.0005 0.0005
Mycobacterium ulcerans monoamine oxidase 0.0068 0.005 0.1926
Schistosoma mansoni glutamate receptor NMDA 0.0275 0.0271 0.0416
Plasmodium vivax aspartyl proteinase, putative 0.0023 0.0001 0.0051
Loa Loa (eye worm) kelch domain-containing protein family protein 0.145 0.1524 0.1524

Activities

Activity type Activity value Assay description Source Reference
AUC (functional) = 1.8 uM hr Area under curve was determined for compound after intraperitoneal administration in mice at 25 microM/kg ChEMBL. 15027863
AUC (functional) = 1.8 uM hr Area under curve was determined for compound after intraperitoneal administration in mice at 25 microM/kg ChEMBL. 15027863
Binding (functional) = 75 % Percentage of compound bound to serum protein was determined ChEMBL. 15027863
Binding (functional) = 75 % Percentage of compound bound to serum protein was determined ChEMBL. 15027863
Cmax (functional) = 1.1 uM Cmax of the compound was determined in mice at 24 microM/kg i.p. administration ChEMBL. 15027863
Cmax (functional) = 1.1 uM Cmax of the compound was determined in mice at 24 microM/kg i.p. administration ChEMBL. 15027863
IC50 (functional) = 0.12 uM Antiproliferative effect against human A2780 cell line was determined in a whole cell 72 h cytotoxicity assay ChEMBL. 15027863
IC50 (functional) = 0.12 uM Antiproliferative effect against human A2780 cell line was determined in a whole cell 72 h cytotoxicity assay ChEMBL. 15027863
IC50 (binding) = 74 uM In vitro inhibitory concentration required for displacement of [ATP] at 25 microM from Cyclin-dependent kinase 2-cyclin E ChEMBL. 15027863
IC50 (binding) = 74 uM In vitro inhibitory concentration required for displacement of [ATP] at 25 microM from Cyclin-dependent kinase 2-cyclin E ChEMBL. 15027863
MRT (functional) = 2.4 hr Mean-residence time was determined for compound after intraperitoneal administration in mice at 25 microM/kg ChEMBL. 15027863
MRT (functional) = 2.4 hr Mean-residence time was determined for compound after intraperitoneal administration in mice at 25 microM/kg ChEMBL. 15027863
MTD (functional) = 22.5 mg kg-1 Maximum tolerated dose was determined against P338 tumor in mice after intraperitoneal administration daily for 7 days ChEMBL. 15027863
MTD (functional) = 22.5 mg kg-1 Maximum tolerated dose was determined against P338 tumor in mice after intraperitoneal administration daily for 7 days ChEMBL. 15027863
ND (functional) 0 Log cell kill for A2780 tumor in mice; No data ChEMBL. 15027863
ND (functional) 0 mg kg-1 Maximum tolerated dose in A2780 tumor in mice after intraperitoneal administration daily for 8 days; No data ChEMBL. 15027863
Survival (functional) = 140 % Increase in life span of the treated mice to those of control was determined ChEMBL. 15027863
Survival (functional) = 140 % Increase in life span of the treated mice to those of control was determined ChEMBL. 15027863
T max (functional) = 0.5 hr Tmax of the compound was determined in mice at 25 microM/kg i.p. administration ChEMBL. 15027863
T1/2 (functional) = 1.9 hr Half life of the compound was determined after intraperitoneal administration in mice at 25 microM/kg ChEMBL. 15027863
T1/2 (functional) = 1.9 hr Half life of the compound was determined after intraperitoneal administration in mice at 25 microM/kg ChEMBL. 15027863
Tmax (functional) = 0.5 hr Tmax of the compound was determined in mice at 25 microM/kg i.p. administration ChEMBL. 15027863

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 15027863

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.