Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0013 | 0.0459 | 0.0481 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0039 | 0.2687 | 0.8441 |
Leishmania major | trypanothione reductase | 0.0038 | 0.2642 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0038 | 0.2642 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0088 | 0.6922 | 0.8837 |
Brugia malayi | glutathione reductase | 0.0038 | 0.2642 | 0.2766 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0039 | 0.2687 | 0.8441 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0013 | 0.0459 | 0.5 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0013 | 0.0459 | 0.1443 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0013 | 0.0459 | 0.1443 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0.0459 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.3183 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0.0459 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0038 | 0.2642 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0038 | 0.2642 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.3183 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.9552 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0013 | 0.0459 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0038 | 0.2642 | 0.2766 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.3183 | 0.3183 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0038 | 0.2642 | 0.2985 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.3183 | 0.3333 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.3183 | 0.3183 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0013 | 0.0459 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.3183 | 0.3333 |
Plasmodium vivax | glutathione reductase, putative | 0.0038 | 0.2642 | 1 |
Treponema pallidum | NADH oxidase | 0.0013 | 0.0459 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0013 | 0.0459 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0088 | 0.6922 | 0.8837 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0013 | 0.0459 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0038 | 0.2642 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0088 | 0.6922 | 0.8837 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0038 | 0.2642 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.9552 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0088 | 0.6922 | 0.8837 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.3183 | 0.3183 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0038 | 0.2642 | 0.2766 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0038 | 0.2642 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.3183 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.9552 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.001 | 0.0152 | 0.0159 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0013 | 0.0459 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0098 | 0.7772 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0088 | 0.6922 | 0.8837 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0098 | 0.7772 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0013 | 0.0459 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0098 | 0.7772 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0088 | 0.6922 | 0.8837 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.3183 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.001 | 0.0152 | 0.0159 |
Brugia malayi | Thioredoxin reductase | 0.0038 | 0.2642 | 0.2766 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0013 | 0.0459 | 0.0459 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0098 | 0.7772 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.