Detailed information for compound 705044

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 480.602 | Formula: C24H24N4O3S2
  • H donors: 0 H acceptors: 5 LogP: 4.03 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C)c2c(c1)nc(s2)N(C(=O)c1ccc(cc1)S(=O)(=O)N(C)C)Cc1cccnc1
  • InChi: 1S/C24H24N4O3S2/c1-16-12-17(2)22-21(13-16)26-24(32-22)28(15-18-6-5-11-25-14-18)23(29)19-7-9-20(10-8-19)33(30,31)27(3)4/h5-14H,15H2,1-4H3
  • InChiKey: XYMDCYVACRLROW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0056 0.0055
Schistosoma mansoni hypothetical protein 0.0083 0.0696 0.0897
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0052 0.0331 0.0383
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0331 0.0426
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.1902 0.2454
Schistosoma mansoni smad1 5 8 and 0.0051 0.0314 0.0405
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0052 0.0331 0.0383
Brugia malayi MH1 domain containing protein 0.0051 0.0314 0.0363
Loa Loa (eye worm) hypothetical protein 0.0052 0.0331 0.0383
Schistosoma mansoni tar DNA-binding protein 0.0386 0.4329 0.5585
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0605 0.0604
Loa Loa (eye worm) MH2 domain-containing protein 0.0051 0.0314 0.0363
Onchocerca volvulus 0.0052 0.0331 0.1782
Echinococcus multilocularis mothers against decapentaplegic 5 0.0051 0.0314 0.0314
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.1902 0.1902
Mycobacterium ulcerans hypothetical protein 0.0337 0.3744 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0331 0.0383
Echinococcus multilocularis FTZ F1 alpha 0.0052 0.0331 0.0331
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.2984 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0605 0.1109
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0052 0.0331 0.0426
Brugia malayi Smad1 0.0051 0.0314 0.0363
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0331 0.0383
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0083 0.0696 0.0897
Loa Loa (eye worm) hypothetical protein 0.0052 0.0331 0.0383
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0303 0.3334 0.4033
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0028 0.0036 0.0035
Brugia malayi MH1 domain containing protein 0.0028 0.0042 0.0048
Schistosoma mansoni tar DNA-binding protein 0.0386 0.4329 0.5585
Echinococcus granulosus ecdysone induced protein 78C 0.0052 0.0331 0.0426
Schistosoma mansoni steroid hormone receptor ad4bp 0.0052 0.0331 0.0426
Loa Loa (eye worm) hypothetical protein 0.0075 0.0605 0.07
Brugia malayi hypothetical protein 0.0028 0.0036 0.0041
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0051 0.0314 0.0314
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0394 0.0394
Brugia malayi MH2 domain containing protein 0.0746 0.8642 1
Echinococcus granulosus importin subunit beta 1 0.0029 0.0056 0.0071
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0039 0.0178 0.1377
Loa Loa (eye worm) Smad1 0.0051 0.0314 0.0363
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0605 0.1109
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0183 0.1902 0.2201
Brugia malayi MH2 domain containing protein 0.0051 0.0314 0.0363
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0 0.0001
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0052 0.0331 0.0383
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.009 0.0783 0.0264
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0394 0.0509
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0183 0.1902 0.2201
Schistosoma mansoni hypothetical protein 0.0311 0.3434 0.443
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0041
Onchocerca volvulus 0.0025 0 0.0001
Echinococcus granulosus mothers against decapentaplegic 5 0.0051 0.0314 0.0405
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0036 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0052 0.0331 0.0383
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0178 0.2224
Echinococcus granulosus Smad4 0.0051 0.0314 0.0405
Onchocerca volvulus 0.0051 0.0311 0.1674
Onchocerca volvulus 0.0075 0.0605 0.3257
Brugia malayi MH2 domain containing protein 0.0051 0.0314 0.0363
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0605 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0203 0.2139 0.2138
Echinococcus multilocularis tar DNA binding protein 0.0386 0.4329 0.4329
Brugia malayi Calcitonin receptor-like protein seb-1 0.0261 0.2835 0.3281
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1856 0.5261
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1856 0.5261
Loa Loa (eye worm) latrophilin receptor protein 2 0.0083 0.0696 0.0805
Echinococcus multilocularis snurportin 1 0.0312 0.3447 0.3447
Onchocerca volvulus 0.0025 0 0.0001
Entamoeba histolytica hypothetical protein 0.0035 0.0125 1
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0311 0.031
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0052 0.0331 0.0383
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0028 0.0036 0.0041
Toxoplasma gondii ABC1 family protein 0.0075 0.0605 0.6193
Brugia malayi nuclear receptor NHR-88 0.0052 0.0331 0.0383
Brugia malayi RNA binding protein 0.0386 0.4329 0.5009
Toxoplasma gondii hypothetical protein 0.0103 0.0942 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.009 0.0783 0.0264
Entamoeba histolytica hypothetical protein 0.0035 0.0125 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.009 0.0783 0.0264
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0311 0.0401
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.064 0.7374 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0083 0.0696 0.0695
Echinococcus granulosus FTZ F1 alpha 0.0052 0.0331 0.0426
Mycobacterium tuberculosis Conserved hypothetical protein 0.0337 0.3744 0.6868
Mycobacterium tuberculosis Conserved protein 0.0075 0.0605 0.1109
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1856 0.5261
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0311 0.1674
Schistosoma mansoni importin beta-1 0.0029 0.0056 0.0071
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.1972 0.5748
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0331 0.0426
Schistosoma mansoni hypothetical protein 0.0083 0.0696 0.0897
Onchocerca volvulus Protein ultraspiracle homolog 0.0052 0.0331 0.1782
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0041
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0311 0.0401
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.3447 0.3988
Echinococcus granulosus tar DNA binding protein 0.0386 0.4329 0.5585
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0041
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0274 0.2984 0.3453
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0394 0.0456
Echinococcus granulosus GPCR family 2 0.0083 0.0696 0.0897
Brugia malayi ecdysteroid receptor 0.0052 0.0331 0.0383
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.2984 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0605 0.078
Schistosoma mansoni hypothetical protein 0.0039 0.0178 0.0229
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0052 0.0331 0.0426
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0178 0.0177
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0394 0.0509
Echinococcus multilocularis microtubule associated protein 2 0.0672 0.7751 0.7751
Loa Loa (eye worm) hypothetical protein 0.0052 0.0331 0.0383
Loa Loa (eye worm) hypothetical protein 0.0051 0.0311 0.0359
Brugia malayi hypothetical protein 0.0035 0.0125 0.0144
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0028 0.0036 0.0046
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0178 0.0206
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0125 0.016
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0311 0.031
Loa Loa (eye worm) steroid hormone receptor 0.0052 0.0331 0.0383
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0261 0.2835 0.3281
Onchocerca volvulus 0.0075 0.0605 0.3257
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0125 0.016
Loa Loa (eye worm) RNA binding protein 0.0386 0.4329 0.5009
Schistosoma mansoni hypothetical protein 0.0035 0.0125 0.016
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0083 0.0696 0.0897
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0331 0.0331
Onchocerca volvulus Glucosylceramidase homolog 0.018 0.1856 1
Schistosoma mansoni hypothetical protein 0.0355 0.3961 0.511
Brugia malayi hypothetical protein 0.0028 0.0036 0.0041
Brugia malayi RNA, U transporter 1 0.0083 0.0702 0.0812
Mycobacterium leprae Probable lipase LipE 0.0075 0.0605 1
Echinococcus multilocularis Smad4 0.0051 0.0314 0.0314
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.1902 0.1902
Loa Loa (eye worm) hypothetical protein 0.0075 0.0605 0.07
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0331 0.0383
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0041
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0052 0.0331 0.0426
Brugia malayi hypothetical protein 0.0036 0.0132 0.0153
Loa Loa (eye worm) beta-lactamase 0.0075 0.0605 0.07
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.1902 0.2454
Schistosoma mansoni smad 0.0051 0.0314 0.0405
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0036 0.0046
Loa Loa (eye worm) hypothetical protein 0.0052 0.0331 0.0383
Loa Loa (eye worm) hypothetical protein 0.0075 0.0605 0.07
Brugia malayi mbt repeat family protein 0.0051 0.0311 0.0359
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0028 0.0036 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.2984 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0052 0.0331 0.0383
Leishmania major mitochondrial DNA polymerase beta 0.064 0.7374 1
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0331 0.0383
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.011 0.1019 0.0613
Brugia malayi RNA recognition motif domain containing protein 0.0386 0.4329 0.5009
Schistosoma mansoni hypothetical protein 0.0312 0.3447 0.4447
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0331 0.0331
Schistosoma mansoni hypothetical protein 0.0179 0.1845 0.238
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0331 0.0426
Loa Loa (eye worm) hypothetical protein 0.0179 0.1845 0.2135
Brugia malayi steroid hormone receptor 0.0052 0.0331 0.0383
Loa Loa (eye worm) TAR-binding protein 0.0386 0.4329 0.5009
Entamoeba histolytica hypothetical protein 0.0035 0.0125 1
Echinococcus multilocularis GPCR, family 2 0.0083 0.0696 0.0695
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0605 0.1109
Loa Loa (eye worm) transcription factor SMAD2 0.0746 0.8642 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0605 0.07
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0605 0.1615
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0052 0.0331 0.0426
Schistosoma mansoni coup transcription factor 0.0052 0.0331 0.0426
Brugia malayi MH1 domain containing protein 0.0051 0.0314 0.0363
Loa Loa (eye worm) hypothetical protein 0.0058 0.0394 0.0456
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0331 0.0426
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0052 0.0331 0.0426
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0331 0.0383
Loa Loa (eye worm) hypothetical protein 0.0052 0.0331 0.0383
Echinococcus granulosus geminin 0.0355 0.3961 0.511
Schistosoma mansoni tar DNA-binding protein 0.0386 0.4329 0.5585
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0331 0.0426
Brugia malayi beta-lactamase family protein 0.0075 0.0605 0.07
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.1902 0.2454
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0083 0.0696 0.0805
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0125 0.0124
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0386 0.4329 0.5009
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.064 0.7374 1
Mycobacterium tuberculosis Conserved protein 0.0075 0.0605 0.1109
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.1902 0.2454
Echinococcus multilocularis thyroid hormone receptor alpha 0.0052 0.0331 0.0331
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0605 0.1109
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0605 0.07
Loa Loa (eye worm) MH2 domain-containing protein 0.0746 0.8642 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0052 0.0331 0.0383
Loa Loa (eye worm) hypothetical protein 0.0083 0.0696 0.0805
Loa Loa (eye worm) hypothetical protein 0.0075 0.0605 0.07
Loa Loa (eye worm) MH1 domain-containing protein 0.0051 0.0314 0.0363
Entamoeba histolytica hypothetical protein 0.0035 0.0125 1
Brugia malayi nuclear hormone receptor 0.0052 0.0331 0.0383
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0052 0.0331 0.0331
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0311 0.0401
Loa Loa (eye worm) nuclear factor I 0.0028 0.0042 0.0048
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0052 0.0331 0.0426
Loa Loa (eye worm) hypothetical protein 0.0052 0.0331 0.0383
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0605 0.078
Echinococcus granulosus snurportin 1 0.0312 0.3447 0.4447
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0052 0.0331 0.0426
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0052 0.0331 0.1782
Onchocerca volvulus 0.0075 0.0605 0.3257
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0052 0.0331 0.0426
Echinococcus granulosus microtubule associated protein 2 0.0672 0.7751 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0056 0.0064
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0274 0.2984 0.3453
Schistosoma mansoni hypothetical protein 0.0083 0.0696 0.0897
Schistosoma mansoni smad1 5 8 and 0.0051 0.0314 0.0405
Schistosoma mansoni Smad4 0.0051 0.0314 0.0405
Onchocerca volvulus Bile acid receptor homolog 0.0052 0.0331 0.1782
Mycobacterium ulcerans lipase LipD 0.0075 0.0605 0.1615
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0331 0.0383
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0605 0.1109
Schistosoma mansoni tar DNA-binding protein 0.0386 0.4329 0.5585
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1856 0.5261
Schistosoma mansoni retinoic acid receptor RXR 0.0052 0.0331 0.0426
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0331 0.0383
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0311 0.0401
Loa Loa (eye worm) hypothetical protein 0.0039 0.0178 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0052 0.0331 0.0383
Trypanosoma brucei mitochondrial DNA polymerase beta 0.064 0.7374 1
Schistosoma mansoni smad1 5 8 and 0.0051 0.0314 0.0405
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0036 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0052 0.0331 0.0383
Echinococcus multilocularis ecdysone induced protein 78C 0.0052 0.0331 0.0331
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.1902 0.2454
Brugia malayi beta-lactamase 0.0075 0.0605 0.07
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0605 0.1109
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.2984 1
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0605 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0203 0.2139 0.2759
Echinococcus multilocularis geminin 0.0355 0.3961 0.3961
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0052 0.0331 0.0383
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1856 0.5261
Mycobacterium ulcerans hypothetical protein 0.0075 0.0605 0.1615
Schistosoma mansoni hypothetical protein 0.0355 0.3961 0.511
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0178 0.0206
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0178 0.0206
Trypanosoma brucei DNA polymerase beta thumb, putative 0.009 0.0783 0.0994
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0394 0.0509
Mycobacterium tuberculosis Conserved protein 0.0075 0.0605 0.1109
Schistosoma mansoni tar DNA-binding protein 0.0386 0.4329 0.5585
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0052 0.0331 0.0331
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0178 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0052 0.0331 0.0383
Brugia malayi beta-lactamase family protein 0.0075 0.0605 0.07
Brugia malayi Steroid receptor seven-up type 2 0.0052 0.0331 0.0383
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0605 0.075
Loa Loa (eye worm) hypothetical protein 0.0075 0.0605 0.07
Leishmania major hypothetical protein, conserved 0.0075 0.0605 0.082
Echinococcus multilocularis smad 0.0051 0.0314 0.0314
Echinococcus granulosus smad 0.0051 0.0314 0.0405
Schistosoma mansoni hypothetical protein 0.0083 0.0696 0.0897
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.2984 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0051 0.0314 0.0405
Schistosoma mansoni RAR-like nuclear receptor 0.0052 0.0331 0.0426
Brugia malayi photoreceptor-specific nuclear receptor 0.0052 0.0331 0.0383
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0311 0.0359
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0311 0.0401
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0083 0.0696 0.0695
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.0331 0.0426
Loa Loa (eye worm) MBCTL1 0.0058 0.0394 0.0456
Brugia malayi MH1 domain containing protein 0.0028 0.0042 0.0048
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.0048
Echinococcus granulosus TGF beta signal transducer SmadC 0.0051 0.0314 0.0405
Brugia malayi Importin beta-1 subunit 0.0029 0.0056 0.0064
Brugia malayi hypothetical protein 0.0036 0.0132 0.0153
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0605 0.1109
Mycobacterium ulcerans beta-lactamase 0.0075 0.0605 0.1615
Brugia malayi Latrophilin receptor protein 2 0.0083 0.0696 0.0805
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0605 0.07
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.2984 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0261 0.2835 0.3281
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.1972 0.5748
Brugia malayi TAR-binding protein 0.0386 0.4329 0.5009
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1856 0.5261
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0052 0.0331 0.0331
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0052 0.0331 0.0383
Mycobacterium tuberculosis Possible penicillin-binding protein 0.048 0.5452 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0052 0.0331 0.0383
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0303 0.3334 0.448
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0605 0.078
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.1856 0.5261
Brugia malayi nuclear receptor RXR 0.0028 0.0036 0.0041
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0052 0.0331 0.0331
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0052 0.0331 0.0426
Loa Loa (eye worm) hypothetical protein 0.0261 0.2835 0.3281
Brugia malayi mbt repeat family protein 0.0051 0.0311 0.0359
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0052 0.0331 0.0383
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0052 0.0331 0.0383
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0052 0.0331 0.0426
Loa Loa (eye worm) hypothetical protein 0.0052 0.0331 0.0383
Brugia malayi latrophilin 2 splice variant baaae 0.0179 0.1845 0.2135
Schistosoma mansoni microtubule-associated protein tau 0.0672 0.7751 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0605 0.1615
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0 0.0001
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0303 0.3334 0.4522

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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