TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 450.553 | Formula: C24H26N4O3S
H donors: 1 H acceptors: 3 LogP: 4.82 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1cc(ccc1OCC)C(=O)NCCc1csc2n1nc(n2)c1ccccc1C
InChi: 1S/C24H26N4O3S/c1-4-30-20-11-10-17(14-21(20)31-5-2)23(29)25-13-12-18-15-32-24-26-22(27-28(18)24)19-9-7-6-8-16(19)3/h6-11,14-15H,4-5,12-13H2,1-3H3,(H,25,29)
InChiKey: SWKXMQAONXZWFK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0071	0.0101
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.001	0.0063	0.0063
Echinococcus granulosus	geminin	0.0164	0.3505	0.3505
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0011	0.0098	0.0727
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0071	0.0143
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0004	0.0095
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0243	0.1801
Onchocerca volvulus		0.0027	0.044	0.0882
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0011	0.0098	0.0727
Loa Loa (eye worm)	hypothetical protein	0.001	0.0071	0.0101
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0379	0.0759
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0011	0.0098	0.0727
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0391	0.2895
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0556	0.0787
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1174	0.1662
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0027	0.044	0.3261
Entamoeba histolytica	Ran family GTPase	0.0022	0.034	0.2306
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0391	0.8879
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0071	0.0071
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0011	0.0098	0.0727
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0011	0.0098	0.0727
Entamoeba histolytica	hypothetical protein	0.0073	0.1476	1
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0011	0.0098	0.2337
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0071	0.0143
Loa Loa (eye worm)	DIX domain-containing protein	0.001	0.0063	0.009
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.1194	0.884
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0011	0.0098	0.0727
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0519	1
Mycobacterium leprae	Conserved hypothetical protein	0.0011	0.0098	0.2594
Loa Loa (eye worm)	hypothetical protein	0.001	0.0071	0.0101
Leishmania major	GTP-binding protein, putative	0.0022	0.034	0.252
Schistosoma mansoni	hypothetical protein	0.0454	1	1
Leishmania major	cytochrome p450-like protein	0.0011	0.0098	0.0727
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.034	0.034
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.002	0.002
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0979	0.0979
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.001	0.0063	0.0127
Schistosoma mansoni	hypothetical protein	0.0017	0.0222	0.0222
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0011	0.0098	0.0727
Mycobacterium ulcerans	carboxylesterase, LipT	0.0027	0.044	0.3261
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0022	0.034	0.6559
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0027	0.044	0.044
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0004	0.0095
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0071	0.0143
Onchocerca volvulus		0.0059	0.1174	0.2351
Trypanosoma brucei	cytochrome P450, putative	0.0011	0.0098	0.1893
Echinococcus granulosus	carboxylesterase 5A	0.0158	0.338	0.338
Loa Loa (eye worm)	cytochrome P450	0.0011	0.0098	0.0139
Brugia malayi	Trypsin-like protease protein 5	0.0059	0.1174	0.2351
Brugia malayi	Carboxylesterase family protein	0.0027	0.044	0.0882
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0071	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0243	0.0344
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0391	0.8879
Schistosoma mansoni	cercarial elastase (S01 family)	0.0059	0.1174	0.1174
Brugia malayi	nuclear receptor NHR-88	0.001	0.0071	0.0143
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0063	0.009
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0011	0.0098	0.0727
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0071	0.0071
Loa Loa (eye worm)	acetylcholinesterase 1	0.0158	0.338	0.4786
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0011	0.0098	0.2337
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.1043	0.209
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0011	0.0098	0.0727
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0004	0.0095
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0379	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.042	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0073	0.1476	0.1476
Onchocerca volvulus		0.0027	0.044	0.0882
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0011	0.0098	0.0727
Loa Loa (eye worm)	hypothetical protein	0.001	0.0071	0.0101
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0379	0.2804
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0027	0.044	0.044
Schistosoma mansoni	cercarial elastase (S01 family)	0.0059	0.1174	0.1174
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0071	0.0143
Trichomonas vaginalis	ran, putative	0.0022	0.034	0.7729
Loa Loa (eye worm)	CYP4Cod1	0.0011	0.0098	0.0139
Schistosoma mansoni	hypothetical protein	0.0012	0.0102	0.0102
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0222	0.0222
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0011	0.0098	0.0727
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.135	1
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.006	0.0121
Brugia malayi	Trypsin family protein	0.0059	0.1174	0.2351
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0071	0.0071
Echinococcus multilocularis	acetylcholinesterase	0.0158	0.338	0.338
Schistosoma mansoni	cercarial elastase (S01 family)	0.0059	0.1174	0.1174
Echinococcus multilocularis	regulator of G protein signaling 7	0.001	0.0063	0.0063
Loa Loa (eye worm)	trypsin family protein	0.0059	0.1174	0.1662
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0071	0.0101
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0004	0.0095
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0059	0.1174	0.1174
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.0102	0.0102
Echinococcus granulosus	glycoprotein Antigen 5	0.0059	0.1174	0.1174
Echinococcus multilocularis	segment polarity protein dishevelled	0.001	0.0063	0.0063
Schistosoma mansoni	hypothetical protein	0.0011	0.0098	0.0098
Entamoeba histolytica	hypothetical protein	0.0025	0.0391	0.265
Schistosoma mansoni	hypothetical protein	0.0164	0.3505	0.3505
Schistosoma mansoni	gliotactin	0.0027	0.044	0.044
Schistosoma mansoni	cercarial elastase (S01 family)	0.0059	0.1174	0.1174
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0004	0.0095
Plasmodium falciparum	importin beta, putative	0.003	0.0519	1
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0011	0.0098	0.0727
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0071	0.0071
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0011	0.0098	0.0727
Schistosoma mansoni	z-protein (S1r protein)	0.001	0.0063	0.0063
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0022	0.034	0.5
Brugia malayi	regulator of G-protein signaling egl-10	0.001	0.0063	0.0127
Brugia malayi	nuclear hormone receptor	0.001	0.0071	0.0143
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0011	0.0098	0.0727
Schistosoma mansoni	coup transcription factor	0.001	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0027	0.044	0.0623
Schistosoma mansoni	cercarial elastase (S01 family)	0.0059	0.1174	0.1174
Brugia malayi	hypothetical protein	0.0073	0.1476	0.2957
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0011	0.0098	0.0727
Loa Loa (eye worm)	hypothetical protein	0.0027	0.044	0.0623
Echinococcus granulosus	transmembrane protease serine 3	0.0059	0.1174	0.1174
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0519	0.3842
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.001	0.0063	0.0063
Brugia malayi	Cytochrome P450 family protein	0.0011	0.0098	0.0197
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0979	0.0979
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0071	0.0143
Schistosoma mansoni	hypothetical protein	0.0037	0.0663	0.0663
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.034	0.0682
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0071	0.0071
Echinococcus multilocularis	segment polarity protein dishevelled	0.001	0.0063	0.0063
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.135	1
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.02	0.4326	0.8667
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0022	0.034	0.6559
Schistosoma mansoni	hypothetical protein	0.0017	0.0222	0.0222
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0071	0.0143
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0243	0.0344
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.002	0.002
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0011	0.0098	0.0727
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0379	0.2566
Echinococcus multilocularis		0.0011	0.0098	0.0098
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0663	0.1329
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0073	0.1476	0.1476
Plasmodium vivax	importin-beta 2, putative	0.003	0.0519	1
Echinococcus multilocularis	transmembrane protease serine 3	0.0059	0.1174	0.1174
Loa Loa (eye worm)	hypothetical protein	0.001	0.0071	0.0101
Entamoeba histolytica	hypothetical protein	0.0073	0.1476	1
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0011	0.0098	0.0727
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.001	0.0063	0.0127
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0027	0.044	0.044
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0011	0.0098	0.0727
Echinococcus granulosus	GPCR family 2	0.0017	0.0222	0.0222
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0222	0.0222
Loa Loa (eye worm)	hypothetical protein	0.001	0.0071	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0243	0.0344
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0221	0.1639
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0379	0.0536
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0222	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0027	0.044	0.0623
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0071	0.0071
Echinococcus multilocularis	snurportin 1	0.0323	0.7062	0.7062
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1043	0.1477
Schistosoma mansoni	cercarial elastase (S01 family)	0.0059	0.1174	0.1174
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0004	0.0095
Brugia malayi	Trypsin family protein	0.023	0.4991	1
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0059	0.1174	0.2351
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0071	0.0143
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0243	0.4686
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0011	0.0098	0.1893
Loa Loa (eye worm)	carboxylesterase	0.0158	0.338	0.4786
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0071	0.0071
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0379	0.2804
Onchocerca volvulus		0.0171	0.366	0.7333
Brugia malayi	RNA, U transporter 1	0.0086	0.1766	0.3538
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0004	0.0095
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0011	0.0098	0.0727
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0071	0.0143
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0059	0.1174	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0027	0.044	0.0623
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0011	0.0098	0.0727
Loa Loa (eye worm)	cytochrome P450 family protein	0.0011	0.0098	0.0139
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0243	0.5
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.135	1
Echinococcus granulosus	neuroligin	0.0027	0.044	0.044
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0011	0.0098	0.0727
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0071	0.0071
Schistosoma mansoni	ran	0.0022	0.034	0.034
Echinococcus granulosus	regulator of G protein signaling 7	0.001	0.0063	0.0063
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0011	0.0098	0.0727
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0243	0.4686
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0071	0.0071
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0011	0.0098	0.0727
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.135	0.135
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0004	0.0095
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.034	0.8095
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0059	0.1174	0.1174
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0071	0.0143
Echinococcus granulosus	para nitrobenzyl esterase	0.0027	0.044	0.044
Brugia malayi	steroid hormone receptor	0.001	0.0071	0.0143
Onchocerca volvulus		0.0059	0.1174	0.2351
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0011	0.0098	0.0727
Echinococcus multilocularis	neuroligin	0.0027	0.044	0.044
Echinococcus granulosus	acetylcholinesterase	0.0158	0.338	0.338
Schistosoma mansoni	cercarial elastase (S01 family)	0.0059	0.1174	0.1174
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0071	0.0101
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0071	0.0071
Echinococcus multilocularis	acetylcholinesterase	0.0158	0.338	0.338
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0011	0.0098	0.0727
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0004	0.0095
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.042	1
Onchocerca volvulus		0.001	0.0063	0.0127
Schistosoma mansoni	cercarial elastase (S01 family)	0.0059	0.1174	0.1174
Brugia malayi	Cytochrome P450 family protein	0.0011	0.0098	0.0197
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.023	0.4991	0.7067
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.042	0.8102
Onchocerca volvulus		0.0027	0.044	0.0882
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0004	0.0095
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0071	0.0101
Schistosoma mansoni	hypothetical protein	0.0059	0.1174	0.1174
Brugia malayi	N-terminal motif family protein	0.02	0.4326	0.8667
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0071	0.0071
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0071	0.0101
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0011	0.0098	0.0727
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0222	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0379	0.0536
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0067	0.135	1
Schistosoma mansoni	regulator of G protein signaling	0.001	0.0063	0.0063
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0979	0.0979
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0222	0.0315
Loa Loa (eye worm)	hypothetical protein	0.001	0.0071	0.0101
Brugia malayi	Carboxylesterase family protein	0.0027	0.044	0.0882
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1174	0.1662
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0027	0.044	0.044
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0071	0.0143
Schistosoma mansoni	hypothetical protein	0.0059	0.1174	0.1174
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0071	0.0143
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0221	0.1639
Onchocerca volvulus		0.0059	0.1174	0.2351
Loa Loa (eye worm)	cytochrome P450 family protein	0.0011	0.0098	0.0139
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.042	0.3113
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0004	0.0095
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0011	0.0098	0.0727
Echinococcus multilocularis	Mastin	0.0059	0.1174	0.1174
Schistosoma mansoni	cercarial elastase (S01 family)	0.0059	0.1174	0.1174
Onchocerca volvulus		0.0027	0.044	0.0882
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0059	0.1174	0.1174
Schistosoma mansoni	hypothetical protein	0.0017	0.0222	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0158	0.338	0.4786
Echinococcus granulosus	segment polarity protein dishevelled	0.001	0.0063	0.0063
Echinococcus granulosus	segment polarity protein dishevelled	0.001	0.0063	0.0063
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.034	0.0482
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0519	1
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0011	0.0098	0.0727
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.1043	0.1477
Brugia malayi	ecdysteroid receptor	0.001	0.0071	0.0143
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0011	0.0098	0.0727
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0059	0.1174	0.1174
Echinococcus granulosus	Mastin	0.0059	0.1174	0.1174
Brugia malayi	Cytochrome P450 family protein	0.0011	0.0098	0.0197
Onchocerca volvulus		0.0032	0.0556	0.1114
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.002	0.002
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0222	0.0222
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0011	0.0098	0.0727
Loa Loa (eye worm)	hypothetical protein	0.02	0.4326	0.6125
Schistosoma mansoni	dep domain containing protein	0.001	0.0063	0.0063
Loa Loa (eye worm)	hypothetical protein	0.023	0.4991	0.7067
Loa Loa (eye worm)	hypothetical protein	0.001	0.0071	0.0101
Echinococcus multilocularis	enteropeptidase	0.0059	0.1174	0.1174
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0379	0.2804
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1174	0.1662
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0323	0.7062	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0979	0.0979
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0071	0.0071
Schistosoma mansoni	cpg binding protein	0.0032	0.0556	0.0556
Trichomonas vaginalis	spcc417.12 protein, putative	0.0027	0.044	1
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0071	0.0143
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0004	0.0095
Brugia malayi	Trypsin family protein	0.0059	0.1174	0.2351
Echinococcus multilocularis	glycoprotein Antigen 5	0.0059	0.1174	0.1174
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.034	0.8095
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0027	0.044	0.3261
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0379	0.0536
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0379	0.2804
Brugia malayi	Importin beta-1 subunit	0.003	0.0519	0.104
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0004	0.0095
Loa Loa (eye worm)	carboxylesterase	0.0027	0.044	0.0623
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.0102	0.0102
Echinococcus granulosus	acetylcholinesterase	0.0158	0.338	0.338
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0063	0.0063
Loa Loa (eye worm)	hypothetical protein	0.001	0.0071	0.0101
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0004	0.0095
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.1043	0.209
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0059	0.1174	0.1174
Echinococcus multilocularis	dnaJ subfamily B	0.0454	1	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0004	0.0095
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0158	0.338	0.338
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0379	0.2566
Toxoplasma gondii	hypothetical protein	0.001	0.0063	0.0468
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0071	0.0101
Onchocerca volvulus		0.023	0.4991	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0379	0.2804
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0379	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0379	0.2804
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0027	0.044	0.0623
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0071	0.0071
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0059	0.1174	0.1174
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0379	0.2804
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.042	0.8102
Echinococcus multilocularis	geminin	0.0164	0.3505	0.3505
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0071	0.0071
Echinococcus granulosus	regulator of G protein signaling 7	0.001	0.0063	0.0063
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.023	0.4991	0.4991
Mycobacterium leprae	putative cytochrome p450	0.0011	0.0098	0.2594
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0071	0.0143
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0379	0.0759
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0071	0.0143
Onchocerca volvulus		0.0024	0.0379	0.0759
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0222	0.0222
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0027	0.044	0.3261
Schistosoma mansoni	cpg binding protein	0.0034	0.0596	0.0596
Leishmania major	hypothetical protein, conserved	0.0026	0.042	0.3113
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0979	0.1386
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0071	0.0071
Onchocerca volvulus		0.001	0.0071	0.0143
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0979	0.1961
Brugia malayi	hypothetical protein	0.001	0.0063	0.0127
Brugia malayi	Cytochrome P450 family protein	0.0053	0.1017	0.2038
Schistosoma mansoni	dishevelled	0.001	0.0063	0.0063
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0011	0.0098	0.0727
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0071	0.0071
Schistosoma mansoni	dishevelled	0.001	0.0063	0.0063
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.034	0.252
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0027	0.044	0.044
Brugia malayi	hypothetical protein	0.0059	0.1174	0.2351
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0011	0.0098	0.0727
Leishmania major	cytochrome p450-like protein	0.0011	0.0098	0.0727
Onchocerca volvulus		0.0027	0.044	0.0882
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0011	0.0098	0.0727
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0071	0.0071
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0379	0.2804
Brugia malayi	hypothetical protein	0.001	0.0063	0.0127
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0222	0.0446
Brugia malayi	Trypsin family protein	0.0059	0.1174	0.2351
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0071	0.0101
Loa Loa (eye worm)	carboxylesterase	0.0027	0.044	0.0623
Brugia malayi	Carboxylesterase family protein	0.0158	0.338	0.6773
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0243	0.1801
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0071	0.0071
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0027	0.044	0.0623
Echinococcus granulosus	cytochrome P450 2K1	0.0011	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0026	0.042	0.0595
Schistosoma mansoni	hypothetical protein	0.0017	0.0222	0.0222
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0071	0.0101
Toxoplasma gondii	aldehyde dehydrogenase	0.0067	0.135	1
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.001	0.0063	0.0127
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.002	0.002
Schistosoma mansoni	cytochrome P450	0.0011	0.0098	0.0098
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0011	0.0098	0.0727
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.034	0.034
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0011	0.0098	0.0727
Schistosoma mansoni	ran	0.0022	0.034	0.034
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0011	0.0098	0.0727
Schistosoma mansoni	cercarial elastase (S01 family)	0.0059	0.1174	0.1174
Echinococcus multilocularis	para nitrobenzyl esterase	0.0027	0.044	0.044
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0979	0.0979
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0379	0.2566
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0027	0.044	1
Echinococcus granulosus	snurportin 1	0.0323	0.7062	0.7062
Mycobacterium ulcerans	hypothetical protein	0.0059	0.1174	0.869
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0379	0.2804
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0379	0.2804
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.042	0.8102
Brugia malayi	DIX domain containing protein	0.001	0.0063	0.0127
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0068	0.1355	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0243	0.0344
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0027	0.044	0.044
Echinococcus granulosus	importin subunit beta 1	0.003	0.0519	0.0519
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0071	0.0071
Loa Loa (eye worm)	cytochrome P450 family protein	0.0053	0.1017	0.144
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0011	0.0098	0.0727
Trichomonas vaginalis	helicase, putative	0.0007	0.0004	0.0095
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0979	0.0979
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0059	0.1174	0.1174
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0379	0.2804
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0011	0.0098	0.2337
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0379	0.2804
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0158	0.338	0.4786
Brugia malayi	hypothetical protein	0.0017	0.0216	0.0432
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0221	0.1639
Schistosoma mansoni	transcription factor LCR-F1	0.0073	0.1476	0.1476
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0556	0.1114
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.135	0.135
Brugia malayi	Carboxylesterase family protein	0.0158	0.338	0.6773
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0663	0.0939
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0059	0.1174	0.1174
Echinococcus granulosus	BC026374 protein S09 family	0.0027	0.044	0.044
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0979	0.0979
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0222	0.0315
Brugia malayi	Carboxylesterase family protein	0.0027	0.044	0.0882
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0027	0.044	0.0623
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0071	0.0071
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0391	0.8879
Schistosoma mansoni	importin beta-1	0.003	0.0519	0.0519
Echinococcus granulosus	enteropeptidase	0.0059	0.1174	0.1174
Onchocerca volvulus		0.0059	0.1174	0.2351
Schistosoma mansoni	hypothetical protein	0.0164	0.3505	0.3505
Brugia malayi	Carboxylesterase family protein	0.0027	0.044	0.0882
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1174	0.1662
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0011	0.0098	0.0727
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0379	0.2804
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0067	0.135	0.135
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0071	0.0071
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0071	0.0071
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0027	0.044	0.044
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0011	0.0098	0.0727
Echinococcus multilocularis	regulator of G protein signaling 7	0.001	0.0063	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1174	0.1662
Leishmania major	cytochrome p450-like protein	0.0011	0.0098	0.0727
Loa Loa (eye worm)	hypothetical protein	0.003	0.0519	0.0735
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.023	0.4991	0.4991
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0391	0.93
Schistosoma mansoni	acetylcholinesterase	0.0027	0.044	0.044
Schistosoma mansoni	hypothetical protein	0.0073	0.1476	0.1476
Loa Loa (eye worm)	hypothetical protein	0.001	0.0063	0.009
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0004	0.0095
Echinococcus granulosus	cpg binding protein	0.0034	0.0596	0.0596
Trypanosoma cruzi	cytochrome P450, putative	0.0011	0.0098	0.2337
Entamoeba histolytica	hypothetical protein	0.0073	0.1476	1
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0011	0.0098	0.0727
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0071	0.0071
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0071	0.0143
Brugia malayi	hypothetical protein	0.0026	0.042	0.0842
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.034	0.6559
Brugia malayi	hypothetical protein	0.0027	0.044	0.0882
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.042	0.8102
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.002	0.002
Schistosoma mansoni	hypothetical protein	0.0323	0.7062	0.7062
Echinococcus granulosus	Pleckstrin G protein interacting region	0.001	0.0063	0.0063
Schistosoma mansoni	BC026374 protein (S09 family)	0.0027	0.044	0.044
Schistosoma mansoni	cercarial elastase (S01 family)	0.0059	0.1174	0.1174
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0071	0.0143
Trypanosoma cruzi	cytochrome P450, putative	0.0011	0.0098	0.2337
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0243	0.0344
Loa Loa (eye worm)	hypothetical protein	0.001	0.0063	0.009
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0221	0.1639
Loa Loa (eye worm)	hypothetical protein	0.001	0.0063	0.009
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0063	0.0063
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0004	0.0095
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0011	0.0098	0.0727
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0071	0.0071
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0519	0.0519
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0379	0.0759
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0071	0.0143
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0071	0.0143
Brugia malayi	cytochrome P450	0.0011	0.0098	0.0197
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0067	0.135	0.135
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0011	0.0098	0.0727
Echinococcus multilocularis	carboxylesterase 5A	0.0158	0.338	0.338
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.001	0.0063	0.009
Onchocerca volvulus		0.0059	0.1174	0.2351
Echinococcus multilocularis	cpg binding protein	0.0034	0.0596	0.0596
Schistosoma mansoni	cpg binding protein	0.0034	0.0596	0.0596
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0067	0.135	1
Entamoeba histolytica	hypothetical protein	0.0073	0.1476	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0059	0.1174	0.1174
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0011	0.0098	0.0727

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 705917