TDR Targets

Basic information

Technical information

TDR Targets ID: 700587
Name: N-(2-methylsulfanylphenyl)-2-(1,1,3-trioxo-1, 2-benzothiazol-2-yl)propanamide
MW: 376.45 | Formula: C17H16N2O4S2
H donors: 1 H acceptors: 4 LogP: 2.4 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CSc1ccccc1NC(=O)C(N1C(=O)c2c(S1(=O)=O)cccc2)C
InChi: 1S/C17H16N2O4S2/c1-11(16(20)18-13-8-4-5-9-14(13)24-2)19-17(21)12-7-3-6-10-15(12)25(19,22)23/h3-11H,1-2H3,(H,18,20)
InChiKey: CGUILSITOPEEGB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-(methylthio)phenyl]-2-(1,1,3-trioxo-1,2-benzothiazol-2-yl)propanamide
N-[2-(methylthio)phenyl]-2-(1,1,3-triketo-1,2-benzothiazol-2-yl)propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	E1-E2 ATPase	0.0009	0.0011	0.0012
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.1226	0.1583
Schistosoma mansoni	tar DNA-binding protein	0.0209	0.883	1
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.1226	0.1217
Loa Loa (eye worm)	hypothetical protein	0.0097	0.3901	0.4418
Brugia malayi	potential phospholipid-transporting ATPase IIB, putative	0.0009	0.0011	0.0012
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0013	0.0169	0.0192
Brugia malayi	E1-E2 ATPase family protein	0.0009	0.0011	0.0012
Schistosoma mansoni	cation-transporting ATPase	0.0009	0.0011	0.0012
Brugia malayi	haloacid dehalogenase-like hydrolase family protein	0.0009	0.0011	0.0012
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0009	0.0011	0.0014
Brugia malayi	beta-lactamase family protein	0.0037	0.1226	0.1388
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.1226	0.1217
Loa Loa (eye worm)	hypothetical protein	0.0055	0.2018	0.2286
Toxoplasma gondii	ABC1 family protein	0.0037	0.1226	1
Onchocerca volvulus		0.0037	0.1226	0.1599
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0872	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.1226	0.1583
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.2018	0.2286
Brugia malayi	RNA binding protein	0.0209	0.883	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.2018	0.2286
Echinococcus granulosus	tar DNA binding protein	0.0209	0.883	1
Mycobacterium tuberculosis	Conserved protein	0.0037	0.1226	0.1217
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.1226	0.1217
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.3887	0.4402
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.3887	0.4402
Brugia malayi	Sodium/potassium-transporting ATPase alpha chain, putative	0.0009	0.0011	0.0012
Echinococcus multilocularis	phosphoserine phosphatase	0.0009	0.0011	0.0012
Mycobacterium leprae	Probable lipase LipE	0.0037	0.1226	1
Leishmania major	hypothetical protein, conserved	0.0037	0.1226	1
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0009	0.0011	0.0014
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.0009	0.0011	0.5
Mycobacterium tuberculosis	Conserved protein	0.0037	0.1226	0.1217
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0009	0.0011	0.5
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.1226	0.1388
Leishmania major	hypothetical protein, conserved	0.0029	0.0872	0.709
Echinococcus multilocularis	sarco:endoplasmic reticulum calcium ATPase	0.0009	0.0011	0.0012
Echinococcus multilocularis	calcium transporting ATPase type 2C member	0.0009	0.0011	0.0012
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0872	0.709
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.1226	1
Schistosoma mansoni	hypothetical protein	0.0013	0.0169	0.0192
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0009	0.0011	0.5
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0872	0.709
Trichomonas vaginalis	esterase, putative	0.0037	0.1226	0.1583
Entamoeba histolytica	plasma membrane calcium-transporting ATPase 1, putative	0.0009	0.0011	0.5
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.1226	0.1217
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0364	0.0412
Trichomonas vaginalis	ATPase, class I, type 8B, putative	0.0009	0.0011	0.0014
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0872	1
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0009	0.0011	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0189	0.7972	0.9028
Echinococcus multilocularis	copper transporting ATPase 1	0.0009	0.0011	0.0012
Echinococcus multilocularis	cation transporting atpase worm	0.0009	0.0011	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1226	0.1388
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.1226	0.1388
Echinococcus multilocularis	phosphoserine phosphatase	0.0009	0.0011	0.0012
Echinococcus granulosus	copper transporting ATPase 1	0.0009	0.0011	0.0012
Schistosoma mansoni	ATPase	0.0009	0.0011	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1253	0.1418
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.1226	1
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0009	0.0011	0.0014
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0181	0.7611	1
Schistosoma mansoni	tar DNA-binding protein	0.0209	0.883	1
Echinococcus multilocularis	muscleblind protein 1	0.0138	0.568	0.6432
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.1226	1
Echinococcus multilocularis	phosphoserine phosphatase	0.0009	0.0011	0.0012
Echinococcus granulosus	phospholipid transporting ATPase VA	0.0009	0.0011	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1226	0.1388
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.1253	0.1418
Echinococcus granulosus	phospholipid transporting ATPase IIB	0.0009	0.0011	0.0012
Brugia malayi	RNA recognition motif domain containing protein	0.0209	0.883	1
Loa Loa (eye worm)	beta-lactamase	0.0037	0.1226	0.1388
Schistosoma mansoni	cation-transporting atpase 13a1 (G-box binding protein)	0.0009	0.0011	0.0012
Echinococcus multilocularis	phospholipid transporting ATPase IIB	0.0009	0.0011	0.0012
Schistosoma mansoni	tar DNA-binding protein	0.0209	0.883	1
Echinococcus granulosus	cation transporting atpase worm	0.0009	0.0011	0.0012
Echinococcus multilocularis	phosphoserine phosphatase	0.0009	0.0011	0.0012
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0364	0.0412
Mycobacterium ulcerans	hypothetical protein	0.0037	0.1226	1
Echinococcus multilocularis	muscleblind protein	0.0138	0.568	0.6432
Brugia malayi	hypothetical protein	0.0029	0.0872	0.0988
Schistosoma mansoni	type V p-type atpase isoform	0.0009	0.0011	0.0012
Loa Loa (eye worm)	RNA binding protein	0.0209	0.883	1
Mycobacterium ulcerans	lipase LipD	0.0037	0.1226	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.1226	0.1583
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0097	0.3887	0.4402
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1226	0.1388
Brugia malayi	MH2 domain containing protein	0.0131	0.5395	0.6109
Loa Loa (eye worm)	hypothetical protein	0.0138	0.568	0.6432
Echinococcus granulosus	sarco:endoplasmic reticulum calcium ATPase	0.0009	0.0011	0.0012
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0364	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1226	0.1388
Onchocerca volvulus		0.0037	0.1226	0.1599
Echinococcus multilocularis	Tetracycline resistance leader peptide, TetL	0.0009	0.0011	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0011	0.0012
Brugia malayi	Probable cation-transporting ATPase C10C6.6 in chromosome IV	0.0009	0.0011	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0364	0.0412
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.0009	0.0011	0.5
Schistosoma mansoni	hypothetical protein	0.0017	0.0364	0.0412
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.1226	0.1217
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.1226	0.1388
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.1226	0.1583
Schistosoma mansoni	cation-transporting atpase worm	0.0009	0.0011	0.0012
Echinococcus multilocularis	phosphoserine phosphatase	0.0009	0.0011	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0011	0.0012
Giardia lamblia	Copper-transporting P-type ATPase	0.0009	0.0011	0.5
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0872	0.709
Loa Loa (eye worm)	transcription factor SMAD2	0.0131	0.5395	0.6109
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0011	0.0012
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.1226	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1226	0.1388
Entamoeba histolytica	plasma membrane calcium ion-transporting ATPase, putative	0.0009	0.0011	0.5
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0097	0.3887	0.4402
Echinococcus granulosus	GPCR family 2	0.0017	0.0364	0.0412
Echinococcus multilocularis	phospholipid transporting ATPase VA	0.0009	0.0011	0.0012
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0364	0.0412
Loa Loa (eye worm)	Na,K-ATPase alpha subunit	0.0009	0.0011	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1226	0.1388
Brugia malayi	hypothetical protein	0.0019	0.0421	0.0476
Loa Loa (eye worm)	calcium ATPase	0.0009	0.0011	0.0012
Schistosoma mansoni	hypothetical protein	0.0017	0.0364	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0181	0.7611	0.8619
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.3887	0.4402
Schistosoma mansoni	tar DNA-binding protein	0.0209	0.883	1
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0013	0.0169	0.0192
Chlamydia trachomatis	metal transport ATPase	0.0009	0.0011	0.5
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0364	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0138	0.568	0.6432
Echinococcus granulosus	calcium transporting ATPase type 2C member	0.0009	0.0011	0.0012
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0364	0.0412
Schistosoma mansoni	hypothetical protein	0.0017	0.0364	0.0412
Brugia malayi	hypothetical protein	0.0097	0.3901	0.4418
Giardia lamblia	Phospholipid-transporting ATPase IA, putative	0.0009	0.0011	0.5
Schistosoma mansoni	eyes absent homolog	0.0097	0.3901	0.4418
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0011	0.0012
Entamoeba histolytica	phospholipid-transporting P-type ATPase, putative	0.0009	0.0011	0.5
Trichomonas vaginalis	phospholipid-transporting ATPase, putative	0.0009	0.0011	0.0014
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.1226	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0364	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0872	0.0988
Loa Loa (eye worm)	hypothetical protein	0.0097	0.3901	0.4418
Schistosoma mansoni	Na+/K+ transporting ATPase subunit alpha	0.0009	0.0011	0.0012
Treponema pallidum	cation-transporting ATPase, P-type	0.0009	0.0011	0.5
Echinococcus multilocularis	cation transporting ATPase 13A3	0.0009	0.0011	0.0012
Echinococcus granulosus	plasma membrane calcium transporting ATPase 2	0.0009	0.0011	0.0012
Echinococcus granulosus	cation transporting ATPase 13A1	0.0009	0.0011	0.0012
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.1226	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0872	0.709
Treponema pallidum	hypothetical protein	0.0009	0.0011	0.5
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0209	0.883	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0131	0.5395	0.6109
Brugia malayi	Muscleblind-like protein	0.0138	0.568	0.6432
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0009	0.0011	0.0014
Echinococcus granulosus	muscleblind protein	0.0138	0.568	0.6432
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0009	0.0011	0.0014
Echinococcus multilocularis	phosphoserine phosphatase	0.0009	0.0011	0.0012
Schistosoma mansoni	ATPase	0.0009	0.0011	0.0012
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.1226	0.1388
Brugia malayi	TAR-binding protein	0.0209	0.883	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.1226	0.1388
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0009	0.0011	0.0014
Onchocerca volvulus		0.0037	0.1226	0.1599
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.1226	1
Echinococcus multilocularis	cation transporting ATPase 13A1	0.0009	0.0011	0.0012
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0189	0.7972	0.9028
Schistosoma mansoni	cation-transporting atpase worm	0.0009	0.0011	0.0012
Trichomonas vaginalis	ATPase, class VI, type 11C, putative	0.0009	0.0011	0.0014
Giardia lamblia	Plasma membrane calcium-transporting ATPase 2	0.0009	0.0011	0.5
Trichomonas vaginalis	cation-transporting ATPase fungi, putative	0.0009	0.0011	0.0014
Entamoeba histolytica	cation-transporting P-typeATPase, putative	0.0009	0.0011	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0184	0.7743	1
Schistosoma mansoni	phosphoserine phosphatase	0.0009	0.0011	0.0012
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.3887	0.4402
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0009	0.0011	0.0014
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.1226	0.1217
Entamoeba histolytica	calcium-transporting P-type ATPase, putative	0.0009	0.0011	0.5
Brugia malayi	E1-E2 ATPase family protein	0.0009	0.0011	0.0012
Echinococcus multilocularis	tar DNA binding protein	0.0209	0.883	1
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0009	0.0011	0.5
Schistosoma mansoni	atpase class VI type 11c	0.0009	0.0011	0.0012
Mycobacterium tuberculosis	Conserved protein	0.0037	0.1226	0.1217
Schistosoma mansoni	hypothetical protein	0.0037	0.1253	0.1418
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0872	0.709
Brugia malayi	beta-lactamase	0.0037	0.1226	0.1388
Mycobacterium ulcerans	beta-lactamase	0.0037	0.1226	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.2018	0.2286
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0011	0.0012
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0009	0.0011	0.0014
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.3887	0.4402
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0009	0.0011	0.0014
Loa Loa (eye worm)	TAR-binding protein	0.0209	0.883	1
Schistosoma mansoni	tar DNA-binding protein	0.0209	0.883	1
Brugia malayi	N-terminal motif family protein	0.0181	0.7611	0.8619
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.3887	0.4402
Echinococcus granulosus	cation transporting ATPase 13A3	0.0009	0.0011	0.0012
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0364	0.0412
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.3887	0.4402
Brugia malayi	hypothetical protein	0.0009	0.0011	0.0012
Schistosoma mansoni	hypothetical protein	0.0017	0.0364	0.0412
Brugia malayi	Na,K-ATPase alpha subunit	0.0009	0.0011	0.0012
Schistosoma mansoni	copper ABC transporter ATPase	0.0009	0.0011	0.0012
Loa Loa (eye worm)	sodium/potassium-transporting ATPase subunit alpha	0.0009	0.0011	0.0012
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.1226	0.1217
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.1226	0.1388
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.1226	0.1583
Brugia malayi	beta-lactamase family protein	0.0037	0.1226	0.1388

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.8526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	5.6234 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1355264
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 700587