Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dihydroorotate dehydrogenase (quinone) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | dihydroorotate dehydrogenase (quinone) | 395 aa | 361 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nephrin | 0.0372 | 0.6637 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.022 | 0.2542 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.022 | 0.2542 | 1 |
Echinococcus granulosus | nephrin | 0.0372 | 0.6637 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.022 | 0.2542 | 0.383 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.022 | 0.2542 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.022 | 0.2542 | 0.383 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.022 | 0.2542 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0476 | 0.9427 | 0.9282 |
Schistosoma mansoni | hypothetical protein | 0.0372 | 0.6637 | 1 |
Echinococcus granulosus | nephrin | 0.0372 | 0.6637 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0476 | 0.9427 | 1 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0372 | 0.6637 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.022 | 0.2542 | 0.383 |
Brugia malayi | isocitrate dehydrogenase | 0.022 | 0.2542 | 0.0659 |
Echinococcus granulosus | Immunoglobulin | 0.0372 | 0.6637 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.022 | 0.2542 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.022 | 0.2542 | 0.383 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.022 | 0.2542 | 0.2696 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.022 | 0.2542 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.022 | 0.2542 | 1 |
Onchocerca volvulus | Basement membrane proteoglycan homolog | 0.0125 | 0 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.022 | 0.2542 | 0.0659 |
Echinococcus multilocularis | Immunoglobulin | 0.0372 | 0.6637 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.022 | 0.2542 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0372 | 0.6637 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.02 | 0.2015 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.022 | 0.2542 | 0.383 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.022 | 0.2542 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.022 | 0.2542 | 0.383 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.02 | 0.2015 | 0.5 |
Echinococcus multilocularis | irregular chiasm roughest protein immunoglobulin set domain containing protein | 0.0372 | 0.6637 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.022 | 0.2542 | 1 |
Echinococcus granulosus | irregular chiasm roughest protein | 0.0372 | 0.6637 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0476 | 0.9427 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.02 | 0.2015 | 0.5 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.022 | 0.2542 | 0.383 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0476 | 0.9427 | 0.9282 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.02 | 0.2015 | 0.3037 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.8 nM | Ability to inhibit proliferation in a mixture of human lymphocytes from two unrelated donors in MLR (human mixed lymphocyte reaction) | ChEMBL. | 9873427 |
Ki (binding) | = 24 nM | Immunosuppressive effect in an isolated enzyme assay using partially purified Dihydroorotate dehydrogenase from human liver for inhibition of the formation of orotate from radiolabeled dihydroorotate | ChEMBL. | 9873427 |
Ki (binding) | = 24 nM | Immunosuppressive effect in an isolated enzyme assay using partially purified Dihydroorotate dehydrogenase from human liver for inhibition of the formation of orotate from radiolabeled dihydroorotate | ChEMBL. | 9873427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.