Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0014 | 0.018 | 0.023 |
Onchocerca volvulus | Cathepsin F homolog | 0.0014 | 0.018 | 0.0366 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.018 | 0.023 |
Loa Loa (eye worm) | ctsf protein | 0.0014 | 0.018 | 0.023 |
Onchocerca volvulus | 0.0014 | 0.018 | 0.0366 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0014 | 0.018 | 0.018 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0014 | 0.018 | 0.018 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0018 | 0.0023 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0053 | 0.156 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.001 | 0.0046 | 0.0046 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0053 | 0.156 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0022 | 0.0484 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0014 | 0.018 | 0.018 |
Loa Loa (eye worm) | fibroinase | 0.0014 | 0.018 | 0.023 |
Echinococcus multilocularis | geminin | 0.0291 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0027 | 0.0649 | 0.0826 |
Echinococcus granulosus | tar DNA binding protein | 0.013 | 0.4297 | 0.4297 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0027 | 0.0649 | 0.0649 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.4297 | 0.4297 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.156 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Onchocerca volvulus | 0.0047 | 0.1356 | 0.3017 | |
Brugia malayi | Cathepsin L-like precursor | 0.0014 | 0.018 | 0.023 |
Onchocerca volvulus | 0.0014 | 0.018 | 0.0366 | |
Onchocerca volvulus | Cathepsin L homolog | 0.0014 | 0.018 | 0.0366 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0014 | 0.018 | 0.023 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1763 | 0.2243 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.1356 | 0.1725 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.4452 | 0.5664 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0014 | 0.018 | 0.018 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.156 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0009 | 0.0018 | 0.0023 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.001 | 0.0046 | 0.0046 |
Loa Loa (eye worm) | TAR-binding protein | 0.013 | 0.4297 | 0.5467 |
Entamoeba histolytica | cysteine protease, putative | 0.0014 | 0.018 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.1763 | 0.1763 |
Schistosoma mansoni | hypothetical protein | 0.001 | 0.0046 | 0.0046 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.156 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.156 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0014 | 0.018 | 0.0366 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0649 | 0.0649 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.013 | 0.4297 | 0.5467 |
Brugia malayi | hypothetical protein | 0.0014 | 0.0202 | 0.0257 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0129 | 0.4248 | 0.5404 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0027 | 0.0649 | 0.0649 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.156 | 1 |
Leishmania major | cathepsin L-like protease | 0.0053 | 0.156 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.156 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0053 | 0.156 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0014 | 0.018 | 0.023 |
Echinococcus multilocularis | cysteine protease | 0.0014 | 0.018 | 0.018 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0022 | 0.0484 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0129 | 0.4248 | 0.5404 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0484 | 0.0616 |
Schistosoma mansoni | hypothetical protein | 0.0291 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0014 | 0.018 | 0.018 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0014 | 0.018 | 0.018 |
Brugia malayi | Cathepsin L-like precursor | 0.0014 | 0.018 | 0.023 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0649 | 0.0649 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0053 | 0.156 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0014 | 0.018 | 0.023 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0027 | 0.0649 | 0.0826 |
Brugia malayi | Cathepsin L-like precursor | 0.0014 | 0.018 | 0.023 |
Echinococcus multilocularis | cysteine protease | 0.0014 | 0.018 | 0.018 |
Brugia malayi | cathepsin L-like precursor | 0.0009 | 0.0018 | 0.0023 |
Onchocerca volvulus | 0.0014 | 0.018 | 0.0366 | |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2723 | 0.3464 |
Brugia malayi | MH2 domain containing protein | 0.0129 | 0.4248 | 0.5404 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0014 | 0.018 | 0.018 |
Echinococcus granulosus | GPCR family 2 | 0.0027 | 0.0649 | 0.0649 |
Leishmania major | cathepsin L-like protease | 0.0053 | 0.156 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.4297 | 0.4297 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0009 | 0.0018 | 0.0023 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0027 | 0.0649 | 0.0826 |
Brugia malayi | RNA binding protein | 0.013 | 0.4297 | 0.5467 |
Brugia malayi | TAR-binding protein | 0.013 | 0.4297 | 0.5467 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0018 | 0.0023 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0027 | 0.0649 | 0.0649 |
Onchocerca volvulus | 0.0014 | 0.018 | 0.0366 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0022 | 0.0484 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0484 | 0.0616 |
Leishmania major | hypothetical protein, conserved | 0.0022 | 0.0484 | 0.2199 |
Onchocerca volvulus | 0.0014 | 0.018 | 0.0366 | |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.023 | 0.786 | 0.786 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.786 | 1 |
Brugia malayi | hypothetical protein | 0.023 | 0.786 | 1 |
Brugia malayi | hypothetical protein | 0.0134 | 0.4452 | 0.5664 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.4297 | 0.4297 |
Onchocerca volvulus | 0.0014 | 0.018 | 0.0366 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0014 | 0.018 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Onchocerca volvulus | 0.0014 | 0.018 | 0.0366 | |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0022 | 0.0484 | 0.2199 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0014 | 0.018 | 0.018 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.156 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.013 | 0.4297 | 0.5467 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0022 | 0.0484 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0014 | 0.018 | 0.023 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.156 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0009 | 0.0018 | 0.0018 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.156 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0086 | 0.2723 | 0.3464 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0018 | 0.0023 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0027 | 0.0649 | 0.0649 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.156 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0649 | 0.0826 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0649 | 0.0649 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0086 | 0.2723 | 0.3464 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0041 | 0.116 | 0.7098 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0022 | 0.0484 | 0.2199 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.4297 | 0.4297 |
Brugia malayi | Cathepsin L-like precursor | 0.0014 | 0.018 | 0.023 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0649 | 0.0649 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0058 | 0.1763 | 0.2243 |
Onchocerca volvulus | 0.0134 | 0.4452 | 1 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0086 | 0.2723 | 0.3464 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0014 | 0.018 | 0.023 |
Schistosoma mansoni | hypothetical protein | 0.0291 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0009 | 0.0018 | 0.0023 |
Loa Loa (eye worm) | RNA binding protein | 0.013 | 0.4297 | 0.5467 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0014 | 0.018 | 0.018 |
Echinococcus multilocularis | tar DNA binding protein | 0.013 | 0.4297 | 0.4297 |
Echinococcus multilocularis | GPCR, family 2 | 0.0027 | 0.0649 | 0.0649 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0014 | 0.018 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0009 | 0.0018 | 0.0018 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.4297 | 0.4297 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1356 | 0.1356 |
Leishmania major | cathepsin L-like protease | 0.0053 | 0.156 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.1356 | 0.1356 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0048 | 0.1398 | 0.8824 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0014 | 0.018 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.156 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.023 | 0.786 | 0.786 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.