Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0208 | 0.3835 | 0.3067 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.044 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0233 | 0.4496 | 0.381 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.3835 | 0.3067 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.044 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.3835 | 0.3067 |
Echinococcus multilocularis | FTZ F1 alpha | 0.044 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.3835 | 0.3067 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0233 | 0.4496 | 0.4496 |
Onchocerca volvulus | 0.044 | 1 | 1 | |
Schistosoma mansoni | nuclear hormone receptor | 0.044 | 1 | 1 |
Onchocerca volvulus | 0.0208 | 0.3835 | 0.3067 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.044 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.044 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.044 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.044 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0208 | 0.3835 | 0.3067 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.044 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.044 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0208 | 0.3835 | 0.3067 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.044 | 1 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0208 | 0.3835 | 0.3067 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0233 | 0.4496 | 0.381 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.3835 | 0.3067 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0208 | 0.3835 | 0.3067 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.4496 | 0.381 |
Brugia malayi | hypothetical protein | 0.0208 | 0.3835 | 0.3067 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.044 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.4496 | 0.381 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.044 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0208 | 0.3835 | 0.3067 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.3835 | 0.3067 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.044 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0208 | 0.3835 | 0.3067 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.3835 | 0.3067 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.1414 | 0.0345 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0233 | 0.4496 | 0.4496 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0208 | 0.3835 | 0.3067 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0208 | 0.3835 | 0.3067 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.044 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.044 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.044 | 1 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0208 | 0.3835 | 0.3067 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0105 | 0.1108 | 0.1108 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.044 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0208 | 0.3835 | 0.3067 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.044 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0208 | 0.3835 | 0.3067 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.3835 | 0.3067 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.044 | 1 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0208 | 0.3835 | 0.3067 |
Brugia malayi | hypothetical protein | 0.0233 | 0.4496 | 0.381 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.044 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.044 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0208 | 0.3835 | 0.3067 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.044 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.044 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.044 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.3835 | 0.3067 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.044 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0208 | 0.3835 | 0.3067 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0208 | 0.3835 | 0.3067 |
Schistosoma mansoni | nuclear hormone receptor | 0.0208 | 0.3835 | 0.3835 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.044 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.3835 | 0.3067 |
Schistosoma mansoni | zinc finger protein | 0.0208 | 0.3835 | 0.3835 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 1 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0208 | 0.3835 | 0.3835 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.1414 | 0.0345 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.044 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0208 | 0.3835 | 0.3067 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.044 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0208 | 0.3835 | 0.3067 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.044 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.044 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0208 | 0.3835 | 0.3067 |
Brugia malayi | nuclear receptor RXR | 0.0233 | 0.4496 | 0.381 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.044 | 1 | 1 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0208 | 0.3835 | 0.3067 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0208 | 0.3835 | 0.3067 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0208 | 0.3835 | 0.3067 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.3835 | 0.3067 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.044 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0208 | 0.3835 | 0.3067 |
Brugia malayi | hypothetical protein | 0.0233 | 0.4496 | 0.381 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.044 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.044 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.044 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.044 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.044 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.044 | 1 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0105 | 0.1108 | 0.1108 |
Trypanosoma brucei | RNA helicase, putative | 0.0063 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.044 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.044 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0208 | 0.3835 | 0.3067 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0208 | 0.3835 | 0.3835 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.3835 | 0.3067 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.044 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.044 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.4496 | 0.381 |
Loa Loa (eye worm) | STAT protein | 0.0388 | 0.8628 | 0.8458 |
Onchocerca volvulus | Bile acid receptor homolog | 0.044 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.044 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0233 | 0.4496 | 0.381 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.4496 | 0.381 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.044 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0208 | 0.3835 | 0.3067 |
Brugia malayi | steroid hormone receptor | 0.044 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.044 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0208 | 0.3835 | 0.3835 |
Loa Loa (eye worm) | DR-78 | 0.0208 | 0.3835 | 0.3067 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.044 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.044 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.044 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.044 | 1 | 1 |
Brugia malayi | STAT protein, DNA binding domain containing protein | 0.0388 | 0.8628 | 0.8458 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.3835 | 0.3067 |
Schistosoma mansoni | coup transcription factor | 0.044 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.1414 | 0.0345 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.044 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.044 | 1 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0208 | 0.3835 | 0.3835 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.4496 | 0.381 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.044 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0233 | 0.4496 | 0.381 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0208 | 0.3835 | 0.3067 |
Onchocerca volvulus | 0.0208 | 0.3835 | 0.3067 | |
Loa Loa (eye worm) | steroid hormone receptor | 0.044 | 1 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0208 | 0.3835 | 0.3067 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.044 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0208 | 0.3835 | 0.3067 |
Brugia malayi | nuclear receptor NHR-88 | 0.044 | 1 | 1 |
Brugia malayi | ecdysone receptor | 0.0208 | 0.3835 | 0.3067 |
Brugia malayi | tailless protein | 0.0208 | 0.3835 | 0.3067 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.044 | 1 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0208 | 0.3835 | 0.3067 |
Schistosoma mansoni | nuclear receptor | 0.0208 | 0.3835 | 0.3835 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.3835 | 0.3067 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0233 | 0.4496 | 0.381 |
Schistosoma mansoni | nuclear receptor | 0.0208 | 0.3835 | 0.3835 |
Schistosoma mansoni | thyroid hormone receptor | 0.044 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.