Detailed information for compound 703593

Basic information

Technical information
  • TDR Targets ID: 703593
  • Name: 2-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-6,7- dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]- N-phenylacetamide
  • MW: 479.495 | Formula: C21H16F3N3O3S2
  • H donors: 1 H acceptors: 2 LogP: 4.81 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1)CSc1nc2CCSc2c(=O)n1c1ccc(cc1)OC(F)(F)F
  • InChi: 1S/C21H16F3N3O3S2/c22-21(23,24)30-15-8-6-14(7-9-15)27-19(29)18-16(10-11-31-18)26-20(27)32-12-17(28)25-13-4-2-1-3-5-13/h1-9H,10-12H2,(H,25,28)
  • InChiKey: SXHQWFGIUZZMBD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-phenyl-acetamide
  • 2-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]thio]-N-phenylacetamide
  • 2-[[4-keto-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]thio]-N-phenyl-acetamide
  • 2-[[4-oxo-3-[4-(trifluoromethoxy)phenyl]-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-phenyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0035 0.0035
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0063 0.0159
Treponema pallidum heat shock protein 90 0.0044 0.0532 1
Leishmania major heat shock protein 83-1 0.0047 0.0574 0.7246
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0444 0.7733
Plasmodium vivax heat shock protein, putative 0.0176 0.2444 1
Echinococcus granulosus tar DNA binding protein 0.0195 0.2706 0.2706
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0063 0.0159
Schistosoma mansoni dishevelled 0.0009 0.0035 0.0035
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0063 0.0063
Echinococcus granulosus endoplasmin 0.0044 0.0532 0.0532
Schistosoma mansoni microtubule-associated protein tau 0.0701 1 1
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0035 0.0088
Schistosoma mansoni tar DNA-binding protein 0.0195 0.2706 0.2706
Loa Loa (eye worm) hypothetical protein 0.0009 0.0035 0.0088
Leishmania major heat shock protein 83-1 0.0047 0.0574 0.7246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0063 0.0159
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0444 0.7733
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0444 0.1124
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0035 0.0035
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0044 0.0532 1
Echinococcus granulosus geminin 0.0174 0.2409 0.2409
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0063 0.0063
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0063 0.0159
Schistosoma mansoni dishevelled 0.0009 0.0035 0.0035
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0063 0.0243
Schistosoma mansoni tar DNA-binding protein 0.0195 0.2706 0.2706
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0063 0.0159
Loa Loa (eye worm) hypothetical protein 0.0009 0.0035 0.0088
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0444 0.1124
Plasmodium vivax endoplasmin, putative 0.0047 0.0574 0.2347
Trypanosoma cruzi Heat shock protein 83, putative 0.0047 0.0574 1
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0574 1
Schistosoma mansoni dep domain containing protein 0.0009 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0011 0.0063 0.0159
Echinococcus multilocularis heat shock protein 90 0.004 0.0477 0.0477
Trypanosoma brucei heat shock protein, putative 0.0047 0.0574 1
Trypanosoma brucei heat shock protein 90, putative 0.0047 0.0574 1
Chlamydia trachomatis DNA gyrase subunit B 0.0007 0 0.5
Echinococcus granulosus heat shock protein 0.0047 0.0574 0.0574
Brugia malayi N-terminal motif family protein 0.0185 0.2573 0.6521
Loa Loa (eye worm) inositol-1 0.0038 0.0444 0.1124
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0044 0.0532 0.6726
Schistosoma mansoni hypothetical protein 0.0174 0.2409 0.2409
Toxoplasma gondii Hsp90 domain-containing protein 0.0176 0.2444 1
Trichomonas vaginalis heat shock protein, putative 0.004 0.0477 0.1208
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0063 0.0159
Leishmania major heat shock protein 83-1 0.0047 0.0574 0.7246
Loa Loa (eye worm) hypothetical protein 0.0011 0.0063 0.0159
Schistosoma mansoni heat shock protein 0.0047 0.0574 0.0574
Trypanosoma brucei heat shock protein 90, putative 0.0047 0.0574 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0063 0.0063
Entamoeba histolytica heat shock protein 90, putative 0.0047 0.0574 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0063 0.0159
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0063 0.0063
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0444 0.5604
Echinococcus multilocularis neuropeptide s receptor 0.0471 0.6694 0.6694
Loa Loa (eye worm) hypothetical protein 0.0011 0.0063 0.0159
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0293 0.1198
Onchocerca volvulus 0.0011 0.0063 0.0243
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0063 0.0063
Brugia malayi follicle stimulating hormone receptor 0.0256 0.3592 0.9104
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0063 0.0063
Trypanosoma brucei heat shock protein, putative 0.0047 0.0574 1
Echinococcus multilocularis neuropeptide receptor A26 0.0471 0.6694 0.6694
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0063 0.0063
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0063 0.0243
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0444 0.1124
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0792 1
Brugia malayi nuclear hormone receptor 0.0011 0.0063 0.0159
Leishmania major heat shock protein, putative 0.0031 0.0349 0.4403
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0063 0.0063
Brugia malayi TAR-binding protein 0.0195 0.2706 0.6857
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0031 0.0349 0.6077
Trypanosoma brucei heat shock protein, putative 0.0047 0.0574 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0063 0.0063
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0185 0.2573 1
Brugia malayi glutaminase DH11.1 0.0281 0.3946 1
Brugia malayi Hsp90 protein 0.0031 0.0349 0.0883
Trichomonas vaginalis endoplasmin, putative 0.0034 0.039 0.0988
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0035 0.0088
Leishmania major heat shock protein 83-1 0.0047 0.0574 0.7246
Mycobacterium ulcerans heat shock protein 90 0.0044 0.0532 0.1349
Leishmania major heat shock protein 83-1 0.0047 0.0574 0.7246
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0293 0.0742
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0035 0.0035
Plasmodium vivax heat shock protein 86, putative 0.0047 0.0574 0.2347
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0063 0.0063
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0063 0.0063
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0444 0.8332
Schistosoma mansoni endoplasmin 0.0047 0.0574 0.0574
Trypanosoma cruzi heat shock protein, putative 0.0031 0.0349 0.6077
Trypanosoma brucei Heat shock protein 83, putative 0.0047 0.0574 1
Leishmania major heat shock protein 83-1 0.0047 0.0574 0.7246
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0063 0.0063
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0035 0.0035
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1279 0.1279
Onchocerca volvulus 0.0009 0.0035 0.0134
Schistosoma mansoni inositol monophosphatase 0.0038 0.0444 0.0444
Leishmania major heat shock protein 83-1 0.0047 0.0574 0.7246
Schistosoma mansoni hypothetical protein 0.0174 0.2409 0.2409
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0063 0.0159
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0063 0.0063
Echinococcus granulosus neuropeptide s receptor 0.0471 0.6694 0.6694
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0063 0.0063
Trypanosoma cruzi heat shock protein 90, putative 0.0047 0.0574 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0035 0.0035
Toxoplasma gondii heat shock protein HSP90 0.0047 0.0574 0.2347
Leishmania major heat shock protein 83-1 0.0047 0.0574 0.7246
Toxoplasma gondii hypothetical protein 0.0009 0.0035 0.0141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1279 0.1279
Echinococcus multilocularis heat shock protein 90 0.0047 0.0574 0.0574
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0035 0.0035
Giardia lamblia Heat shock protein HSP 90-alpha 0.004 0.0477 0.8311
Loa Loa (eye worm) hypothetical protein 0.0185 0.2573 0.6521
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0792 0.2006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0063 0.0159
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0792 0.2006
Brugia malayi hypothetical protein 0.0009 0.0035 0.0088
Echinococcus multilocularis endoplasmin 0.0044 0.0532 0.0532
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.1279 0.3242
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0063 0.0063
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0184 0.3205
Loa Loa (eye worm) RNA binding protein 0.0195 0.2706 0.6857
Echinococcus multilocularis heat shock protein 0.0047 0.0574 0.0574
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0063 0.0159
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0063 0.0159
Trypanosoma brucei heat shock protein, putative 0.0047 0.0574 1
Loa Loa (eye worm) glutaminase 0.0281 0.3946 1
Schistosoma mansoni heat shock protein 0.0047 0.0574 0.0574
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0035 0.0035
Schistosoma mansoni heat shock protein 0.0031 0.0349 0.0349
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0063 0.0063
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0792 0.0792
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0387 0.4888
Loa Loa (eye worm) heat shock protein 75 0.0031 0.0349 0.0883
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0007 0 0.5
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0792 0.0792
Schistosoma mansoni tar DNA-binding protein 0.0195 0.2706 0.2706
Trichomonas vaginalis glutaminase, putative 0.0281 0.3946 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0063 0.0159
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0063 0.0159
Leishmania major heat shock protein 83-1 0.0047 0.0574 0.7246
Trichomonas vaginalis heat shock protein, putative 0.0034 0.039 0.0988
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0035 0.0035
Loa Loa (eye worm) TAR-binding protein 0.0195 0.2706 0.6857
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0063 0.0159
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0574 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0444 0.7733
Chlamydia trachomatis DNA gyrase subunit B 0.0007 0 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0063 0.0063
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0031 0.0349 0.0349
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0063 0.0063
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1279 0.1279
Trypanosoma cruzi heat shock protein 90, putative 0.004 0.0477 0.8311
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0063 0.0063
Echinococcus multilocularis geminin 0.0174 0.2409 0.2409
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0792 0.0792
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0063 0.0063
Trichomonas vaginalis heat shock protein, putative 0.0044 0.0532 0.1349
Giardia lamblia Grp94/Hsp90 0.0044 0.0532 0.9282
Trypanosoma brucei heat shock protein, putative 0.0047 0.0574 1
Leishmania major heat shock protein 83-1 0.0047 0.0574 0.7246
Brugia malayi heat shock protein 90 0.0047 0.0574 0.1454
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0063 0.0159
Brugia malayi Inositol-1 0.0038 0.0444 0.1124
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0035 0.0134
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0444 0.7733
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0063 0.0063
Entamoeba histolytica heat shock protein 90, putative 0.0047 0.0574 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0063 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0063 0.0159
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0044 0.0532 0.6726
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0387 0.7268
Loa Loa (eye worm) endoplasmin 0.0047 0.0574 0.1454
Brugia malayi DIX domain containing protein 0.0009 0.0035 0.0088
Echinococcus granulosus heat shock protein 90 0.004 0.0477 0.0477
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0444 0.1815
Echinococcus granulosus neuropeptide receptor A26 0.0471 0.6694 0.6694
Schistosoma mansoni tar DNA-binding protein 0.0195 0.2706 0.2706
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0031 0.0349 0.0349
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1279 0.1279
Brugia malayi nuclear receptor NHR-88 0.0011 0.0063 0.0159
Loa Loa (eye worm) glutaminase 2 0.0281 0.3946 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0063 0.0063
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0063 0.0063
Leishmania major heat shock protein 83-1 0.0047 0.0574 0.7246
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0792 1
Trypanosoma brucei heat shock protein 84, putative 0.0031 0.0349 0.6077
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0035 0.0088
Trypanosoma brucei heat shock protein, putative 0.0047 0.0574 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1279 0.1279
Brugia malayi RNA recognition motif domain containing protein 0.0195 0.2706 0.6857
Loa Loa (eye worm) hypothetical protein 0.0011 0.0063 0.0159
Plasmodium falciparum endoplasmin, putative 0.0034 0.039 0.1595
Leishmania major heat shock protein 83-1 0.0047 0.0574 0.7246
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0035 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0063 0.0159
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0792 0.0792
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0195 0.2706 0.6857
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0063 0.0159
Brugia malayi ecdysteroid receptor 0.0011 0.0063 0.0159
Leishmania major heat shock protein 83-1 0.0047 0.0574 0.7246
Loa Loa (eye worm) hypothetical protein 0.0011 0.0063 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0063 0.0159
Plasmodium falciparum heat shock protein 90, putative 0.0176 0.2444 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0035 0.0088
Loa Loa (eye worm) hypothetical protein 0.0011 0.0063 0.0159
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0035 0.0088
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0035 0.0035
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0044 0.0532 1
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0035 0.0035
Leishmania major heat shock protein 83-1 0.0047 0.0574 0.7246
Trypanosoma cruzi heat shock protein 85, putative 0.004 0.0477 0.8311
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0063 0.0159
Leishmania major heat shock protein 83-1 0.0047 0.0574 0.7246
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0444 0.1124
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0063 0.0063
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0574 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0792 0.2006
Trichomonas vaginalis heat shock protein, putative 0.0047 0.0574 0.1454
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0063 0.0243
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.004 0.0477 0.0477
Echinococcus granulosus heat shock protein 90 0.0047 0.0574 0.0574
Brugia malayi hypothetical protein 0.0009 0.0035 0.0088
Schistosoma mansoni glutaminase 0.0281 0.3946 0.3946
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1279 0.1279
Leishmania major heat shock protein 83-1 0.0047 0.0574 0.7246
Trypanosoma brucei heat shock protein, putative 0.0047 0.0574 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.1279 0.3242
Giardia lamblia Heat shock protein HSP 90-alpha 0.0047 0.0574 1
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0063 0.0063
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0035 0.0035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0063 0.0063
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0063 0.0063
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0444 0.0444
Loa Loa (eye worm) hypothetical protein 0.0011 0.0063 0.0159
Leishmania major heat shock protein 83-1 0.0047 0.0574 0.7246
Mycobacterium ulcerans glutaminase 0.0281 0.3946 1
Plasmodium vivax heat shock protein 90, putative 0.0031 0.0349 0.1426
Toxoplasma gondii heat shock protein 75, putative 0.0031 0.0349 0.1426
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0063 0.0063
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0031 0.0349 0.1355
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0035 0.0035
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0063 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0063 0.0159
Brugia malayi steroid hormone receptor 0.0011 0.0063 0.0159
Echinococcus multilocularis tar DNA binding protein 0.0195 0.2706 0.2706
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1279 0.1279
Trypanosoma brucei heat shock protein, putative 0.0047 0.0574 1
Brugia malayi RNA binding protein 0.0195 0.2706 0.6857
Trichomonas vaginalis heat shock protein, putative 0.0044 0.0532 0.1349
Plasmodium falciparum heat shock protein 90 0.0047 0.0574 0.2347
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0256 0.3592 0.9104
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0063 0.0063
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0444 0.0444
Echinococcus multilocularis microtubule associated protein 2 0.0701 1 1
Loa Loa (eye worm) heat shock protein 90 0.0047 0.0574 0.1454
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0063 0.0159
Brugia malayi Endoplasmin precursor 0.0047 0.0574 0.1454
Schistosoma mansoni coup transcription factor 0.0011 0.0063 0.0063
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0035 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0195 0.2706 0.2706
Schistosoma mansoni endoplasmin 0.0047 0.0574 0.0574
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0792 0.3239
Toxoplasma gondii heat shock protein 90, putative 0.0047 0.0574 0.2347
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0063 0.0159
Schistosoma mansoni inositol monophosphatase 0.0038 0.0444 0.0444
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0063 0.0159

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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