TDR Targets

Basic information

Technical information

TDR Targets ID: 700138
Name: 3,4-difluoro-N-[2-[2-(3-methylphenyl)-1,3-thi azol-4-yl]ethyl]benzamide
MW: 358.405 | Formula: C19H16F2N2OS
H donors: 1 H acceptors: 2 LogP: 4.45 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cccc(c1)c1scc(n1)CCNC(=O)c1ccc(c(c1)F)F
InChi: 1S/C19H16F2N2OS/c1-12-3-2-4-14(9-12)19-23-15(11-25-19)7-8-22-18(24)13-5-6-16(20)17(21)10-13/h2-6,9-11H,7-8H2,1H3,(H,22,24)
InChiKey: CUFMADIQNYOBRL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3,4-difluoro-N-[2-[2-(3-methylphenyl)thiazol-4-yl]ethyl]benzamide
3,4-difluoro-N-[2-[2-(3-methylphenyl)-4-thiazolyl]ethyl]benzamide
ZINC04570816

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	photoreceptor-specific nuclear receptor	0.0041	0.0335	0.0787
Toxoplasma gondii	ornithine aminotransferase, mitochondrial precursor, putative	0.0021	0.0092	0.0744
Onchocerca volvulus		0.006	0.0566	1
Schistosoma mansoni	microtubule-associated protein tau	0.0686	0.8272	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0335	0.0787
Brugia malayi	glutathione reductase	0.0039	0.0319	0.0749
Echinococcus granulosus	cpg binding protein	0.0063	0.0608	0.0733
Schistosoma mansoni	thyroid hormone receptor	0.0041	0.0335	0.0403
Schistosoma mansoni	nuclear receptor	0.0019	0.007	0.0083
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0041	0.0335	0.0333
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0014	0.0002	0.0004
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0119	0.3715
Schistosoma mansoni	hypothetical protein	0.0094	0.0993	0.1199
Loa Loa (eye worm)	histone methyltransferase	0.0018	0.006	0.0142
Brugia malayi	Heterochromatin protein 1	0.0073	0.0727	0.171
Brugia malayi	MH1 domain containing protein	0.0024	0.0135	0.0316
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0261	0.1572
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0019	0.007	0.0164
Echinococcus multilocularis	tar DNA binding protein	0.0317	0.3736	0.3735
Echinococcus multilocularis	dnaJ subfamily B	0.0422	0.5025	0.5024
Echinococcus multilocularis	smad	0.0024	0.0135	0.0133
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0561	0.0676
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0094	0.0993	0.1199
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0163	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0019	0.007	0.0164
Brugia malayi	Thioredoxin reductase	0.0039	0.0319	0.0749
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0039	0.0313	0.0312
Plasmodium falciparum	glutathione reductase	0.0039	0.0319	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0041	0.0335	0.0787
Plasmodium falciparum	ornithine aminotransferase	0.0021	0.0092	0.2862
Brugia malayi	RNA recognition motif domain containing protein	0.0317	0.3736	0.8786
Loa Loa (eye worm)	glutathione reductase	0.0039	0.0319	0.0749
Mycobacterium tuberculosis	Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase)	0.0021	0.0092	0.0354
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0019	0.007	0.0068
Brugia malayi	MH2 domain containing protein	0.0359	0.4253	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0041	0.0335	0.0787
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0261	0.0314
Schistosoma mansoni	tar DNA-binding protein	0.0317	0.3736	0.4516
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0561	1
Echinococcus multilocularis	chromobox protein 1	0.0073	0.0727	0.0726
Echinococcus multilocularis	microtubule associated protein 2	0.0686	0.8272	0.8271
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0098	0.0231
Brugia malayi	F/Y-rich N-terminus family protein	0.0018	0.0057	0.0135
Brugia malayi	CXXC zinc finger family protein	0.006	0.0566	0.1332
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0041	0.0335	0.0787
Leishmania major	trypanothione reductase	0.0039	0.0319	0.567
Trypanosoma brucei	trypanothione reductase	0.0039	0.0319	1
Schistosoma mansoni	ap endonuclease	0.0039	0.0313	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0335	0.0787
Schistosoma mansoni	zinc finger protein	0.0019	0.007	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0019	0.007	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0261	0.0615
Brugia malayi	Nuclear hormone receptor E75	0.0019	0.007	0.0164
Schistosoma mansoni	Smad4	0.0024	0.0135	0.0161
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0186	0.0223
Schistosoma mansoni	coup transcription factor	0.0041	0.0335	0.0403
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0025	0.0146	0.0872
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0041	0.0335	0.0787
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0094	0.0993	0.1199
Onchocerca volvulus	Protein ultraspiracle homolog	0.0041	0.0335	0.5333
Brugia malayi	nuclear receptor RXR	0.0019	0.007	0.0164
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0021	0.0092	0.0549
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0561	0.3383
Loa Loa (eye worm)	hypothetical protein	0.0019	0.007	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0335	0.0787
Echinococcus multilocularis	thioredoxin glutathione reductase	0.004	0.0325	0.0324
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0041	0.0335	0.0403
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0372	0.2244
Schistosoma mansoni	tar DNA-binding protein	0.0317	0.3736	0.4516
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0098	0.0231
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0019	0.0069	0.0407
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0039	0.0313	0.9834
Mycobacterium tuberculosis	Probable reductase	0.009	0.094	0.3657
Brugia malayi	Nuclear hormone receptor-like 1	0.0041	0.0335	0.0787
Loa Loa (eye worm)	nuclear hormone receptor	0.0019	0.007	0.0164
Echinococcus granulosus	thyroid hormone receptor alpha	0.0019	0.007	0.0083
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0039	0.0313	0.0377
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0261	0.1013
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0039	0.0319	0.1235
Mycobacterium tuberculosis	Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase)	0.0021	0.0092	0.0354
Echinococcus granulosus	dnaJ subfamily B	0.0422	0.5025	0.6074
Loa Loa (eye worm)	Smad1	0.0024	0.0135	0.0316
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0039	0.0313	0.3096
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0041	0.0335	0.0787
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0041	0.0335	0.0787
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0041	0.0335	0.0787
Schistosoma mansoni	hypothetical protein	0.0506	0.6066	0.7333
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0015	0.0022	0.002
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.001	0.0024
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0261	0.1572
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0113	0.1222	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0157	0.037
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0261	0.0615
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.0727	0.4389
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0024	0.0135	0.0161
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0261	0.0615
Schistosoma mansoni	smad	0.0024	0.0135	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0098	0.0231
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0019	0.007	0.0164
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0261	0.1572
Loa Loa (eye worm)	hypothetical protein	0.0019	0.007	0.0164
Toxoplasma gondii	ABC1 family protein	0.0035	0.0261	0.213
Brugia malayi	chromobox protein homolog 3	0.0041	0.0334	0.0786
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0025	0.0146	0.0872
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0041	0.0335	0.0403
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0019	0.007	0.0068
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0261	0.0615
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0186	0.5818
Brugia malayi	conserved hypotetical protein	0.0019	0.007	0.0164
Loa Loa (eye worm)	thioredoxin reductase	0.0039	0.0319	0.0749
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0019	0.007	0.0083
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0298	0.3498	0.8225
Schistosoma mansoni	cpg binding protein	0.006	0.0566	0.0683
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0041	0.0335	0.0403
Toxoplasma gondii	exonuclease III APE	0.0039	0.0313	0.2555
Schistosoma mansoni	nuclear receptor	0.0019	0.007	0.0083
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0039	0.0313	0.5576
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0119	0.0713
Echinococcus multilocularis	chromobox protein 1	0.0073	0.0727	0.0726
Mycobacterium tuberculosis	Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at)	0.0021	0.0092	0.0354
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0372	0.2244
Schistosoma mansoni	smad1 5 8 and	0.0024	0.0135	0.0161
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0041	0.0335	0.0333
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0044	0.0372	0.6094
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0039	0.0313	0.1215
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0039	0.0313	0.9834
Schistosoma mansoni	cpg binding protein	0.0063	0.0608	0.0733
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	0.0148	0.1654	0.644
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0041	0.0335	0.0787
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0261	0.1572
Loa Loa (eye worm)	hypothetical protein	0.0019	0.007	0.0164
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0041	0.0335	0.0787
Entamoeba histolytica	hypothetical protein	0.0074	0.0746	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0041	0.0335	0.0787
Loa Loa (eye worm)	RNA binding protein	0.0317	0.3736	0.8786
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0561	0.0676
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0261	0.1013
Echinococcus multilocularis	ornithine aminotransferase	0.0021	0.0092	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0335	0.0787
Brugia malayi	ecdysteroid receptor	0.0041	0.0335	0.0787
Schistosoma mansoni	retinoic acid receptor RXR	0.0041	0.0335	0.0403
Trypanosoma cruzi	trypanothione reductase, putative	0.0039	0.0319	1
Schistosoma mansoni	nuclear hormone receptor	0.0019	0.007	0.0083
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0041	0.0335	0.0333
Mycobacterium leprae	PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA	0.0148	0.1654	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0094	0.0993	0.0992
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0306	0.3597	0.8459
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.009	0.094	0.3657
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0041	0.0335	0.0333
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0041	0.0335	0.0787
Brugia malayi	TAR-binding protein	0.0317	0.3736	0.8786
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0261	0.0615
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0261	0.1572
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0041	0.0335	0.0403
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0261	0.1013
Echinococcus granulosus	thioredoxin glutathione reductase	0.004	0.0325	0.0391
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0015	0.0016	0.0014
Brugia malayi	steroid hormone receptor	0.0041	0.0335	0.0787
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0041	0.0335	0.0403
Schistosoma mansoni	transcription factor LCR-F1	0.0074	0.0746	0.09
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0019	0.007	0.0083
Echinococcus multilocularis	geminin	0.0506	0.6066	0.6065
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0041	0.0335	0.0333
Echinococcus granulosus	intermediate filament protein	0.0027	0.0163	0.0195
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0019	0.007	0.0068
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0019	0.007	0.0083
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0015	0.0016	0.0017
Brugia malayi	latrophilin 2 splice variant baaae	0.0204	0.2339	0.5499
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0025	0.0146	0.0872
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.009	0.094	0.3657
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0098	0.0231
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0025	0.0146	0.0872
Schistosoma mansoni	nuclear hormone receptor	0.0019	0.007	0.0083
Schistosoma mansoni	smad1 5 8 and	0.0024	0.0135	0.0161
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0041	0.0335	0.0787
Echinococcus granulosus	ecdysone induced protein 78C	0.0041	0.0335	0.0403
Loa Loa (eye worm)	MH2 domain-containing protein	0.0359	0.4253	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0039	0.0313	1
Loa Loa (eye worm)	hypothetical protein	0.0204	0.2339	0.5499
Echinococcus multilocularis	ecdysone induced protein 78C	0.0041	0.0335	0.0333
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.009	0.094	0.5428
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0188	0.1129
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0334	0.2013
Trichomonas vaginalis	ap endonuclease, putative	0.0039	0.0313	0.1886
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.01	0.1064	0.6219
Loa Loa (eye worm)	hypothetical protein	0.0019	0.007	0.0164
Echinococcus granulosus	nuclear receptor nhr 48	0.0019	0.007	0.0083
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0561	0.3383
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0041	0.0335	0.0333
Brugia malayi	MH2 domain containing protein	0.0024	0.0135	0.0316
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0041	0.0335	0.0333
Mycobacterium ulcerans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	0.0148	0.1654	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.01	0.1064	0.4139
Schistosoma mansoni	chromobox protein	0.0073	0.0727	0.0877
Echinococcus granulosus	Smad4	0.0024	0.0135	0.0161
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0094	0.0993	0.2335
Echinococcus granulosus	tar DNA binding protein	0.0317	0.3736	0.4516
Trichomonas vaginalis	ap endonuclease, putative	0.0039	0.0313	0.1886
Brugia malayi	nuclear hormone receptor	0.0019	0.007	0.0164
Schistosoma mansoni	RAR-like nuclear receptor	0.0041	0.0335	0.0403
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0021	0.0092	0.0549
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.001	0.0024
Schistosoma mansoni	importin beta-1	0.0029	0.0186	0.0223
Echinococcus multilocularis	Aminotransferase class III	0.0021	0.0092	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0163	0.0384
Leishmania major	hypothetical protein, conserved	0.0035	0.0261	0.4647
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0261	0.0314
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0119	0.0713
Brugia malayi	orphan nuclear receptor NR2E1	0.0019	0.007	0.0164
Brugia malayi	Nuclear hormone receptor E75	0.0019	0.007	0.0164
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0019	0.007	0.0083
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0261	0.1013
Echinococcus granulosus	microtubule associated protein 2	0.0686	0.8272	1
Brugia malayi	beta-lactamase family protein	0.0035	0.0261	0.0615
Brugia malayi	CHD4 protein	0.0015	0.0022	0.0051
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0261	0.1013
Schistosoma mansoni	lamin	0.0027	0.0163	0.0195
Onchocerca volvulus		0.0035	0.0261	0.3859
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0015	0.0022	0.0024
Onchocerca volvulus	Bile acid receptor homolog	0.0041	0.0335	0.5333
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0094	0.0993	0.2335
Echinococcus multilocularis	nuclear receptor nhr 48	0.0019	0.007	0.0068
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0119	0.2106
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0025	0.0146	0.0872
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0261	0.1013
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0018	0.006	0.0059
Echinococcus multilocularis	lamin dm0	0.0027	0.0163	0.0162
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0041	0.0335	0.0787
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0024	0.0135	0.0133
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0039	0.0313	1
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0261	0.1013
Mycobacterium ulcerans	acetylornithine aminotransferase	0.0021	0.0092	0.0549
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.0727	0.4389
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0335	0.0787
Schistosoma mansoni	hypothetical protein	0.0204	0.2339	0.2826
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0186	0.1512
Plasmodium falciparum	importin beta, putative	0.0029	0.0186	0.5818
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0098	0.0231
Brugia malayi	nuclear hormone receptor family member odr-7	0.0019	0.007	0.0164
Schistosoma mansoni	smad1 5 8 and	0.0024	0.0135	0.0161
Brugia malayi	nuclear receptor NHR-67	0.0019	0.007	0.0164
Loa Loa (eye worm)	TAR-binding protein	0.0317	0.3736	0.8786
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0039	0.0313	0.0737
Brugia malayi	exodeoxyribonuclease III family protein	0.0039	0.0313	0.0737
Onchocerca volvulus		0.0041	0.0335	0.5333
Loa Loa (eye worm)	MH2 domain-containing protein	0.0024	0.0135	0.0316
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0261	0.8197
Schistosoma mansoni	lamin	0.0027	0.0163	0.0195
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0041	0.0335	0.0403
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0015	0.0016	0.0017
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0019	0.007	0.0164
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0024	0.0135	0.0161
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0022	0.0098	0.0117
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0261	0.1013
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0041	0.0335	0.0787
Plasmodium falciparum	thioredoxin reductase	0.0039	0.0319	1
Brugia malayi	Latrophilin receptor protein 2	0.0094	0.0993	0.2335
Echinococcus granulosus	snurportin 1	0.0306	0.3597	0.4348
Brugia malayi	MH2 domain containing protein	0.0024	0.0135	0.0316
Schistosoma mansoni	nuclear receptor nhr-48	0.0019	0.007	0.0083
Echinococcus multilocularis	lamin	0.0027	0.0163	0.0162
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0041	0.0335	0.0403
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0041	0.0335	0.0403
Trichomonas vaginalis	acetylornithine aminotransferase, putative	0.0148	0.1654	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0025	0.0146	0.0872
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0561	0.2179
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0039	0.0313	1
Onchocerca volvulus		0.0032	0.0226	0.3148
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0335	0.0787
Loa Loa (eye worm)	hypothetical protein	0.0019	0.007	0.0164
Schistosoma mansoni	chromobox protein	0.0073	0.0727	0.0877
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0039	0.0313	0.9834
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0094	0.0993	0.0992
Brugia malayi	tailless protein	0.0019	0.007	0.0164
Brugia malayi	hypothetical protein	0.0019	0.007	0.0164
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0261	0.1572
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0041	0.0335	0.0787
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0335	0.0787
Onchocerca volvulus		0.0035	0.0261	0.3859
Schistosoma mansoni	tar DNA-binding protein	0.0317	0.3736	0.4516
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0018	0.0057	0.0333
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0561	0.3383
Echinococcus granulosus	mothers against decapentaplegic 5	0.0024	0.0135	0.0161
Toxoplasma gondii	thioredoxin reductase	0.0039	0.0319	0.2598
Echinococcus multilocularis	musashi	0.0027	0.0163	0.0162
Schistosoma mansoni	thyroid hormone receptor	0.0041	0.0335	0.0403
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0019	0.007	0.0068
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0119	0.0713
Schistosoma mansoni	tar DNA-binding protein	0.0317	0.3736	0.4516
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0041	0.0335	0.0787
Entamoeba histolytica	hypothetical protein	0.0074	0.0746	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0074	0.0746	0.09
Loa Loa (eye worm)	DR-78	0.0019	0.007	0.0164
Brugia malayi	nuclear receptor RXR	0.0022	0.0098	0.0231
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0261	0.1572
Schistosoma mansoni	hypothetical protein	0.0074	0.0746	0.09
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0015	0.0022	0.0024
Mycobacterium tuberculosis	Probable oxidoreductase	0.01	0.1064	0.4139
Mycobacterium tuberculosis	Probable dehydrogenase	0.009	0.094	0.3657
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.009	0.094	0.3657
Schistosoma mansoni	cpg binding protein	0.0063	0.0608	0.0733
Echinococcus multilocularis	ornithine aminotransferase	0.0021	0.0092	0.0091
Mycobacterium ulcerans	L-lysine aminotransferase	0.0021	0.0092	0.0549
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0298	0.3498	0.8225
Echinococcus granulosus	lamin dm0	0.0027	0.0163	0.0195
Echinococcus multilocularis	Smad4	0.0024	0.0135	0.0133
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0261	0.1083
Brugia malayi	beta-lactamase	0.0035	0.0261	0.0615
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0261	0.026
Echinococcus granulosus	ornithine aminotransferase	0.0021	0.0092	0.011
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0261	0.1572
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0163	0.0384
Loa Loa (eye worm)	CHromoDomain protein family member	0.0015	0.0022	0.0051
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0098	0.0117
Onchocerca volvulus		0.0035	0.0261	0.3859
Brugia malayi	hypothetical protein	0.0022	0.0098	0.0231
Chlamydia trachomatis	glutamate-1-semialdehyde-2,1-aminomutase	0.0021	0.0092	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0041	0.0335	0.0403
Echinococcus multilocularis	FTZ F1 alpha	0.0041	0.0335	0.0333
Plasmodium vivax	glutathione reductase, putative	0.0039	0.0319	1
Schistosoma mansoni	hypothetical protein	0.0094	0.0993	0.1199
Loa Loa (eye worm)	transcription factor SMAD2	0.0359	0.4253	1
Brugia malayi	hypothetical protein	0.0022	0.0098	0.0231
Entamoeba histolytica	hypothetical protein	0.0074	0.0746	1
Schistosoma mansoni	nuclear hormone receptor	0.0041	0.0335	0.0403
Echinococcus granulosus	Aminotransferase class III	0.0021	0.0092	0.011
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0041	0.0335	0.0403
Schistosoma mansoni	hypothetical protein	0.0094	0.0993	0.1199
Onchocerca volvulus		0.0027	0.0163	0.188
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0222	0.2568	1
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0163	0.0195
Brugia malayi	hypothetical protein	0.0019	0.007	0.0164
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0261	0.8197
Echinococcus granulosus	smad	0.0024	0.0135	0.0161
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0163	0.0384
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0041	0.0335	0.0787
Loa Loa (eye worm)	hypothetical protein	0.0019	0.007	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0019	0.007	0.0164
Mycobacterium ulcerans	ornithine aminotransferase RocD1 and RocD2	0.0021	0.0092	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0261	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0261	0.0615
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0039	0.0313	0.9834
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0335	0.0787
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0022	0.0098	0.0097
Echinococcus granulosus	geminin	0.0506	0.6066	0.7333
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0022	0.0098	0.0117
Echinococcus granulosus	FTZ F1 alpha	0.0041	0.0335	0.0403
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0261	0.0615
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0261	0.8197
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0188	0.1129
Loa Loa (eye worm)	hypothetical protein	0.0019	0.007	0.0164
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0261	0.1572
Onchocerca volvulus		0.0027	0.0163	0.188
Brugia malayi	nuclear receptor NHR-88	0.0019	0.007	0.0164
Mycobacterium tuberculosis	Probable aminotransferase	0.0148	0.1654	0.644
Echinococcus multilocularis	cpg binding protein	0.0063	0.0608	0.0607
Loa Loa (eye worm)	steroid hormone receptor	0.0041	0.0335	0.0787
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0039	0.0313	0.1886
Mycobacterium ulcerans	hypothetical protein	0.0148	0.1654	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0041	0.0335	0.5333
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0025	0.0146	0.0872
Echinococcus granulosus	lamin	0.0027	0.0163	0.0195
Mycobacterium ulcerans	lipase LipD	0.0035	0.0261	0.1572
Echinococcus granulosus	GPCR family 2	0.0094	0.0993	0.1199
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0226	0.0532
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0041	0.0335	0.0787
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0022	0.0098	0.0231
Mycobacterium tuberculosis	Probable acetylornithine aminotransferase ArgD	0.0021	0.0092	0.0354
Brugia malayi	nuclear receptor NHR-88	0.0041	0.0335	0.0787
Loa Loa (eye worm)	heterochromatin protein 1	0.0073	0.0727	0.171
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0024	0.0135	0.0133
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0186	0.0184
Trichomonas vaginalis	esterase, putative	0.0035	0.0261	0.1572
Loa Loa (eye worm)	hypothetical protein	0.0298	0.3498	0.8225
Schistosoma mansoni	tar DNA-binding protein	0.0317	0.3736	0.4516
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0261	0.0615
Schistosoma mansoni	hypothetical protein	0.0506	0.6066	0.7333
Echinococcus granulosus	chromobox protein 1	0.0073	0.0727	0.0877
Brugia malayi	ecdysone receptor	0.0019	0.007	0.0164
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0069	0.0407
Schistosoma mansoni	ap endonuclease	0.0039	0.0313	0.0377
Brugia malayi	MH1 domain containing protein	0.0024	0.0135	0.0316
Echinococcus multilocularis	snurportin 1	0.0306	0.3597	0.3596
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0561	0.0676
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0993	0.2335
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0334	0.2013
Loa Loa (eye worm)	MH1 domain-containing protein	0.0024	0.0135	0.0316
Plasmodium vivax	ornithine aminotransferase, putative	0.0021	0.0092	0.2862
Schistosoma mansoni	hypothetical protein	0.0422	0.5025	0.6074
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0041	0.0335	0.0403
Entamoeba histolytica	hypothetical protein	0.0074	0.0746	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0015	0.0016	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0019	0.007	0.0164
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0317	0.3736	0.8786
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0098	0.0231
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0298	0.3498	0.8225
Brugia malayi	nuclear hormone receptor	0.0041	0.0335	0.0787
Brugia malayi	hypothetical protein	0.0074	0.0746	0.1754
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0041	0.0335	0.0787
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0098	0.0231
Brugia malayi	RNA, U transporter 1	0.0081	0.0836	0.1966
Brugia malayi	Smad1	0.0024	0.0135	0.0316
Schistosoma mansoni	hypothetical protein	0.0094	0.0993	0.1199
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0261	0.1013
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0019	0.007	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0186	0.0438
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0019	0.007	0.0164
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0041	0.0335	0.0787
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0561	0.0559
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0261	0.1013
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0186	0.5818
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0126	0.1388	0.1676
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0019	0.007	0.0068
Brugia malayi	4-aminobutyrate aminotransferase, mitochondrial precursor	0.0021	0.0092	0.0217
Brugia malayi	intermediate filament protein	0.0027	0.0163	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0334	0.0786
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.009	0.094	0.3657
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0074	0.0746	0.0744
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0261	0.0314
Schistosoma mansoni	hypothetical protein	0.0306	0.3597	0.4348
Echinococcus granulosus	chromobox protein 1	0.0073	0.0727	0.0877
Brugia malayi	Importin beta-1 subunit	0.0029	0.0186	0.0438
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0041	0.0335	0.0403
Wolbachia endosymbiont of Brugia malayi	acetylornithine transaminase protein	0.0021	0.0092	0.291
Mycobacterium ulcerans	glutamate-1-semialdehyde aminotransferase	0.0021	0.0092	0.0549
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0039	0.0313	0.9834
Loa Loa (eye worm)	hypothetical protein	0.0019	0.007	0.0164
Echinococcus multilocularis	GPCR, family 2	0.0094	0.0993	0.0992
Loa Loa (eye worm)	CXXC zinc finger family protein	0.006	0.0566	0.1332
Brugia malayi	Steroid receptor seven-up type 2	0.0041	0.0335	0.0787
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0186	0.5818
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0041	0.0335	0.0403
Loa Loa (eye worm)	hypothetical protein	0.0019	0.007	0.0164
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0261	0.8197
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0561	0.4582
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0261	0.1083
Plasmodium vivax	thioredoxin reductase, putative	0.0039	0.0319	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0025	0.0146	0.0872
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0041	0.0335	0.0403
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.01	0.1064	0.4139
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0334	0.5328
Brugia malayi	beta-lactamase family protein	0.0035	0.0261	0.0615
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0019	0.007	0.0083
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0015	0.0016	0.0014
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0018	0.006	0.0071
Brugia malayi	RNA binding protein	0.0317	0.3736	0.8786
Schistosoma mansoni	ornithine--oxo-acid transaminase	0.0021	0.0092	0.011

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 700138