TDR Targets

Basic information

Technical information

TDR Targets ID: 702961
Name: 2-ethyl-5-[(3-methoxyphenyl)-piperidin-1-ylme thyl]-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-ol
MW: 372.484 | Formula: C19H24N4O2S
H donors: 1 H acceptors: 3 LogP: 4.04 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCc1nn2c(n1)sc(c2O)C(c1cccc(c1)OC)N1CCCCC1
InChi: 1S/C19H24N4O2S/c1-3-15-20-19-23(21-15)18(24)17(26-19)16(22-10-5-4-6-11-22)13-8-7-9-14(12-13)25-2/h7-9,12,16,24H,3-6,10-11H2,1-2H3
InChiKey: RHHSEVGOMWKQOK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-ethyl-5-[(3-methoxyphenyl)-(1-piperidyl)methyl]thiazolo[2,3-e][1,2,4]triazol-6-ol
2-ethyl-5-[(3-methoxyphenyl)-(1-piperidyl)methyl]-6-thiazolo[2,3-e][1,2,4]triazolol
2-ethyl-5-[(3-methoxyphenyl)-piperidino-methyl]thiazolo[2,3-e][1,2,4]triazol-6-ol
2-ethyl-5-[(3-methoxyphenyl)-piperidin-1-yl-methyl]-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0767	0.0874
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0131	0.3899	0.3772
Schistosoma mansoni	hypothetical protein	0.003	0.0252	0.0129
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0084	0.2227	0.2904
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0067	0.1604	0.2092
Plasmodium falciparum	thioredoxin reductase	0.0038	0.0539	0.5
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0253	0.005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.1782	0.2323
Trypanosoma brucei	trypanothione reductase	0.0038	0.0539	0.1654
Brugia malayi	Pre-SET motif family protein	0.003	0.0253	0.0076
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0204	0.0266
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0084	0.2227	0.2904
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0093	0.2559	0.366
Echinococcus granulosus	GPCR family 2	0.003	0.0252	0.0049
Plasmodium vivax	thioredoxin reductase, putative	0.0038	0.0539	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0093	0.2559	0.366
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1491	0.2
Trichomonas vaginalis	PIKK family atypical protein kinase	0.005	0.1002	0.1306
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0827	0.1078
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0084	0.2227	0.5
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.1359	0.926
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0035	0.0447	0.1204
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0253	0.0132
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.1359	0.5
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0084	0.2227	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0084	0.2227	0.3143
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0067	0.1604	0.2092
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0084	0.2227	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0204	0.0266
Schistosoma mansoni	cellular tumor antigen P53	0.0044	0.0767	0.1523
Schistosoma mansoni	thyroid hormone receptor	0.0131	0.3899	1
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.1359	0.3125
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0084	0.2227	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0086	0.2274	0.8342
Schistosoma mansoni	hypothetical protein	0.003	0.0252	0.0129
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0057	0.1225	0.1597
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0084	0.2227	0.2065
Trichomonas vaginalis	PIKK family atypical protein kinase	0.005	0.0984	0.1283
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0055	0.1159	0.1511
Brugia malayi	Pre-SET motif family protein	0.0206	0.6639	1
Schistosoma mansoni	thyroid hormone receptor	0.0131	0.3899	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0067	0.1604	0.2092
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0067	0.1604	0.2092
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.1359	0.1179
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0084	0.2227	1
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0112	0.3213	0.3072
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0204	0.0266
Brugia malayi	Thioredoxin reductase	0.0038	0.0539	0.052
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.1359	0.5708
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0063	0.1447	0.1887
Mycobacterium tuberculosis	Probable reductase	0.0086	0.2274	0.8342
Echinococcus granulosus	thioredoxin glutathione reductase	0.0038	0.0557	0.036
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.1359	0.1179
Schistosoma mansoni	hypothetical protein	0.0064	0.1491	0.3483
Loa Loa (eye worm)	glutathione reductase	0.0038	0.0539	0.052
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0204	0.0266
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0253	0.0132
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0067	0.1607	0.6934
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0827	0.1078
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0084	0.2227	1
Leishmania major	trypanothione reductase	0.0038	0.0539	0.1654
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0084	0.2227	0.2904
Loa Loa (eye worm)	hypothetical protein	0.003	0.0253	0.0076
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0827	0.1078
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.1359	0.3941
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.004	0.0623	0.207
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0095	0.2619	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.003	0.0252	0.0049
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0067	0.1604	0.2092
Loa Loa (eye worm)	latrophilin receptor protein 2	0.003	0.0252	0.0074
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0253	0.005
Onchocerca volvulus		0.0235	0.7669	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0063	0.1447	0.1887
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0038	0.0557	0.036
Toxoplasma gondii	thioredoxin reductase	0.0038	0.0539	0.2393
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.003	0.0252	0.0049
Echinococcus multilocularis	tumor protein p63	0.03	1	1
Schistosoma mansoni	hypothetical protein	0.003	0.0252	0.0129
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0063	0.1447	0.1887
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.003	0.0252	0.0049
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0086	0.2274	0.8342
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0084	0.2227	1
Onchocerca volvulus		0.0044	0.0767	0.0693
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0095	0.2619	1
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0112	0.3213	0.3072
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0213	0.001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0063	0.1447	0.1887
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0824	0.1075
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0084	0.2227	0.3143
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0095	0.2619	1
Brugia malayi	Latrophilin receptor protein 2	0.003	0.0252	0.0074
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0084	0.2227	0.2065
Mycobacterium tuberculosis	Probable dehydrogenase	0.0086	0.2274	0.8342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0063	0.1447	0.1887
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0086	0.2274	0.8342
Brugia malayi	glutathione reductase	0.0038	0.0539	0.052
Plasmodium vivax	glutathione reductase, putative	0.0038	0.0539	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0063	0.1447	0.1887
Trichomonas vaginalis	set domain proteins, putative	0.0235	0.7669	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.003	0.0252	0.0074
Trypanosoma cruzi	trypanothione reductase, putative	0.0038	0.0539	0.1654
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0824	0.1075
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0086	0.2274	0.8342
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0253	0.005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.005	0.0984	0.1283
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0827	0.1078
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0253	0.0132
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0204	0.0266
Trichomonas vaginalis	PIKK family atypical protein kinase	0.005	0.1002	0.1306
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0063	0.1447	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2559	0.366
Schistosoma mansoni	hypothetical protein	0.0112	0.3213	0.8145
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0093	0.2559	0.366
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.1359	0.5
Plasmodium falciparum	glutathione reductase	0.0038	0.0539	0.5
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.1359	0.3125
Echinococcus multilocularis	GPCR, family 2	0.003	0.0252	0.0049
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0084	0.2227	0.5474
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.003	0.0252	0.0049
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.1359	0.5
Trypanosoma cruzi	target of rapamycin kinase 3	0.0067	0.1607	0.6934
Mycobacterium tuberculosis	Probable oxidoreductase	0.0095	0.2619	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0064	0.1491	0.2
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0824	0.1075
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0067	0.1607	0.6934
Schistosoma mansoni	hypothetical protein	0.003	0.0252	0.0129
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0253	0.0132
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0206	0.6639	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0252	0.0074
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0084	0.2227	0.5
Loa Loa (eye worm)	thioredoxin reductase	0.0038	0.0539	0.052
Trichomonas vaginalis	PIKK family atypical protein kinase	0.005	0.1002	0.1306
Giardia lamblia	GTOR	0.0084	0.2227	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0063	0.1447	0.1887

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 702961