Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0129 | 0.4191 | 0.5599 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0125 | 0.3971 | 0.3889 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0107 | 0.3157 | 0.4188 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0142 | 0.4773 | 0.6337 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.024 | 0.9418 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0142 | 0.4773 | 0.6376 |
Giardia lamblia | Methyltransferase like 2 | 0.004 | 0 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0142 | 0.4773 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0142 | 0.4773 | 0.6376 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0 | 0.5 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0133 | 0.4383 | 0.5834 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0133 | 0.4383 | 0.5856 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1625 | 0.0823 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0152 | 0.526 | 0.5573 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0199 | 0.7486 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0199 | 0.7486 | 1 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0152 | 0.526 | 0.526 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0199 | 0.7486 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0142 | 0.4773 | 0.6357 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0129 | 0.4191 | 0.5599 |
Brugia malayi | AMP-binding enzyme family protein | 0.0041 | 0.0039 | 0.0039 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0087 | 0.218 | 0.2574 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0107 | 0.3157 | 0.4188 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0152 | 0.526 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0133 | 0.4383 | 0.581 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0042 | 0.0081 | 0.0056 |
Brugia malayi | AMP-binding enzyme family protein | 0.0125 | 0.3971 | 0.3971 |
Mycobacterium ulcerans | polyketide synthase | 0.0133 | 0.4383 | 0.5834 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0142 | 0.4773 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0133 | 0.4383 | 0.5856 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0107 | 0.3157 | 0.4155 |
Loa Loa (eye worm) | fatty acid synthase | 0.0132 | 0.43 | 0.4318 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0054 | 0.0647 | 0.0864 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0088 | 0.2258 | 0.2981 |
Mycobacterium ulcerans | polyketide synthase | 0.0142 | 0.4773 | 0.6357 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0046 | 0.0267 | 0.0356 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0133 | 0.4383 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0096 | 0.2616 | 0.3495 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0142 | 0.4773 | 0.6357 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0152 | 0.526 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0133 | 0.4383 | 0.5856 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0133 | 0.4383 | 0.581 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0095 | 0.2576 | 0.3708 |
Mycobacterium ulcerans | thioesterase TesA | 0.0111 | 0.3337 | 0.443 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0088 | 0.2258 | 0.2941 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0041 | 0.0039 | 0.0052 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0109 | 0.324 | 0.4329 |
Onchocerca volvulus | 0.0232 | 0.9028 | 0.9285 | |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0076 | 0.1676 | 0.224 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0125 | 0.3971 | 0.5305 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0111 | 0.3337 | 0.4459 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0088 | 0.2258 | 0.2981 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0199 | 0.7486 | 1 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0111 | 0.3337 | 0.4398 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0042 | 0.0081 | 0.0108 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0133 | 0.4383 | 0.4383 |
Mycobacterium ulcerans | thioesterase | 0.0111 | 0.3337 | 0.443 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0133 | 0.4383 | 0.5834 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.8648 | 1 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0152 | 0.526 | 0.5 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0142 | 0.4773 | 0.6376 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0133 | 0.4383 | 0.5834 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0152 | 0.526 | 1 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0142 | 0.4773 | 0.6337 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 140 nM | Inhibition of binding to Grb2 SH2 domain | ChEMBL. | 9599224 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.