TDR Targets

Basic information

Technical information

TDR Targets ID: 700894
Name: N-(4-carbamoylphenyl)-1-[(4-fluorophenyl)meth yl]-2-oxo-1,8-naphthyridine-3-carboxamide
MW: 416.404 | Formula: C23H17FN4O3
H donors: 2 H acceptors: 4 LogP: 2.3 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)Cn1c(=O)c(cc2c1nccc2)C(=O)Nc1ccc(cc1)C(=O)N
InChi: 1S/C23H17FN4O3/c24-17-7-3-14(4-8-17)13-28-21-16(2-1-11-26-21)12-19(23(28)31)22(30)27-18-9-5-15(6-10-18)20(25)29/h1-12H,13H2,(H2,25,29)(H,27,30)
InChiKey: VTFIRMWKTUGUBZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-carbamoylphenyl)-1-(4-fluorobenzyl)-2-keto-1,8-naphthyridine-3-carboxamide
N-(4-aminocarbonylphenyl)-1-[(4-fluorophenyl)methyl]-2-oxo-1,8-naphthyridine-3-carboxamide
ZINC05305078

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0031	0.0085	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0413	0.1228
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0109	0.0581
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0133	0.072
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0144	0.078
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0022	0.0024	0.0366
Loa Loa (eye worm)	hypothetical protein	0.004	0.0149	0.043
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0133	0.2898
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0144	0.078
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0053	0.0237	0.1317
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0031	0.0085	0.0816
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0082	0.044	0.5849
Echinococcus granulosus	neuropeptide receptor A26	0.0981	0.6688	0.6688
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0053	0.0237	0.5304
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0218	0.1387	0.4178
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0031	0.0085	0.179
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0083	0.0446	0.133
Brugia malayi	Bromodomain containing protein	0.0082	0.0445	0.1324
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0599	0.1791
Entamoeba histolytica	hypothetical protein	0.0023	0.003	0.0237
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0034	0.0109	0.0106
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0169	0.1049	0.3156
Brugia malayi	RNA recognition motif domain containing protein	0.0415	0.2757	0.8327
Brugia malayi	Pre-SET motif family protein	0.0237	0.1521	0.4584
Mycobacterium ulcerans	acyl-CoA synthetase	0.0031	0.0085	0.1047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0069	0.0352
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0069	0.0351	0.0351
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0105	0.0599	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0117	0.0627
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.004	0.0147	0.0147
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0031	0.0085	0.1047
Brugia malayi	latrophilin 2 splice variant baaae	0.0149	0.0908	0.2726
Echinococcus granulosus	neutral alpha glucosidase AB	0.0038	0.0133	0.0133
Schistosoma mansoni	acetyl-CoA synthetase	0.0031	0.0085	0.0083
Echinococcus multilocularis	GPCR, family 2	0.0069	0.0351	0.0351
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0163	0.0888
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0095	0.0536	0.0536
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0126	0.0747	0.0747
Echinococcus multilocularis	tumor protein p63	0.076	0.5153	0.5153
Mycobacterium ulcerans	hypothetical protein	0.0105	0.0599	0.7988
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0019	0.0002	0.0002
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0042	0.0163	0.3583
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0031	0.0085	0.1047
Echinococcus granulosus	snurportin 1	0.0318	0.208	0.208
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.004	0.0183
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0053	0.0237	0.5304
Trichomonas vaginalis	set domain proteins, putative	0.027	0.1749	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0069	0.0351	0.1043
Schistosoma mansoni	cellular tumor antigen P53	0.0111	0.0645	0.0643
Leishmania major	GTP-binding protein, putative	0.0022	0.0024	0.0221
Schistosoma mansoni	tar DNA-binding protein	0.0415	0.2757	0.2755
Brugia malayi	AMP-binding enzyme family protein	0.0031	0.0085	0.0234
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0031	0.0085	0.179
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0066	0.0328	0.0328
Onchocerca volvulus		0.0111	0.0645	0.3363
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0031	0.0085	0.1047
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0031	0.0085	0.1047
Echinococcus granulosus	tumor protein p63	0.076	0.5153	0.5153
Loa Loa (eye worm)	hypothetical protein	0.003	0.0079	0.0217
Echinococcus granulosus	lysine specific demethylase 5A	0.0063	0.0312	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0415	0.1235
Leishmania major	4-coumarate:coa ligase-like protein	0.0105	0.0599	0.7988
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0069	0.035
Brugia malayi	AMP-binding enzyme family protein	0.0031	0.0085	0.0234
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0163	0.0888
Schistosoma mansoni	hypothetical protein	0.0156	0.0957	0.0955
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0023	0.003	0.0304
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0133	0.072
Loa Loa (eye worm)	phosphatidylinositol 3	0.0053	0.0237	0.0697
Schistosoma mansoni	alpha-glucosidase	0.0146	0.0885	0.0883
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0024	0.0377
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0023	0.003	0.0304
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0074	0.0385	0.5103
Onchocerca volvulus		0.0098	0.0553	0.281
Brugia malayi	Pre-SET motif family protein	0.0034	0.0109	0.0305
Brugia malayi	AMP-binding enzyme family protein	0.0105	0.0599	0.1789
Echinococcus granulosus	GPCR family 2	0.0069	0.0351	0.0351
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.003	0.0552
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0126	0.0747	0.0747
Schistosoma mansoni	ran	0.0022	0.0024	0.0022
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.0536	0.0533
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0038	0.0133	0.0382
Leishmania major	alpha glucosidase II subunit, putative	0.0038	0.0133	0.1695
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0066	0.0328	0.0328
Onchocerca volvulus		0.0105	0.0599	0.3084
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0034	0.0109	0.1362
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0078	0.0415	0.5504
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0133	0.2898
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0126	0.0747	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0105	0.0599	0.7988
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0318	0.208	0.6277
Echinococcus granulosus	importin subunit beta 1	0.003	0.0079	0.0079
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0053	0.0237	0.0695
Plasmodium vivax	importin-beta 2, putative	0.003	0.0079	0.1743
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0082	0.044	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0415	0.2757	0.8327
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0079	0.0079
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0031	0.0085	0.1047
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0038	0.0133	0.038
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0053	0.0237	0.2417
Entamoeba histolytica	hypothetical protein	0.0156	0.0957	1
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0024	0.004	0.004
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0133	0.072
Brugia malayi	intermediate filament protein	0.0083	0.0446	0.1328
Onchocerca volvulus		0.0081	0.0435	0.2102
Mycobacterium ulcerans	acyl-CoA synthetase	0.0031	0.0085	0.1047
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0031	0.0085	0.1047
Loa Loa (eye worm)	hypothetical protein	0.0149	0.0908	0.2728
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0008	0.0008
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0031	0.0085	0.1047
Echinococcus multilocularis	inositol monophosphatase 1	0.0082	0.044	0.044
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0031	0.0085	0.1902
Echinococcus granulosus	histone lysine methyltransferase setb	0.0053	0.0239	0.0239
Echinococcus multilocularis	microtubule associated protein 2	0.1458	1	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0038	0.0133	0.1321
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0163	0.0888
Echinococcus granulosus	lamin	0.0083	0.0446	0.0446
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0038	0.0133	0.1695
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0031	0.0085	0.179
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0022	0.0024	0.0401
Brugia malayi	AMP-binding enzyme family protein	0.0031	0.0085	0.0234
Schistosoma mansoni	ap endonuclease	0.002	0.0008	0.0006
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0031	0.0085	0.1047
Schistosoma mansoni	tar DNA-binding protein	0.0415	0.2757	0.2755
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0031	0.0085	0.1902
Trypanosoma cruzi	target of rapamycin kinase 3	0.0042	0.0163	0.3583
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0082	0.044	1
Leishmania major	hypothetical protein, conserved	0.0054	0.0246	0.3226
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0031	0.0085	0.1047
Schistosoma mansoni	inositol monophosphatase	0.0082	0.044	0.0438
Plasmodium vivax	ataxin-2 like protein, putative	0.0054	0.0246	0.5862
Mycobacterium ulcerans	acyl-CoA synthetase	0.0105	0.0599	0.7988
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0415	0.1235
Schistosoma mansoni	jumonji domain containing protein	0.0061	0.0297	0.0295
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0053	0.0239	0.0237
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0079	0.164
Brugia malayi	hypothetical protein	0.0035	0.0114	0.0321
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0109	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0218	0.1387	0.418
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0033	0.01	0.01
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.004	0.0736
Schistosoma mansoni	hypothetical protein	0.0318	0.208	0.2078
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0031	0.0085	0.179
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0095	0.0536	0.1601
Mycobacterium ulcerans	acyl-CoA synthetase	0.0031	0.0085	0.1047
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0246	0.0725
Brugia malayi	jmjC domain containing protein	0.0063	0.0312	0.092
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0081	0.0435	0.0435
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0169	0.1049	0.3154
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0031	0.0085	0.1047
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.0024	0.0221
Schistosoma mansoni	hypothetical protein	0.0149	0.0908	0.0906
Schistosoma mansoni	bromodomain containing protein	0.007	0.0356	0.0353
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0053	0.0239	0.0239
Toxoplasma gondii	propionate-CoA ligase	0.0031	0.0085	0.1047
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0198	0.0578
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0163	0.0888
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0415	0.1235
Brugia malayi	Latrophilin receptor protein 2	0.0069	0.0351	0.1041
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.0536	0.0533
Mycobacterium ulcerans	acyl-CoA synthetase	0.0031	0.0085	0.1047
Loa Loa (eye worm)	TAR-binding protein	0.0415	0.2757	0.8327
Schistosoma mansoni	alpha glucosidase	0.0038	0.0133	0.0131
Schistosoma mansoni	ap endonuclease	0.002	0.0008	0.0006
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0082	0.044	0.2483
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0105	0.0599	0.7988
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.004	0.0149	0.0149
Echinococcus multilocularis	lysine specific demethylase 5A	0.0061	0.0297	0.0297
Loa Loa (eye worm)	MH2 domain-containing protein	0.0139	0.0836	0.2511
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0024	0.0024
Entamoeba histolytica	Ran family GTPase	0.0022	0.0024	0.0172
Echinococcus granulosus	zinc finger protein	0.0022	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0599	0.1791
Brugia malayi	AMP-binding enzyme family protein	0.0105	0.0599	0.1789
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0038	0.0133	0.072
Trichomonas vaginalis	antibiotic synthetase, putative	0.0031	0.0085	0.0445
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0034	0.0109	0.0109
Brugia malayi	jmjC domain containing protein	0.0061	0.0297	0.0876
Schistosoma mansoni	hypothetical protein	0.0069	0.0351	0.0349
Brugia malayi	RNA binding protein	0.0415	0.2757	0.8327
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0105	0.0599	0.7988
Loa Loa (eye worm)	inositol-1	0.0082	0.044	0.1312
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0044	0.0042
Trichomonas vaginalis	antibiotic synthetase, putative	0.0031	0.0085	0.0445
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0031	0.0085	0.1047
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0038	0.0133	0.072
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0144	0.078
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0031	0.0085	0.1047
Schistosoma mansoni	transcription factor LCR-F1	0.0156	0.0957	0.0955
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0126	0.0747	1
Plasmodium falciparum	importin beta, putative	0.003	0.0079	0.1743
Onchocerca volvulus		0.027	0.1749	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0126	0.0747	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.009	0.0473
Mycobacterium ulcerans	acyl-CoA synthetase	0.0105	0.0599	0.7988
Echinococcus granulosus	intermediate filament protein	0.0083	0.0446	0.0446
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0069	0.035
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0053	0.0237	0.0235
Brugia malayi	Intermediate filament tail domain containing protein	0.0083	0.0446	0.1328
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0031	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0085	0.0237
Entamoeba histolytica	hypothetical protein	0.0156	0.0957	1
Brugia malayi	TAR-binding protein	0.0415	0.2757	0.8327
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0165	0.0479
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0144	0.078
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0069	0.035
Loa Loa (eye worm)	oxidoreductase	0.0031	0.0085	0.0237
Brugia malayi	Bromodomain containing protein	0.0042	0.0165	0.0475
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0031	0.0085	0.1047
Mycobacterium ulcerans	acyl-CoA synthetase	0.0031	0.0085	0.1047
Entamoeba histolytica	hypothetical protein	0.0024	0.004	0.0335
Brugia malayi	cytoplasmic intermediate filament protein	0.0044	0.018	0.052
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0019	0.0002	0.0002
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0079	0.164
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0031	0.0085	0.179
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0023	0.003	0.0519
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0069	0.0351	0.1041
Brugia malayi	MH2 domain containing protein	0.0139	0.0836	0.2509
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0031	0.0085	0.1047
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0237	0.1521	0.4586
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0073	0.0381	0.5043
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0105	0.0599	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0069	0.0352
Schistosoma mansoni	inositol monophosphatase	0.0082	0.044	0.0438
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0031	0.0085	0.1047
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0105	0.0599	0.7988
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0053	0.0237	0.0237
Mycobacterium leprae	POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0031	0.0085	0.0967
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0053	0.0237	0.2417
Loa Loa (eye worm)	PHD-finger family protein	0.0023	0.003	0.0069
Leishmania major	4-coumarate:coa ligase-like protein	0.0105	0.0599	0.7988
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0053	0.0237	0.0237
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0053	0.0237	0.3102
Trichomonas vaginalis	ran, putative	0.0022	0.0024	0.0094
Schistosoma mansoni	hypothetical protein	0.0069	0.0351	0.0349
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0169	0.1049	0.1049
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.004	0.0149	0.0149
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0074	0.0385	0.5103
Echinococcus granulosus	inositol monophosphatase 1	0.0082	0.044	0.044
Brugia malayi	PHD-finger family protein	0.0027	0.0062	0.0165
Brugia malayi	RNA, U transporter 1	0.0085	0.046	0.137
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0031	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0446	0.133
Onchocerca volvulus		0.0083	0.0446	0.2169
Brugia malayi	Importin beta-1 subunit	0.003	0.0079	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0139	0.0398
Echinococcus granulosus	L aminoadipate semialdehyde	0.0081	0.0435	0.0435
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0074	0.0385	0.5103
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0023	0.003	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0061	0.0297	0.0297
Trichomonas vaginalis	inositol monophosphatase, putative	0.0082	0.044	0.2483
Brugia malayi	AMP-binding enzyme family protein	0.0105	0.0599	0.1789
Echinococcus granulosus	tar DNA binding protein	0.0415	0.2757	0.2757
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.0536	0.0533
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0144	0.078
Schistosoma mansoni	hypothetical protein	0.0357	0.2352	0.235
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0144	0.078
Echinococcus granulosus	lysosomal alpha glucosidase	0.0169	0.1049	0.1049
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0082	0.044	1
Brugia malayi	hypothetical protein	0.0156	0.0957	0.2874
Echinococcus granulosus	geminin	0.0357	0.2352	0.2352
Echinococcus multilocularis	musashi	0.0083	0.0446	0.0446
Toxoplasma gondii	aldehyde dehydrogenase	0.0126	0.0747	1
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0073	0.0381	0.6168
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0024	0.0024
Echinococcus multilocularis	lamin dm0	0.0083	0.0446	0.0446
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0031	0.0085	0.1047
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0218	0.1387	0.418
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0031	0.0085	0.1047
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.003	0.0552
Schistosoma mansoni	hypothetical protein	0.0069	0.0351	0.0349
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0063	0.0312	0.0309
Plasmodium falciparum	acyl-CoA synthetase	0.0078	0.0415	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0184	0.101
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0025	0.0045	0.0852
Echinococcus multilocularis	neuropeptide s receptor	0.0981	0.6688	0.6688
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0078	0.0415	1
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0645	0.1932
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0133	0.072
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0074	0.0385	0.5103
Schistosoma mansoni	aldehyde dehydrogenase	0.0126	0.0747	0.0745
Trypanosoma brucei	PAB1-binding protein , putative	0.0054	0.0246	0.5516
Entamoeba histolytica	hypothetical protein	0.0156	0.0957	1
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0024	0.004	0.004
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.003	0.0519
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.009	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0435	0.1296
Schistosoma mansoni	aldehyde dehydrogenase	0.0126	0.0747	0.0745
Brugia malayi	AMP-binding enzyme family protein	0.0031	0.0085	0.0234
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0031	0.0085	0.1047
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0082	0.044	0.5849
Schistosoma mansoni	tar DNA-binding protein	0.0415	0.2757	0.2755
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0061	0.0297	0.0297
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0081	0.0435	0.0433
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0218	0.1387	0.4178
Entamoeba histolytica	hypothetical protein	0.0156	0.0957	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0031	0.0085	0.1047
Schistosoma mansoni	hypothetical protein	0.0357	0.2352	0.235
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0022	0.0024	0.0711
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0095	0.0536	0.0536
Schistosoma mansoni	lamin	0.0083	0.0446	0.0444
Echinococcus multilocularis	lamin	0.0083	0.0446	0.0446
Mycobacterium ulcerans	acyl-CoA synthetase	0.0105	0.0599	0.7988
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0169	0.1049	0.1049
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0156	0.0957	0.0957
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0031	0.0085	0.1047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0088	0.046
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.004	0.0147	0.0147
Trypanosoma brucei	glucosidase, putative	0.0038	0.0133	0.2898
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0022	0.0024	0.0401
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0139	0.0398
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0024	0.0049
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0044	0.0044
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0133	0.072
Trypanosoma cruzi	PAB1-binding protein , putative	0.0054	0.0246	0.5516
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0023	0.003	0.0304
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0082	0.044	0.4558
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0031	0.0085	0.0234
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0069	0.0352
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0031	0.0085	0.1047
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0105	0.0599	0.7988
Trypanosoma cruzi	PAB1-binding protein , putative	0.0054	0.0246	0.5516
Schistosoma mansoni	lamin	0.0083	0.0446	0.0444
Echinococcus multilocularis	neuropeptide receptor A26	0.0981	0.6688	0.6688
Leishmania major	importin beta-1 subunit, putative	0.0024	0.004	0.043
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0082	0.044	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0069	0.0351	0.0351
Mycobacterium tuberculosis	PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0056	0.0646
Entamoeba histolytica	acyl-coA synthetase, putative	0.0105	0.0599	0.6225
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0031	0.0085	0.0967
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0095	0.0536	0.0536
Schistosoma mansoni	alpha-glucosidase	0.0146	0.0885	0.0883
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0024	0.0377
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0031	0.0085	0.1047
Mycobacterium leprae	POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE)	0.0031	0.0085	0.0967
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0126	0.0747	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0082	0.044	0.2483
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.009	0.0473
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0038	0.0133	0.072
Echinococcus multilocularis	tar DNA binding protein	0.0415	0.2757	0.2757
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0495	0.3309	1
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0023	0.003	0.0304
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0105	0.0599	0.7988
Echinococcus multilocularis	geminin	0.0357	0.2352	0.2352
Echinococcus multilocularis	zinc finger protein	0.0022	0.0022	0.0022
Plasmodium falciparum	ataxin-2 like protein, putative	0.0054	0.0246	0.5862
Schistosoma mansoni	importin beta-1	0.003	0.0079	0.0077
Loa Loa (eye worm)	RNA binding protein	0.0415	0.2757	0.8327
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0053	0.0237	0.5304
Brugia malayi	hypothetical protein	0.0054	0.0246	0.0723
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0053	0.0237	0.3102
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0069	0.0352
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0436	0.1298
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0105	0.0599	0.6225
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0082	0.044	0.5849
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0053	0.0239	0.0237
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0053	0.0237	0.1317
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0053	0.0237	0.1317
Brugia malayi	Inositol-1	0.0082	0.044	0.131
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0351	0.1043
Schistosoma mansoni	tar DNA-binding protein	0.0415	0.2757	0.2755
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0038	0.0133	0.0133
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0031	0.0085	0.0237
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0105	0.0599	0.6225
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0095	0.0536	0.1598
Schistosoma mansoni	microtubule-associated protein tau	0.1458	1	1
Schistosoma mansoni	hypothetical protein	0.0023	0.003	0.0027
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0031	0.0085	0.0234
Loa Loa (eye worm)	intermediate filament protein	0.0083	0.0446	0.133
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0008	0.0003
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0095	0.0536	0.0536
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.004	0.0183
Mycobacterium ulcerans	acyl-CoA synthetase	0.0031	0.0085	0.1047
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.004	0.0183
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0023	0.003	0.0304
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0042	0.0163	0.2095
Plasmodium vivax	acyl-CoA synthetase, putative	0.0078	0.0415	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0139	0.0836	0.2511
Leishmania major	acetyl-CoA synthetase, putative	0.0031	0.0085	0.1047
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0081	0.0435	0.1294
Plasmodium vivax	SET domain protein, putative	0.0034	0.0109	0.2474
Leishmania major	phosphopantetheinyl transferase-like protein	0.0023	0.003	0.0304
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0063	0.0312	0.0309
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0126	0.0747	1
Giardia lamblia	GTOR	0.0053	0.0237	1
Schistosoma mansoni	tar DNA-binding protein	0.0415	0.2757	0.2755
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0088	0.046
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0079	0.0959
Leishmania major	acetyl-CoA synthetase, putative	0.0031	0.0085	0.1047
Brugia malayi	follicle stimulating hormone receptor	0.0495	0.3309	1
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.0024	0.0377
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0053	0.0237	0.5304
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0008	0.0008
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0144	0.078
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0239	0.0702
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0415	0.1235
Loa Loa (eye worm)	jmjC domain-containing protein	0.0063	0.0312	0.0922
Echinococcus granulosus	lamin dm0	0.0083	0.0446	0.0446
Schistosoma mansoni	intermediate filament proteins	0.0083	0.0446	0.0444
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0156	0.0957	0.0957
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0038	0.0133	0.1321
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0031	0.0085	0.179
Mycobacterium ulcerans	acyl-CoA synthetase	0.0031	0.0085	0.1047
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0183	0.0534
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0031	0.0085	0.1047
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0044	0.018	0.0523
Leishmania major	4-coumarate:coa ligase-like protein	0.0105	0.0599	0.7988
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0069	0.0351	0.0351
Onchocerca volvulus		0.0083	0.0446	0.2169
Toxoplasma gondii	LsmAD domain-containing protein	0.0054	0.0246	0.3226
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0069	0.0351	0.0351
Echinococcus granulosus	neuropeptide s receptor	0.0981	0.6688	0.6688
Onchocerca volvulus		0.0034	0.0109	0.014
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0044	0.0044
Plasmodium falciparum	ataxin-2 like protein, putative	0.0054	0.0246	0.5862
Schistosoma mansoni	zinc finger protein	0.0022	0.0022	0.0019
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0039	0.0144	0.1836
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0415	0.1235
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0599	0.1791
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0024	0.0052
Echinococcus multilocularis	snurportin 1	0.0318	0.208	0.208
Schistosoma mansoni	hypothetical protein	0.0024	0.004	0.0038
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0163	0.0888
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0085	0.0237
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0078	0.0415	0.5504
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0031	0.0085	0.1047
Schistosoma mansoni	ran	0.0022	0.0024	0.0022
Schistosoma mansoni	hypothetical protein	0.0069	0.0351	0.0349
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0038	0.0133	0.072

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 700894