Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0016 | 0.0366 | 0.1502 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0162 | 0.0028 |
Schistosoma mansoni | DNA helicase recq1 | 0.001 | 0.0162 | 0.0162 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0107 | 0.3449 | 1 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0029 | 0.0809 | 0.2119 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0029 | 0.0809 | 0.0565 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0107 | 0.3449 | 1 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.2435 | 0.6938 |
Echinococcus multilocularis | bloom syndrome protein | 0.0024 | 0.0631 | 0.1497 |
Loa Loa (eye worm) | RecQ helicase | 0.0024 | 0.0631 | 0.0503 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.001 | 0.0162 | 0.0082 |
Schistosoma mansoni | Smad4 | 0.0009 | 0.0134 | 0.0134 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.3449 | 0.3275 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.2435 | 0.5 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0024 | 0.0631 | 0.0382 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0134 | 0.0134 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0029 | 0.0809 | 0.0565 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.3853 | 0.377 |
Brugia malayi | MH2 domain containing protein | 0.0131 | 0.4273 | 0.4195 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0131 | 0.4273 | 0.4195 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0131 | 0.4273 | 0.4195 |
Trichomonas vaginalis | glutaminase, putative | 0.0301 | 1 | 1 |
Brugia malayi | phosphofructokinase | 0.0107 | 0.3449 | 0.336 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0107 | 0.3449 | 0.1342 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0027 | 0.0729 | 0.2112 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.001 | 0.0162 | 0.0082 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.001 | 0.0162 | 0.0082 |
Schistosoma mansoni | smad | 0.0009 | 0.0134 | 0.0134 |
Entamoeba histolytica | recQ family helicase, putative | 0.0013 | 0.0259 | 0.075 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0009 | 0.0134 | 0.0134 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0107 | 0.3449 | 0.3449 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.0029 | 0.0809 | 0.3324 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0027 | 0.0729 | 0.1728 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.3449 | 0.3275 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0107 | 0.3449 | 1 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0029 | 0.0809 | 0.2849 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.2435 | 0.7058 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0107 | 0.3449 | 0.3449 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.2435 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.2435 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0301 | 1 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0024 | 0.0631 | 0.0503 |
Schistosoma mansoni | DNA helicase recq5 | 0.001 | 0.0162 | 0.0162 |
Echinococcus granulosus | bloom syndrome protein | 0.0024 | 0.0631 | 0.1497 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0107 | 0.3449 | 0.336 |
Brugia malayi | 6-phosphofructokinase | 0.0107 | 0.3449 | 0.336 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0107 | 0.3449 | 0.336 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0107 | 0.3449 | 1 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0029 | 0.0809 | 0.2346 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0019 | 0.0463 | 0.0463 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.2435 | 1 |
Toxoplasma gondii | 6-phosphofructokinase | 0.0029 | 0.0809 | 0.3324 |
Brugia malayi | 6-phosphofructokinase | 0.0107 | 0.3449 | 0.336 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0162 | 0.0664 |
Brugia malayi | Probable ClpP-like protease | 0.0077 | 0.2435 | 0.2331 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0107 | 0.3449 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0162 | 0.0028 |
Loa Loa (eye worm) | glutaminase 2 | 0.0301 | 1 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.3449 | 0.3275 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.2435 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0029 | 0.0809 | 0.0565 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0029 | 0.0809 | 0.2849 |
Schistosoma mansoni | glutaminase | 0.0301 | 1 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0162 | 0.0028 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0029 | 0.0809 | 0.0565 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0077 | 0.2435 | 0.2435 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.0029 | 0.0809 | 0.3324 |
Mycobacterium ulcerans | glutaminase | 0.0301 | 1 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0134 | 0.0134 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0029 | 0.0809 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0077 | 0.2435 | 0.627 |
Loa Loa (eye worm) | phosphofructokinase | 0.0107 | 0.3449 | 0.336 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.2435 | 0.6938 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0107 | 0.3449 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0162 | 0.0664 |
Echinococcus granulosus | peptidase Clp S14 family | 0.005 | 0.1538 | 0.4233 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0077 | 0.2435 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.0631 | 0.0382 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.005 | 0.1538 | 0.2974 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0107 | 0.3449 | 0.3275 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0134 | 0.0134 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0107 | 0.3449 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0027 | 0.0729 | 0.2993 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.001 | 0.0162 | 0.0082 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.005 | 0.1538 | 0.4233 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0027 | 0.0729 | 0.2494 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.2435 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.0534 | 0.1637 |
Trichomonas vaginalis | 6-phosphofructokinase, putative | 0.0029 | 0.0809 | 0.0565 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0107 | 0.3449 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0029 | 0.0809 | 0.0565 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0029 | 0.0809 | 0.0565 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0107 | 0.3449 | 1 |
Entamoeba histolytica | pyrophosphate-dependent phosphofructokinase | 0.0029 | 0.0809 | 0.2346 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.2435 | 0.2331 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0107 | 0.3449 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.001 | 0.0162 | 0.0028 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0107 | 0.3449 | 1 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0029 | 0.0809 | 0.2119 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.