TDR Targets

Basic information

Technical information

TDR Targets ID: 701006
Name: N-(4-chlorophenyl)-2-[[1-(2-morpholin-4-yleth yl)-2-oxo-5,6,7,8-tetrahydroquinazolin-4-yl]s ulfanyl]acetamide
MW: 462.993 | Formula: C22H27ClN4O3S
H donors: 1 H acceptors: 2 LogP: 2.81 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc(cc1)Cl)CSc1nc(=O)n(c2c1CCCC2)CCN1CCOCC1
InChi: 1S/C22H27ClN4O3S/c23-16-5-7-17(8-6-16)24-20(28)15-31-21-18-3-1-2-4-19(18)27(22(29)25-21)10-9-26-11-13-30-14-12-26/h5-8H,1-4,9-15H2,(H,24,28)
InChiKey: DCSZIKAPGYGBJD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-chlorophenyl)-2-[[1-(2-morpholinoethyl)-2-oxo-5,6,7,8-tetrahydroquinazolin-4-yl]sulfanyl]acetamide
N-(4-chlorophenyl)-2-[[1-(2-morpholinoethyl)-2-oxo-5,6,7,8-tetrahydroquinazolin-4-yl]thio]acetamide
N-(4-chlorophenyl)-2-[[2-keto-1-(2-morpholinoethyl)-5,6,7,8-tetrahydroquinazolin-4-yl]thio]acetamide
N-(4-chlorophenyl)-2-[[1-(2-morpholin-4-ylethyl)-2-oxo-5,6,7,8-tetrahydroquinazolin-4-yl]sulfanyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.003	0.0207	0.0243
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0158	0.0288
Brugia malayi	nuclear receptor NHR-88	0.003	0.0207	0.0377
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.0016	0.0017
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0046	0.0415	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0001	0.0002
Echinococcus granulosus	acetylcholinesterase	0.0062	0.0617	0.0726
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.0016	0.0029
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0251	0.3057	0.3603
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0021	0.0091	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0415	0.0755
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.0023	0.0042
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0061	0.114
Schistosoma mansoni	hypothetical protein	0.0015	0.0017	0.0018
Brugia malayi	nuclear hormone receptor family member odr-7	0.0014	0.0001	0.0002
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0017	0.0016
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0021	0.0091	0.0913
Echinococcus granulosus	microtubule associated protein 2	0.0672	0.8483	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0046	0.0415	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0392	0.0461
Echinococcus multilocularis	musashi	0.0026	0.0158	0.0157
Trypanosoma cruzi	cytochrome P450, putative	0.0039	0.0316	0.8175
Schistosoma mansoni	hypothetical protein	0.0033	0.0248	0.0291
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0061	0.1238
Echinococcus granulosus	geminin	0.0165	0.1945	0.2292
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0207	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0152	0.0277
Loa Loa (eye worm)	hypothetical protein	0.044	0.5492	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0061	0.1238
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0046	0.0415	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0635	0.1156
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0058	0.0106
Toxoplasma gondii	exonuclease III APE	0.0019	0.0058	0.0683
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0001	0.0002
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0016	0.0023	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0001	0.0002
Schistosoma mansoni	hypothetical protein	0.0165	0.1945	0.2292
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0021	0.0091	0.0913
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0016	0.0023	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0001	0.0002
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0021	0.0091	0.0913
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0061	0.0071
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.002	0.0074	0.2352
Loa Loa (eye worm)	steroid hormone receptor	0.003	0.0207	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0001	0.0002
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0021	0.0091	0.1876
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0058	0.1151
Schistosoma mansoni	lamin	0.0026	0.0158	0.0185
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0061	0.1238
Schistosoma mansoni	coup transcription factor	0.003	0.0207	0.0243
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.003	0.0207	0.0243
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0016	0.0023	0.0042
Echinococcus multilocularis	muscleblind protein	0.044	0.5492	0.5492
Trypanosoma brucei	DNA polymerase eta, putative	0.0044	0.0383	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0061	0.1238
Echinococcus multilocularis	lamin dm0	0.0026	0.0158	0.0157
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0061	0.114
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0061	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.003	0.0207	0.0206
Echinococcus granulosus	tissue type plasminogen activator	0.002	0.0074	0.0086
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0207	0.0377
Echinococcus granulosus	ecdysone induced protein 78C	0.003	0.0207	0.0243
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0016	0.0015
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0016	0.0015
Brugia malayi	Carboxylesterase family protein	0.0062	0.0617	0.1123
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0021	0.0091	0.1876
Onchocerca volvulus		0.0046	0.0415	0.2471
Leishmania major	4-coumarate:coa ligase-like protein	0.0046	0.0415	1
Leishmania major	DNA polymerase eta, putative	0.0044	0.0383	0.9209
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0001	0.0002
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0021	0.0091	0.0913
Echinococcus multilocularis		0.0021	0.0091	0.009
Brugia malayi	Kringle domain containing protein	0.002	0.0074	0.0135
Brugia malayi	cytochrome P450	0.0021	0.0091	0.0165
Brugia malayi	tailless protein	0.0014	0.0001	0.0002
Echinococcus granulosus	carboxylesterase 5A	0.0062	0.0617	0.0726
Echinococcus multilocularis	muscleblind protein 1	0.044	0.5492	0.5492
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0415	0.0755
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0061	0.006
Trypanosoma cruzi	DNA polymerase eta, putative	0.0031	0.0215	0.5422
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0207	0.0377
Mycobacterium ulcerans	acyl-CoA synthetase	0.0046	0.0415	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0447	0.0815
Loa Loa (eye worm)	cytochrome P450 family protein	0.0039	0.0316	0.0576
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0001	0.0002
Schistosoma mansoni	lamin	0.0026	0.0158	0.0185
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0239	0.5604
Brugia malayi	Cytochrome P450 family protein	0.0039	0.0316	0.0576
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0021	0.0091	0.0913
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0061	0.0071
Schistosoma mansoni	steroid hormone receptor ad4bp	0.003	0.0207	0.0243
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0021	0.0091	0.1876
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0264	0.048
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.0016	0.0029
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0392	0.0391
Loa Loa (eye worm)	hypothetical protein	0.002	0.0074	0.0135
Brugia malayi	hypothetical protein	0.0016	0.0023	0.0042
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0021	0.0091	0.1876
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0021	0.0091	0.1876
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0021	0.0091	0.1876
Brugia malayi	Steroid receptor seven-up type 2	0.003	0.0207	0.0377
Loa Loa (eye worm)	hypothetical protein	0.003	0.0207	0.0377
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.003	0.0207	0.0243
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0017	0.0031
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.1326	0.2414
Echinococcus multilocularis	geminin	0.0165	0.1945	0.1944
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.003	0.0207	0.0377
Echinococcus granulosus	GPCR family 2	0.0015	0.0017	0.0018
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0058	0.5
Trypanosoma cruzi	cytochrome P450, putative	0.0039	0.0316	0.8175
Leishmania major	cytochrome p450-like protein	0.0021	0.0091	0.1876
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0061	0.1238
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.003	0.0207	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0023	0.0042
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0447	0.0815
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0021	0.0091	0.0913
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0016	0.0015
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0021	0.0091	0.1876
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0001	0.0002
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0392	0.0713
Loa Loa (eye worm)	carboxylesterase	0.0062	0.0617	0.1123
Brugia malayi	Nuclear hormone receptor E75	0.0014	0.0001	0.0002
Echinococcus multilocularis	tissue type plasminogen activator	0.002	0.0074	0.0073
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.003	0.0207	0.0206
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0281	0.3447	0.3446
Trypanosoma cruzi	hypothetical protein, conserved	0.002	0.0074	0.1587
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0016	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0447	0.0815
Brugia malayi	Cytochrome P450 family protein	0.0039	0.0316	0.0576
Brugia malayi	AMP-binding enzyme family protein	0.0046	0.0415	0.0755
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0058	0.106
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0021	0.0091	0.0913
Brugia malayi	ecdysteroid receptor	0.003	0.0207	0.0377
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0158	0.0288
Loa Loa (eye worm)	hypothetical protein	0.044	0.5492	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.003	0.0207	0.0377
Onchocerca volvulus		0.0026	0.0158	0.0938
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0617	0.1123
Schistosoma mansoni	hypothetical protein	0.0251	0.3057	0.3603
Echinococcus multilocularis	neuropeptide receptor A26	0.045	0.5624	0.5624
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0021	0.0091	0.0913
Brugia malayi	Nuclear hormone receptor E75	0.0014	0.0001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0023	0.0042
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0061	0.1238
Mycobacterium ulcerans	hypothetical protein	0.0046	0.0415	1
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0021	0.0091	0.2037
Leishmania major	DNA polymerase eta, putative	0.0031	0.0215	0.4993
Loa Loa (eye worm)	hypothetical protein	0.003	0.0207	0.0377
Brugia malayi	orphan nuclear receptor NR2E1	0.0014	0.0001	0.0002
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0021	0.0091	0.0913
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0017	0.0016
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0058	0.0067
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0207	0.0243
Plasmodium vivax	acyl-CoA synthetase, putative	0.0035	0.0264	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.003	0.0207	0.0206
Brugia malayi	hypothetical protein	0.0014	0.0001	0.0002
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0021	0.0091	0.0913
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.003	0.0207	0.0243
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.003	0.0207	0.0377
Mycobacterium ulcerans	acyl-CoA synthetase	0.0046	0.0415	1
Echinococcus granulosus	lamin dm0	0.0026	0.0158	0.0185
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0392	0.0461
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0061	0.1238
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0046	0.0415	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0023	0.0042
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0061	0.1238
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0021	0.0091	0.0913
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0039	0.0316	0.7235
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0017	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0043	0.0078
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0061	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0264	0.048
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0021	0.0091	0.0913
Echinococcus granulosus	acetylcholinesterase	0.0062	0.0617	0.0726
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0014	0.0001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0264	0.048
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0061	0.0089
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0061	0.114
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0239	0.5604
Toxoplasma gondii	hypothetical protein	0.0063	0.0635	1
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0016	0.0015
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.0023	0.0042
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0021	0.0091	0.0913
Onchocerca volvulus	Protein ultraspiracle homolog	0.003	0.0207	0.1229
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0635	0.1156
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.003	0.0207	0.0243
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0061	0.1238
Schistosoma mansoni	cytochrome P450	0.0021	0.0091	0.0106
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0021	0.0091	0.2037
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0058	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0017	0.0031
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0021	0.0091	0.0913
Schistosoma mansoni	hypothetical protein	0.0015	0.0017	0.0018
Loa Loa (eye worm)	hypothetical protein	0.003	0.0207	0.0377
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.003	0.0207	0.0377
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0207	0.0206
Schistosoma mansoni	thyroid hormone receptor	0.0281	0.3447	0.4062
Loa Loa (eye worm)	CYP4Cod1	0.0039	0.0316	0.0576
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.003	0.0207	0.0377
Echinococcus granulosus	lamin	0.0026	0.0158	0.0185
Brugia malayi	conserved hypotetical protein	0.0014	0.0001	0.0002
Onchocerca volvulus		0.002	0.0074	0.0436
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0014	0.0001	0.0002
Echinococcus granulosus	dna polymerase eta	0.0044	0.0383	0.045
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0447	0.0815
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0021	0.0091	0.1876
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0014	0.0001	0.0002
Echinococcus granulosus	neuropeptide receptor A26	0.045	0.5624	0.663
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.0175	0.208	0.3787
Echinococcus multilocularis	lamin	0.0026	0.0158	0.0157
Schistosoma mansoni	ap endonuclease	0.0019	0.0058	0.0067
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0061	0.0112
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.003	0.0207	0.0377
Loa Loa (eye worm)	hypothetical protein	0.003	0.0207	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0617	0.1123
Echinococcus granulosus	cytochrome P450 2K1	0.0021	0.0091	0.0106
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0058	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0392	0.0461
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0207	0.0377
Brugia malayi	hypothetical protein	0.0014	0.0001	0.0002
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0158	0.0185
Brugia malayi	nuclear hormone receptor	0.0014	0.0001	0.0002
Mycobacterium ulcerans	acyl-CoA synthetase	0.0046	0.0415	1
Brugia malayi	Muscleblind-like protein	0.044	0.5492	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0046	0.0415	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.003	0.0207	0.0377
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0207	0.0206
Brugia malayi	hypothetical protein	0.0016	0.0023	0.0042
Brugia malayi	nuclear receptor RXR	0.0016	0.0023	0.0042
Onchocerca volvulus		0.0144	0.1675	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.002	0.0074	0.0135
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0017	0.0018
Echinococcus multilocularis	carboxylesterase 5A	0.0062	0.0617	0.0616
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0021	0.0091	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0158	0.0288
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0035	0.0264	0.5
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0062	0.0617	0.0726
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0021	0.0091	0.1876
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0016	0.0023	0.0026
Onchocerca volvulus	Huntingtin homolog	0.0119	0.1356	0.8093
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0014	0.0001	0.0002
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0239	0.5604
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0017	0.0016
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0061	0.0071
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0061	0.0071
Echinococcus multilocularis	acetylcholinesterase	0.0062	0.0617	0.0616
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0058	0.1706
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0001	0.0002
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0021	0.0091	0.1876
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0392	0.0713
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0021	0.0091	0.1876
Brugia malayi	AMP-binding enzyme family protein	0.0046	0.0415	0.0755
Brugia malayi	Carboxylesterase family protein	0.0062	0.0617	0.1123
Brugia malayi	isocitrate dehydrogenase	0.0015	0.0016	0.0029
Brugia malayi	Cytochrome P450 family protein	0.0021	0.0091	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0383	0.0698
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0016	0.0015
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0061	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0392	0.0461
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0021	0.0091	0.0913
Echinococcus multilocularis	neuropeptide s receptor	0.045	0.5624	0.5624
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0021	0.0091	0.0913
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0017	0.0031
Loa Loa (eye worm)	acetylcholinesterase 1	0.0062	0.0617	0.1123
Brugia malayi	photoreceptor-specific nuclear receptor	0.003	0.0207	0.0377
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0021	0.0091	0.1876
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0021	0.0091	0.1876
Brugia malayi	Cytochrome P450 family protein	0.0097	0.1073	0.1953
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0058	0.0057
Schistosoma mansoni	DNA polymerase eta	0.0044	0.0383	0.045
Loa Loa (eye worm)	cytochrome P450 family protein	0.0039	0.0316	0.0576
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0392	0.0391
Schistosoma mansoni	ap endonuclease	0.0019	0.0058	0.0067
Loa Loa (eye worm)	hypothetical protein	0.003	0.0207	0.0377
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0021	0.0091	0.2037
Echinococcus granulosus	intermediate filament protein	0.0026	0.0158	0.0185
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0207	0.0377
Leishmania major	4-coumarate:coa ligase-like protein	0.0046	0.0415	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0207	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0001	0.0002
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0021	0.0091	0.1876
Schistosoma mansoni	hypothetical protein	0.002	0.0074	0.0086
Onchocerca volvulus	Bile acid receptor homolog	0.003	0.0207	0.1229
Brugia malayi	nuclear receptor NHR-67	0.0014	0.0001	0.0002
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.003	0.0207	0.0377
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0046	0.0415	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0058	0.106
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0061	0.0112
Brugia malayi	ImpB/MucB/SamB family protein	0.0044	0.0383	0.0698
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0264	0.048
Echinococcus multilocularis	dna polymerase eta	0.0044	0.0383	0.0382
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0061	0.1238
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0021	0.0091	0.1876
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.003	0.0207	0.0243
Schistosoma mansoni	RAR-like nuclear receptor	0.003	0.0207	0.0243
Brugia malayi	nuclear receptor NHR-88	0.0014	0.0001	0.0002
Schistosoma mansoni	hypothetical protein	0.0165	0.1945	0.2292
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.003	0.0207	0.0243
Schistosoma mansoni	hypothetical protein	0.0021	0.0091	0.0106
Echinococcus granulosus	muscleblind protein	0.044	0.5492	0.6474
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1356	0.2469
Loa Loa (eye worm)	hypothetical protein	0.003	0.0207	0.0377
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0046	0.0415	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.003	0.0207	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0001	0.0002
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0061	0.1238
Brugia malayi	nuclear hormone receptor	0.003	0.0207	0.0377
Trypanosoma brucei	unspecified product	0.0019	0.0061	0.1238
Schistosoma mansoni	thyroid hormone receptor	0.0281	0.3447	0.4062
Onchocerca volvulus		0.0026	0.0158	0.0938
Echinococcus multilocularis	acetylcholinesterase	0.0062	0.0617	0.0616
Schistosoma mansoni	nuclear hormone receptor	0.003	0.0207	0.0243
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.003	0.0207	0.0377
Entamoeba histolytica	acyl-coA synthetase, putative	0.0046	0.0415	1
Echinococcus granulosus	neuropeptide s receptor	0.045	0.5624	0.663
Loa Loa (eye worm)	cytochrome P450	0.0021	0.0091	0.0165
Loa Loa (eye worm)	hypothetical protein	0.003	0.0207	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0001	0.0002
Brugia malayi	steroid hormone receptor	0.003	0.0207	0.0377
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0061	0.1238
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.003	0.0207	0.1229
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.003	0.0207	0.0206
Trypanosoma cruzi	DNA polymerase eta, putative	0.0044	0.0383	1
Brugia malayi	ecdysone receptor	0.0014	0.0001	0.0002
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.003	0.0207	0.0243
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.003	0.0207	0.0377
Echinococcus multilocularis	microtubule associated protein 2	0.0672	0.8483	0.8483
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0061	0.114
Schistosoma mansoni	hypothetical protein	0.0015	0.0017	0.0018
Echinococcus multilocularis	FTZ F1 alpha	0.003	0.0207	0.0206
Brugia malayi	AMP-binding enzyme family protein	0.0046	0.0415	0.0755
Onchocerca volvulus		0.003	0.0207	0.1229
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0021	0.0091	0.0913
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0035	0.0264	0.5766
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0021	0.0091	0.2037
Brugia malayi	MH2 domain containing protein	0.0117	0.1326	0.2414
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0248	0.0452
Loa Loa (eye worm)	cytochrome P450 family protein	0.0097	0.1073	0.1953
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0023	0.0042
Brugia malayi	Protein kinase domain containing protein	0.002	0.0074	0.0135
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0058	0.1151
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0046	0.0415	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0392	0.0461
Plasmodium falciparum	cysteine repeat modular protein 1	0.002	0.0074	0.2352
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0046	0.0415	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0415	0.0755
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0031	0.0215	0.3217
Leishmania major	hypothetical protein, conserved	0.002	0.0074	0.1462
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0239	0.5604
Echinococcus granulosus	FTZ F1 alpha	0.003	0.0207	0.0243
Onchocerca volvulus	Huntingtin homolog	0.0119	0.1356	0.8093
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0061	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0023	0.0042
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0021	0.0091	0.1876
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0035	0.0264	0.6215
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0061	0.0089
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.003	0.0207	0.0206
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.003	0.0207	0.0377
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0046	0.0415	1
Loa Loa (eye worm)	DR-78	0.0014	0.0001	0.0002
Schistosoma mansoni	hypothetical protein	0.0015	0.0017	0.0018
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0046	0.0415	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0058	0.1151
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0021	0.0091	0.1876
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0021	0.0091	0.1209
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0061	1
Brugia malayi	nuclear receptor RXR	0.0014	0.0001	0.0002
Brugia malayi	hypothetical protein	0.0119	0.1356	0.2469
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0021	0.0091	0.1876
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.003	0.0207	0.0243
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.003	0.0207	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0264	0.048
Brugia malayi	Nuclear hormone receptor-like 1	0.003	0.0207	0.0377
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.1326	0.2414
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0061	0.006
Schistosoma mansoni	retinoic acid receptor RXR	0.003	0.0207	0.0243
Loa Loa (eye worm)	hypothetical protein	0.003	0.0207	0.0377
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0061	0.1238
Leishmania major	cytochrome p450-like protein	0.0039	0.0316	0.7529
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0021	0.0091	0.1876
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0058	0.1706
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.003	0.0207	0.0377
Loa Loa (eye worm)	nuclear hormone receptor	0.0014	0.0001	0.0002
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0017	0.0031
Schistosoma mansoni	microtubule-associated protein tau	0.0672	0.8483	1
Brugia malayi	intermediate filament protein	0.0026	0.0158	0.0288
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0021	0.0091	0.1876
Plasmodium falciparum	acyl-CoA synthetase	0.0035	0.0264	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0061	0.1238
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0021	0.0091	0.1876
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0061	0.1238
Leishmania major	cytochrome p450-like protein	0.0021	0.0091	0.1876
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0251	0.3057	0.3057
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.003	0.0207	0.0243
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1356	0.2469
Trypanosoma brucei	cytochrome P450, putative	0.0039	0.0316	0.8175
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0248	0.0452
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0207	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0175	0.208	0.3787
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0061	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0001	0.0002
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0158	0.0288
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0021	0.0091	0.0913
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0016	0.0023	0.0022
Toxoplasma gondii	kringle domain-containing protein	0.002	0.0074	0.0942

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 701006