Detailed information for compound 70357

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 178.191 | Formula: C8H10N4O
  • H donors: 1 H acceptors: 4 LogP: 1.36 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1ncn2c1cnnc2O
  • InChi: 1S/C8H10N4O/c1-2-3-6-7-4-10-11-8(13)12(7)5-9-6/h4-5H,2-3H2,1H3,(H,11,13)
  • InChiKey: BIBFDUJJUVJHDI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0019 0.1053
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0008 0.0006
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0008 0.0376
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0103 0.032
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0084 0.0083
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0103 0.6292
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0024 0.0056
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0034 0.0082
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0008 0.1572
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0008 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.2507
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0103 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0002 0.018
Onchocerca volvulus 0.001 0.0007 0.1442
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0007 0.2508
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0034 0.3181
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0008 0.0006
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0019 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.2507
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0007 0.0548
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0024 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0008 0.0006
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0019 0.0053
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0163 0.0508
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0008 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0008 0.0006
Entamoeba histolytica hypothetical protein 0.001 0.0007 0.1722
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0019 0.1053
Onchocerca volvulus 0.001 0.0008 0.1572
Echinococcus granulosus GPCR family 2 0.0016 0.0019 0.1053
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0024 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0021 0.2005
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0007 0.2507
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.2012 0.3922 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0163 0.0161
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0034 0.3181
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0163 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0034 0.3304
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0024 0.007
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0006
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0008 0.0376
Brugia malayi hypothetical protein 0.001 0.0007 0.0006
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0016 0.0014
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0103 0.6292
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.004 0.0039
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0034 0.0032
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0021 0.2005
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0008 0.0376
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0007 0.2508
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0008 0.0376
Brugia malayi nuclear receptor NHR-88 0.001 0.0008 0.0006
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0103 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0024 0.2185
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0008 0.0376
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0034 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0007 0.2507
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0008 0.0019
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0034 1
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0007 0.0006
Brugia malayi ecdysteroid receptor 0.001 0.0008 0.0006
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.004 0.0039
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0008 0.0376
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0084 0.0083
Schistosoma mansoni lamin 0.0027 0.004 0.2391
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0007 0.0014
Schistosoma mansoni ap endonuclease 0.0018 0.0024 0.1375
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0007 0.0345
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0002 0.018
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0084 0.0083
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0019 0.0017
Schistosoma mansoni hypothetical protein 0.0016 0.0019 0.1053
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0034 0.3181
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0007 0.0014
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0034 0.0082
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0034 0.3181
Echinococcus granulosus lamin dm0 0.0027 0.004 0.2391
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0006
Brugia malayi topoisomerase 0.001 0.0007 0.0006
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1628 0.3173 1
Schistosoma mansoni DNA ligase IV 0.001 0.0007 0.0345
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0007 0.0014
Schistosoma mansoni thyroid hormone receptor 0.001 0.0008 0.0376
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0163 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0084 0.0083
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0103 1
Brugia malayi nuclear hormone receptor 0.001 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0008 0.0006
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0034 0.3181
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0034 0.3181
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0007 0.0018
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0007 0.2508
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0007 0.2508
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0024 1
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0023 0.9348
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0103 0.0258
Echinococcus granulosus nibrin 0.001 0.0007 0.0345
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0002 0.018
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.2012 0.3922 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0006
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0008 0.0019
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0024 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0163 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0024 0.0056
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0054 0.0052
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0103 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0008 0.0376
Echinococcus granulosus FTZ F1 alpha 0.001 0.0008 0.0376
Brugia malayi intermediate filament protein 0.0027 0.004 0.0039
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0024 1
Schistosoma mansoni hypothetical protein 0.0016 0.0019 0.1053
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0163 1
Brugia malayi hypothetical protein 0.001 0.0007 0.0006
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0014 0.0037
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0023 0.2042
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0008 0.0019
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0002 0.018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0163 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0002 0.018
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0034 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.512 1 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0024 0.6869
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0024 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0032
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0034 0.0082
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0019 0.0017
Echinococcus multilocularis nibrin 0.001 0.0007 0.0018
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0007 0.0014
Schistosoma mansoni ap endonuclease 0.0018 0.0024 0.1375
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0008 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0008 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0021
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0024 0.0017
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0016 0.0014
Toxoplasma gondii exonuclease III APE 0.0018 0.0024 0.2185
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0011
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0034 1
Onchocerca volvulus 0.0027 0.004 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0006
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0008 0.0376
Echinococcus multilocularis lamin 0.0027 0.004 0.0121
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0024 0.0056
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0163 0.0161
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0002 0.018
Echinococcus multilocularis lamin dm0 0.0027 0.004 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0008 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0008 0.0006
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0023 0.2186
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0008 0.1572
Loa Loa (eye worm) hypothetical protein 0.0026 0.0039 0.0038
Echinococcus multilocularis GPCR, family 2 0.0016 0.0019 0.0053
Schistosoma mansoni hypothetical protein 0.0034 0.0054 0.324
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0024 0.1375
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0006
Schistosoma mansoni topbp1 0.001 0.0007 0.0345
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0034 0.0032
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0008 0.0376
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0008 0.0376
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0024 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0008 0.0006
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0002 0.018
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0002 0.018
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0008 0.1572
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0008 0.0019
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0007 0.0548
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0008 0.0376
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0021
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0007 0.1722
Onchocerca volvulus 0.0027 0.004 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0008 0.0376
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0008 0.0006
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0024 0.0056
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0006
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0007 0.0006
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0014 0.0723
Echinococcus granulosus lamin 0.0027 0.004 0.2391
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0008 0.0019
Brugia malayi DKFZp564C0469 protein 0.001 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0006
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0019 0.0017
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0034 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0008 0.0006
Schistosoma mansoni coup transcription factor 0.001 0.0008 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.2507
Mycobacterium ulcerans hypothetical protein 0.0023 0.0034 0.3181
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0103 0.6292
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0007 0.2508
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0032
Schistosoma mansoni hypothetical protein 0.0016 0.0019 0.1053
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0012
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0103 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0024 0.2326
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0024 0.0022
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 0.512 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0034 0.3304
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0002 0.018
Echinococcus granulosus intermediate filament protein 0.0027 0.004 0.2391
Schistosoma mansoni topbp1 0.001 0.0007 0.0345
Schistosoma mansoni intermediate filament proteins 0.0027 0.004 0.2391
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0008 0.0376
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0008 0.0376
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0006
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0023 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0008 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0008 0.0006
Echinococcus granulosus replication factor c subunit 1 0.001 0.0007 0.0345
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0008 0.0376
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0008 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0163 0.0508
Schistosoma mansoni hypothetical protein 0.0016 0.0019 0.1053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0008 0.0006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0021 0.2005
Onchocerca volvulus 0.0011 0.0009 0.1895
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0021 0.2005
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0007 0.0548
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0008 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0008 0.0006
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0007 0.1722
Brugia malayi steroid hormone receptor 0.001 0.0008 0.0006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0006
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0002 0.018
Loa Loa (eye worm) intermediate filament protein 0.0027 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0027 0.004 0.0039
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0034 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0008 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.2507
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0002 0.018
Leishmania major malonyl-coa decarboxylase-like protein 0.2012 0.3922 1
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.2012 0.3922 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0008 0.0019
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0008 0.0376
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0034 0.3181
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0021
Onchocerca volvulus 0.0023 0.0034 0.8371
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.2507
Schistosoma mansoni nuclear hormone receptor 0.001 0.0008 0.0376
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0008 0.0019
Schistosoma mansoni lamin 0.0027 0.004 0.2391
Echinococcus multilocularis musashi 0.0027 0.004 0.0121
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0007 0.0014
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0008 0.0376
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0023 0.9348

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 48 uM Inhibitory activity against histamine release from antigen-challenged, sensitized human basophils ChEMBL. 2415706
IC50 (functional) > 48 uM Inhibitory activity against histamine release from antigen-challenged, sensitized human basophils ChEMBL. 2415706

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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