Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | patched 1 | 0.0532 | 0.3921 | 0.3921 |
Schistosoma mansoni | nephrin | 0.0056 | 0.0112 | 0.0112 |
Echinococcus multilocularis | protein patched | 0.0532 | 0.3921 | 0.3921 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0223 | 0.1445 | 0.1445 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0607 | 0.4514 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0391 | 0.2794 | 0.2794 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.0391 | 0.2794 | 0.2794 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1293 | 1 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0532 | 0.3921 | 0.3921 |
Echinococcus multilocularis | roundabout 2 | 0.0064 | 0.0175 | 0.0175 |
Loa Loa (eye worm) | TK protein kinase | 0.0405 | 0.2906 | 0.2906 |
Echinococcus granulosus | twitchin | 0.0056 | 0.0112 | 0.0112 |
Brugia malayi | CHE-14 protein | 0.0532 | 0.3921 | 0.3921 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0062 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0175 | 0.0175 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0532 | 0.3921 | 0.3921 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0532 | 0.3921 | 0.3921 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0187 | 0.1161 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0532 | 0.3921 | 0.3921 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.0391 | 0.2794 | 0.2794 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0532 | 0.3921 | 0.3921 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0532 | 0.3921 | 0.3921 |
Loa Loa (eye worm) | hypothetical protein | 0.1293 | 1 | 1 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.0391 | 0.2794 | 0.2794 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0607 | 0.4514 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0223 | 0.1445 | 0.1445 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.005 | 0.0062 | 0.0062 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0607 | 0.4514 | 1 |
Echinococcus granulosus | neuroglian | 0.0056 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0532 | 0.3921 | 0.3921 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.0391 | 0.2794 | 0.2794 |
Loa Loa (eye worm) | hypothetical protein | 0.0532 | 0.3921 | 0.3921 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0405 | 0.2906 | 0.2906 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0607 | 0.4514 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1293 | 1 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1293 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0175 | 0.0175 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1293 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1293 | 1 | 0.5 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1293 | 1 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.005 | 0.0062 | 0.0062 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1293 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1293 | 1 | 1 |
Echinococcus multilocularis | neuroglian | 0.0056 | 0.0112 | 0.0112 |
Echinococcus granulosus | roundabout 2 | 0.0064 | 0.0175 | 0.0175 |
Echinococcus multilocularis | protein dispatched 1 | 0.0532 | 0.3921 | 0.3921 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.73 uM | Inhibition of Staphylococcus aureus 7,8-dihydroneopterin aldolase | ChEMBL. | 15027862 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.