Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | alcohol dehydrogenase 1B (class I), beta polypeptide | Starlite/ChEMBL | References |
Equus caballus | Alcohol dehydrogenase | Starlite/ChEMBL | References |
Homo sapiens | alcohol dehydrogenase 1A (class I), alpha polypeptide | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | likely Zinc-binding dehydrogenase, one of two genes similar to S. cerevisiae YAL060W and BDH1 (YAL060W) butanediol dehydrogenase | Alcohol dehydrogenase | 374 aa | 366 aa | 24.6 % |
Mycobacterium tuberculosis | Possible dehydrogenase | alcohol dehydrogenase 1B (class I), beta polypeptide | 375 aa | 352 aa | 26.4 % |
Mycobacterium tuberculosis | Possible dehydrogenase | alcohol dehydrogenase 1A (class I), alpha polypeptide | 375 aa | 356 aa | 27.0 % |
Onchocerca volvulus | Alcohol dehydrogenase | 374 aa | 376 aa | 48.9 % | |
Onchocerca volvulus | Putative ATP-dependent RNA helicase DDX52 | Alcohol dehydrogenase | 374 aa | 337 aa | 21.4 % |
Trypanosoma cruzi | oxidoreductase, putative | Alcohol dehydrogenase | 374 aa | 318 aa | 20.1 % |
Toxoplasma gondii | quinone oxidoreductase, putative | Alcohol dehydrogenase | 374 aa | 323 aa | 23.8 % |
Mycobacterium tuberculosis | Possible dehydrogenase | Alcohol dehydrogenase | 374 aa | 350 aa | 26.0 % |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.7 uM | Inhibition of horse liver alcohol dehydrogenase activity | ChEMBL. | 9572895 |
Ki (binding) | = 1.7 uM | Inhibition of horse liver alcohol dehydrogenase activity | ChEMBL. | 9572895 |
Ki (binding) | = 2.9 uM | Inhibition of human alcohol dehydrogenase beta 1 activity | ChEMBL. | 9572895 |
Ki (binding) | = 2.9 uM | Inhibition of human alcohol dehydrogenase beta 1 activity | ChEMBL. | 9572895 |
Ki (binding) | = 3.8 uM | Inhibition of human alcohol dehydrogenase alpha activity | ChEMBL. | 9572895 |
Ki (binding) | = 3.8 uM | Inhibition of human alcohol dehydrogenase alpha activity | ChEMBL. | 9572895 |
Ki (binding) | = 45 uM | Inhibition of human alcohol dehydrogenase gamma2 activity | ChEMBL. | 9572895 |
Ki (binding) | = 45 uM | Inhibition of human alcohol dehydrogenase gamma2 activity | ChEMBL. | 9572895 |
Ki (binding) | = 54 uM | Inhibitory activity against human alcohol dehydrogenase sigma. | ChEMBL. | 9572895 |
Ki (binding) | = 54 uM | Inhibitory activity against human alcohol dehydrogenase sigma. | ChEMBL. | 9572895 |
Ki (binding) | = 450 uM | Inhibition of human alcohol dehydrogenase pi activity | ChEMBL. | 9572895 |
Ki (binding) | = 450 uM | Inhibition of human alcohol dehydrogenase pi activity | ChEMBL. | 9572895 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.