Detailed information for compound 700280

Basic information

Technical information
  • TDR Targets ID: 700280
  • Name: 3,4-dichloro-N-[4-(6-morpholin-4-ylpyridazin- 3-yl)phenyl]benzenesulfonamide
  • MW: 465.353 | Formula: C20H18Cl2N4O3S
  • H donors: 1 H acceptors: 4 LogP: 3.37 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1Cl)S(=O)(=O)Nc1ccc(cc1)c1ccc(nn1)N1CCOCC1
  • InChi: 1S/C20H18Cl2N4O3S/c21-17-6-5-16(13-18(17)22)30(27,28)25-15-3-1-14(2-4-15)19-7-8-20(24-23-19)26-9-11-29-12-10-26/h1-8,13,25H,9-12H2
  • InChiKey: CPKADVGGEYVDQP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,4-dichloro-N-[4-(6-morpholinopyridazin-3-yl)phenyl]benzenesulfonamide
  • 3,4-dichloro-N-[4-(6-morpholino-3-pyridazinyl)phenyl]benzenesulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0111 0.0075
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0252 0.0252
Echinococcus granulosus neutral amino acid transporter 0.1311 0.7509 1
Mycobacterium leprae PROBABLE HYDROLASE 0.0094 0.0427 0.0455
Echinococcus multilocularis Excitatory amino acid transporter 0.1311 0.7509 0.7509
Echinococcus granulosus muscleblind protein 0.0328 0.1784 0.2376
Brugia malayi follicle stimulating hormone receptor 0.0249 0.1328 0.1754
Loa Loa (eye worm) hypothetical protein 0.0064 0.0252 0.0336
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.1008 0.1327
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.015 0.0752 0.7176
Brugia malayi Excitatory amino acid transporter 0.1311 0.7509 1
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0332 0.089
Plasmodium vivax importin-beta 2, putative 0.0065 0.0253 0.2211
Echinococcus granulosus excitatory amino acid transporter 2 0.1311 0.7509 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.015 0.0752 0.1002
Trypanosoma brucei hypothetical protein, conserved 0.015 0.0752 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0087 0.0087
Loa Loa (eye worm) glutathione reductase 0.004 0.0111 0.0148
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1666 0.581
Treponema pallidum glutamate/aspartate transporter 0.0581 0.326 1
Onchocerca volvulus 0.015 0.0752 0.0925
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.015 0.0752 0.0986
Echinococcus granulosus acetylcholinesterase 0.0048 0.0159 0.0212
Echinococcus multilocularis protein patched 0.0046 0.0146 0.0146
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0078 0.0332 0.0426
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.033 0.0423
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0111 0.0000013674
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0332 0.3651
Echinococcus multilocularis carboxylesterase 5A 0.0048 0.0159 0.0159
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0063 0.0063
Echinococcus multilocularis disintegrin and metalloproteinase 0.0023 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0044 0.0136 0.0164
Echinococcus granulosus Niemann Pick C1 protein 0.0108 0.0503 0.067
Schistosoma mansoni cpg binding protein 0.0064 0.0251 0.0317
Echinococcus multilocularis excitatory amino acid transporter 2 0.1311 0.7509 0.7509
Schistosoma mansoni hypothetical protein 0.0205 0.1069 0.1408
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0078 0.0332 0.1422
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.015 0.0752 0.0986
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0146 0.0146
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0078 0.0332 0.1532
Giardia lamblia Fructose-bisphosphate aldolase 0.0307 0.1666 1
Schistosoma mansoni hypothetical protein 0.0044 0.0136 0.0164
Loa Loa (eye worm) carboxylesterase 0.0048 0.0159 0.0212
Mycobacterium tuberculosis Probable conserved lipoprotein 0.015 0.0752 0.0866
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1666 0.581
Brugia malayi beta-lactamase 0.015 0.0752 0.0986
Loa Loa (eye worm) hypothetical protein 0.0114 0.054 0.0719
Onchocerca volvulus 0.015 0.0752 0.0925
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0048 0.0154 0.0686
Onchocerca volvulus 0.0078 0.0329 0.0356
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0063 0.0067
Echinococcus multilocularis snurportin 1 0.0689 0.3891 0.3891
Brugia malayi steroid hormone receptor 0.0032 0.0063 0.0067
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0063 0.0067
Loa Loa (eye worm) matrixin family protein 0.0172 0.0879 0.117
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0102 0.0471 0.175
Echinococcus multilocularis Excitatory amino acid transporter 0.1311 0.7509 0.7509
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0063 0.0063
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0102 0.0471 0.0486
Onchocerca volvulus 0.0061 0.0231 0.0225
Trypanosoma brucei importin beta-1 subunit, putative 0.0065 0.0253 0.2449
Loa Loa (eye worm) acetylcholinesterase 1 0.0048 0.0159 0.0212
Echinococcus granulosus dnaJ subfamily B 0.0865 0.4915 0.6545
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0231 0.0307
Toxoplasma gondii aldehyde dehydrogenase 0.0194 0.1005 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0087 0.0116
Schistosoma mansoni hypothetical protein 0.0036 0.0087 0.0098
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0282 0.1519 0.2023
Loa Loa (eye worm) excitatory amino acid transporter 0.1311 0.7509 1
Schistosoma mansoni ran 0.0048 0.0154 0.0188
Brugia malayi hypothetical protein 0.0097 0.0442 0.0572
Brugia malayi Matrixin family protein 0.0078 0.0329 0.0421
Trichomonas vaginalis penicillin-binding protein, putative 0.015 0.0752 0.2439
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.015 0.0752 0.0866
Schistosoma mansoni survival motor neuron protein 0.0051 0.0172 0.0212
Echinococcus granulosus neutral amino acid transporter A 0.1311 0.7509 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0329 0.0438
Echinococcus multilocularis expressed conserved protein 0.0101 0.0465 0.0465
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0063 0.0067
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0048 0.0154 0.0273
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0111 0.0306
Loa Loa (eye worm) hypothetical protein 0.0032 0.0063 0.0084
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1666 0.581
Toxoplasma gondii thioredoxin reductase 0.004 0.0111 0.0222
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0063 0.0084
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.0842 0.1105
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0092 0.0412 0.0406
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0063 0.0067
Schistosoma mansoni hypothetical protein 0.0044 0.0136 0.0164
Brugia malayi Carboxylesterase family protein 0.0048 0.0159 0.0195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0063 0.0084
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0194 0.1008 0.1327
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0052 0.0182 0.0335
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0091 0.0091
Echinococcus granulosus expressed conserved protein 0.0101 0.0465 0.062
Schistosoma mansoni alpha-glucosidase 0.0143 0.0707 0.0926
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0252 0.1766
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.0842 0.1121
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0087 0.0098
Echinococcus multilocularis neutral amino acid transporter A 0.1311 0.7509 0.7509
Echinococcus multilocularis Niemann Pick C1 protein 0.0108 0.0503 0.0503
Loa Loa (eye worm) beta-lactamase 0.015 0.0752 0.1002
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0114 0.0114
Onchocerca volvulus 0.0096 0.0435 0.0499
Schistosoma mansoni ap endonuclease 0.004 0.0111 0.0131
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.0561 0.514
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0252 0.0319
Brugia malayi RNA, U transporter 1 0.0184 0.0946 0.1245
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0063 0.0067
Onchocerca volvulus Matrix metalloproteinase homolog 0.0172 0.0879 0.1095
Loa Loa (eye worm) hypothetical protein 0.0032 0.0063 0.0084
Schistosoma mansoni hypothetical protein 0.0036 0.0087 0.0098
Mycobacterium tuberculosis Probable esterase LipL 0.015 0.0752 0.0866
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.0751 0.7162
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0194 0.1005 0.1338
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0078 0.0332 0.0426
Mycobacterium ulcerans hydrolase 0.0094 0.0427 0.3534
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0111 0.0131
Brugia malayi Pre-SET motif family protein 0.0064 0.0252 0.0319
Echinococcus multilocularis microtubule associated protein 2 0.0742 0.42 0.42
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0048 0.0159 0.0195
Mycobacterium tuberculosis Conserved protein 0.015 0.0752 0.0866
Mycobacterium tuberculosis Probable oxidoreductase 0.0102 0.0471 0.0486
Chlamydia trachomatis glutamate symporter 0.1311 0.7509 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0063 0.0067
Schistosoma mansoni hypothetical protein 0.0205 0.1069 0.1408
Loa Loa (eye worm) hypothetical protein 0.0032 0.0063 0.0084
Loa Loa (eye worm) hypothetical protein 0.015 0.0752 0.1002
Loa Loa (eye worm) hypothetical protein 0.0032 0.0063 0.0084
Echinococcus multilocularis acetylcholinesterase 0.0048 0.0159 0.0159
Echinococcus multilocularis excitatory amino acid transporter 3 0.1311 0.7509 0.7509
Brugia malayi hypothetical protein 0.0249 0.1325 0.1749
Loa Loa (eye worm) hypothetical protein 0.0328 0.1784 0.2376
Echinococcus granulosus microtubule associated protein 2 0.0742 0.42 0.5593
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0078 0.0332 0.2642
Echinococcus granulosus Excitatory amino acid transporter 0.1311 0.7509 1
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0053 0.0183 0.0227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0063 0.0084
Echinococcus multilocularis acetylcholinesterase 0.0048 0.0159 0.0159
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0078 0.0332 0.0426
Schistosoma mansoni patched 1 0.0046 0.0146 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0063 0.0067
Loa Loa (eye worm) hypothetical protein 0.0046 0.0146 0.0194
Loa Loa (eye worm) hypothetical protein 0.0048 0.0159 0.0212
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0063 0.0084
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0063 0.0063
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0237 0.0237
Treponema pallidum glutamate transporter 0.0581 0.326 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0048 0.0154 0.0948
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0063 0.0067
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0842 0.0842
Brugia malayi Carboxylesterase family protein 0.0048 0.0159 0.0195
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0114 0.054 0.0703
Onchocerca volvulus 0.015 0.0752 0.0925
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1311 0.7509 1
Echinococcus granulosus GPCR family 2 0.0036 0.0087 0.0116
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0063 0.0067
Mycobacterium ulcerans aldehyde dehydrogenase 0.0194 0.1005 1
Brugia malayi Matrixin family protein 0.0078 0.0329 0.0421
Loa Loa (eye worm) matrixin family protein 0.0188 0.0969 0.129
Plasmodium vivax hypothetical protein, conserved 0.015 0.0752 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1666 0.581
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0063 0.0084
Brugia malayi ecdysteroid receptor 0.0032 0.0063 0.0067
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0063 0.0067
Echinococcus granulosus excitatory amino acid transporter 3 0.1311 0.7509 1
Schistosoma mansoni hypothetical protein 0.0078 0.033 0.0423
Loa Loa (eye worm) hypothetical protein 0.0032 0.0063 0.0084
Trichomonas vaginalis D-aminoacylase, putative 0.015 0.0752 0.2439
Trichomonas vaginalis ran, putative 0.0048 0.0154 0.0231
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0111 0.0111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.1008 0.1327
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0091 0.0121
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0194 0.1005 1
Entamoeba histolytica Ran family GTPase 0.0048 0.0154 0.0398
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0063 0.0084
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1311 0.7509 0.7509
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0146 0.0194
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.1325 0.1764
Echinococcus granulosus adam 17 protease 0.0258 0.1379 0.1837
Plasmodium falciparum importin beta, putative 0.0065 0.0253 0.2211
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0172 0.0212
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0111 0.0128
Schistosoma mansoni cpg binding protein 0.0064 0.0251 0.0317
Trypanosoma cruzi hypothetical protein, conserved 0.015 0.0752 1
Plasmodium falciparum ataxin-2 like protein, putative 0.015 0.0752 1
Onchocerca volvulus Matrilysin homolog 0.0172 0.0879 0.1095
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0111 0.0522 0.0679
Plasmodium vivax SET domain protein, putative 0.0064 0.0252 0.2201
Schistosoma mansoni hypothetical protein 0.0865 0.4915 0.6539
Echinococcus granulosus neuropeptide receptor A26 0.0499 0.2782 0.3705
Loa Loa (eye worm) matrix metalloproteinase 0.0078 0.0329 0.0438
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0023 0.0013 0.0013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.1008 0.1342
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0111 0.0148
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0111 0.0075
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0063 0.0067
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0063 0.0084
Mycobacterium tuberculosis Possible penicillin-binding protein 0.096 0.5469 0.7242
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0048 0.0154 0.0948
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0078 0.0332 0.0332
Echinococcus granulosus importin subunit beta 1 0.0065 0.0253 0.0337
Echinococcus granulosus GTP binding nuclear protein Ran 0.0048 0.0154 0.0205
Echinococcus multilocularis Niemann Pick C1 protein 0.0154 0.0772 0.0772
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0063 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0063 0.0067
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0041 0.0115 0.0135
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0282 0.1519 0.1519
Brugia malayi Pre-SET motif family protein 0.0442 0.2448 0.3248
Echinococcus granulosus Niemann Pick C1 protein 0.0154 0.0772 0.1028
Brugia malayi Hemopexin family protein 0.011 0.0517 0.0672
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1666 0.581
Trichomonas vaginalis D-aminoacylase, putative 0.015 0.0752 0.2439
Echinococcus granulosus neuropeptide s receptor 0.0499 0.2782 0.3705
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0108 0.0503 0.2617
Echinococcus granulosus acetylcholinesterase 0.0048 0.0159 0.0212
Echinococcus multilocularis excitatory amino acid transporter 2 0.1311 0.7509 0.7509
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0063 0.0084
Mycobacterium ulcerans hypothetical protein 0.015 0.0752 0.7176
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0111 0.0522 0.0679
Loa Loa (eye worm) hypothetical protein 0.0065 0.0253 0.0337
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0078 0.0332 0.089
Loa Loa (eye worm) hypothetical protein 0.0108 0.0503 0.067
Loa Loa (eye worm) hypothetical protein 0.0032 0.0063 0.0084
Echinococcus multilocularis dnaJ subfamily B 0.0865 0.4915 0.4915
Echinococcus granulosus Excitatory amino acid transporter 0.1311 0.7509 1
Echinococcus granulosus disintegrin and metalloproteinase 0.0023 0.0013 0.0018
Trypanosoma cruzi importin beta-1 subunit, putative 0.0052 0.0182 0.1374
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0332 0.3651
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0111 0.0148
Echinococcus multilocularis neutral amino acid transporter A 0.1311 0.7509 0.7509
Mycobacterium tuberculosis Conserved protein 0.015 0.0752 0.0866
Brugia malayi Niemann-Pick C1 protein precursor 0.0108 0.0503 0.0654
Loa Loa (eye worm) hypothetical protein 0.0023 0.0013 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0063 0.0084
Schistosoma mansoni aldehyde dehydrogenase 0.0194 0.1005 0.1323
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0442 0.2448 0.326
Leishmania major GTP-binding protein, putative 0.0048 0.0154 0.0686
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1666 0.581
Echinococcus multilocularis GPCR, family 2 0.0036 0.0087 0.0087
Echinococcus granulosus adam 0.0041 0.0115 0.0153
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0048 0.0154 0.0662
Echinococcus granulosus ubiquitin specific protease 41 0.0078 0.0332 0.0443
Echinococcus multilocularis adam 17 protease 0.0235 0.1243 0.1243
Brugia malayi MH2 domain containing protein 0.0144 0.0717 0.0938
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0252 0.0319
Brugia malayi beta-lactamase family protein 0.015 0.0752 0.0986
Echinococcus multilocularis importin subunit beta 1 0.0065 0.0253 0.0253
Schistosoma mansoni aldehyde dehydrogenase 0.0194 0.1005 0.1323
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1311 0.7509 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0048 0.0154 0.0154
Brugia malayi Thioredoxin reductase 0.004 0.0111 0.0131
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.015 0.0752 0.0866
Toxoplasma gondii HEAT repeat-containing protein 0.0065 0.0253 0.1773
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0078 0.0332 0.089
Trypanosoma cruzi PAB1-binding protein , putative 0.015 0.0752 0.9999
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0094 0.0427 0.0427
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0717 0.0954
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0063 0.0067
Trypanosoma brucei trypanothione reductase 0.004 0.0111 0.0306
Schistosoma mansoni alpha-glucosidase 0.0143 0.0707 0.0926
Mycobacterium ulcerans aldehyde dehydrogenase 0.0194 0.1005 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0257 0.0343
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0078 0.0332 0.0443
Brugia malayi Calcitonin receptor-like protein seb-1 0.0114 0.054 0.0703
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0581 0.326 0.326
Loa Loa (eye worm) hypothetical protein 0.0249 0.1325 0.1764
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0063 0.0067
Brugia malayi beta-lactamase family protein 0.015 0.0752 0.0986
Trichomonas vaginalis penicillin-binding protein, putative 0.015 0.0752 0.2439
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0087 0.0116
Loa Loa (eye worm) reprolysin 0.0023 0.0013 0.0018
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0257 0.0326
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0063 0.0067
Mycobacterium leprae Probable lipase LipE 0.015 0.0752 1
Mycobacterium ulcerans lipase LipD 0.015 0.0752 0.7176
Schistosoma mansoni hypothetical protein 0.0051 0.0172 0.0212
Onchocerca volvulus 0.0502 0.2802 0.3678
Trichomonas vaginalis D-aminoacylase, putative 0.015 0.0752 0.2439
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0091 0.0104
Mycobacterium ulcerans beta-lactamase 0.015 0.0752 0.7176
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0048 0.0154 0.0662
Echinococcus granulosus cpg binding protein 0.0064 0.0251 0.0334
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0111 0.0222
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0063 0.0063
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0102 0.0471 0.0486
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0111 0.0306
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0842 0.0842
Schistosoma mansoni ap endonuclease 0.004 0.0111 0.0131
Echinococcus multilocularis muscleblind protein 0.0328 0.1784 0.1784
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0092 0.0412 0.0406
Treponema pallidum fructose-bisphosphate aldolase 0.0307 0.1666 0.4938
Brugia malayi nuclear receptor NHR-88 0.0032 0.0063 0.0067
Toxoplasma gondii exonuclease III APE 0.004 0.0111 0.0222
Mycobacterium tuberculosis Probable lipase LipD 0.015 0.0752 0.0866
Echinococcus multilocularis ubiquitin specific protease 41 0.0078 0.0332 0.0332
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0087 0.0116
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0252 0.0336
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1311 0.7509 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0114 0.0152
Mycobacterium ulcerans esterase/lipase LipP 0.015 0.0752 0.7176
Loa Loa (eye worm) hypothetical protein 0.015 0.0752 0.1002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1666 0.581
Echinococcus granulosus neutral amino acid transporter A 0.1311 0.7509 1
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0111 0.0522 0.0522
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0146 0.0202
Brugia malayi nuclear hormone receptor 0.0032 0.0063 0.0067
Brugia malayi CXXC zinc finger family protein 0.0061 0.0231 0.029
Echinococcus multilocularis geminin 0.0205 0.1069 0.1069
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0109 0.0513 0.0667
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.0751 0.9963
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.1008 0.1008
Schistosoma mansoni hypothetical protein 0.0036 0.0087 0.0098
Loa Loa (eye worm) hypothetical protein 0.015 0.0752 0.1002
Leishmania major hypothetical protein, conserved 0.015 0.0752 0.7238
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0194 0.1008 0.1342
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0194 0.1005 0.1005
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0063 0.0084
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0048 0.0154 0.0205
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0257 0.0343
Onchocerca volvulus 0.0064 0.0252 0.0254
Loa Loa (eye worm) hypothetical protein 0.015 0.0752 0.1002
Echinococcus multilocularis muscleblind protein 1 0.0328 0.1784 0.1784
Schistosoma mansoni cpg binding protein 0.0061 0.0231 0.029
Echinococcus multilocularis neuropeptide s receptor 0.0499 0.2782 0.2782
Loa Loa (eye worm) hypothetical protein 0.0036 0.0087 0.0116
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0146 0.0194
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0048 0.0154 0.0948
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0063 0.0063
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0249 0.1328 0.1769
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0581 0.326 0.326
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0092 0.0412 0.0406
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0332 0.3651
Loa Loa (eye worm) hypothetical protein 0.0048 0.0159 0.0212
Onchocerca volvulus 0.0051 0.0172 0.0146
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1311 0.7509 0.7509
Echinococcus granulosus snurportin 1 0.0689 0.3891 0.5182
Loa Loa (eye worm) hypothetical protein 0.0078 0.0329 0.0438
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0257 0.0326
Loa Loa (eye worm) hypothetical protein 0.0493 0.2748 0.3659
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.011 0.0517 0.0672
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.1008 0.1008
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0114 0.054 0.0719
Loa Loa (eye worm) hypothetical protein 0.015 0.0752 0.1002
Loa Loa (eye worm) hypothetical protein 0.015 0.0752 0.1002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0063 0.0067
Echinococcus granulosus carboxylesterase 5A 0.0048 0.0159 0.0212
Echinococcus multilocularis beta LACTamase domain containing family member 0.015 0.0752 0.0752
Echinococcus granulosus geminin 0.0205 0.1069 0.1423
Schistosoma mansoni microtubule-associated protein tau 0.0742 0.42 0.5585
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0237 0.0299
Brugia malayi Matrixin family protein 0.0078 0.0329 0.0421
Loa Loa (eye worm) hypothetical protein 0.0328 0.1784 0.2376
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.1008 0.1327
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0231 0.0308
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0078 0.0332 0.0443
Loa Loa (eye worm) hypothetical protein 0.0078 0.0329 0.0438
Trypanosoma cruzi hypothetical protein, conserved 0.015 0.0752 1
Schistosoma mansoni coup transcription factor 0.0032 0.0063 0.0067
Loa Loa (eye worm) hypothetical protein 0.0032 0.0063 0.0084
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.0751 0.0865
Schistosoma mansoni alpha glucosidase 0.0037 0.0091 0.0104
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0063 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0063 0.0067
Brugia malayi jmjC domain containing protein 0.0065 0.0257 0.0326
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0237 0.0316
Brugia malayi Matrixin family protein 0.0078 0.0329 0.0421
Trichomonas vaginalis importin beta-1, putative 0.0052 0.0182 0.0335
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0063 0.0067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0252 0.0319
Leishmania major hypothetical protein, conserved 0.015 0.0752 0.7238
Echinococcus granulosus beta LACTamase domain containing family member 0.015 0.0752 0.1002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0063 0.0067
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0094 0.0427 0.0552
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0063 0.0067
Mycobacterium leprae conserved hypothetical protein 0.015 0.0752 1
Onchocerca volvulus 0.011 0.0517 0.061
Schistosoma mansoni hypothetical protein 0.0044 0.0136 0.0164
Toxoplasma gondii ABC1 family protein 0.015 0.0752 0.7238
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0048 0.0154 0.0188
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0063 0.0084
Mycobacterium ulcerans aldehyde dehydrogenase 0.0194 0.1005 1
Trichomonas vaginalis set domain proteins, putative 0.0502 0.2802 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0067 0.027 0.0359
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0063 0.0067
Schistosoma mansoni hypothetical protein 0.0689 0.3891 0.5173
Schistosoma mansoni hypothetical protein 0.0067 0.027 0.0342
Trypanosoma brucei importin beta-1 subunit, putative 0.0065 0.0253 0.2449
Trypanosoma cruzi PAB1-binding protein , putative 0.015 0.0752 0.9999
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.1666 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0063 0.0084
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0063 0.0063
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0063 0.0067
Mycobacterium tuberculosis Probable dehydrogenase 0.0092 0.0412 0.0406
Brugia malayi hypothetical protein 0.0041 0.0115 0.0135
Echinococcus granulosus excitatory amino acid transporter 2 0.1311 0.7509 1
Brugia malayi CHE-14 protein 0.0046 0.0146 0.0177
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0111 0.0148
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0067 0.027 0.027
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0063 0.0063
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0078 0.0332 0.0332
Brugia malayi Muscleblind-like protein 0.0328 0.1784 0.2363
Brugia malayi Matrixin family protein 0.0188 0.0969 0.1275
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1311 0.7509 1
Plasmodium vivax ataxin-2 like protein, putative 0.015 0.0752 0.9999
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0111 0.0306
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0091 0.0121
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.1666 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0092 0.0412 0.0406
Mycobacterium tuberculosis Probable lipase LipE 0.015 0.0752 0.0866
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0147 0.0734 0.0734
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0063 0.0084
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0581 0.326 0.4331
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0581 0.326 0.4331
Schistosoma mansoni hypothetical protein 0.0036 0.0087 0.0098
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0111 0.0522 0.0695
Loa Loa (eye worm) hypothetical protein 0.0057 0.0206 0.0275
Toxoplasma gondii LsmAD domain-containing protein 0.015 0.0752 0.7238
Trichomonas vaginalis esterase, putative 0.015 0.0752 0.2439
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.1008 0.1342
Echinococcus multilocularis adam 0.0041 0.0115 0.0115
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0147 0.0734 0.0978
Leishmania major trypanothione reductase 0.004 0.0111 0.0222
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.1325 0.1325
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0063 0.0084
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0063 0.0063
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0063 0.0067
Brugia malayi glutathione reductase 0.004 0.0111 0.0131
Echinococcus multilocularis protein dispatched 1 0.0053 0.0184 0.0184
Schistosoma mansoni importin beta-1 0.0065 0.0253 0.032
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0063 0.0067
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0111 0.0306
Echinococcus granulosus sodium:dicarboxylate symporter 0.1311 0.7509 1
Entamoeba histolytica hypothetical protein 0.0052 0.0182 0.0577
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.1666 0.581
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0063 0.0084
Loa Loa (eye worm) hypothetical protein 0.0032 0.0063 0.0084
Brugia malayi Importin beta-1 subunit 0.0065 0.0253 0.032
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0235 0.1243 0.1641
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0717 0.0954
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0063 0.0084
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0063 0.0067
Brugia malayi jmjC domain containing protein 0.0062 0.0237 0.0299
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0063 0.0067
Loa Loa (eye worm) hypothetical protein 0.0078 0.033 0.044
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0689 0.3891 0.5182
Echinococcus multilocularis neuropeptide receptor A26 0.0499 0.2782 0.2782
Loa Loa (eye worm) hypothetical protein 0.0094 0.0427 0.0569
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0087 0.0087
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0252 0.0319
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0194 0.1005 0.1207
Brugia malayi hypothetical protein 0.015 0.0752 0.0986
Schistosoma mansoni ran 0.0048 0.0154 0.0188
Loa Loa (eye worm) hypothetical protein 0.0078 0.0332 0.0443
Mycobacterium tuberculosis Conserved protein 0.015 0.0752 0.0866
Mycobacterium tuberculosis Probable reductase 0.0092 0.0412 0.0406
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0023 0.0013 0.0018
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0237 0.0237
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0078 0.0329 0.0421
Onchocerca volvulus Matrilysin homolog 0.0078 0.0329 0.0356
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0052 0.0182 0.0335
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0063 0.0067
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0087 0.0098
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0131 0.0641 0.0837
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.0842 0.1121
Echinococcus multilocularis neutral amino acid transporter A 0.1311 0.7509 0.7509
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0252 0.0252
Echinococcus multilocularis cpg binding protein 0.0064 0.0251 0.0251
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0146 0.0194
Trypanosoma brucei PAB1-binding protein , putative 0.015 0.0752 0.9999
Plasmodium falciparum ataxin-2 like protein, putative 0.015 0.0752 1
Leishmania major importin beta-1 subunit, putative 0.0052 0.0182 0.0994
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.015 0.0752 0.0986
Loa Loa (eye worm) hypothetical protein 0.015 0.0752 0.1002
Mycobacterium tuberculosis Probable hydrolase 0.015 0.0752 0.0866

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 35.251 um PUBCHEM_BIOASSAY: Luminescence Biochemical Dose Response HTS to Identify Inhibitors of Luciferase. (Class of assay: confirmatory) [Related pubchem assays: 1663 (Primary HTS), 1678 (Summary of Project)] ChEMBL. No reference
Potency (functional) 1.4581 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Saccharomyces cerevisiae ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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