Detailed information for compound 705384

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 399.483 | Formula: C22H29N3O4
  • H donors: 1 H acceptors: 2 LogP: 2.39 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)NC(=O)Cn1cc(OC)c(=O)cc1CN1CCCCC1
  • InChi: 1S/C22H29N3O4/c1-3-29-19-9-7-17(8-10-19)23-22(27)16-25-15-21(28-2)20(26)13-18(25)14-24-11-5-4-6-12-24/h7-10,13,15H,3-6,11-12,14,16H2,1-2H3,(H,23,27)
  • InChiKey: AKWZFRLFUIFGRX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0071 0.0093
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0611 0.7608 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0375 0.0492
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0159 0.0154
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0101 0.0133
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0202 0.0182
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0242 0.0266
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.0375 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.007 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0206 0.0271
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.0375 0.0412
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0288 0.0317
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.007 0.0092
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0658 0.1676
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0328 0.8746
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.007 0.0092
Loa Loa (eye worm) hypothetical protein 0.0081 0.0867 0.0954
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0405 0.373
Schistosoma mansoni tar DNA-binding protein 0.0728 0.909 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0081 0.0867 0.2834
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0282 0.6953
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.0867 0.114
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0056 0.0147
Trypanosoma cruzi ISWI complex protein 0.0016 0.004 0.0052
Leishmania major mitochondrial DNA polymerase beta 0.0611 0.7608 1
Schistosoma mansoni cpg binding protein 0.0032 0.0243 0.0267
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.007 0.0092
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0282 0.0896
Schistosoma mansoni cpg binding protein 0.0029 0.0196 0.0216
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1348 0.1483
Schistosoma mansoni hypothetical protein 0.0017 0.0043 0.0047
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0289 0.3512 0.4616
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.007 0.0077
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.007 0.0077
Loa Loa (eye worm) hypothetical protein 0.0022 0.0114 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Echinococcus granulosus GPCR family 2 0.0017 0.0043 0.0025
Entamoeba histolytica hypothetical protein 0.0023 0.0128 0.1908
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0056 0.0147
Trypanosoma cruzi ISWI complex protein 0.0016 0.004 0.0052
Giardia lamblia DINP protein human, muc B family 0.0043 0.0375 1
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0867 0.2834
Loa Loa (eye worm) TAR-binding protein 0.0728 0.909 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1861 0.1845
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0375 0.0492
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0405 0.1303
Brugia malayi Heterochromatin protein 1 0.0068 0.0697 0.0767
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0499 0.0549
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.162 0.1765
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0101 0.0111
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0287 0.3487 0.3836
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.007 0.0092
Schistosoma mansoni eyes absent homolog 0.009 0.0972 0.107
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0159 0.021
Brugia malayi Pre-SET motif family protein 0.0032 0.0242 0.0266
Schistosoma mansoni hypothetical protein 0.0722 0.9013 0.9916
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0128 0.0387
Schistosoma mansoni DNA polymerase eta 0.0043 0.0375 0.0412
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0867 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0375 0.0492
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0202 0.1858
Schistosoma mansoni bromodomain containing protein 0.0073 0.0759 0.0835
Mycobacterium tuberculosis Probable lipase LipD 0.0081 0.0867 0.0811
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0101 0.0133
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0375 0.0355
Loa Loa (eye worm) beta-lactamase 0.0081 0.0867 0.0954
Echinococcus multilocularis zinc finger protein 0.0026 0.0164 0.0144
Brugia malayi RNA, U transporter 1 0.0082 0.0873 0.096
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.028 0.026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.007 0.0092
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0347 0.0327
Mycobacterium tuberculosis Conserved protein 0.0081 0.0867 0.0811
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0282 0.0896
Loa Loa (eye worm) hypothetical protein 0.009 0.0972 0.107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Trichomonas vaginalis esterase, putative 0.0081 0.0867 0.2834
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.007 0.0647
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.0518 0.057
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.1861 0.2048
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0213 0.2536 0.2774
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0043 0.0025
Schistosoma mansoni ran 0.0021 0.0101 0.0111
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0375 0.1202
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0375 0.0492
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0128 0.0387
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0128 0.0387
Schistosoma mansoni alpha-glucosidase 0.0137 0.1579 0.1737
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0287 0.3487 0.3836
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0375 0.0492
Brugia malayi jmjC domain containing protein 0.0095 0.1044 0.1149
Toxoplasma gondii ABC1 family protein 0.0081 0.0867 0.799
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0287 0.3487 0.3836
Brugia malayi RNA binding protein 0.0728 0.909 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0282 0.0371
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0321 0.0301
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.007 0.005
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0043 0.0023
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0056 0.0147
Echinococcus granulosus importin subunit beta 1 0.0029 0.0198 0.0196
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0405 0.373
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0206 0.0271
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0658 0.0724
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0658 0.1676
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0175 0.0542
Schistosoma mansoni tar DNA-binding protein 0.0728 0.909 1
Trypanosoma brucei hypothetical protein, conserved 0.0081 0.0867 0.114
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0282 0.2596
Echinococcus granulosus histone lysine methyltransferase setb 0.0051 0.0474 0.0501
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0697 0.0767
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0282 0.6953
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.0518 0.0499
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0242 0.2226
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0375 0.0954
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0101 0.2694
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0159 0.0175
Schistosoma mansoni cpg binding protein 0.0032 0.0243 0.0267
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.0375 0.0391
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0287 0.3487 0.3823
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0658 0.0724
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0405 0.0425
Brugia malayi RNA recognition motif domain containing protein 0.0728 0.909 1
Echinococcus multilocularis microtubule associated protein 2 0.0717 0.8946 0.8944
Schistosoma mansoni tar DNA-binding protein 0.0728 0.909 1
Mycobacterium ulcerans beta-lactamase 0.0081 0.0867 0.2209
Schistosoma mansoni chromobox protein 0.0068 0.0697 0.0767
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Brugia malayi chromobox protein homolog 3 0.0038 0.0317 0.0348
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1861 0.1845
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0282 0.0371
Loa Loa (eye worm) hypothetical protein 0.0061 0.0613 0.0674
Echinococcus granulosus geminin 0.0722 0.9013 0.9916
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0282 0.031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0287 0.3487 0.3474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Brugia malayi MH2 domain containing protein 0.0119 0.1348 0.1483
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0375 0.0492
Trypanosoma brucei glucosidase, putative 0.0035 0.0282 0.0371
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0658 0.1676
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.007 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.1975 0.6502
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0159 0.1469
Loa Loa (eye worm) hypothetical protein 0.0081 0.0867 0.0954
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0159 0.014
Schistosoma mansoni importin beta-1 0.0029 0.0198 0.0217
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0375 0.0492
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0867 0.2834
Giardia lamblia GTOR 0.0019 0.007 0.1876
Loa Loa (eye worm) hypothetical protein 0.0047 0.0431 0.0474
Mycobacterium tuberculosis Possible penicillin-binding protein 0.052 0.6451 1
Loa Loa (eye worm) hypothetical protein 0.0173 0.2035 0.2239
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.0375 0.0355
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0159 0.0175
Loa Loa (eye worm) hypothetical protein 0.0041 0.0354 0.0389
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0071 0.0093
Brugia malayi Bromodomain containing protein 0.0085 0.0919 0.1011
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0242 0.0222
Echinococcus granulosus chromobox protein 1 0.0068 0.0697 0.0747
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0159 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0317 0.1011
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0328 1
Schistosoma mansoni hypothetical protein 0.0017 0.0043 0.0047
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.0613 0.0674
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0347 0.036
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0198 0.026
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.3741 0.4115
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0474 0.0521
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0159 0.049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0474 0.0521
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0518 0.0549
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0287 0.3487 0.3836
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0658 0.0704
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0198 0.026
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0375 0.0492
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0047
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0321 0.0332
Plasmodium falciparum phd finger protein, putative 0.0029 0.0202 0.6155
Brugia malayi beta-lactamase 0.0081 0.0867 0.0954
Leishmania major GTP-binding protein, putative 0.0021 0.0101 0.0133
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.007 0.0092
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0202 0.2325
Mycobacterium tuberculosis Probable lipase LipE 0.0081 0.0867 0.0811
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0375 0.0492
Onchocerca volvulus 0.0252 0.3032 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0289 0.3512 0.4616
Schistosoma mansoni zinc finger protein 0.0026 0.0164 0.018
Leishmania major importin beta-1 subunit, putative 0.0023 0.0128 0.0169
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0375 0.0492
Plasmodium vivax SET domain protein, putative 0.0032 0.0242 0.2786
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.0867 0.114
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0282 0.0896
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0375 0.0492
Trichomonas vaginalis penicillin-binding protein, putative 0.0081 0.0867 0.2834
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0081 0.0867 0.0954
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1348 0.1483
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0219 0.0219
Brugia malayi Importin beta-1 subunit 0.0029 0.0198 0.0217
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0159 0.014
Schistosoma mansoni hypothetical protein 0.0017 0.0043 0.0047
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0196 0.0216
Echinococcus granulosus cpg binding protein 0.0032 0.0243 0.0246
Echinococcus multilocularis chromobox protein 1 0.0068 0.0697 0.0678
Mycobacterium ulcerans hypothetical protein 0.0081 0.0867 0.2209
Loa Loa (eye worm) hypothetical protein 0.005 0.0466 0.0513
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.0375 0.0412
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0101 0.093
Echinococcus granulosus zinc finger protein 0.0026 0.0164 0.0159
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0202 0.1858
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.1861 0.203
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0375 0.0492
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0064 0.0048
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0101 0.3081
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.0375 0.0412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Loa Loa (eye worm) hypothetical protein 0.0081 0.0867 0.0954
Loa Loa (eye worm) hypothetical protein 0.0076 0.0794 0.0874
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0159 0.0154
Echinococcus granulosus dnaJ subfamily B 0.0408 0.5026 0.5519
Loa Loa (eye worm) hypothetical protein 0.0036 0.0288 0.0317
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.0613 0.0654
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0198 0.0178
Schistosoma mansoni hypothetical protein 0.0017 0.0043 0.0047
Echinococcus granulosus dna polymerase eta 0.0043 0.0375 0.0391
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0287 0.3487 0.3823
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0081 0.0867 0.0811
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0175 0.0542
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0326 0.0359
Entamoeba histolytica hypothetical protein 0.0026 0.0159 0.2932
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0375 0.0954
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0213 0.2536 0.2521
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0658 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0375 0.0492
Onchocerca volvulus Alhambra homolog 0.0029 0.0202 0.0019
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0086 0.0925 0.1216
Echinococcus multilocularis tar DNA binding protein 0.0728 0.909 0.9088
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.1044 0.1026
Brugia malayi mbt repeat family protein 0.0054 0.0518 0.057
Loa Loa (eye worm) hypothetical protein 0.0043 0.0375 0.0412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Entamoeba histolytica Ran family GTPase 0.0021 0.0101 0.1007
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.1861 0.2048
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0101 0.0089
Loa Loa (eye worm) RNA binding protein 0.0728 0.909 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.007 0.0092
Schistosoma mansoni zinc finger protein 0.0016 0.004 0.0044
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0611 0.7608 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0043 0.0023
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0173 0.2035 0.2239
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0017 0.002
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0317 0.0425
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0282 0.0896
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.062 0.0682
Echinococcus multilocularis chromobox protein 1 0.0068 0.0697 0.0678
Trichomonas vaginalis set domain proteins, putative 0.0252 0.3032 1
Leishmania major DNA polymerase kappa, putative 0.0043 0.0375 0.0492
Loa Loa (eye worm) hypothetical protein 0.0029 0.0202 0.0222
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0795 0.0874
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0058 0.0064
Schistosoma mansoni hypothetical protein 0.0722 0.9013 0.9916
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0518 0.057
Echinococcus granulosus beta LACTamase domain containing family member 0.0081 0.0867 0.0934
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0375 0.1202
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0101 0.0081
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0697 0.227
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0101 0.1163
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.002 0.0022
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0282 0.031
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.007 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Mycobacterium tuberculosis Conserved protein 0.0081 0.0867 0.0811
Leishmania major DNA polymerase eta, putative 0.0043 0.0375 0.0492
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.0613 0.0674
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Onchocerca volvulus 0.0092 0.1006 0.2854
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0697 0.227
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0105 0.0115
Loa Loa (eye worm) hypothetical protein 0.0054 0.0518 0.057
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0596 0.0656
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0043 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0056 0.0147
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.1704 0.1875
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0202 0.0222
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0328 0.8456
Schistosoma mansoni ran 0.0021 0.0101 0.0111
Echinococcus multilocularis peregrin 0.0035 0.0279 0.026
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0043 0.0047
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.0613 0.0594
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.007 0.0092
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0375 0.0492
Schistosoma mansoni hypothetical protein 0.0307 0.3741 0.4115
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0282 0.0896
Loa Loa (eye worm) hypothetical protein 0.0081 0.0867 0.0954
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0114 0.0149
Schistosoma mansoni chromobox protein 0.0068 0.0697 0.0767
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0375 0.0492
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0287 0.3487 0.3474
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0017 0.002
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0353 0.1133
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.007 0.0092
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0405 0.4668
Leishmania major hypothetical protein, conserved 0.0081 0.0867 0.114
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0086 0.0925 0.1216
Trypanosoma brucei unspecified product 0.0029 0.0206 0.0271
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0658 0.0865
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.1704 0.1875
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0101 0.0133
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0287 0.3487 0.3836
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0317 0.1011
Echinococcus multilocularis beta LACTamase domain containing family member 0.0081 0.0867 0.0849
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0086 0.0925 0.1216
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0326 0.0359
Loa Loa (eye worm) hypothetical protein 0.0081 0.0867 0.0954
Onchocerca volvulus 0.003 0.0212 0.0055
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0101 0.0111
Trypanosoma brucei unspecified product 0.0043 0.0375 0.0492
Schistosoma mansoni tar DNA-binding protein 0.0728 0.909 1
Echinococcus multilocularis dna polymerase eta 0.0043 0.0375 0.0355
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.007 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Brugia malayi Pre-SET motif family protein 0.0221 0.2644 0.2909
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0202 0.02
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0064 0.007
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0282 0.0896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Mycobacterium ulcerans hypothetical protein 0.0322 0.3927 1
Onchocerca volvulus 0.0081 0.0867 0.2367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Schistosoma mansoni hypothetical protein 0.0029 0.0202 0.0222
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0128 0.0169
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0326 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0159 0.0175
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0282 0.0263
Plasmodium vivax importin-beta 2, putative 0.0029 0.0198 0.2278
Loa Loa (eye worm) hypothetical protein 0.009 0.0972 0.107
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0375 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0375 0.0412
Mycobacterium leprae conserved hypothetical protein 0.0081 0.0867 0.5
Echinococcus granulosus snurportin 1 0.0307 0.3741 0.4102
Brugia malayi beta-lactamase family protein 0.0081 0.0867 0.0954
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0289 0.3512 0.4616
Onchocerca volvulus 0.0081 0.0867 0.2367
Mycobacterium tuberculosis Conserved protein 0.0081 0.0867 0.0811
Echinococcus multilocularis cpg binding protein 0.0032 0.0243 0.0223
Schistosoma mansoni hypothetical protein 0.0328 0.4003 0.4404
Giardia lamblia PHD finger protein 15 0.0029 0.0202 0.5384
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0086 0.0925 0.1216
Loa Loa (eye worm) acetyltransferase 0.0147 0.1704 0.1875
Brugia malayi hypothetical protein 0.009 0.0972 0.107
Schistosoma mansoni hypothetical protein 0.0036 0.0288 0.0317
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0282 0.0896
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0081 0.0867 0.0811
Onchocerca volvulus 0.0054 0.0518 0.1134
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.007 0.0077
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0518 0.0499
Loa Loa (eye worm) MBCTL1 0.0061 0.0613 0.0674
Schistosoma mansoni alpha glucosidase 0.0035 0.0282 0.031
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0499 0.0549
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0081 0.0867 0.2209
Schistosoma mansoni tar DNA-binding protein 0.0728 0.909 1
Brugia malayi mbt repeat family protein 0.0054 0.0518 0.057
Trypanosoma brucei unspecified product 0.0029 0.0206 0.0271
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.0613 0.0594
Schistosoma mansoni hypothetical protein 0.0022 0.0112 0.0124
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.0518 0.1134
Schistosoma mansoni alpha-glucosidase 0.0137 0.1579 0.1737
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.002 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Mycobacterium tuberculosis Probable hydrolase 0.0081 0.0867 0.0811
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0056 0.0147
Brugia malayi TAR-binding protein 0.0728 0.909 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0064 0.0044
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.5026 0.5016
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0051 0.0474 0.0455
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.1044 0.1129
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0658 0.6063
Trypanosoma brucei ISWI complex protein 0.0016 0.004 0.0052
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.007 0.0092
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.007 0.0092
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0375 0.0492
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0658 0.064
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0611 0.7608 1
Brugia malayi Bromodomain containing protein 0.0045 0.0398 0.0438
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.2644 0.2909
Loa Loa (eye worm) hypothetical protein 0.0051 0.0478 0.0526
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.071 0.0692
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0375 0.0412
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0728 0.909 1
Toxoplasma gondii hypothetical protein 0.0099 0.1086 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0202 0.0222
Loa Loa (eye worm) hypothetical protein 0.0053 0.0499 0.0549
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0198 0.182
Echinococcus multilocularis geminin 0.0722 0.9013 0.9011
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0282 0.0896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0064 0.007
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.007 0.0092
Plasmodium falciparum importin beta, putative 0.0029 0.0198 0.6032
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0081 0.0867 0.0954
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0081 0.0867 0.0954
Brugia malayi beta-lactamase family protein 0.0081 0.0867 0.0954
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0326 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Echinococcus granulosus chromobox protein 1 0.0068 0.0697 0.0747
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0615 0.5661
Echinococcus granulosus microtubule associated protein 2 0.0717 0.8946 0.9841
Loa Loa (eye worm) hypothetical protein 0.0051 0.0474 0.0521
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0282 0.0896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.007 0.0056
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.007 0.0056
Echinococcus multilocularis GPCR, family 2 0.0017 0.0043 0.0023
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.007 0.0092
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0043 0.0047
Mycobacterium tuberculosis Conserved hypothetical protein 0.0322 0.3927 0.5847
Mycobacterium ulcerans lipase LipD 0.0081 0.0867 0.2209
Mycobacterium leprae Probable lipase LipE 0.0081 0.0867 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0081 0.0867 0.0954
Brugia malayi CXXC zinc finger family protein 0.0029 0.0196 0.0216
Brugia malayi Bromodomain containing protein 0.0035 0.0279 0.0307
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0375 0.0492
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0375 0.0492
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0056 0.0147
Onchocerca volvulus 0.0043 0.0383 0.066
Echinococcus granulosus peregrin 0.0035 0.0279 0.0286
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.071 0.0761
Brugia malayi CHD4 protein 0.0015 0.002 0.0022
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0282 0.0371
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0056 0.0147
Loa Loa (eye worm) hypothetical protein 0.0081 0.0867 0.0954
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0499 0.0549
Onchocerca volvulus 0.0081 0.0867 0.2367
Brugia malayi PHD-finger family protein 0.0029 0.0202 0.0222
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0383 0.0422
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0206 0.0271
Schistosoma mansoni microtubule-associated protein tau 0.0717 0.8946 0.9842
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0117 0.0129
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.007 0.005
Mycobacterium tuberculosis Probable esterase LipL 0.0081 0.0867 0.0811
Echinococcus granulosus tar DNA binding protein 0.0728 0.909 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0405 0.1303
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0353 0.1133
Loa Loa (eye worm) hypothetical protein 0.0029 0.0198 0.0217
Echinococcus granulosus dna polymerase kappa 0.0043 0.0375 0.0391
Schistosoma mansoni hypothetical protein 0.0408 0.5026 0.5529
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.0518 0.0549
Trichomonas vaginalis ran, putative 0.0021 0.0101 0.0296
Brugia malayi jmjC domain containing protein 0.0039 0.0326 0.0359
Schistosoma mansoni hypothetical protein 0.0016 0.004 0.0044
Leishmania major hypothetical protein, conserved 0.0016 0.004 0.0052
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.0518 0.057
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0056 0.0147
Loa Loa (eye worm) hypothetical protein 0.0038 0.0317 0.0348
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0375 0.0492
Loa Loa (eye worm) hypothetical protein 0.003 0.0212 0.0233
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0518 0.057
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0043 0.0047
Echinococcus multilocularis snurportin 1 0.0307 0.3741 0.3728
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0081 0.0867 0.0811
Brugia malayi PHD-finger family protein 0.0032 0.0236 0.026
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.0613 0.0654
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.007 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0353 0.0555
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Mycobacterium ulcerans esterase/lipase LipP 0.0081 0.0867 0.2209
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0105 0.1164 0.153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.007 0.0195
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.1704 0.1688
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0112 0.0124
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0282 0.0289
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0867 0.2834

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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