TDR Targets

Basic information

Technical information

TDR Targets ID: 704590
Name: N-(3,4-dimethylphenyl)-1-(4-fluorophenyl)-3,4 -dihydro-1H-pyrrolo[2,1-c]pyrazine-2-carboxam ide
MW: 363.428 | Formula: C22H22FN3O
H donors: 1 H acceptors: 1 LogP: 3.61 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)C1N(CCn2c1ccc2)C(=O)Nc1ccc(c(c1)C)C
InChi: 1S/C22H22FN3O/c1-15-5-10-19(14-16(15)2)24-22(27)26-13-12-25-11-3-4-20(25)21(26)17-6-8-18(23)9-7-17/h3-11,14,21H,12-13H2,1-2H3,(H,24,27)
InChiKey: JXKXVWFVHCBDGX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	nuclear hormone receptor	0.0165	0.182	0.4555
Echinococcus multilocularis	sodium bile acid cotransporter	0.0118	0.1263	0.1263
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0165	0.182	0.4555
Loa Loa (eye worm)	hypothetical protein	0.035	0.3996	1
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0045	0.0405	0.1012
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.035	0.3996	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.035	0.3996	1
Brugia malayi	Niemann-Pick C1 protein precursor	0.0104	0.1106	0.2768
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.035	0.3996	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.035	0.3996	0.3996
Brugia malayi	hypothetical protein	0.0038	0.0326	0.0816
Brugia malayi	Nuclear hormone receptor-like 1	0.0185	0.2053	0.5138
Loa Loa (eye worm)	hypothetical protein	0.0165	0.182	0.4555
Onchocerca volvulus		0.0165	0.182	0.4555
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0019	0.0098	0.5677
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.035	0.3996	0.3996
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0173	0.5
Loa Loa (eye worm)	hypothetical protein	0.0165	0.182	0.4555
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.035	0.3996	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.035	0.3996	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0165	0.182	0.4555
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0173	0.5
Echinococcus multilocularis	tar DNA binding protein	0.0067	0.0668	0.0668
Brugia malayi	hypothetical protein	0.0165	0.182	0.4555
Onchocerca volvulus		0.0165	0.182	0.4555
Loa Loa (eye worm)	steroid hormone receptor	0.035	0.3996	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0173	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0173	1
Echinococcus granulosus	sodium bile acid cotransporter	0.0118	0.1263	0.316
Schistosoma mansoni	nuclear hormone receptor	0.0165	0.182	0.4555
Echinococcus multilocularis	Niemann Pick C1 protein	0.0149	0.1634	0.1634
Brugia malayi	hypothetical protein	0.0251	0.2829	0.708
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0326	0.0816
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0098	0.0246
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.0479	0.1199
Brugia malayi	hypothetical protein	0.0185	0.2053	0.5138
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0165	0.182	0.4555
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0185	0.2053	0.5138
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0165	0.182	0.4555
Brugia malayi	Nuclear hormone receptor E75	0.0165	0.182	0.4555
Echinococcus multilocularis	sodium bile acid cotransporter	0.0118	0.1263	0.1263
Onchocerca volvulus		0.0051	0.0479	0.1199
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0668	0.1671
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0173	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0098	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0165	0.182	0.4555
Brugia malayi	CHE-14 protein	0.0045	0.0405	0.1012
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0173	0.0433
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0098	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.035	0.3996	0.3996
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0185	0.2053	0.5138
Loa Loa (eye worm)	hypothetical protein	0.0165	0.182	0.4555
Loa Loa (eye worm)	hypothetical protein	0.0165	0.182	0.4555
Brugia malayi	Nuclear hormone receptor-like 1	0.0185	0.2053	0.5138
Loa Loa (eye worm)	hypothetical protein	0.0165	0.182	0.4555
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0098	0.0246
Brugia malayi	Steroid receptor seven-up type 2	0.035	0.3996	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.035	0.3996	1
Onchocerca volvulus		0.0025	0.0173	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0098	0.0246
Toxoplasma gondii	ATPase, AAA family protein	0.001	0.00000034704	1
Schistosoma mansoni	nuclear receptor	0.0165	0.182	0.4555
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.035	0.3996	1
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.00000034704	0.00000034704
Brugia malayi	nuclear receptor RXR	0.0165	0.182	0.4555
Brugia malayi	photoreceptor-specific nuclear receptor	0.035	0.3996	1
Brugia malayi	nuclear receptor NHR-88	0.0165	0.182	0.4555
Echinococcus multilocularis	expressed conserved protein	0.0098	0.1032	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0185	0.2053	0.5138
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.035	0.3996	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.035	0.3996	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0165	0.182	0.4555
Loa Loa (eye worm)	hypothetical protein	0.035	0.3996	1
Schistosoma mansoni	survival motor neuron protein	0.0051	0.0479	0.1199
Loa Loa (eye worm)	hypothetical protein	0.0165	0.182	0.4555
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0165	0.182	0.4555
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.035	0.3996	1
Loa Loa (eye worm)	hypothetical protein	0.035	0.3996	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0251	0.2829	0.2829
Schistosoma mansoni	sodium-bile acid cotransporter related	0.0118	0.1263	0.316
Loa Loa (eye worm)	hypothetical protein	0.0104	0.1106	0.2768
Entamoeba histolytica	hypothetical protein	0.0038	0.0326	0.2949
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0098	0.0246
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0106	0.1125	0.2816
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0173	0.0433
Schistosoma mansoni	hypothetical protein	0.0038	0.0326	0.0816
Loa Loa (eye worm)	hypothetical protein	0.0185	0.2053	0.5138
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.035	0.3996	1
Loa Loa (eye worm)	hypothetical protein	0.0185	0.2053	0.5138
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0405	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0185	0.2053	0.5138
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0165	0.182	0.182
Loa Loa (eye worm)	hypothetical protein	0.0165	0.182	0.4555
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0165	0.182	0.4555
Loa Loa (eye worm)	hypothetical protein	0.035	0.3996	1
Schistosoma mansoni	nuclear hormone receptor	0.035	0.3996	1
Schistosoma mansoni	hypothetical protein	0.0043	0.0386	0.0965
Schistosoma mansoni	thyroid hormone receptor	0.035	0.3996	1
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0173	1
Brugia malayi	conserved hypotetical protein	0.0165	0.182	0.4555
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0173	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.035	0.3996	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.035	0.3996	1
Schistosoma mansoni	RAR-like nuclear receptor	0.035	0.3996	1
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0173	0.0433
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0098	1
Brugia malayi	TAR-binding protein	0.0067	0.0668	0.1671
Brugia malayi	ecdysone receptor	0.0165	0.182	0.4555
Onchocerca volvulus		0.0118	0.1263	0.316
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0	0.5
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0173	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.035	0.3996	1
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.001	0.00000034704	0.0000031374
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.035	0.3996	1
Loa Loa (eye worm)	DR-78	0.0165	0.182	0.4555
Brugia malayi	nuclear receptor NHR-88	0.035	0.3996	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.182	0.4555
Schistosoma mansoni	hypothetical protein	0.0043	0.0386	0.0965
Onchocerca volvulus	Bile acid receptor homolog	0.035	0.3996	1
Brugia malayi	nuclear receptor NHR-67	0.0165	0.182	0.4555
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0173	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0104	0.1106	0.1106
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0326	0.0326
Schistosoma mansoni	sodium-bile acid cotransporter related	0.0118	0.1263	0.316
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0173	0.0433
Echinococcus granulosus	ecdysone induced protein 78C	0.035	0.3996	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.035	0.3996	0.3996
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.035	0.3996	1
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.00000034704	0.000008579
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0173	1
Echinococcus granulosus	tar DNA binding protein	0.0067	0.0668	0.1671
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0165	0.182	0.4555
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0173	1
Brugia malayi	steroid hormone receptor	0.035	0.3996	1
Schistosoma mansoni	hypothetical protein	0.0043	0.0386	0.0965
Echinococcus multilocularis	thyroid hormone receptor alpha	0.035	0.3996	0.3996
Brugia malayi	hypothetical protein	0.0185	0.2053	0.5138
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0165	0.182	0.4555
Loa Loa (eye worm)	hypothetical protein	0.0165	0.182	0.4555
Loa Loa (eye worm)	hypothetical protein	0.0185	0.2053	0.5138
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0185	0.2053	0.2053
Loa Loa (eye worm)	nuclear hormone receptor	0.0165	0.182	0.4555
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0173	0.1565
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.035	0.3996	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.0165	0.182	0.4555
Entamoeba histolytica	hypothetical protein	0.0038	0.0326	0.2949
Onchocerca volvulus		0.035	0.3996	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0165	0.182	0.4555
Schistosoma mansoni	thyroid hormone receptor	0.035	0.3996	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.035	0.3996	1
Brugia malayi	hypothetical protein	0.0165	0.182	0.4555
Loa Loa (eye worm)	hypothetical protein	0.0165	0.182	0.4555
Giardia lamblia	Replication factor C, subunit 1	0.001	0.00000034704	0.5
Trypanosoma cruzi	FHA domain containing protein, putative	0.001	0	0.5
Echinococcus multilocularis	protein patched	0.0045	0.0405	0.0405
Echinococcus granulosus	Protein patched homolog 1	0.0045	0.0405	0.1012
Loa Loa (eye worm)	hypothetical protein	0.0118	0.1263	0.316
Loa Loa (eye worm)	hypothetical protein	0.035	0.3996	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0098	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0405	0.1012
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0173	0.0433
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0	0.5
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.035	0.3996	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.035	0.3996	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0165	0.182	0.4555
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.035	0.3996	1
Loa Loa (eye worm)	hypothetical protein	0.0185	0.2053	0.5138
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0173	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0523	0.1309
Schistosoma mansoni	patched 1	0.0045	0.0405	0.1012
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0	0.5
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0173	0.1565
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0668	0.1671
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0173	1
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.00000034704	0.000008579
Echinococcus multilocularis	sodium bile acid cotransporter	0.0118	0.1263	0.1263
Loa Loa (eye worm)	hypothetical protein	0.0165	0.182	0.4555
Schistosoma mansoni	zinc finger protein	0.0165	0.182	0.4555
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0173	1
Loa Loa (eye worm)	hypothetical protein	0.035	0.3996	1
Schistosoma mansoni	nuclear hormone receptor	0.0165	0.182	0.4555
Echinococcus granulosus	sodium bile acid cotransporter	0.0118	0.1263	0.316
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0165	0.182	0.182
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.035	0.3996	1
Loa Loa (eye worm)	hypothetical protein	0.0251	0.2829	0.708
Loa Loa (eye worm)	hypothetical protein	0.035	0.3996	1
Brugia malayi	nuclear hormone receptor	0.035	0.3996	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.035	0.3996	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0165	0.182	0.4555
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0098	0.139
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0173	1
Echinococcus granulosus	replication factor c subunit 1	0.001	0.00000034704	0.00000086845
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0173	0.0433
Echinococcus granulosus	expressed conserved protein	0.0098	0.1032	0.2582
Loa Loa (eye worm)	hypothetical protein	0.0165	0.182	0.4555
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0668	0.1671
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.035	0.3996	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0045	0.0405	0.0405
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.001	0	0.5
Schistosoma mansoni	hypothetical protein	0.0043	0.0386	0.0965
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0	0.5
Brugia malayi	RNA recognition motif domain containing protein	0.0067	0.0668	0.1671
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.035	0.3996	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0173	0.1565
Loa Loa (eye worm)	TAR-binding protein	0.0067	0.0668	0.1671
Schistosoma mansoni	nuclear receptor	0.0165	0.182	0.4555
Echinococcus granulosus	sodium bile acid cotransporter	0.0118	0.1263	0.316
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.035	0.3996	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.035	0.3996	1
Brugia malayi	Nuclear hormone receptor-like 1	0.035	0.3996	1
Loa Loa (eye worm)	hypothetical protein	0.035	0.3996	1
Brugia malayi	Nuclear hormone receptor E75	0.0165	0.182	0.4555
Brugia malayi	tailless protein	0.0165	0.182	0.4555
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0165	0.182	0.4555
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0165	0.182	0.182
Echinococcus granulosus	survival motor neuron protein 1	0.0251	0.2829	0.708
Schistosoma mansoni	retinoic acid receptor RXR	0.035	0.3996	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.035	0.3996	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.035	0.3996	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.035	0.3996	0.3996
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0067	0.0668	0.1671
Echinococcus multilocularis	nuclear receptor nhr 48	0.0165	0.182	0.182
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.035	0.3996	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0104	0.1106	0.2768
Schistosoma mansoni	coup transcription factor	0.035	0.3996	1
Brugia malayi	ecdysteroid receptor	0.035	0.3996	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0165	0.182	0.4555
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.035	0.3996	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0326	0.0816
Brugia malayi	Sodium Bile acid symporter family protein	0.0118	0.1263	0.316
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.00000034704	0.00000086845
Schistosoma mansoni	nuclear receptor nhr-48	0.0165	0.182	0.4555
Echinococcus multilocularis	ecdysone induced protein 78C	0.035	0.3996	0.3996
Entamoeba histolytica	hypothetical protein	0.0038	0.0326	0.2949
Entamoeba histolytica	hypothetical protein	0.0038	0.0326	0.2949
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0165	0.182	0.182
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.035	0.3996	0.3996
Echinococcus multilocularis	FTZ F1 alpha	0.035	0.3996	0.3996
Treponema pallidum	DNA ligase (lig)	0.001	0	0.5
Schistosoma mansoni	hypothetical protein	0.0051	0.0479	0.1199
Echinococcus granulosus	sterol regulatory element binding protein	0.0045	0.0405	0.1012
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0668	0.1671
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0668	0.1671
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0104	0.1106	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0165	0.182	0.4555
Onchocerca volvulus	Protein ultraspiracle homolog	0.035	0.3996	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0165	0.182	0.182
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.00000034704	0.000008579
Brugia malayi	nuclear receptor RXR	0.0185	0.2053	0.5138
Echinococcus granulosus	FTZ F1 alpha	0.035	0.3996	1
Brugia malayi	RNA binding protein	0.0067	0.0668	0.1671
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.035	0.3996	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.035	0.3996	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.035	0.3996	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.035	0.3996	1
Loa Loa (eye worm)	RNA binding protein	0.0067	0.0668	0.1671
Echinococcus multilocularis	protein dispatched 1	0.0051	0.0479	0.0479
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0185	0.2053	0.5138
Echinococcus granulosus	Niemann Pick C1 protein	0.0149	0.1634	0.4088

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 704590