Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.185 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0127 | 0.1234 | 0.1234 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.008 | 0.0659 | 0.3564 |
Echinococcus multilocularis | serine:threonine protein phosphatase 2B | 0.0042 | 0.0209 | 0.0209 |
Trypanosoma cruzi | serine/threonine protein phosphatase 2B catalytic subunit A2, putative | 0.0042 | 0.0209 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0058 | 0.0397 | 0.2149 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0127 | 0.1234 | 0.6673 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0502 | 0.2712 |
Plasmodium vivax | serine/threonine protein phosphatase 2B catalytic subunit A, putative | 0.0042 | 0.0209 | 0.0501 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0022 | 0.0179 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.0502 | 0.4563 |
Echinococcus multilocularis | musashi | 0.0058 | 0.0397 | 0.0397 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0502 | 0.2712 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0028 | 0.0035 | 0.0189 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.185 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.037 | 0.4173 | 1 |
Schistosoma mansoni | protein phosphatase-2b | 0.0042 | 0.0209 | 0.1131 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0659 | 0.5341 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0468 | 0.1122 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.0502 | 0.4563 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.037 | 0.4173 | 1 |
Brugia malayi | intermediate filament protein | 0.0058 | 0.0397 | 0.3615 |
Trypanosoma brucei | protein phosphatase 2B, putative | 0.0042 | 0.0209 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0031 | 0.0072 | 0.0656 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.037 | 0.4173 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0502 | 0.2712 |
Onchocerca volvulus | 0.0058 | 0.0397 | 1 | |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0064 | 0.0468 | 0.1122 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0502 | 0.2712 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0064 | 0.0468 | 0.0468 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.008 | 0.0659 | 0.0659 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.0502 | 0.4064 |
Echinococcus multilocularis | geminin | 0.0178 | 0.185 | 0.185 |
Plasmodium falciparum | serine/threonine protein phosphatase 2B catalytic subunit A | 0.0042 | 0.0209 | 0.0501 |
Brugia malayi | RNA binding protein | 0.0067 | 0.0502 | 0.4563 |
Entamoeba histolytica | calcineurin catalytic subunit A, putative | 0.0042 | 0.0209 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.0468 | 0.2532 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.008 | 0.0659 | 0.3564 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.0468 | 0.2532 |
Schistosoma mansoni | lamin | 0.0058 | 0.0397 | 0.2149 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0064 | 0.0468 | 0.1122 |
Schistosoma mansoni | protein phosphatase-2b | 0.0042 | 0.0209 | 0.1131 |
Echinococcus granulosus | serine:threonine protein phosphatase 2B | 0.0042 | 0.0209 | 0.1131 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.008 | 0.0659 | 0.3564 |
Schistosoma mansoni | intermediate filament proteins | 0.0058 | 0.0397 | 0.2149 |
Loa Loa (eye worm) | intermediate filament protein | 0.0058 | 0.0397 | 0.322 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0659 | 0.5341 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.0502 | 0.4064 |
Echinococcus multilocularis | serotonin receptor | 0.0127 | 0.1234 | 0.1234 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0058 | 0.0397 | 0.322 |
Trypanosoma cruzi | serine/threonine protein phosphatase, putative | 0.0042 | 0.0209 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0064 | 0.0468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0209 | 0.1694 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.0502 | 0.0502 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.008 | 0.0659 | 0.5341 |
Onchocerca volvulus | 0.0058 | 0.0397 | 1 | |
Echinococcus granulosus | intermediate filament protein | 0.0058 | 0.0397 | 0.2149 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1234 | 1 |
Trypanosoma cruzi | serine/threonine protein phosphatase, putative | 0.0042 | 0.0209 | 1 |
Entamoeba histolytica | Ser/Thr protein phosphatase, putative | 0.0042 | 0.0209 | 1 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.008 | 0.0659 | 0.0659 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0202 | 0.1636 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0064 | 0.0468 | 0.2532 |
Echinococcus granulosus | geminin | 0.0178 | 0.185 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0468 | 0.1122 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0397 | 0.322 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0028 | 0.0035 | 0.0035 |
Entamoeba histolytica | Ser/Thr protein phosphatase, putative | 0.0042 | 0.0209 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0031 | 0.0072 | 0.0585 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0385 | 0.3116 |
Brugia malayi | Serine/threonine protein phosphatase 2B catalytic subunit 2 | 0.0042 | 0.0209 | 0.1902 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0502 | 0.2712 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.1099 | 0.8907 |
Entamoeba histolytica | calcineurin catalytic subunit A, putative | 0.0042 | 0.0209 | 1 |
Echinococcus multilocularis | serine:threonine protein phosphatase 2B | 0.0042 | 0.0209 | 0.0209 |
Echinococcus multilocularis | lamin | 0.0058 | 0.0397 | 0.0397 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.037 | 0.4173 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.037 | 0.4173 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.037 | 0.4173 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.037 | 0.4173 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.037 | 0.4173 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.008 | 0.0659 | 0.5996 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.008 | 0.0659 | 0.3564 |
Echinococcus multilocularis | lamin dm0 | 0.0058 | 0.0397 | 0.0397 |
Echinococcus granulosus | serine:threonine protein phosphatase 2B | 0.0042 | 0.0209 | 0.1131 |
Entamoeba histolytica | calcineurin catalytic subunit A, putative | 0.0042 | 0.0209 | 1 |
Entamoeba histolytica | calcineurin catalytic subunit A, putative | 0.0042 | 0.0209 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0035 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0022 | 0.0179 |
Leishmania major | serine/threonine protein phosphatase, putative | 0.0042 | 0.0209 | 0.4466 |
Echinococcus granulosus | lamin | 0.0058 | 0.0397 | 0.2149 |
Schistosoma mansoni | lamin | 0.0058 | 0.0397 | 0.2149 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0127 | 0.1234 | 0.6673 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0058 | 0.0397 | 0.3615 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.1099 | 0.8907 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1234 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.0502 | 0.4064 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0468 | 0.1122 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.1099 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.0502 | 0.2712 |
Leishmania major | serine/threonine protein phosphatase 2B catalytic subunit A2, putative | 0.0042 | 0.0209 | 0.4466 |
Toxoplasma gondii | protein phosphatase 2B catalytic subunit, calcineurin family phosphatse superfamily protein | 0.0042 | 0.0209 | 0.0501 |
Trichomonas vaginalis | hypothetical protein | 0.037 | 0.4173 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.