TDR Targets

Basic information

Technical information

TDR Targets ID: 702614
Name: 2-(4-ethylsulfonylphenyl)-N-(1,3-thiazol-2-yl )acetamide
MW: 310.392 | Formula: C13H14N2O3S2
H donors: 1 H acceptors: 4 LogP: 1.66 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCS(=O)(=O)c1ccc(cc1)CC(=O)Nc1nccs1
InChi: 1S/C13H14N2O3S2/c1-2-20(17,18)11-5-3-10(4-6-11)9-12(16)15-13-14-7-8-19-13/h3-8H,2,9H2,1H3,(H,14,15,16)
InChiKey: ZGLOAGNASTUPGH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(4-ethylsulfonylphenyl)-N-thiazol-2-yl-acetamide
2-(4-ethylsulfonylphenyl)-N-(2-thiazolyl)acetamide
2-(4-ethylsulfonylphenyl)-N-(1,3-thiazol-2-yl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Conserved protein	0.003	0.1345	0.1345
Echinococcus granulosus	ferritin	0.0007	0.0117	0.0108
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0006	0.0042	0.0042
Entamoeba histolytica	hypothetical protein	0.0059	0.2886	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0081	0.4045	0.7135
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0006	0.0042	0.0042
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0006	0.0045	0.0004
Trichomonas vaginalis	penicillin-binding protein, putative	0.003	0.1345	1
Onchocerca volvulus		0.003	0.1345	1
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0142	0.0144
Echinococcus multilocularis	expressed protein	0.0007	0.0117	0.0108
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0019	0.0771	0.5593
Mycobacterium leprae	Probable lipase LipE	0.003	0.1345	1
Mycobacterium tuberculosis	Probable esterase LipL	0.003	0.1345	0.1345
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0874	0.1482
Brugia malayi	CXXC zinc finger family protein	0.0023	0.097	0.1654
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1102	0.1888
Onchocerca volvulus		0.0019	0.0771	0.5593
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0026	0.1102	0.1888
Loa Loa (eye worm)	intermediate filament protein	0.0022	0.0895	0.152
Mycobacterium ulcerans	bacterioferritin BfrB	0.0007	0.0117	0.0577
Echinococcus granulosus	smad	0.0008	0.0142	0.0144
Schistosoma mansoni	Smad4	0.0008	0.0142	0.0144
Entamoeba histolytica	hypothetical protein	0.0059	0.2886	1
Leishmania major	hypothetical protein, conserved	0.003	0.1345	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0026	0.1102	0.1522
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0771	0.0771
Loa Loa (eye worm)	hypothetical protein	0.0014	0.051	0.0834
Schistosoma mansoni	ferritin	0.0007	0.0117	0.0108
Schistosoma mansoni	lamin	0.0022	0.0895	0.1225
Loa Loa (eye worm)	beta-lactamase	0.003	0.1345	0.2323
Loa Loa (eye worm)	hypothetical protein	0.001	0.0297	0.0454
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0142	0.0144
Trypanosoma cruzi	hypothetical protein, conserved	0.003	0.1345	1
Toxoplasma gondii	ABC1 family protein	0.003	0.1345	0.6423
Echinococcus multilocularis	Smad4	0.0008	0.0142	0.0144
Schistosoma mansoni	hypothetical protein	0.0026	0.1102	0.1522
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0019	0.0771	0.2563
Loa Loa (eye worm)	hypothetical protein	0.001	0.0276	0.0416
Trichomonas vaginalis	ferritin, putative	0.0007	0.0117	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0771	0.1299
Mycobacterium ulcerans	hypothetical protein	0.0019	0.0771	0.5593
Trichomonas vaginalis	D-aminoacylase, putative	0.003	0.1345	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.003	0.1345	0.1345
Schistosoma mansoni	hypothetical protein	0.0026	0.1102	0.1522
Brugia malayi	hypothetical protein	0.0059	0.2886	0.5069
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0142	0.0144
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0019	0.0771	0.5593
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0006	0.0042	0.0042
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0142	0.0178
Brugia malayi	MH2 domain containing protein	0.0111	0.5652	1
Entamoeba histolytica	hypothetical protein	0.0059	0.2886	1
Schistosoma mansoni	lamin	0.0022	0.0895	0.1225
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0468	0.0468
Trypanosoma brucei	hypothetical protein, conserved	0.003	0.1345	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0007	0.0115	0.013
Schistosoma mansoni	apoferritin-2	0.0007	0.0117	0.0108
Brugia malayi	AMP-binding enzyme family protein	0.0019	0.0771	0.1299
Schistosoma mansoni	hypothetical protein	0.0026	0.1102	0.1522
Mycobacterium tuberculosis	Probable lipase LipE	0.003	0.1345	0.1345
Brugia malayi	MH1 domain containing protein	0.0008	0.0142	0.0178
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.0007	0.0117	0.0577
Brugia malayi	AMP-binding enzyme family protein	0.0019	0.0771	0.1299
Schistosoma mansoni	hypothetical protein	0.0059	0.2886	0.4086
Loa Loa (eye worm)	hypothetical protein	0.0081	0.4045	0.7135
Loa Loa (eye worm)	hypothetical protein	0.003	0.1345	0.2323
Echinococcus granulosus	cpg binding protein	0.0024	0.104	0.1434
Schistosoma mansoni	ferritin light chain	0.0007	0.0117	0.0108
Onchocerca volvulus		0.0023	0.097	0.712
Mycobacterium tuberculosis	Conserved protein	0.003	0.1345	0.1345
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0019	0.0771	0.5593
Schistosoma mansoni	hypothetical protein	0.0136	0.7001	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0019	0.0771	0.0771
Brugia malayi	AMP-binding enzyme family protein	0.0019	0.0771	0.1299
Echinococcus granulosus	Smad4	0.0008	0.0142	0.0144
Echinococcus granulosus	geminin	0.0136	0.7001	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0019	0.0771	0.5593
Brugia malayi	Intermediate filament tail domain containing protein	0.0022	0.0895	0.152
Brugia malayi	MH2 domain containing protein	0.0008	0.0142	0.0178
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0142	0.0178
Onchocerca volvulus		0.0022	0.0895	0.6544
Echinococcus granulosus	lamin	0.0022	0.0895	0.1225
Trichomonas vaginalis	antibiotic synthetase, putative	0.0006	0.0042	0.0181
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0014	0.051	0.3591
Schistosoma mansoni	hypothetical protein	0.0055	0.2683	0.3794
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0019	0.0771	0.2563
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0006	0.0042	0.0042
Schistosoma mansoni	smad	0.0008	0.0142	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0055	0.2683	0.4707
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0026	0.1102	0.1888
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0468	0.0468
Loa Loa (eye worm)	histone methyltransferase	0.0007	0.012	0.0139
Schistosoma mansoni	cpg binding protein	0.0024	0.104	0.1434
Schistosoma mansoni	intermediate filament proteins	0.0022	0.0895	0.1225
Schistosoma mansoni	hypothetical protein	0.0136	0.7001	1
Brugia malayi	beta-lactamase family protein	0.003	0.1345	0.2323
Brugia malayi	beta-lactamase family protein	0.003	0.1345	0.2323
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0044	0.2071	1
Echinococcus multilocularis	ferritin	0.0007	0.0117	0.0108
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0059	0.2886	0.4086
Echinococcus multilocularis	lamin dm0	0.0022	0.0895	0.1225
Schistosoma mansoni	ferritin	0.0007	0.0117	0.0108
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.012	0.0112
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0014	0.051	0.5
Loa Loa (eye worm)	hypothetical protein	0.003	0.1345	0.2323
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0006	0.0042	0.0042
Schistosoma mansoni	apoferritin-2	0.0007	0.0117	0.0108
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0006	0.0042	0.0042
Brugia malayi	Smad1	0.0008	0.0142	0.0178
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.003	0.1345	0.1345
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0006	0.0045	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0014	0.051	0.0834
Mycobacterium ulcerans	beta-lactamase	0.003	0.1345	1
Brugia malayi	MH1 domain containing protein	0.0008	0.0142	0.0178
Schistosoma mansoni	ferritin	0.0007	0.0117	0.0108
Trichomonas vaginalis	esterase, putative	0.003	0.1345	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.003	0.1345	0.1873
Loa Loa (eye worm)	hypothetical protein	0.0014	0.051	0.0834
Onchocerca volvulus		0.003	0.1345	1
Mycobacterium tuberculosis	Conserved protein	0.003	0.1345	0.1345
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0142	0.0144
Echinococcus granulosus	intermediate filament protein	0.0022	0.0895	0.1225
Leishmania major	4-coumarate:coa ligase-like protein	0.0019	0.0771	0.5593
Schistosoma mansoni	ferritin	0.0007	0.0117	0.0108
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0081	0.4045	0.7135
Loa Loa (eye worm)	hypothetical protein	0.0014	0.051	0.0834
Plasmodium vivax	hypothetical protein, conserved	0.003	0.1345	1
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0142	0.0144
Mycobacterium leprae	conserved hypothetical protein	0.003	0.1345	1
Mycobacterium tuberculosis	Probable lipase LipD	0.003	0.1345	0.1345
Entamoeba histolytica	acyl-coA synthetase, putative	0.0019	0.0771	0.2563
Brugia malayi	latrophilin 2 splice variant baaae	0.0055	0.2683	0.4707
Trichomonas vaginalis	D-aminoacylase, putative	0.003	0.1345	1
Schistosoma mansoni	ferritin light chain	0.0007	0.0117	0.0108
Mycobacterium tuberculosis	Probable hydrolase	0.003	0.1345	0.1345
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0081	0.4045	0.7135
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0007	0.0117	0.5
Treponema pallidum	bacterioferrin (TpF1)	0.0007	0.0117	0.5
Echinococcus granulosus	expressed protein	0.0007	0.0117	0.0108
Loa Loa (eye worm)	hypothetical protein	0.001	0.0276	0.0416
Brugia malayi	cytoplasmic intermediate filament protein	0.0012	0.0358	0.0564
Echinococcus multilocularis	geminin	0.0136	0.7001	1
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.001	0.0297	0.0366
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0026	0.1102	0.1522
Echinococcus granulosus	GPCR family 2	0.0026	0.1102	0.1522
Schistosoma mansoni	transcription factor LCR-F1	0.0059	0.2886	0.4086
Mycobacterium ulcerans	bacterioferritin BfrA	0.0007	0.0117	0.0577
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0006	0.0042	0.0042
Plasmodium vivax	acyl-CoA synthetase, putative	0.0014	0.051	0.3591
Mycobacterium ulcerans	lipase LipD	0.003	0.1345	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0019	0.0771	0.5593
Plasmodium falciparum	acyl-CoA synthetase	0.0014	0.051	1
Onchocerca volvulus		0.0022	0.0895	0.6544
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.003	0.1345	0.1345
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0142	0.0144
Mycobacterium ulcerans	hypothetical protein	0.003	0.1345	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0895	0.152
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.0007	0.0117	0.0117
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0049	0.235	0.3316
Echinococcus multilocularis	cpg binding protein	0.0024	0.104	0.1434
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0012	0.0358	0.0564
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0026	0.1102	0.1522
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.003	0.1345	1
Onchocerca volvulus		0.003	0.1345	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0019	0.0771	0.5593
Echinococcus granulosus	lamin dm0	0.0022	0.0895	0.1225
Loa Loa (eye worm)	hypothetical protein	0.003	0.1345	0.2323
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0006	0.0045	0.0004
Loa Loa (eye worm)	hypothetical protein	0.003	0.1345	0.2323
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0026	0.1102	0.1522
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0771	0.1299
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0019	0.0771	0.5593
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0023	0.097	0.1654
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0006	0.0042	0.0042
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0006	0.0042	0.0042
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0006	0.0045	0.0004
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.012	0.0112
Loa Loa (eye worm)	hypothetical protein	0.003	0.1345	0.2323
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0771	0.1299
Loa Loa (eye worm)	hypothetical protein	0.003	0.1345	0.2323
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0142	0.0144
Leishmania major	4-coumarate:coa ligase-like protein	0.0019	0.0771	0.5593
Echinococcus multilocularis	musashi	0.0022	0.0895	0.1225
Loa Loa (eye worm)	hypothetical protein	0.0014	0.051	0.0834
Schistosoma mansoni	cpg binding protein	0.0023	0.097	0.1333
Trichomonas vaginalis	penicillin-binding protein, putative	0.003	0.1345	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0022	0.0895	0.152
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.001	0.0297	0.0366
Brugia malayi	Latrophilin receptor protein 2	0.0026	0.1102	0.1888
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0468	0.0468
Trichomonas vaginalis	antibiotic synthetase, putative	0.0006	0.0042	0.0181
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0006	0.0042	0.0042
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0006	0.0045	0.0004
Loa Loa (eye worm)	transcription factor SMAD2	0.0111	0.5652	1
Echinococcus multilocularis	lamin	0.0022	0.0895	0.1225
Brugia malayi	beta-lactamase	0.003	0.1345	0.2323
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.003	0.1345	0.2323
Echinococcus granulosus	beta LACTamase domain containing family member	0.003	0.1345	0.1873
Schistosoma mansoni	cpg binding protein	0.0024	0.104	0.1434
Loa Loa (eye worm)	MH2 domain-containing protein	0.0111	0.5652	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0019	0.0771	0.5593
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.003	0.1345	0.2323
Mycobacterium ulcerans	esterase/lipase LipP	0.003	0.1345	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.003	0.1345	0.1873
Echinococcus multilocularis	smad	0.0008	0.0142	0.0144
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0019	0.0771	0.5593
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0006	0.0042	0.0042
Trypanosoma cruzi	hypothetical protein, conserved	0.003	0.1345	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0019	0.0771	0.5593
Entamoeba histolytica	hypothetical protein	0.0059	0.2886	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0014	0.051	0.051
Trichomonas vaginalis	D-aminoacylase, putative	0.003	0.1345	1
Brugia malayi	MH2 domain containing protein	0.0008	0.0142	0.0178
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.0007	0.0117	0.0117
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0468	0.0468
Schistosoma mansoni	hypothetical protein	0.0026	0.1102	0.1522
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0142	0.0144
Echinococcus multilocularis	GPCR, family 2	0.0026	0.1102	0.1522
Echinococcus multilocularis	beta LACTamase domain containing family member	0.003	0.1345	0.1873
Loa Loa (eye worm)	Smad1	0.0008	0.0142	0.0178
Brugia malayi	intermediate filament protein	0.0022	0.0895	0.152
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0059	0.2886	0.4086

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 4.6	Inhibition of APC-labeled RORgammat receptor ligand binding domain (unknown origin) after 1 hr by FRET assay	ChEMBL.	24388993

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 702614