Detailed information for compound 700306

Basic information

Technical information
  • TDR Targets ID: 700306
  • Name: 4-nitro-N-[3-(6-pyrrolidin-1-ylpyridazin-3-yl )phenyl]benzenesulfonamide
  • MW: 425.461 | Formula: C20H19N5O4S
  • H donors: 1 H acceptors: 6 LogP: 2.8 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc(cc1)S(=O)(=O)Nc1cccc(c1)c1ccc(nn1)N1CCCC1
  • InChi: 1S/C20H19N5O4S/c26-25(27)17-6-8-18(9-7-17)30(28,29)23-16-5-3-4-15(14-16)19-10-11-20(22-21-19)24-12-1-2-13-24/h3-11,14,23H,1-2,12-13H2
  • InChiKey: QFLWDYMRLXXURS-UHFFFAOYSA-N  


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Synonyms

  • 4-nitro-N-[3-(6-1-pyrrolidinyl-3-pyridazinyl)phenyl]benzenesulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.0855 0.0818
Echinococcus granulosus Excitatory amino acid transporter 0.1279 1 1
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1279 1 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0185 1
Schistosoma mansoni alpha-glucosidase 0.0145 0.1033 0.0996
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0461 0.0422
Echinococcus multilocularis excitatory amino acid transporter 2 0.1279 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0175 0.0175
Toxoplasma gondii ABC1 family protein 0.0072 0.0461 0.4561
Echinococcus multilocularis neutral amino acid transporter A 0.1279 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0117 0.1364
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0263 0.0223
Trichomonas vaginalis esterase, putative 0.0072 0.0461 0.2144
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0185 0.0859
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0461 0.0413
Brugia malayi beta-lactamase family protein 0.0072 0.0461 0.0461
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0175 0.0135
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0117 0.1364
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0185 0.0859
Entamoeba histolytica hypothetical protein 0.0035 0.0168 0.9079
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0168 0.0127
Trypanosoma brucei glucosidase, putative 0.0037 0.0185 0.4006
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0461 0.0413
Brugia malayi hypothetical protein 0.003 0.0131 0.0131
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0461 0.0422
Mycobacterium tuberculosis Conserved protein 0.0072 0.0461 0.0413
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0461 0.0422
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1279 1 0.5
Mycobacterium ulcerans beta-lactamase 0.0072 0.0461 0.505
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0461 0.505
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0185 0.0859
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0131 0.2838
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.1217 0.1181
Brugia malayi Pre-SET motif family protein 0.0251 0.1877 0.1877
Loa Loa (eye worm) hypothetical protein 0.0072 0.0461 0.0461
Entamoeba histolytica hypothetical protein 0.0035 0.0168 0.9079
Brugia malayi hypothetical protein 0.002 0.0046 0.0046
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0461 0.0461
Onchocerca volvulus 0.0036 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0072 0.0461 0.0461
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0117 0.0719
Brugia malayi MH2 domain containing protein 0.0123 0.0863 0.0863
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0567 0.4371 0.4348
Echinococcus granulosus neutral amino acid transporter A 0.1279 1 1
Chlamydia trachomatis glutamate symporter 0.1279 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0041 0.0041
Treponema pallidum glutamate/aspartate transporter 0.0567 0.4371 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0185 0.0859
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0117 0.0719
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0185 0.0145
Echinococcus granulosus Excitatory amino acid transporter 0.1279 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0165 0.0124
Mycobacterium tuberculosis Conserved protein 0.0072 0.0461 0.0413
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.1217 0.1217
Trichomonas vaginalis set domain proteins, putative 0.0286 0.2151 1
Brugia malayi follicle stimulating hormone receptor 0.0239 0.1777 0.1777
Brugia malayi hypothetical protein 0.0035 0.0168 0.0168
Echinococcus granulosus neutral amino acid transporter 0.1279 1 1
Entamoeba histolytica hypothetical protein 0.0035 0.0168 0.9079
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0117 0.0117
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0461 1
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0567 0.4371 0.4348
Echinococcus multilocularis Excitatory amino acid transporter 0.1279 1 1
Brugia malayi Pre-SET motif family protein 0.0036 0.0175 0.0175
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0175 0.0135
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0131 0.1779
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0461 0.2144
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0263 0.0223
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0175 0.0135
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0185 0.0145
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0263 0.0263
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0185 0.2161
Onchocerca volvulus 0.0072 0.0461 0.0461
Echinococcus multilocularis neutral amino acid transporter A 0.1279 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0117 0.0117
Schistosoma mansoni alpha-glucosidase 0.0145 0.1033 0.0996
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0855 0.0818
Mycobacterium leprae Probable lipase LipE 0.0072 0.0461 1
Echinococcus multilocularis excitatory amino acid transporter 3 0.1279 1 1
Chlamydia trachomatis neutral amino acid transporter 0.0567 0.4371 0.4338
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0366 0.0366
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0117 0.0067
Loa Loa (eye worm) hypothetical protein 0.0072 0.0461 0.0461
Echinococcus multilocularis muscleblind protein 1 0.0154 0.1107 0.1071
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0567 0.4371 0.4348
Onchocerca volvulus 0.0072 0.0461 0.0461
Echinococcus granulosus excitatory amino acid transporter 2 0.1279 1 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.1107 0.1107
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0041 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0175 0.0135
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0185 0.0859
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0461 0.0413
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0117 0.0067
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0117 0.0719
Echinococcus multilocularis excitatory amino acid transporter 2 0.1279 1 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0461 0.0461
Loa Loa (eye worm) beta-lactamase 0.0072 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0154 0.1107 0.1107
Loa Loa (eye worm) hypothetical protein 0.006 0.0366 0.0366
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0117 0.6311
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0461 0.2144
Loa Loa (eye worm) hypothetical protein 0.003 0.0131 0.0131
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0855 1
Echinococcus multilocularis muscleblind protein 0.0154 0.1107 0.1071
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0175 0.0135
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0117 0.0117
Onchocerca volvulus 0.0286 0.2151 0.2151
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0059
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0117 0.0719
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1279 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0461 0.2144
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0168 0.0127
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0263 0.0223
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0175 0.0135
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.1217 0.1217
Loa Loa (eye worm) hypothetical protein 0.0041 0.0216 0.0216
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.0855 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0131 0.2838
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0117 0.1364
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.7631 0.7621
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0175 0.0135
Echinococcus granulosus neutral amino acid transporter A 0.1279 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0263 0.0223
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.0855 0.0809
Schistosoma mansoni hypothetical protein 0.0041 0.0216 0.0175
Onchocerca volvulus 0.0029 0.0117 0.0117
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1877 0.1877
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0461 0.0461
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.0855 1
Leishmania major hypothetical protein, conserved 0.003 0.0131 0.1531
Onchocerca volvulus 0.0097 0.0658 0.0658
Schistosoma mansoni hypothetical protein 0.0035 0.0168 0.0127
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0855 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0185 0.0859
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0461 0.505
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0461 0.0413
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0041
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0131 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0185 0.4006
Echinococcus multilocularis neutral amino acid transporter A 0.1279 1 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0117 0.6311
Mycobacterium tuberculosis Conserved protein 0.0072 0.0461 0.0413
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0185 0.4006
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0041 0.0041
Echinococcus multilocularis Excitatory amino acid transporter 0.1279 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0185 0.0859
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1279 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0863 0.0863
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0131 0.2838
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0366 0.0366
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0175 0.0612
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0263 0.0223
Loa Loa (eye worm) hypothetical protein 0.0029 0.0117 0.0117
Echinococcus granulosus excitatory amino acid transporter 2 0.1279 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0131 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0263 0.0263
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.1217 0.1181
Mycobacterium ulcerans lipase LipD 0.0072 0.0461 0.505
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.0855 0.0818
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.1777 0.1777
Plasmodium vivax SET domain protein, putative 0.0036 0.0175 0.2883
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0461 0.2144
Treponema pallidum glutamate transporter 0.0567 0.4371 0.5
Brugia malayi beta-lactamase 0.0072 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0059
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0855 0.0818
Loa Loa (eye worm) hypothetical protein 0.0029 0.0117 0.0117
Echinococcus granulosus muscleblind protein 0.0154 0.1107 0.1071
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0117 0.0719
Schistosoma mansoni alpha glucosidase 0.0037 0.0185 0.0145
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0117 0.0719
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0461 0.0413
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0461 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0263 0.0223
Mycobacterium ulcerans hypothetical protein 0.0072 0.0461 0.505
Brugia malayi beta-lactamase family protein 0.0072 0.0461 0.0461
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0185 0.0859
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0366 0.0366
Leishmania major hypothetical protein, conserved 0.0072 0.0461 0.5394
Onchocerca volvulus 0.0072 0.0461 0.0461
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0461 1
Loa Loa (eye worm) excitatory amino acid transporter 0.1279 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0117 0.0719
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0185 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0168 0.0127
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0059
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0185 0.0859
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0117 0.6311
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0461 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0263 0.0223
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0185 0.0744
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0567 0.4371 0.4348
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0461 0.0413
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0461 0.0413
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0461 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0461 0.0461
Echinococcus granulosus excitatory amino acid transporter 3 0.1279 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0461 0.2144
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0461 0.0422
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0059
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1279 1 1
Mycobacterium ulcerans hypothetical protein 0.0029 0.0117 0.0719
Entamoeba histolytica hypothetical protein 0.0035 0.0168 0.9079
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0059
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.1217 0.1181
Loa Loa (eye worm) hypothetical protein 0.0072 0.0461 0.0461
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0855 1
Echinococcus granulosus sodium:dicarboxylate symporter 0.1279 1 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0461 0.3538 0.3505
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0059 0.0009
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0216 0.0216
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0185 0.0185
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0863 0.0863
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0185 0.0185
Brugia malayi Muscleblind-like protein 0.0154 0.1107 0.1107
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1279 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1042 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.7305 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.3183 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.9955 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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