Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0077 | 0.1841 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0096 | 0.3805 | 0.3805 |
Brugia malayi | FAD binding domain containing protein | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.8899 | 0.8899 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0155 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0155 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0155 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0155 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0059 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0155 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0155 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0096 | 0.3805 | 0.2407 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0155 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0155 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0077 | 0.1841 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0059 | 0 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0155 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0059 | 0 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.8899 | 0.8899 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0155 | 1 | 1 |
Treponema pallidum | flavodoxin | 0.0059 | 0 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0155 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0096 | 0.3805 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0137 | 0.8159 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.8899 | 0.8899 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0059 | 0 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0155 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0155 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0137 | 0.8159 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0096 | 0.3805 | 0.3805 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0155 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0137 | 0.8159 | 0.8159 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0155 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0137 | 0.8159 | 0.8159 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0155 | 1 | 0.5 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0137 | 0.8159 | 0.8159 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0078 | 0.1964 | 0.0151 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0155 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0155 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0059 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 59.4 uM | Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex formation in t-PA-induced fibrin clot lysis assay | ChEMBL. | 12729646 |
IC50 (binding) | = 59.4 uM | Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex formation in t-PA-induced fibrin clot lysis assay | ChEMBL. | 12729646 |
Inhibition (functional) | > 100 ug ml-1 | Compound was tested for brine shrimp (Artemia salina) toxicity measured as the lowest value at which severe inhibition of nauplii movement was observed | ChEMBL. | 10673087 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.