Detailed information for compound 700982

Basic information

Technical information
  • TDR Targets ID: 700982
  • Name: N-(3,4-difluorophenyl)-2-[[1-(2-dimethylamino ethyl)-2-oxo-5,6,7,8-tetrahydroquinazolin-4-y l]sulfanyl]acetamide
  • MW: 422.492 | Formula: C20H24F2N4O2S
  • H donors: 1 H acceptors: 2 LogP: 2.75 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCn1c(=O)nc(c2c1CCCC2)SCC(=O)Nc1ccc(c(c1)F)F)C
  • InChi: 1S/C20H24F2N4O2S/c1-25(2)9-10-26-17-6-4-3-5-14(17)19(24-20(26)28)29-12-18(27)23-13-7-8-15(21)16(22)11-13/h7-8,11H,3-6,9-10,12H2,1-2H3,(H,23,27)
  • InChiKey: SJQTZGPUWMNUQO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3,4-difluorophenyl)-2-[[1-(2-dimethylaminoethyl)-2-oxo-5,6,7,8-tetrahydroquinazolin-4-yl]thio]acetamide
  • N-(3,4-difluorophenyl)-2-[[1-(2-dimethylaminoethyl)-2-keto-5,6,7,8-tetrahydroquinazolin-4-yl]thio]acetamide
  • N-(3,4-difluorophenyl)-2-[[1-(2-dimethylaminoethyl)-2-oxo-5,6,7,8-tetrahydroquinazolin-4-yl]sulfanyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni aldehyde dehydrogenase 0.0195 0.1058 0.1058
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0142 0.027
Toxoplasma gondii hypothetical protein 0.0225 0.124 1
Entamoeba histolytica Ran family GTPase 0.0021 0.0019 0.0029
Echinococcus granulosus intermediate filament protein 0.0058 0.0241 0.0241
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0012 0.0012
Mycobacterium tuberculosis Probable lipase LipD 0.008 0.0371 0.0365
Echinococcus multilocularis GPCR, family 2 0.0089 0.0423 0.0423
Brugia malayi Latrophilin receptor protein 2 0.0089 0.0423 0.0423
Mycobacterium tuberculosis Probable hydrolase 0.008 0.0371 0.0365
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0012 0.0012
Brugia malayi Muscleblind-like protein 0.0322 0.1823 0.1823
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0199 0.1083 0.1083
Echinococcus granulosus peregrin 0.0046 0.0168 0.0168
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.014 0.0382
Plasmodium falciparum pyruvate kinase 0.0037 0.0113 0.0872
Mycobacterium ulcerans aldehyde dehydrogenase 0.0195 0.1058 0.4673
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0012 0.0012
Echinococcus multilocularis phd:f box containing protein 0.0028 0.0057 0.0057
Onchocerca volvulus 0.008 0.0371 0.0371
Brugia malayi beta-lactamase 0.008 0.0371 0.0371
Trypanosoma brucei unspecified product 0.0021 0.002 0.0042
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.002 0.0042
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0425 0.2442 0.2442
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0012 0.0012
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0154 0.0818 0.0818
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0109 0.0547 0.0547
Echinococcus multilocularis muscleblind protein 1 0.0322 0.1823 0.1823
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0225 0.124 0.124
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0168 0.3004
Schistosoma mansoni hypothetical protein 0.0339 0.1922 0.1922
Echinococcus multilocularis geminin 0.0325 0.1839 0.1839
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0032 0.0081 0.0081
Schistosoma mansoni protein phosphatase 2C 0.0028 0.0057 0.0057
Loa Loa (eye worm) beta-lactamase 0.008 0.0371 0.0371
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.002 0.0015
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0241 0.0241
Entamoeba histolytica hypothetical protein 0.0101 0.0496 0.1037
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0057 0.0146
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0012 0.0012
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0142 0.1105
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.008 0.0371 0.0365
Chlamydia trachomatis neutral amino acid transporter 0.0747 0.4372 0.4308
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0142 0.027
Mycobacterium tuberculosis Conserved protein 0.008 0.0371 0.0365
Onchocerca volvulus 0.0023 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0225 0.124 0.124
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0142 0.0142
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0053 0.0212 0.0587
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0028 0.0057 0.042
Echinococcus multilocularis dna polymerase eta 0.0021 0.002 0.002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0021 0.0021
Schistosoma mansoni phd/f-box containing protein 0.0028 0.0057 0.0057
Brugia malayi jmjC domain containing protein 0.0028 0.0057 0.0057
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.006 0.006
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0012 0.0012
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0142 0.027
Entamoeba histolytica hypothetical protein 0.0101 0.0496 0.1037
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0606 0.3522 0.3522
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0012 0.0012
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0142 0.027
Onchocerca volvulus 0.0118 0.0598 0.0598
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0006 0.0006
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0606 0.3522 1
Echinococcus granulosus excitatory amino acid transporter 2 0.1686 1 1
Mycobacterium tuberculosis Probable esterase LipL 0.008 0.0371 0.0365
Loa Loa (eye worm) hypothetical protein 0.008 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.0225 0.124 0.124
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0012 0.0012
Onchocerca volvulus 0.002 0.0012 0.0012
Brugia malayi Thioredoxin reductase 0.0038 0.0121 0.0121
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1659 0.4702
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0012
Brugia malayi steroid hormone receptor 0.002 0.0012 0.0012
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0753 0.4408 0.4408
Loa Loa (eye worm) hypothetical protein 0.008 0.0371 0.0371
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0121 0.0115
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0188 0.1018 0.1018
Brugia malayi jmjC domain containing protein 0.0028 0.0057 0.0057
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0371 0.0726
Echinococcus granulosus pyruvate kinase 0.0037 0.0113 0.0113
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0169 0.0907 0.0907
Schistosoma mansoni cpg binding protein 0.0071 0.0317 0.0317
Echinococcus granulosus GPCR family 2 0.0089 0.0423 0.0423
Leishmania major importin beta-1 subunit, putative 0.0046 0.0169 0.0465
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0142 0.027
Loa Loa (eye worm) RNA binding protein 0.0135 0.0701 0.0701
Echinococcus granulosus lysine specific demethylase 6a 0.0028 0.0057 0.0057
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0371 0.0726
Echinococcus granulosus sodium:dicarboxylate symporter 0.1686 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0225 0.124 0.124
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0169 0.0907 0.0907
Echinococcus multilocularis carbonic anhydrase 0.0225 0.124 0.124
Loa Loa (eye worm) hypothetical protein 0.0191 0.1039 0.1039
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0057 0.0057
Toxoplasma gondii thioredoxin reductase 0.0038 0.0121 0.0939
Echinococcus granulosus neuropeptide s receptor 0.0455 0.2619 0.2619
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0192 0.0192
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0121 0.2139
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0059 0.0989
Echinococcus granulosus cpg binding protein 0.0075 0.0341 0.0341
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.005 0.0192 0.0192
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0425 0.2442 0.2442
Brugia malayi follicle stimulating hormone receptor 0.0504 0.2912 0.2912
Loa Loa (eye worm) CXXC zinc finger family protein 0.0071 0.0317 0.0317
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0808 0.4733 0.9407
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0012 0.0012
Schistosoma mansoni thyroid hormone receptor 0.002 0.0012 0.0012
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.0415 0.041
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0121 0.0328
Trypanosoma brucei hypothetical protein, conserved 0.008 0.0371 0.1038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0012 0.0012
Echinococcus multilocularis muscleblind protein 0.0322 0.1823 0.1823
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0195 0.1058 0.1058
Brugia malayi nuclear hormone receptor 0.002 0.0012 0.0012
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0113 0.0213
Schistosoma mansoni hypothetical protein 0.0097 0.0471 0.0471
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0053 0.0212 0.0587
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0012 0.0012
Echinococcus multilocularis Excitatory amino acid transporter 0.1686 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0169 0.0907 0.0907
Echinococcus multilocularis neutral amino acid transporter A 0.1686 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.028 0.1571 0.1571
Schistosoma mansoni hypothetical protein 0.061 0.3545 0.3545
Onchocerca volvulus 0.0097 0.0471 0.0471
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0511 0.2952 0.2948
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0039 0.0066
Schistosoma mansoni hypothetical protein 0.0046 0.0168 0.0168
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.002 0.002
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0012 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0042
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0747 0.4372 0.4372
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.002 0.0031
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0221 0.1216 0.1216
Echinococcus granulosus JmjC domain containing protein 4 0.0028 0.0057 0.0057
Brugia malayi latrophilin 2 splice variant baaae 0.0191 0.1039 0.1039
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0169 0.0325
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0021 0.0021
Trichomonas vaginalis chromobox protein, putative 0.0052 0.0201 0.0389
Loa Loa (eye worm) hypothetical protein 0.0055 0.0222 0.0222
Echinococcus multilocularis dna polymerase kappa 0.0021 0.002 0.002
Schistosoma mansoni cpg binding protein 0.0075 0.0341 0.0341
Schistosoma mansoni alpha-glucosidase 0.0162 0.0861 0.0861
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0195 0.1058 0.1058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0012 0.0012
Onchocerca volvulus 0.0109 0.0543 0.0543
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0012 0.0012
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0079 0.0079
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0169 0.0907 0.0907
Loa Loa (eye worm) glutathione reductase 0.0038 0.0121 0.0121
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0039 0.0066
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0747 0.4372 0.4372
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0371 0.0726
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.1659 0.4702
Brugia malayi beta-lactamase family protein 0.008 0.0371 0.0371
Echinococcus granulosus beta LACTamase domain containing family member 0.008 0.0371 0.0371
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0113 0.1986
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.0101 0.0496 0.1037
Echinococcus granulosus dna polymerase eta 0.0021 0.002 0.002
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0012 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0371 0.1038
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0135 0.0701 0.0701
Schistosoma mansoni jumonji/arid domain-containing protein 0.0108 0.0536 0.0536
Echinococcus multilocularis PHD finger protein rhinoceros 0.0046 0.0168 0.0168
Brugia malayi jmjC domain containing protein 0.0028 0.0057 0.0057
Toxoplasma gondii PHD-finger domain-containing protein 0.0046 0.0168 0.1319
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0019 0.0019
Echinococcus multilocularis carbonic anhydrase 0.0225 0.124 0.124
Giardia lamblia DINP protein human, muc B family 0.0021 0.002 0.0032
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0701 0.0701
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0823 0.0817
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0195 0.1058 0.1052
Brugia malayi Bromodomain containing protein 0.0046 0.0168 0.0168
Brugia malayi MH2 domain containing protein 0.0258 0.1435 0.1435
Brugia malayi glutathione reductase 0.0038 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.028 0.1571 0.1571
Schistosoma mansoni carbonic anhydrase-related 0.0225 0.124 0.124
Brugia malayi Calcitonin receptor-like protein seb-1 0.028 0.1571 0.1571
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0012 0.0012
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.008 0.0371 0.0371
Trichomonas vaginalis esterase, putative 0.008 0.0371 0.0726
Echinococcus granulosus PHD finger protein rhinoceros 0.0046 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0322 0.1823 0.1823
Giardia lamblia PHD finger protein 15 0.0046 0.0168 0.0345
Loa Loa (eye worm) hypothetical protein 0.0028 0.006 0.006
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0104 0.0514 0.0514
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.002 0.002
Schistosoma mansoni myelin transcription factor 1 myt1 0.0063 0.0268 0.0268
Echinococcus multilocularis Excitatory amino acid transporter 0.1686 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0028
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0221 0.1216 0.1216
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0046 0.0168 0.0168
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0234 0.0649
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.002 0.0042
Schistosoma mansoni alpha glucosidase 0.0042 0.0142 0.0142
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0053 0.0212 0.0212
Brugia malayi F/Y-rich N-terminus family protein 0.0041 0.0136 0.0136
Loa Loa (eye worm) jmjC domain-containing protein 0.0095 0.0462 0.0462
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0055 0.0222 0.0222
Plasmodium falciparum phd finger protein, putative 0.0046 0.0168 0.1319
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0012 0.0012
Brugia malayi mbt repeat family protein 0.0055 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0028 0.0057 0.0057
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1686 1 1
Brugia malayi PHD-finger family protein 0.0019 0.0006 0.0006
Echinococcus multilocularis carbonic anhydrase II 0.0606 0.3522 0.3522
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.0474 0.0468
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0055 0.0222 0.0222
Echinococcus granulosus SAM and MBT domain containing protein 0.0055 0.0222 0.0222
Toxoplasma gondii histone lysine methyltransferase SET1 0.0138 0.0721 0.5801
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.0474 0.0468
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0012
Schistosoma mansoni jumonji domain containing protein 0.0168 0.0897 0.0897
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0169 0.0907 0.0907
Onchocerca volvulus 0.0121 0.0615 0.0615
Leishmania major DNA polymerase eta, putative 0.0021 0.002 0.0042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0808 0.4733 0.9407
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.002 0.0042
Brugia malayi hypothetical protein 0.0101 0.0496 0.0496
Echinococcus granulosus neutral amino acid transporter 0.1686 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0371 0.1038
Echinococcus granulosus chromobox protein 1 0.0052 0.0201 0.0201
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0031 0.0078 0.0078
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1686 1 1
Brugia malayi chromobox protein homolog 3 0.0029 0.0065 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0012 0.0012
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0028 0.0057 0.0057
Echinococcus multilocularis tumor protein p63 0.0342 0.1942 0.1942
Brugia malayi jmjC domain containing protein 0.0199 0.1083 0.1083
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0371 0.0371
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.002 0.002
Loa Loa (eye worm) latrophilin receptor protein 2 0.0089 0.0423 0.0423
Echinococcus granulosus carbonic anhydrase 0.0225 0.124 0.124
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0169 0.0465
Schistosoma mansoni carbonic anhydrase-related 0.0225 0.124 0.124
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0234 0.0649
Onchocerca volvulus 0.0071 0.0317 0.0317
Schistosoma mansoni hypothetical protein 0.0089 0.0423 0.0423
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0856 0.5024 0.5024
Plasmodium vivax glutathione reductase, putative 0.0038 0.0121 0.2139
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0012 0.0012
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0008 0.005
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0121 0.0121
Brugia malayi Pre-SET motif family protein 0.0109 0.0547 0.0547
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0026 0.0046 0.0046
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0028 0.0057 0.042
Toxoplasma gondii PHD-finger domain-containing protein 0.0046 0.0168 0.1319
Mycobacterium tuberculosis Conserved protein 0.008 0.0371 0.0365
Loa Loa (eye worm) TAR-binding protein 0.0135 0.0701 0.0701
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0471 0.0471
Echinococcus granulosus muscleblind protein 0.0322 0.1823 0.1823
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0012 0.0012
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0059 0.0151
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0012 0.0012
Brugia malayi beta-lactamase family protein 0.008 0.0371 0.0371
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0118 0.0598 0.0598
Echinococcus granulosus jumonji domain containing 1A 0.0028 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0012
Echinococcus granulosus pyruvate kinase 0.0037 0.0113 0.0113
Onchocerca volvulus 0.008 0.0371 0.0371
Mycobacterium ulcerans hypothetical protein 0.008 0.0371 0.1621
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0012 0.0012
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0241 0.0241
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0012 0.0012
Onchocerca volvulus 0.0857 0.5031 0.5031
Plasmodium falciparum thioredoxin reductase 0.0038 0.0121 0.0939
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0113 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0142 0.0386
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0225 0.124 0.124
Echinococcus granulosus dnaJ subfamily B 0.067 0.391 0.391
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0053 0.0212 0.0212
Echinococcus multilocularis survival motor neuron protein 1 0.0474 0.2731 0.2731
Onchocerca volvulus 0.0058 0.0241 0.0241
Treponema pallidum glutamate transporter 0.0747 0.4372 0.9237
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0606 0.3522 0.3522
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0065 0.0119
Loa Loa (eye worm) hypothetical protein 0.0092 0.0442 0.0442
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0199 0.1083 0.1083
Echinococcus granulosus tumor protein p63 0.0342 0.1942 0.1942
Echinococcus multilocularis histone acetyltransferase MYST2 0.0063 0.0268 0.0268
Plasmodium falciparum carbonic anhydrase 0.0225 0.124 1
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0008 0.0022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0039 0.0066
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.0415 0.041
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0142 0.027
Echinococcus granulosus carbonic anhydrase II 0.0606 0.3522 0.3522
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0054 0.0054
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0142 0.0386
Echinococcus granulosus Excitatory amino acid transporter 0.1686 1 1
Schistosoma mansoni hypothetical protein 0.0325 0.1839 0.1839
Leishmania major GTP-binding protein, putative 0.0021 0.0019 0.0039
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0395 0.2257 1
Brugia malayi hypothetical protein 0.0474 0.2731 0.2731
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0053 0.0212 0.0212
Echinococcus multilocularis pyruvate kinase 0.0019 0.0005 0.0005
Plasmodium vivax hypothetical protein, conserved 0.008 0.0371 0.674
Loa Loa (eye worm) MH2 domain-containing protein 0.0258 0.1435 0.1435
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0195 0.1058 0.2991
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0053 0.0212 0.0587
Schistosoma mansoni transcription factor LCR-F1 0.0101 0.0496 0.0496
Mycobacterium tuberculosis Probable reductase 0.0087 0.0415 0.041
Loa Loa (eye worm) jmjC domain-containing protein 0.0108 0.0536 0.0536
Loa Loa (eye worm) hypothetical protein 0.0028 0.0057 0.0057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0169 0.0907 0.0907
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.014 0.0382
Schistosoma mansoni hypothetical protein 0.0089 0.0423 0.0423
Loa Loa (eye worm) hypothetical protein 0.0063 0.0268 0.0268
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.061 0.3545 0.3545
Echinococcus multilocularis neuropeptide s receptor 0.0455 0.2619 0.2619
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0808 0.4733 0.9407
Schistosoma mansoni pyruvate kinase 0.0037 0.0113 0.0113
Schistosoma mansoni cpg binding protein 0.0075 0.0341 0.0341
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0142 0.027
Plasmodium vivax JmjC domain containing protein 0.0028 0.0057 0.0956
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0234 0.0234
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0089 0.0423 0.0423
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0032 0.0081 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0012 0.0012
Brugia malayi intermediate filament protein 0.0058 0.0241 0.0241
Schistosoma mansoni DNA polymerase eta 0.0021 0.002 0.002
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.008 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.0322 0.1823 0.1823
Brugia malayi RNA binding protein 0.0135 0.0701 0.0701
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0109 0.0547 0.0547
Trypanosoma brucei trypanothione reductase 0.0038 0.0121 0.0328
Echinococcus multilocularis dnaJ subfamily B 0.067 0.391 0.391
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0006 0.001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0047 0.0047
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0808 0.4733 0.9407
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.1018 0.1018
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0425 0.2442 0.2442
Echinococcus multilocularis jumonji domain containing 1A 0.0028 0.0057 0.0057
Loa Loa (eye worm) carbonic anhydrase 3 0.0606 0.3522 0.3522
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0089 0.0423 0.0423
Echinococcus granulosus dna polymerase kappa 0.0021 0.002 0.002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0047 0.0047
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.014 0.0382
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.0415 0.041
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0142 0.027
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.002
Mycobacterium ulcerans beta-lactamase 0.008 0.0371 0.1621
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0012 0.0012
Mycobacterium ulcerans aldehyde dehydrogenase 0.0195 0.1058 0.4673
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0006 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0012 0.0012
Echinococcus multilocularis musashi 0.0058 0.0241 0.0241
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0142 0.0142
Brugia malayi hypothetical protein 0.0028 0.0059 0.0059
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0225 0.124 0.124
Schistosoma mansoni phosphatidylserine receptor 0.0028 0.0057 0.0057
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.008 0.0371 0.0365
Loa Loa (eye worm) mbt repeat family protein 0.0055 0.0222 0.0222
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0747 0.4372 0.4372
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0169 0.0325
Echinococcus granulosus snurportin 1 0.061 0.3545 0.3545
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0371 0.0726
Loa Loa (eye worm) hypothetical protein 0.0089 0.0423 0.0423
Brugia malayi Pre-SET motif family protein 0.0753 0.4408 0.4408
Echinococcus multilocularis neuropeptide receptor A26 0.0455 0.2619 0.2619
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.0415 0.141
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0808 0.4733 0.9407
Brugia malayi nuclear receptor NHR-88 0.002 0.0012 0.0012
Loa Loa (eye worm) MBCTL1 0.0063 0.0268 0.0268
Echinococcus granulosus Excitatory amino acid transporter 0.1686 1 1
Schistosoma mansoni lamin 0.0058 0.0241 0.0241
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0169 0.0907 0.0907
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0042
Echinococcus multilocularis jumonji domain containing protein 0.0064 0.0276 0.0276
Schistosoma mansoni carbonic anhydrase-related 0.0225 0.124 0.124
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0728 0.2054
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.0046 0.0169 0.0346
Brugia malayi jmjC domain containing protein 0.0028 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0057 0.0234 0.0234
Schistosoma mansoni jumonji/arid domain-containing protein 0.0108 0.0536 0.0536
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0012
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0053 0.0212 0.0437
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0039 0.0066
Trichomonas vaginalis chromobox protein, putative 0.0052 0.0201 0.0389
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0606 0.3522 0.3522
Echinococcus granulosus carbonic anhydrase 0.0225 0.124 0.124
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.0415 0.041
Loa Loa (eye worm) PHD-finger family protein 0.0046 0.0168 0.0168
Echinococcus granulosus lysosomal alpha glucosidase 0.0188 0.1018 0.1018
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0012
Loa Loa (eye worm) heterochromatin protein 1 0.0052 0.0201 0.0201
Trichomonas vaginalis set domain proteins, putative 0.0857 0.5031 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0019 0.0019
Mycobacterium leprae Probable lipase LipE 0.008 0.0371 0.1202
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0042
Echinococcus multilocularis polycomb protein SCMH1 0.0055 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0225 0.124 0.124
Echinococcus multilocularis carbonic anhydrase 0.0225 0.124 0.124
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0053 0.0212 0.0212
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0012 0.0012
Echinococcus granulosus histone acetyltransferase MYST2 0.0063 0.0268 0.0268
Schistosoma mansoni chromobox protein 0.0052 0.0201 0.0201
Mycobacterium ulcerans aldehyde dehydrogenase 0.0195 0.1058 0.4673
Echinococcus granulosus chromobox protein 1 0.0052 0.0201 0.0201
Schistosoma mansoni hypothetical protein 0.0101 0.0496 0.0496
Brugia malayi TAR-binding protein 0.0135 0.0701 0.0701
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0042
Leishmania major hypothetical protein, conserved 0.0028 0.0059 0.0151
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.002 0.0065
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0701 0.0701
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0012 0.0012
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0019 0.0039
Brugia malayi RNA recognition motif domain containing protein 0.0135 0.0701 0.0701
Echinococcus granulosus pyruvate kinase 0.0019 0.0005 0.0005
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0089 0.0423 0.0423
Echinococcus granulosus neuropeptide receptor A26 0.0455 0.2619 0.2619
Onchocerca volvulus Alhambra homolog 0.0046 0.0168 0.0168
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0728 0.2054
Entamoeba histolytica hypothetical protein 0.0101 0.0496 0.1037
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0089 0.0423 0.0423
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0371 0.0371
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0059 0.0434
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0113 0.0305
Schistosoma mansoni ran 0.0021 0.0019 0.0019
Echinococcus multilocularis pyruvate kinase 0.0019 0.0005 0.0005
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0019 0.0114
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0019 0.003
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0046 0.0046
Mycobacterium tuberculosis Conserved protein 0.008 0.0371 0.0365
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0042
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0225 0.124 0.124
Toxoplasma gondii exonuclease III APE 0.0019 0.0006 0.0005
Brugia malayi CXXC zinc finger family protein 0.0071 0.0317 0.0317
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0234 0.1852
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0012 0.0012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.002 0.0042
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0057 0.0057
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0225 0.124 0.124
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0059 0.0434
Loa Loa (eye worm) hypothetical protein 0.0046 0.0168 0.0168
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.008 0.0371 0.0371
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0039 0.0066
Onchocerca volvulus 0.008 0.0371 0.0371
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0142 0.0142
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0113 0.0113
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1686 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.002 0.0042
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0142 0.0287
Echinococcus granulosus tar DNA binding protein 0.0135 0.0701 0.0701
Leishmania major trypanothione reductase 0.0038 0.0121 0.0328
Brugia malayi PHD-finger family protein 0.0046 0.0168 0.0168
Mycobacterium ulcerans lipase LipD 0.008 0.0371 0.1621
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0101 0.0496 0.0496
Treponema pallidum glutamate/aspartate transporter 0.0747 0.4372 0.9237
Schistosoma mansoni hypothetical protein 0.0089 0.0423 0.0423
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0039 0.0066
Echinococcus granulosus lamin 0.0058 0.0241 0.0241
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.1018 0.1018
Trypanosoma brucei glucosidase, putative 0.0042 0.0142 0.0386
Loa Loa (eye worm) histone methyltransferase 0.0026 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0037 0.0113 0.0113
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0606 0.3522 0.3522
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0015 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0042
Mycobacterium tuberculosis Probable lipase LipE 0.008 0.0371 0.0365
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0113 0.0113
Echinococcus granulosus importin subunit beta 1 0.0057 0.0234 0.0234
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0222 0.0222
Echinococcus multilocularis chromobox protein 1 0.0052 0.0201 0.0201
Trichomonas vaginalis ran, putative 0.0021 0.0019 0.0027
Echinococcus multilocularis JmjC domain containing protein 4 0.0028 0.0057 0.0057
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.0474 0.1683
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0142 0.0386
Giardia lamblia Fructose-bisphosphate aldolase 0.0808 0.4733 1
Echinococcus multilocularis tar DNA binding protein 0.0135 0.0701 0.0701
Echinococcus multilocularis cpg binding protein 0.0075 0.0341 0.0341
Schistosoma mansoni alpha-glucosidase 0.0162 0.0861 0.0861
Loa Loa (eye worm) hypothetical protein 0.0121 0.0615 0.0615
Schistosoma mansoni coup transcription factor 0.002 0.0012 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0701 0.0701
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0012 0.0012
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0079 0.0079
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1659 0.4702
Mycobacterium leprae conserved hypothetical protein 0.008 0.0371 0.1202
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0113 0.0113
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0046 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0012 0.0012
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0728 0.2054
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0101 0.0496 0.0496
Plasmodium falciparum glutathione reductase 0.0038 0.0121 0.0939
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0113 0.0305
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0222 0.0222
Schistosoma mansoni thyroid hormone receptor 0.002 0.0012 0.0012
Plasmodium falciparum importin beta, putative 0.0057 0.0234 0.1852
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0065 0.0119
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0006 0.0001
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0059 0.0151
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0808 0.4733 0.9407
Leishmania major pyruvate kinase 0.0037 0.0113 0.0305
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0059 0.0151
Loa Loa (eye worm) transcription factor SMAD2 0.0258 0.1435 0.1435
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0142 0.0142
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0012 0.0012
Echinococcus multilocularis lamin 0.0058 0.0241 0.0241
Echinococcus multilocularis SAM and MBT domain containing protein 0.0055 0.0222 0.0222
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0042
Echinococcus granulosus jumonji domain containing protein 0.0064 0.0276 0.0276
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0029 0.0065 0.0065
Echinococcus granulosus geminin 0.0325 0.1839 0.1839
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0015 0.0018
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0028 0.0057 0.0146
Loa Loa (eye worm) hypothetical protein 0.0109 0.0547 0.0547
Echinococcus multilocularis neutral amino acid transporter A 0.1686 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0195 0.0537
Echinococcus multilocularis lysine specific demethylase 5A 0.0103 0.0512 0.0512
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0019 0.0019
Echinococcus granulosus polycomb protein SCMH1 0.0055 0.0222 0.0222
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0037 0.0111 0.0111
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.008 0.0371 0.1621
Schistosoma mansoni hypothetical protein 0.0325 0.1839 0.1839
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0019 0.0019
Echinococcus multilocularis transcription factor Dp 1 0.0031 0.0077 0.0077
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0113 0.0113
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0113 0.0113
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0142 0.027
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0109 0.0547 0.4392
Echinococcus granulosus lysine specific demethylase 5A 0.0108 0.0536 0.0536
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0012 0.0012
Loa Loa (eye worm) excitatory amino acid transporter 0.1686 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0006 0.0006
Treponema pallidum fructose-bisphosphate aldolase 0.0808 0.4733 1
Echinococcus multilocularis lamin dm0 0.0058 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.008 0.0371 0.0371
Echinococcus granulosus neutral amino acid transporter A 0.1686 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0012 0.0012
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0504 0.2912 0.2912
Schistosoma mansoni aldehyde dehydrogenase 0.0195 0.1058 0.1058
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0089 0.0423 0.0423
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0058 0.0241 0.0241
Leishmania major hypothetical protein, conserved 0.008 0.0371 0.1038
Giardia lamblia Pyruvate kinase 0.0037 0.0113 0.0228
Brugia malayi jmjC domain containing protein 0.0108 0.0536 0.0536
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0606 0.3522 1
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0012
Schistosoma mansoni survival motor neuron protein 0.0097 0.0471 0.0471
Onchocerca volvulus 0.0058 0.0241 0.0241
Echinococcus multilocularis pyruvate kinase 0.0029 0.0066 0.0066
Echinococcus multilocularis chromobox protein 1 0.0052 0.0201 0.0201
Schistosoma mansoni hypothetical protein 0.0089 0.0423 0.0423
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0109 0.0547 0.0547
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0113 0.0107
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0425 0.2442 0.2442
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0006 0.0005
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0012 0.0012
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.008 0.0371 0.0371
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0063 0.0268 0.0268
Trichomonas vaginalis chromobox protein, putative 0.0031 0.0078 0.0145
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.002 0.0065
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0701 0.0701
Trypanosoma brucei carbonic anhydrase-like protein 0.0606 0.3522 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0113 0.0305
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.0474 0.0468
Schistosoma mansoni lamin 0.0058 0.0241 0.0241
Brugia malayi ecdysteroid receptor 0.002 0.0012 0.0012
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.002 0.0042
Echinococcus multilocularis snurportin 1 0.061 0.3545 0.3545
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1686 1 1
Loa Loa (eye worm) hypothetical protein 0.0474 0.2731 0.2731
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0012 0.0012
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.002 0.002
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0701 0.0701
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1686 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0371 0.0726
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0012 0.0012
Leishmania major carbonic anhydrase-like protein 0.0606 0.3522 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0808 0.4733 0.9407
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0042
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.002 0.0029
Onchocerca volvulus 0.005 0.0192 0.0192
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0019 0.0039
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.002 0.002
Echinococcus multilocularis pyruvate kinase 0.0019 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0225 0.124 0.124
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0019 0.0039
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0039 0.0066
Echinococcus granulosus FTZ F1 alpha 0.002 0.0012 0.0012
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0113 0.0872
Echinococcus multilocularis excitatory amino acid transporter 3 0.1686 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.002 0.0042
Echinococcus granulosus phd:f box containing protein 0.0028 0.0057 0.0057
Leishmania major DNA polymerase kappa, putative 0.0021 0.002 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0012 0.0012
Toxoplasma gondii hypothetical protein 0.0048 0.0177 0.1389
Chlamydia trachomatis glutamate symporter 0.1686 1 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.002 0.002
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.1659 0.4702
Echinococcus multilocularis pyruvate kinase 0.0037 0.0113 0.0113
Mycobacterium ulcerans hypothetical protein 0.0155 0.0823 0.363
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0012 0.0012
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0606 0.3522 0.3522
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0241 0.0241
Schistosoma mansoni hypothetical protein 0.067 0.391 0.391
Echinococcus granulosus transcription factor Dp 1 0.0031 0.0077 0.0077
Brugia malayi Importin beta-1 subunit 0.0057 0.0234 0.0234
Schistosoma mansoni nuclear hormone receptor 0.002 0.0012 0.0012
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0012 0.0012
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0053 0.0212 0.0212
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0169 0.0907 0.0907
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0425 0.2442 0.2442
Echinococcus multilocularis neutral amino acid transporter A 0.1686 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0059 0.0059
Schistosoma mansoni pyruvate kinase 0.0019 0.0005 0.0005
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0006 0.0006
Toxoplasma gondii ABC1 family protein 0.008 0.0371 0.296
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.002 0.0042
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0808 0.4733 1
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0747 0.4372 0.4372
Loa Loa (eye worm) hypothetical protein 0.0029 0.0065 0.0065
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0395 0.2257 1
Brugia malayi Heterochromatin protein 1 0.0052 0.0201 0.0201
Schistosoma mansoni chromobox protein 0.0052 0.0201 0.0201
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.0415 0.041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0012 0.0012
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0113 0.0476
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0057 0.0146
Echinococcus granulosus pyruvate kinase 0.0019 0.0005 0.0005
Schistosoma mansoni ap endonuclease 0.0019 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0057 0.0235 0.0235
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0109 0.0547 0.0547
Plasmodium falciparum JmjC domain-containing protein, putative 0.0028 0.0057 0.042
Echinococcus granulosus carbonic anhydrase 0.0225 0.124 0.124
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0109 0.0547 0.0547
Brugia malayi Glycosyl hydrolases family 31 protein 0.0188 0.1018 0.1018
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0042
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.014 0.0382
Echinococcus granulosus excitatory amino acid transporter 3 0.1686 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0012
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.002 0.0015
Echinococcus granulosus histone lysine methyltransferase setb 0.0109 0.0547 0.0547
Echinococcus multilocularis beta LACTamase domain containing family member 0.008 0.0371 0.0371
Plasmodium vivax SET domain protein, putative 0.0109 0.0547 1
Leishmania major pyruvate kinase 0.0037 0.0113 0.0305
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1686 1 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0019 0.0114
Brugia malayi hypothetical protein 0.0121 0.0615 0.0615
Schistosoma mansoni carbonic anhydrase 0.0225 0.124 0.124
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0169 0.0325
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0169 0.0907 0.0907
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.028 0.1571 0.1571
Loa Loa (eye worm) hypothetical protein 0.008 0.0371 0.0371
Echinococcus granulosus excitatory amino acid transporter 2 0.1686 1 1
Echinococcus multilocularis pyruvate kinase 0.0037 0.0113 0.0113
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0124 0.0124
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0019 0.0261
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0012 0.0012
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0053 0.0212 0.0587
Echinococcus granulosus pyruvate kinase 0.0019 0.0005 0.0005
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.006 0.006
Schistosoma mansoni jumonji domain containing protein 0.0028 0.0057 0.0057
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0063 0.0268 0.0268
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0142 0.0287
Toxoplasma gondii aldehyde dehydrogenase 0.0195 0.1058 0.8524
Brugia malayi mbt repeat family protein 0.0055 0.0222 0.0222
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0012 0.0012
Plasmodium vivax importin-beta 2, putative 0.0057 0.0234 0.4218
Echinococcus multilocularis peregrin 0.0046 0.0168 0.0168
Echinococcus granulosus survival motor neuron protein 1 0.0474 0.2731 0.2731
Schistosoma mansoni ran 0.0021 0.0019 0.0019
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0059 0.0434
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.002 0.0042
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0012 0.0012
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0063 0.0268 0.0268
Leishmania major hypothetical protein, conserved 0.0028 0.0057 0.0146
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.002 0.0042
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.002 0.002
Brugia malayi RNA, U transporter 1 0.0162 0.0865 0.0865
Loa Loa (eye worm) hypothetical protein 0.0027 0.0054 0.0054
Mycobacterium tuberculosis Probable conserved lipoprotein 0.008 0.0371 0.0365
Mycobacterium ulcerans esterase/lipase LipP 0.008 0.0371 0.1621
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.002 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0012 0.0012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0039 0.0066
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0113 0.0305
Echinococcus granulosus neutral amino acid transporter A 0.1686 1 1
Schistosoma mansoni hypothetical protein 0.0191 0.1039 0.1039
Schistosoma mansoni importin beta-1 0.0057 0.0234 0.0234
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0808 0.4733 0.9407
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0395 0.2257 0.2252
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0021 0.0021
Echinococcus multilocularis excitatory amino acid transporter 2 0.1686 1 1
Echinococcus multilocularis excitatory amino acid transporter 2 0.1686 1 1
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0113 0.0113
Onchocerca volvulus 0.0055 0.0222 0.0222
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0012 0.0012
Echinococcus granulosus lamin dm0 0.0058 0.0241 0.0241
Trichomonas vaginalis chromobox protein, putative 0.0031 0.0078 0.0145
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0057 0.0057
Echinococcus multilocularis lysine specific demethylase 6a 0.0028 0.0057 0.0057
Schistosoma mansoni ap endonuclease 0.0019 0.0006 0.0006
Schistosoma mansoni intermediate filament proteins 0.0058 0.0241 0.0241
Schistosoma mansoni pyruvate kinase 0.0037 0.0113 0.0113
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0808 0.4733 1
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0113 0.0213

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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