Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0093 | 0.4411 | 0.8972 |
Trichomonas vaginalis | Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase | 0.0074 | 0.3362 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.1748 | 0.3743 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1686 | 0.1447 |
Leishmania major | CAAX prenyl protease 1, putative,metallo-peptidase, Clan M-, Family M48 | 0.0074 | 0.3362 | 1 |
Brugia malayi | Inositol-1 | 0.0044 | 0.1748 | 0.1511 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0093 | 0.4411 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0093 | 0.4411 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.1748 | 0.3743 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0044 | 0.1748 | 0.3962 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1686 | 0.3429 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0061 | 0.2672 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0044 | 0.1748 | 0.3912 |
Brugia malayi | Trypsin family protein | 0.0103 | 0.4916 | 0.477 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.004 | 0.1498 | 0.5545 |
Echinococcus multilocularis | caax prenyl protease 1 | 0.0074 | 0.3362 | 0.7623 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0093 | 0.4411 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0044 | 0.1748 | 0.3962 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0032 | 0.1103 | 0.0885 |
Mycobacterium leprae | ATP-dependent Clp protease proteolytic subunit 1 | 0.0032 | 0.1103 | 0.2438 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0093 | 0.4411 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0044 | 0.1748 | 0.3912 |
Trypanosoma cruzi | CAAX prenyl protease 1, putative | 0.0074 | 0.3362 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.0093 | 0.4411 | 0.425 |
Toxoplasma gondii | hypothetical protein | 0.0032 | 0.1103 | 0.0885 |
Trypanosoma brucei | metallo- peptidase, Clan M- Family M48 | 0.0074 | 0.3362 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.1748 | 0.3743 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0032 | 0.1103 | 0.0885 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.004 | 0.1498 | 0.3341 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0044 | 0.1748 | 0.5145 |
Schistosoma mansoni | farnesylated-protein converting enzyme 1 (M48 family) | 0.0074 | 0.3362 | 0.684 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0024 | 0.0685 | 0.195 |
Brugia malayi | Peptidase family M48 containing protein | 0.0074 | 0.3362 | 0.3172 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0024 | 0.0685 | 0.195 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.4411 | 0.3937 |
Onchocerca volvulus | 0.0103 | 0.4916 | 0.0665 | |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0093 | 0.4411 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0044 | 0.1748 | 0.2662 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0103 | 0.4916 | 1 |
Loa Loa (eye worm) | peptidase family M48 containing protein | 0.0074 | 0.3362 | 0.28 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0093 | 0.4411 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1686 | 0.3822 |
Trichomonas vaginalis | Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase | 0.0074 | 0.3362 | 1 |
Trypanosoma cruzi | metallo- peptidase, Clan M- Family M48 | 0.0074 | 0.3362 | 1 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0782 | 0.0517 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0197 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1686 | 0.3822 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0061 | 0.2672 | 0.6025 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0103 | 0.4916 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0044 | 0.1748 | 0.3743 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0093 | 0.4411 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0093 | 0.4411 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0061 | 0.2672 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0093 | 0.4411 | 0.5 |
Echinococcus granulosus | caax prenyl protease 1 | 0.0074 | 0.3362 | 0.7623 |
Entamoeba histolytica | CAAX prenyl protease, putative | 0.0074 | 0.3362 | 1 |
Toxoplasma gondii | CAAX metallo endopeptidase | 0.0074 | 0.3362 | 0.7111 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0044 | 0.1748 | 0.0369 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0093 | 0.4411 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0044 | 0.1748 | 0.3555 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0044 | 0.1748 | 0.5145 |
Loa Loa (eye worm) | inositol-1 | 0.0044 | 0.1748 | 0.1048 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0061 | 0.2672 | 0.6058 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0093 | 0.4411 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0093 | 0.4411 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0093 | 0.4411 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0044 | 0.1748 | 0.5145 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0061 | 0.2672 | 0.6058 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1686 | 0.3429 |
Schistosoma mansoni | inositol monophosphatase | 0.0044 | 0.1748 | 0.3555 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.4916 | 0.4485 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.4916 | 0.4485 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.