TDR Targets

Basic information

Technical information

TDR Targets ID: 703961
Name: N-butyl-N-(1,1-dioxothiolan-3-yl)-3-(trifluor omethyl)benzamide
MW: 363.395 | Formula: C16H20F3NO3S
H donors: 0 H acceptors: 3 LogP: 3.09 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCCN(C(=O)c1cccc(c1)C(F)(F)F)C1CCS(=O)(=O)C1
InChi: 1S/C16H20F3NO3S/c1-2-3-8-20(14-7-9-24(22,23)11-14)15(21)12-5-4-6-13(10-12)16(17,18)19/h4-6,10,14H,2-3,7-9,11H2,1H3
InChiKey: WXDVULCKZYJDRI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-butyl-N-(1,1-dioxo-3-thiolanyl)-3-(trifluoromethyl)benzamide
N-butyl-N-(1,1-diketothiolan-3-yl)-3-(trifluoromethyl)benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	MAP kinase sur-1	0.0051	0.3663	0.3663
Loa Loa (eye worm)	hypothetical protein	0.001	0.0245	0.0245
Trichomonas vaginalis	aldo-keto reductase, putative	0.0126	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0126	1	1
Brugia malayi	hypothetical protein	0.0016	0.079	0.079
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0093	0.7215	0.7215
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.7019	0.7019
Onchocerca volvulus		0.0093	0.7215	0.7215
Trichomonas vaginalis	aldo-keto reductase, putative	0.0036	0.2477	0.2477
Mycobacterium ulcerans	hypothetical protein	0.0024	0.1421	0.1421
Loa Loa (eye worm)	hypothetical protein	0.001	0.0245	0.0245
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.1548	0.6249
Onchocerca volvulus		0.0126	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.2477	0.2477
Loa Loa (eye worm)	hypothetical protein	0.001	0.0245	0.0245
Plasmodium vivax	aldehyde reductase, putative	0.0036	0.2477	1
Echinococcus granulosus	voltage gated potassium channel subunit	0.0036	0.2477	0.2477
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0126	1	1
Giardia lamblia	Kinase, CMGC MAPK	0.0051	0.3663	0.3504
Trichomonas vaginalis	aldo-keto reductase, putative	0.0126	1	1
Echinococcus granulosus	aldo keto reductase	0.0126	1	1
Brugia malayi	hypothetical protein	0.001	0.0245	0.0245
Loa Loa (eye worm)	hypothetical protein	0.001	0.0245	0.0245
Onchocerca volvulus		0.0093	0.7215	0.7215
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0126	1	1
Echinococcus multilocularis	aldo keto reductase	0.0126	1	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.7215	0.7215
Echinococcus granulosus	replication factor c subunit 1	0.001	0.0245	0.0245
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.0245	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0093	0.7215	0.7215
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0912	0.3683
Schistosoma mansoni	aldo-keto reductase	0.0126	1	1
Schistosoma mansoni	topbp1	0.001	0.0245	0.0245
Onchocerca volvulus		0.0093	0.7215	0.7215
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0036	0.2477	0.2477
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0912	0.0912
Echinococcus multilocularis	aldo keto reductase	0.0126	1	1
Onchocerca volvulus		0.0126	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0126	1	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.1421	0.1421
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0036	0.2477	0.2477
Toxoplasma gondii	ATPase, AAA family protein	0.001	0.0245	0.0245
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0126	1	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.083	0.083
Echinococcus granulosus	aldo keto reductase	0.0126	1	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0912	0.0912
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0245	0.0245
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0126	1	1
Echinococcus multilocularis	dnaJ subfamily C 6	0.0062	0.4606	0.4606
Onchocerca volvulus		0.001	0.0245	0.0245
Onchocerca volvulus		0.0036	0.2477	0.2477
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0051	0.3663	0.3663
Leishmania major	hypothetical protein, conserved	0.0025	0.1548	0.1548
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0126	1	1
Brugia malayi	Protein kinase domain containing protein	0.009	0.7019	0.7019
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0912	1
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0036	0.2477	1
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0093	0.7215	0.7215
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0126	1	1
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.0245	0.0245
Loa Loa (eye worm)	oxidoreductase	0.0126	1	1
Schistosoma mansoni	aldo-keto reductase	0.0126	1	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.1421	0.1421
Schistosoma mansoni	potassium channel beta	0.0036	0.2477	0.2477
Trichomonas vaginalis	aldo-keto reductase, putative	0.0126	1	1
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0036	0.2477	0.2477
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0051	0.3663	0.3663
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.009	0.7019	0.7019
Loa Loa (eye worm)	hypothetical protein	0.0024	0.1421	0.1421
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0245	0.0245
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.3663	0.3663
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0245	0.0245
Loa Loa (eye worm)	hypothetical protein	0.001	0.0245	0.0245
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0126	1	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.1421	0.1421
Mycobacterium leprae	Conserved hypothetical protein	0.0089	0.6932	0.6932
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0245	0.0245
Mycobacterium ulcerans	oxidoreductase	0.0126	1	1
Entamoeba histolytica	aldose reductase, putative	0.0126	1	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0051	0.3663	0.3663
Schistosoma mansoni	hypothetical protein	0.0062	0.4606	0.4606
Loa Loa (eye worm)	hypothetical protein	0.009	0.6942	0.6942
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.1421	0.1421
Loa Loa (eye worm)	oxidoreductase	0.0126	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0245	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0912	0.0912
Loa Loa (eye worm)	hypothetical protein	0.001	0.0245	0.0245
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.009	0.7019	0.7019
Plasmodium falciparum	aldehyde reductase, putative	0.0036	0.2477	1
Echinococcus granulosus	mitogen activated protein kinase	0.0051	0.3663	0.3663
Trypanosoma cruzi	aldo/keto reductase, putative	0.0126	1	1
Trypanosoma cruzi	aldo-keto reductase	0.0126	1	1
Schistosoma mansoni	hypothetical protein	0.0011	0.0369	0.0369
Brugia malayi	topoisomerase	0.001	0.0245	0.0245
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.1421	0.1421
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0126	1	1
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.001	0.0245	0.0245
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.1548	0.1548
Echinococcus granulosus	aldehyde reductase	0.0089	0.6932	0.6932
Entamoeba histolytica	aldose reductase, putative	0.0126	1	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.1548	0.6249
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.1421	0.1421
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.1548	0.1548
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1548	0.1548
Trichomonas vaginalis	aldo-keto reductase, putative	0.0036	0.2477	0.2477
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0093	0.7215	0.7215
Echinococcus multilocularis	mitogen activated protein kinase	0.0051	0.3663	0.3663
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0126	1	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.1548	0.6249
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0126	1	1
Brugia malayi	hypothetical protein	0.0025	0.1548	0.1548
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0036	0.2477	0.2477
Echinococcus granulosus	dual specificity	0.009	0.7019	0.7019
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.083	0.083
Entamoeba histolytica	hypothetical protein	0.001	0.0245	0.0245
Giardia lamblia	Aldose reductase	0.0126	1	1
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0051	0.3663	0.3663
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0126	1	1
Trypanosoma brucei	prostaglandin f synthase	0.0126	1	1
Echinococcus multilocularis	nibrin	0.001	0.0245	0.0245
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0126	1	1
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0126	1	1
Schistosoma mansoni	tyrosinase precursor	0.0093	0.7215	0.7215
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.3663	0.3663
Echinococcus granulosus	mitogen activated protein kinase 3	0.0051	0.3663	0.3663
Brugia malayi	DnaJ domain containing protein	0.0062	0.4606	0.4606
Entamoeba histolytica	aldose reductase, putative	0.0126	1	1
Brugia malayi	ShTK domain containing protein	0.0093	0.7215	0.7215
Brugia malayi	Common central domain of tyrosinase family protein	0.0093	0.7215	0.7215
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.009	0.7019	0.7019
Trypanosoma brucei	aldo/keto reductase, putative	0.0036	0.2477	0.2477
Mycobacterium ulcerans	hypothetical protein	0.0036	0.2477	0.2477
Brugia malayi	hypothetical protein	0.001	0.0245	0.0245
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0369	0.0369
Trypanosoma cruzi	aldo/keto reductase, putative	0.0036	0.2477	0.2477
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0126	1	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0126	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0126	1	1
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0036	0.2477	0.2477
Onchocerca volvulus		0.0126	1	1
Onchocerca volvulus		0.0024	0.1421	0.1421
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.1421	0.1421
Toxoplasma gondii	aldose reductase, putative	0.0126	1	1
Echinococcus granulosus	aldo keto reductase	0.0126	1	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.1421	0.1421
Onchocerca volvulus		0.0011	0.0328	0.0328
Trichomonas vaginalis	aldo-keto reductase, putative	0.0126	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0126	1	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.1421	0.1421
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0051	0.3663	0.3663
Onchocerca volvulus		0.0126	1	1
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.3663	0.3663
Echinococcus multilocularis	aldo keto reductase	0.0126	1	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.1548	0.1548
Trichomonas vaginalis	aldo-keto reductase, putative	0.0126	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0912	0.0912
Loa Loa (eye worm)	hypothetical protein	0.009	0.6942	0.6942
Loa Loa (eye worm)	DnaJ domain-containing protein	0.0062	0.4606	0.4606
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.083	0.083
Entamoeba histolytica	protein kinase, putative	0.009	0.7019	0.7019
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0051	0.3663	0.3663
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.001	0.0245	0.0245
Schistosoma mansoni	serine/threonine protein kinase	0.009	0.7019	0.7019
Schistosoma mansoni	tyrosinase precursor	0.0093	0.7215	0.7215
Brugia malayi	NADH-dependent xylose reductase	0.0036	0.2477	0.2477
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0036	0.2477	0.2477
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0093	0.7215	0.7215
Trichomonas vaginalis	aldo/keto reductase, putative	0.0126	1	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.1421	0.1421
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.1421	0.1421
Trypanosoma brucei	protein kinase, putative	0.0051	0.3663	0.3663
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.1421	0.1421
Trichomonas vaginalis	aldo-keto reductase, putative	0.0126	1	1
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0369	0.0369
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0126	1	1
Loa Loa (eye worm)	tyrosinase 1	0.0093	0.7215	0.7215
Onchocerca volvulus		0.0126	1	1
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0245	0.0245
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0245	0.0245
Schistosoma mansoni	DNA ligase IV	0.001	0.0245	0.0245
Trichomonas vaginalis	aldo-keto reductase, putative	0.0126	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0126	1	1
Entamoeba histolytica	protein kinase, putative	0.009	0.7019	0.7019
Loa Loa (eye worm)	hypothetical protein	0.0126	1	1
Echinococcus granulosus	dnaJ subfamily C 6	0.0062	0.4606	0.4606
Loa Loa (eye worm)	oxidoreductase	0.0126	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.1421	0.1421
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.3663	0.3663
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0126	1	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0126	1	1
Loa Loa (eye worm)	oxidoreductase	0.0126	1	1
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.001	0.0245	0.5
Schistosoma mansoni	topbp1	0.001	0.0245	0.0245
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.001	0.0245	0.0245
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0036	0.2477	0.2477
Treponema pallidum	DNA ligase (lig)	0.001	0.0245	0.5
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0912	0.0912
Loa Loa (eye worm)	hypothetical protein	0.0024	0.1421	0.1421
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.3663	0.3663
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.1421	0.1421
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0126	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0126	1	1
Echinococcus multilocularis	aldo keto reductase	0.0126	1	1
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.001	0.0245	0.0245
Onchocerca volvulus		0.0126	1	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.083	0.083
Trichomonas vaginalis	aldo-keto reductase, putative	0.0126	1	1
Trypanosoma brucei	aldo-keto reductase, putative	0.0126	1	1
Loa Loa (eye worm)	ShTK domain-containing protein	0.0093	0.7215	0.7215
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.1421	0.1421
Trichomonas vaginalis	protein kinase inhibitor, putative	0.0062	0.4606	0.4606
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0126	1	1
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0245	0.0245
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.009	0.7019	0.7019
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.3663	0.3663
Giardia lamblia	Aldose reductase	0.0126	1	1
Trypanosoma cruzi	FHA domain containing protein, putative	0.001	0.0245	0.0245
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0036	0.2477	0.2477
Trichomonas vaginalis	aldo-keto reductase, putative	0.0126	1	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.1548	0.1548
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0245	0.0245
Brugia malayi	Pax transcription activation domain interacting protein	0.001	0.0245	0.0245
Echinococcus granulosus	nibrin	0.001	0.0245	0.0245
Echinococcus multilocularis	aldehyde reductase	0.0089	0.6932	0.6932
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0036	0.2477	0.2477
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.1421	0.1421
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0051	0.3663	0.3663
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0245	0.0245
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0051	0.3663	0.3663
Leishmania major	prostaglandin f synthase, putative	0.0126	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0912	0.0912
Mycobacterium tuberculosis	Probable oxidoreductase	0.0126	1	1
Loa Loa (eye worm)	ShTK domain-containing protein	0.0093	0.7215	0.7215
Echinococcus multilocularis	dual specificity	0.009	0.7019	0.7019
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0245	0.0245
Trichomonas vaginalis	aldo-keto reductase, putative	0.0126	1	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0126	1	1
Mycobacterium tuberculosis	Conserved protein	0.0036	0.2477	0.2477
Entamoeba histolytica	hypothetical protein	0.009	0.7019	0.7019
Leishmania major	aldo-keto reductase-like protein	0.0126	1	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0126	1	1
Mycobacterium leprae	Possible oxidoreductase	0.0036	0.2477	0.2477
Plasmodium falciparum	replication factor C subunit 1, putative	0.001	0.0245	0.0988
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.1421	0.1421
Schistosoma mansoni	pol-related	0.0126	1	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0126	1	1
Echinococcus granulosus	hypothetical protein	0.0126	1	1
Plasmodium falciparum	aldo-keto reductase, putative	0.0036	0.2477	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0126	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.1421	0.1421
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0912	0.3683
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0126	1	1
Brugia malayi	DKFZp564C0469 protein	0.001	0.0245	0.0245
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.3663	0.3663
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0036	0.2477	0.2477
Plasmodium vivax	replication factor C subunit 1, putative	0.001	0.0245	0.0988
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.0245	0.0245
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0245	0.0245
Toxoplasma gondii	aldo-keto reductase	0.0036	0.2477	0.2477
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.1421	0.1421
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.1421	0.1421
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0126	1	1
Loa Loa (eye worm)	oxidoreductase	0.0126	1	1
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.1421	0.1421
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.009	0.7019	0.7019
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0245	0.0245
Trichomonas vaginalis	aldo-keto reductase, putative	0.0036	0.2477	0.2477
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0912	0.0912
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0126	1	1
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.001	0.0245	0.0245
Onchocerca volvulus		0.0093	0.7215	0.7215

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 703961