Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0114 | 0.1992 | 0.2262 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0022 | 0.0003 |
Brugia malayi | phosphofructokinase | 0.0114 | 0.1992 | 0.2262 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0031 | 0.026 | 0.0241 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0141 | 0.257 | 0.2925 |
Echinococcus granulosus | tar DNA binding protein | 0.0141 | 0.257 | 0.6833 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0063 | 0.0927 | 0.535 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.009 | 0.1507 | 1 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0114 | 0.1992 | 0.5284 |
Brugia malayi | hypothetical protein | 0.0172 | 0.3217 | 0.3667 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0063 | 0.0927 | 0.2431 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0668 | 0.0743 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0031 | 0.026 | 0.0241 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0057 | 0.0813 | 0.2125 |
Echinococcus multilocularis | tar DNA binding protein | 0.0141 | 0.257 | 0.6833 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0019 | 0.0022 | 0.0014 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0159 | 0.0706 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.2904 | 0.3308 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0437 | 0.874 | 1 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.009 | 0.1507 | 0.3984 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0022 | 0.0003 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0114 | 0.1992 | 0.1976 |
Loa Loa (eye worm) | MBCTL1 | 0.0057 | 0.0813 | 0.091 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0114 | 0.1992 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.3217 | 0.3667 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.257 | 0.4268 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.257 | 0.4268 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0063 | 0.0927 | 0.1518 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0707 | 0.0789 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0159 | 0.0706 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0079 | 0.1277 | 0.3368 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0159 | 0.016 |
Brugia malayi | 6-phosphofructokinase | 0.0114 | 0.1992 | 0.2262 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0159 | 0.0706 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.005 | 0.0668 | 0.1736 |
Echinococcus granulosus | muscleblind protein | 0.0157 | 0.2904 | 0.7727 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0031 | 0.026 | 1 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0057 | 0.0813 | 0.2125 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.1507 | 0.1705 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.005 | 0.0668 | 0.1736 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0031 | 0.026 | 1 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.0668 | 0.0743 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0063 | 0.0927 | 0.1518 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0159 | 0.0706 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0159 | 0.016 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.005 | 0.0668 | 0.1736 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0057 | 0.0813 | 0.091 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0019 | 0.0097 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0114 | 0.1992 | 1 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0114 | 0.1992 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0063 | 0.0927 | 0.1518 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0114 | 0.1992 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0159 | 0.016 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.0159 | 0.0706 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0114 | 0.1992 | 0.2262 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.0668 | 0.0743 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0813 | 0.091 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0114 | 0.1992 | 0.1976 |
Schistosoma mansoni | hypothetical protein | 0.0305 | 0.5996 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0157 | 0.2904 | 0.3308 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0114 | 0.1992 | 1 |
Loa Loa (eye worm) | cyclic AMP specific phosphodiesterase PDE4D5A | 0.0079 | 0.1277 | 0.1442 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0057 | 0.0813 | 0.2125 |
Plasmodium vivax | SET domain protein, putative | 0.0063 | 0.0927 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.0668 | 0.1085 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.009 | 0.1507 | 1 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0114 | 0.1992 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.0668 | 0.1085 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0159 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.2235 | 0.2541 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0022 | 0.0111 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0031 | 0.026 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0022 | 0.0003 |
Onchocerca volvulus | 0.0172 | 0.3217 | 0.3108 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0707 | 0.0789 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0114 | 0.1992 | 0.1976 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.006 | 0.0879 | 0.2302 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0063 | 0.0927 | 0.1518 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.009 | 0.1507 | 0.3984 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.009 | 0.1507 | 0.3984 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0159 | 0.0706 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0026 | 0.0159 | 0.0706 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0031 | 0.026 | 0.0241 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.0159 | 0.0706 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.0159 | 0.0796 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.2235 | 0.2541 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0363 | 0.0394 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0031 | 0.026 | 0.0241 |
Onchocerca volvulus | Huntingtin homolog | 0.0125 | 0.2235 | 0.211 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0114 | 0.1992 | 0.5284 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0157 | 0.2904 | 0.7727 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0141 | 0.257 | 0.2925 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0198 | 0.3752 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0114 | 0.1992 | 0.3301 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0927 | 0.1041 |
Loa Loa (eye worm) | phosphofructokinase | 0.0114 | 0.1992 | 0.2262 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0707 | 0.0789 |
Onchocerca volvulus | 0.005 | 0.0668 | 0.0517 | |
Brugia malayi | Pre-SET motif family protein | 0.0437 | 0.874 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0159 | 0.0706 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0079 | 0.1277 | 0.3368 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0022 | 0.0003 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.0079 | 0.1277 | 0.1442 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0114 | 0.1992 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0141 | 0.257 | 0.2925 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0022 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.2904 | 0.3308 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0114 | 0.1992 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0114 | 0.1992 | 0.2262 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.0159 | 0.0706 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0198 | 0.3752 | 1 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0057 | 0.0813 | 0.2125 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0063 | 0.0927 | 0.2431 |
Brugia malayi | RNA binding protein | 0.0141 | 0.257 | 0.2925 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.257 | 0.4268 |
Echinococcus multilocularis | muscleblind protein | 0.0157 | 0.2904 | 0.7727 |
Loa Loa (eye worm) | RNA binding protein | 0.0141 | 0.257 | 0.2925 |
Onchocerca volvulus | 0.0063 | 0.0927 | 0.0781 | |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.005 | 0.0668 | 0.0517 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0019 | 0.0097 |
Onchocerca volvulus | Huntingtin homolog | 0.0125 | 0.2235 | 0.211 |
Trichomonas vaginalis | 6-phosphofructokinase, putative | 0.0031 | 0.026 | 0.0241 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0707 | 0.0789 |
Loa Loa (eye worm) | mbt repeat family protein | 0.005 | 0.0668 | 0.0743 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0114 | 0.1992 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0159 | 0.0706 |
Brugia malayi | hypothetical protein | 0.0125 | 0.2235 | 0.2541 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0363 | 0.0574 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0031 | 0.026 | 0.0241 |
Brugia malayi | TAR-binding protein | 0.0141 | 0.257 | 0.2925 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0031 | 0.026 | 0.1616 |
Entamoeba histolytica | pyrophosphate-dependent phosphofructokinase | 0.0031 | 0.026 | 0.1219 |
Trichomonas vaginalis | set domain proteins, putative | 0.0497 | 1 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0114 | 0.1992 | 0.3301 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.257 | 0.4268 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0031 | 0.026 | 0.0241 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0159 | 0.016 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0114 | 0.1992 | 0.1976 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.005 | 0.0668 | 0.1085 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0031 | 0.026 | 0.2627 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0159 | 0.016 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0031 | 0.026 | 1 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0114 | 0.1992 | 1 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0057 | 0.0813 | 0.1328 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0063 | 0.0927 | 0.2431 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.257 | 0.4268 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.005 | 0.0668 | 0.1736 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.0159 | 0.0706 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.0159 | 0.0796 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0159 | 0.0706 |
Brugia malayi | Pre-SET motif family protein | 0.0063 | 0.0927 | 0.1041 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.009 | 0.1507 | 0.2488 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.009 | 0.1507 | 0.3984 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0363 | 0.0394 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0159 | 0.0706 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0031 | 0.026 | 0.2627 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.