Detailed information for compound 700112

Basic information

Technical information
  • TDR Targets ID: 700112
  • Name: 2-[[5,7-bis(ethylamino)-[1,2,4]triazolo[5,4-f ][1,3,5]triazin-3-yl]sulfanyl]-N-(4-ethylphen yl)acetamide
  • MW: 400.501 | Formula: C18H24N8OS
  • H donors: 3 H acceptors: 5 LogP: 4.21 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNc1nc(NCC)nc2n1c(SCC(=O)Nc1ccc(cc1)CC)nn2
  • InChi: 1S/C18H24N8OS/c1-4-12-7-9-13(10-8-12)21-14(27)11-28-18-25-24-17-23-15(19-5-2)22-16(20-6-3)26(17)18/h7-10H,4-6,11H2,1-3H3,(H,21,27)(H2,19,20,22,23,24)
  • InChiKey: JSVVSLZATDTHTJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[5,7-bis(ethylamino)-[1,2,4]triazolo[5,4-f][1,3,5]triazin-3-yl]thio]-N-(4-ethylphenyl)acetamide
  • 2-[[5,7-bis(ethylamino)-[1,2,4]triazolo[5,4-f][1,3,5]triazin-3-yl]sulfanyl]-N-(4-ethylphenyl)ethanamide
  • ZINC04570520

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Starlite/ChEMBL No references
Trypanosoma brucei hypothetical protein, conserved Starlite/ChEMBL No references
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens regulator of G-protein signaling 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium ulcerans 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania donovani HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania infantum ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma congolense ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans hypothetical protein Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Brugia malayi phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania mexicana 6-phospho-1-fructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania braziliensis ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trypanosoma brucei hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear receptor NHR-88 0.0011 0.0052 0.0006
Brugia malayi intermediate filament protein 0.003 0.0294 0.0719
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.1621 0.1599
Onchocerca volvulus 0.0032 0.032 0.0744
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0447 0.1003
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.1621 0.4754
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0052 0.0001
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0209 0.0183
Mycobacterium ulcerans hypothetical protein 0.004 0.0433 0.1056
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0052 0.0026
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0052 0.0026
Loa Loa (eye worm) hypothetical protein 0.0023 0.0209 0.0463
Echinococcus multilocularis geminin 0.0187 0.2344 0.2324
Schistosoma mansoni cpg binding protein 0.0032 0.032 0.0294
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1396 0.3824
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0052 0.0026
Trichomonas vaginalis set domain proteins, putative 0.0287 0.3651 1
Giardia lamblia Kinase, PLK 0.0114 0.1396 1
Onchocerca volvulus 0.0037 0.0386 0.0929
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0209 0.0183
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0052 0.0001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.08 0.0776
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0433 0.0408
Echinococcus granulosus cpg binding protein 0.0033 0.0343 0.0318
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0052 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0209 0.0572
Loa Loa (eye worm) hypothetical protein 0.004 0.0433 0.1123
Leishmania major hypothetical protein, conserved 0.004 0.0433 0.0957
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.1621 0.4754
Brugia malayi 6-phosphofructokinase 0.0131 0.1621 0.4623
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.0209 0.0183
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0052 0.0026
Echinococcus granulosus dnaJ subfamily B 0.0451 0.5791 0.5779
Brugia malayi follicle stimulating hormone receptor 0.0255 0.3238 0.9384
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0433 0.1186
Brugia malayi CXXC zinc finger family protein 0.0032 0.032 0.0794
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0052 0.0026
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0023 0.0209 0.0572
Loa Loa (eye worm) hypothetical protein 0.0055 0.0624 0.1684
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0214 0.0188
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0052 0.0026
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0052 0.0025
Onchocerca volvulus 0.004 0.0433 0.1059
Plasmodium vivax hypothetical protein, conserved 0.004 0.0433 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0386 0.0361
Brugia malayi hypothetical protein 0.026 0.3308 0.9589
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0564 0.0539
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0209 0.0467
Brugia malayi beta-lactamase 0.004 0.0433 0.1128
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0052 0.0026
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.0209 0.0183
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0397 0.102
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.1396 0.3735
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0114 0.0185
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0386 0.441
Entamoeba histolytica heat shock transcription factor, putative 0.0109 0.1333 0.796
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0052 0.0026
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0433 0.0954
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0564 0.0539
Schistosoma mansoni kinase 0.0058 0.0664 0.0639
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0052 0.0001
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0433 0.0954
Loa Loa (eye worm) hypothetical protein 0.0023 0.0209 0.0463
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.037 0.4118
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0052 0.0006
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.1621 0.1599
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0433 0.0954
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.0209 0.0467
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0293 0.0509
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.1621 0.1599
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0209 0.0183
Onchocerca volvulus 0.0053 0.06 0.1524
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0052 0.0006
Echinococcus multilocularis GPCR, family 2 0.0017 0.0133 0.0107
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0624 0.1688
Onchocerca volvulus 0.003 0.0294 0.0674
Echinococcus granulosus expressed protein 0.0451 0.5794 0.5783
Mycobacterium tuberculosis Conserved protein 0.003 0.0293 0.0507
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0706 1
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.0209 0.0467
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1396 0.4036
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0052 0.0006
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.1621 1
Brugia malayi hypothetical protein 0.0023 0.0209 0.0467
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0564 0.0539
Brugia malayi PXA domain containing protein 0.0023 0.0209 0.0467
Onchocerca volvulus Huntingtin homolog 0.0135 0.1669 0.4492
Schistosoma mansoni coup transcription factor 0.0011 0.0052 0.0026
Loa Loa (eye worm) hypothetical protein 0.004 0.0433 0.1123
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0094 0.0067
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0052 0.0026
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0133 0.0241
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0131 0.1621 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0209 0.0572
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0109 0.1333 0.3559
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1396 0.3824
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0209 0.0183
Entamoeba histolytica heat shock transcription factor, putative 0.0109 0.1333 0.796
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0433 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0209 0.0572
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0447 0.0422
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0433 0.1056
Loa Loa (eye worm) hypothetical protein 0.0135 0.1669 0.4762
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0134 0.0108
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0052 0.0026
Echinococcus multilocularis beta adrenergic receptor kinase 0.0024 0.0214 0.0188
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0294 0.0719
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0447 0.1225
Brugia malayi hypothetical protein 0.0135 0.1669 0.4765
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0433 0.1056
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.1621 0.4439
Loa Loa (eye worm) hypothetical protein 0.0011 0.0052 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0209 0.0572
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0052 0.0001
Entamoeba histolytica heat shock transcription factor, putative 0.0109 0.1333 0.796
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.06 0.162
Echinococcus multilocularis dnaJ subfamily B 0.0451 0.5791 0.5779
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0433 0.1186
Schistosoma mansoni hypothetical protein 0.0038 0.0397 0.0371
Loa Loa (eye worm) hypothetical protein 0.0014 0.0087 0.0103
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0052 0.0026
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0433 0.0408
Loa Loa (eye worm) hypothetical protein 0.0037 0.0386 0.0986
Trypanosoma brucei polo-like protein kinase 0.0114 0.1396 0.4036
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.037 0.1139
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0052 0.0026
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0386 0.0361
Plasmodium vivax SET domain protein, putative 0.0037 0.0386 0.8438
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0209 0.0183
Loa Loa (eye worm) hypothetical protein 0.004 0.0433 0.1123
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0052 0.0026
Echinococcus granulosus GPCR family 2 0.0017 0.0133 0.0107
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.037 0.1012
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0134 0.0108
Echinococcus granulosus survival motor neuron protein 1 0.026 0.3308 0.3291
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.037 0.788
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.1621 1
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.037 0.1012
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0433 0.0954
Echinococcus multilocularis expressed protein 0.0451 0.5794 0.5783
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.1396 0.841
Onchocerca volvulus 0.003 0.0294 0.0674
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0052 0.0026
Echinococcus granulosus lamin 0.003 0.0294 0.0269
Brugia malayi Pre-SET motif family protein 0.0252 0.3198 0.9265
Loa Loa (eye worm) hypothetical protein 0.004 0.0433 0.1123
Brugia malayi photoreceptor-specific nuclear receptor 0.0271 0.3448 1
Schistosoma mansoni hypothetical protein 0.0187 0.2344 0.2324
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1396 0.3824
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.037 0.5
Trichomonas vaginalis esterase, putative 0.004 0.0433 0.1186
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0209 0.0467
Brugia malayi beta-lactamase family protein 0.004 0.0433 0.1128
Mycobacterium ulcerans lipase LipD 0.004 0.0433 0.1056
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0134 0.0247
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0447 0.0422
Schistosoma mansoni hypothetical protein 0.0053 0.06 0.0575
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0564 0.0539
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0209 0.0572
Trichomonas vaginalis Citrate lyase beta chain, putative 0.003 0.0293 0.0802
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0214 0.0188
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0052 0.0026
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0209 0.0183
Loa Loa (eye worm) hypothetical protein 0.0135 0.1669 0.4762
Loa Loa (eye worm) hypothetical protein 0.004 0.0433 0.1123
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0447 0.0422
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0447 0.0422
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.3262 1
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.037 0.1012
Loa Loa (eye worm) hypothetical protein 0.0023 0.0209 0.0463
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0052 0.0025
Brugia malayi steroid hormone receptor 0.0011 0.0052 0.0006
Loa Loa (eye worm) RGS-3 protein 0.0023 0.0209 0.0463
Schistosoma mansoni microtubule-associated protein tau 0.0773 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.036 0.0334
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0447 0.1003
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0094 0.0067
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0024 0.0214 0.0477
Echinococcus granulosus beta-adrenergic receptor kinase 0.0024 0.0214 0.0188
Schistosoma mansoni hypothetical protein 0.0017 0.0133 0.0107
Leishmania major hypothetical protein, conserved 0.0257 0.3262 1
Onchocerca volvulus 0.004 0.0433 0.1059
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0209 0.0183
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.037 0.5
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0134 0.0108
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0447 0.0422
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0209 0.0183
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.0209 0.0183
Onchocerca volvulus 0.004 0.0433 0.1059
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0447 0.1003
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0386 0.0361
Brugia malayi phosphofructokinase 0.0131 0.1621 0.4623
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0209 0.0183
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0293 0.0509
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0133 0.0245
Schistosoma mansoni hypothetical protein 0.0187 0.2344 0.2324
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0209 0.0183
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0386 0.0361
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0052 0.0006
Brugia malayi Pre-SET motif family protein 0.0037 0.0386 0.099
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0433 0.1186
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1396 0.3824
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0052 0.0026
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1396 0.3824
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0052 0.0001
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0209 0.0183
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0209 0.0463
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0447 0.0422
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0133 0.0107
Loa Loa (eye worm) hypothetical protein 0.0038 0.0397 0.1016
Loa Loa (eye worm) hypothetical protein 0.0011 0.0052 0.0001
Echinococcus granulosus citrate lyase subunit beta protein 0.003 0.0293 0.0267
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0209 0.0183
Mycobacterium tuberculosis Conserved protein 0.004 0.0433 0.0954
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.0209 0.0183
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0133 0.0107
Echinococcus multilocularis citrate lyase subunit beta protein 0.003 0.0293 0.0267
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0052 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0052 0.0006
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0052 0.0026
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.3198 0.9265
Schistosoma mansoni lamin 0.003 0.0294 0.0269
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0052 0.0006
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0114 0.0189
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.1396 0.1374
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.1621 0.4439
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0133 0.0107
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0209 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0447 0.1225
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0447 0.0422
Loa Loa (eye worm) hypothetical protein 0.0023 0.0209 0.0463
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0255 0.3238 0.9383
Mycobacterium ulcerans beta-lactamase 0.004 0.0433 0.1056
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.037 0.4118
Loa Loa (eye worm) hypothetical protein 0.026 0.3308 0.9589
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.1396 0.1374
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0293 0.0509
Echinococcus multilocularis microtubule associated protein 2 0.0773 1 1
Schistosoma mansoni cpg binding protein 0.0033 0.0343 0.0318
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0624 0.1688
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0052 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0052 0.0006
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0052 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.3262 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0052 0.0001
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0024 0.0214 0.0482
Brugia malayi HSF-type DNA-binding domain containing protein 0.0109 0.1333 0.3775
Loa Loa (eye worm) hypothetical protein 0.0011 0.0052 0.0001
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0134 0.0108
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0433 0.0954
Echinococcus multilocularis cpg binding protein 0.0033 0.0343 0.0318
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.037 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0052 0.0006
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.1396 0.3962
Brugia malayi 6-phosphofructokinase 0.0131 0.1621 0.4623
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.0209 0.0463
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0447 0.1689
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0052 0.0026
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0644 0.1763
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0209 0.0183
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0564 0.0539
Loa Loa (eye worm) hypothetical protein 0.0011 0.0052 0.0001
Loa Loa (eye worm) hypothetical protein 0.003 0.0294 0.0715
Loa Loa (eye worm) hypothetical protein 0.0041 0.0447 0.1165
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0564 0.1514
Echinococcus multilocularis lamin dm0 0.003 0.0294 0.0269
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0134 0.0242
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0433 0.1128
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0386 0.0361
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.1621 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.1621 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.1333 0.3772
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0209 0.0183
Toxoplasma gondii ABC1 family protein 0.004 0.0433 0.5226
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0209 0.0572
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.0209 0.0183
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0131 0.1621 0.474
Loa Loa (eye worm) hypothetical protein 0.0271 0.3448 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0052 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0052 0.0001
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0294 0.0715
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.1621 0.1599
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.1396 0.4036
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1396 0.4036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0564 0.0539
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0052 0.0006
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.003 0.0293 0.0507
Brugia malayi PXA domain containing protein 0.0023 0.0209 0.0467
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.0209 0.0183
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0386 0.0361
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0133 0.0107
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.037 0.1012
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0209 0.0183
Mycobacterium tuberculosis Conserved protein 0.004 0.0433 0.0954
Loa Loa (eye worm) hypothetical protein 0.0014 0.0087 0.0103
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0433 0.0957
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0433 0.1186
Onchocerca volvulus 0.0287 0.3651 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0052 0.0001
Schistosoma mansoni survival motor neuron protein 0.0053 0.06 0.0575
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0133 0.0245
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.037 0.788
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.1396 0.3959
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.0209 0.0467
Mycobacterium tuberculosis Conserved protein 0.004 0.0433 0.0954
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0433 0.0957
Schistosoma mansoni cpg binding protein 0.0033 0.0343 0.0318
Echinococcus multilocularis survival motor neuron protein 1 0.026 0.3308 0.3291
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.1621 0.4754
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.037 1
Loa Loa (eye worm) beta-lactamase 0.004 0.0433 0.1123
Schistosoma mansoni hypothetical protein 0.0451 0.5791 0.5779
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.3262 1
Schistosoma mansoni lamin 0.003 0.0294 0.0269
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0052 0.0006
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0052 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0133 0.0241
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0052 0.0026
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.1621 0.4439
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0564 0.0539
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1396 0.3824
Loa Loa (eye worm) hypothetical protein 0.0023 0.0209 0.0463
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0024 0.0214 0.0477
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0433 0.0954
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.1621 1
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.0209 0.0183
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0433 0.0954
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0258 0.3271 1
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0209 0.0183
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0134 0.0108
Loa Loa (eye worm) hypothetical protein 0.004 0.0433 0.1123
Brugia malayi ecdysteroid receptor 0.0011 0.0052 0.0006
Loa Loa (eye worm) phosphofructokinase 0.0131 0.1621 0.4621
Loa Loa (eye worm) intermediate filament protein 0.003 0.0294 0.0715
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0209 0.0183
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0644 0.1763
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0052 0.0006
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.037 0.4118
Echinococcus granulosus geminin 0.0187 0.2344 0.2324
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0052 0.0006
Loa Loa (eye worm) hypothetical protein 0.0014 0.0094 0.0124
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0447 0.1003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0287 0.0694
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.037 0.1012
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.037 0.1012
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0052 0.0006
Onchocerca volvulus Huntingtin homolog 0.0135 0.1669 0.4492
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0209 0.0183
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0052 0.0001
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0209 0.0183
Brugia malayi hypothetical protein 0.0023 0.0209 0.0467
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0433 0.0408
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0134 0.0108
Loa Loa (eye worm) hypothetical protein 0.0023 0.0209 0.0463
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0386 0.0361
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.1621 0.4621
Brugia malayi beta-lactamase family protein 0.004 0.0433 0.1128
Schistosoma mansoni hypothetical protein 0.0017 0.0133 0.0107
Schistosoma mansoni intermediate filament proteins 0.003 0.0294 0.0269
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0134 0.0108
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0447 0.0422
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.1621 0.4621
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0052 0.0001
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0052 0.0026
Echinococcus granulosus lamin dm0 0.003 0.0294 0.0269
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0447 0.0757
Echinococcus granulosus intermediate filament protein 0.003 0.0294 0.0269
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.1621 0.4439
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0052 0.0026
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0447 0.117
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0052 0.0026
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0052 0.0026
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0052 0.0026
Schistosoma mansoni hypothetical protein 0.0017 0.0133 0.0107
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0624 0.1684
Brugia malayi isocitrate dehydrogenase 0.0017 0.0134 0.0247
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1396 0.3824
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0052 0.0026
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0209 0.0183
Echinococcus multilocularis lamin 0.003 0.0294 0.0269
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0564 0.151
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0052 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0214 0.0188
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0433 0.1186
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0433 0.1123
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1396 0.1374
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.032 0.0789
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0052 0.0026
Echinococcus multilocularis musashi 0.003 0.0294 0.0269
Brugia malayi nuclear hormone receptor 0.0011 0.0052 0.0006
Schistosoma mansoni hypothetical protein 0.0017 0.0133 0.0107
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0433 0.0957
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0447 0.1225
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.037 0.1012

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 75.6 uM PUBCHEM_BIOASSAY: Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493012, AID493028] ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 6.7016 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.9441 uM PUBCHEM_BIOASSAY: Inhibitors of T. brucei phosphofructokinase: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768] ChEMBL. No reference
Potency (functional) 16.9441 uM PUBCHEM_BIOASSAY: Tb PFK orthogonal confirmatory assay using ATP depletion (Kinase-Glo Plus) as an alternative measure of Tb PFK activity: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 70.7946 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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