Detailed information for compound 704847

Basic information

Technical information
  • TDR Targets ID: 704847
  • Name: 3-(trifluoromethyl)-N-[5-(3,4,5-trimethoxyphe nyl)-1,3,4-oxadiazol-2-yl]benzamide
  • MW: 423.343 | Formula: C19H16F3N3O5
  • H donors: 1 H acceptors: 3 LogP: 3.38 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)c1nnc(o1)NC(=O)c1cccc(c1)C(F)(F)F
  • InChi: 1S/C19H16F3N3O5/c1-27-13-8-11(9-14(28-2)15(13)29-3)17-24-25-18(30-17)23-16(26)10-5-4-6-12(7-10)19(20,21)22/h4-9H,1-3H3,(H,23,25,26)
  • InChiKey: LWELKQHYCLUISH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, conserved 0.0025 0.0289 0.0121
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0289 0.3442
Entamoeba histolytica DNA repair and recombination protein, putative 0.025 0.7615 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0289 0.0121
Plasmodium vivax importin-beta 2, putative 0.003 0.046 1
Brugia malayi Importin beta-1 subunit 0.003 0.046 0.2018
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0289 0.3442
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.025 0.7615 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0953 0.0769
Schistosoma mansoni hypothetical protein 0.0323 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0289 0.0091
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0273 0.01
Brugia malayi hypothetical protein 0.0025 0.0289 0.1269
Entamoeba histolytica hypothetical protein 0.0025 0.0273 0.01
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0199 0.0875
Leishmania major importin beta-1 subunit, putative 0.0025 0.0273 0.01
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.046 0.0351
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0953 0.0769
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0953 0.0769
Echinococcus multilocularis importin subunit beta 1 0.003 0.046 0.0266
Schistosoma mansoni hypothetical protein 0.025 0.7615 0.7566
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0953 0.0769
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.025 0.7615 0.7566
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0953 0.0769
Loa Loa (eye worm) hypothetical protein 0.003 0.046 0.0266
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.046 0.0351
Giardia lamblia Rrm3p helicase 0.025 0.7615 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0289 0.3442
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.025 0.7615 1
Schistosoma mansoni importin beta-1 0.003 0.046 0.0266
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.025 0.7615 1
Trichomonas vaginalis conserved hypothetical protein 0.025 0.7615 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0953 0.0769
Brugia malayi RNA, U transporter 1 0.0086 0.2278 1
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.046 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0953 0.0769
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0273 0.01
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.025 0.7615 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0289 0.0121
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0289 0.0121
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.025 0.7615 1
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.025 0.7615 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0953 0.0769
Plasmodium falciparum importin beta, putative 0.003 0.046 1
Entamoeba histolytica hypothetical protein, conserved 0.025 0.7615 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0273 0.01
Echinococcus multilocularis snurportin 1 0.0323 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0953 0.4185
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0289 0.3442
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.025 0.7615 1
Echinococcus granulosus importin subunit beta 1 0.003 0.046 0.0266
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.025 0.7615 0.7566
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0273 0.01

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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